{"id":"https://openalex.org/W2902516645","doi":null,"title":"Application of pharmacometric methods to understand warfarin dose response","display_name":"Application of pharmacometric methods to understand warfarin dose response","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2902516645","mag":"2902516645"},"language":"en","primary_location":{"id":"pmh:oai:alma.64OTAGO_INST:11396906020001891","doi":null,"is_oa":true,"landing_page_url":"https://ourarchive.otago.ac.nz/esploro/outputs/doctoral/Application-of-pharmacometric-methods-to-understand/9926480103201891","pdf_url":"https://ourarchive.otago.ac.nz/view/delivery/64OTAGO_INST/12396906010001891/13397319140001891","source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ourarchive.otago.ac.nz/view/delivery/64OTAGO_INST/12396906010001891/13397319140001891","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040606475","display_name":"Qing Xi Ooi","orcid":"https://orcid.org/0000-0003-4310-9842","observed_orcids":["https://orcid.org/0000-0003-4310-9842"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Qing Xi Ooi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4310-9842","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5040606475"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.663100004196167,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.663100004196167,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.13819999992847443,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.12349999696016312,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.7409999966621399},{"id":"https://openalex.org/keywords/pharmacometrics","display_name":"pharmacometrics","score":0.48500001430511475},{"id":"https://openalex.org/keywords/international-normalized-ratio","display_name":"international normalized ratio","score":0.7929999828338623},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/coagulation-factors","display_name":"coagulation factors","score":0.8519999980926514},{"id":"https://openalex.org/keywords/coagulation-kinetics","display_name":"coagulation kinetics","score":0.9399999976158142},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.590166449546814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4301770329475403},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37105298042297363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18211179971694946},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0916847288608551}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:alma.64OTAGO_INST:11396906020001891","doi":null,"is_oa":true,"landing_page_url":"https://ourarchive.otago.ac.nz/esploro/outputs/doctoral/Application-of-pharmacometric-methods-to-understand/9926480103201891","pdf_url":"https://ourarchive.otago.ac.nz/view/delivery/64OTAGO_INST/12396906010001891/13397319140001891","source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral Thesis"},{"id":"pmh:oai:ourarchive.otago.ac.nz:10523/8613","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10523/8613","pdf_url":null,"source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},{"id":"mag:2902516645","doi":null,"is_oa":false,"landing_page_url":"https://ourarchive.otago.ac.nz/handle/10523/8613","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:alma.64OTAGO_INST:11396906020001891","doi":null,"is_oa":true,"landing_page_url":"https://ourarchive.otago.ac.nz/esploro/outputs/doctoral/Application-of-pharmacometric-methods-to-understand/9926480103201891","pdf_url":"https://ourarchive.otago.ac.nz/view/delivery/64OTAGO_INST/12396906010001891/13397319140001891","source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2902516645.pdf","grobid_xml":"https://content.openalex.org/works/W2902516645.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3197932802","https://openalex.org/W2885511764","https://openalex.org/W272287124","https://openalex.org/W2943502855","https://openalex.org/W1487136851","https://openalex.org/W2469696538","https://openalex.org/W3158746622","https://openalex.org/W2153736951","https://openalex.org/W4229731436","https://openalex.org/W2133225759"],"abstract_inverted_index":{"Existing":[0],"warfarin":[1,8,45,65,110,136,313,425,495],"dosing":[2],"methods":[3,102,429],"do":[4],"not":[5,521],"accurately":[6],"predict":[7],"maintenance":[9,496],"doses":[10],"for":[11,44,262,306,359,525],"patients":[12,353],"in":[13,78,86,393,468],"the":[14,30,33,56,61,81,87,105,109,120,133,164,180,190,198,211,220,251,272,276,280,293,297,300,307,323,378,381,389,402,405,411,421,458,476,488,492,540,551,556],"lower":[15],"or":[16],"upper":[17],"quartile":[18],"of":[19,32,42,51,74,89,95,122,135,171,213,253,282,288,299,309,322,362,383,404,457,478,494,528,545,555],"dose":[20,46,66,111,426,506],"requirements.":[21],"It":[22,265],"was":[23,54,98,129,186,222,266,314,330,341,365,371,448,530],"argued":[24],"that":[25,55,71,159,237,250,268,279,511],"this":[26,52,96,394,408,469],"is":[27,239,260,271],"related":[28],"to":[29,67,80,99,103,114,119,125,131,188,200,242,292,312,332,373,400,419,452,460,486,491,538,542,548,558],"use":[31,281,340,564],"international":[34],"normalised":[35],"ratio":[36],"(INR)":[37],"as":[38,285,431],"a":[39,72,116,202,206,228,286,318,355,357,369,472,505,513,523,543],"sole":[40],"marker":[41,287],"anticoagulation":[43,289],"individualisation.":[47],"The":[48,93,155,327,386,481],"overarching":[49],"premise":[50],"thesis":[53,97,395,470],"coagulation":[57,75,106,142,173,181,214,230,257,324,422],"proteins":[58,143,150,174,182,215],"are":[59],"on":[60,137,219,225,275,317,377,475],"causal":[62],"path":[63],"from":[64,227,345],"INR":[68,82,221,238,263,277],"response":[69,77,112,124,311,517],"and":[70,113,149,152,167,194,216,245,278,338,350,380,398,413,438,450,503,553,562],"measure":[73],"protein":[76,258],"addition":[79,291],"will":[83,195],"be":[84,197,333,485,537],"helpful":[85],"prediction":[88,121,298,308,328,477,493],"future":[90,534],"anticoagulant":[91,123,301,310,479],"response.":[92,427,480],"aim":[94],"apply":[100,539],"pharmacometric":[101,390,415],"understand":[104],"kinetics":[107,423],"underpinning":[108,388,424],"introduce":[115],"new":[117,203,473],"perspective":[118,474],"warfarin.\\n\\nA":[126],"joint":[127],"model":[128,363,434,563],"developed":[130,315],"quantify":[132],"influence":[134,212],"all":[138,179],"six":[139],"vitamin":[140],"K-dependent":[141],"(factors":[144],"II,":[145],"VII,":[146],"IX,":[147],"X,":[148],"C":[151],"S)":[153],"simultaneously.":[154],"full":[156],"correlation":[157],"structures":[158],"exist":[160],"between":[161,168],"parameters":[162],"at":[163],"individual":[165],"level":[166],"residual":[169],"errors":[170],"different":[172,559],"were":[175,396,417,441],"accounted":[176],"for.":[177],"Of":[178],"considered,":[183],"factor":[184,243,269,283,303,514],"VII":[185,244,270,284],"found":[187],"have":[189],"shortest":[191],"degradation":[192],"half-life":[193],"therefore":[196],"first":[199],"reach":[201],"steady-state":[204],"following":[205],"perturbation":[207],"introduced":[208],"by":[209],"warfarin.\\n\\nSubsequently,":[210],"their":[217],"interactions":[218],"explored":[223],"based":[224,316,376],"simulations":[226],"mechanistic":[229],"network":[231,325],"model.":[232,326],"A":[233,443],"sensitivity":[234,439],"analysis":[235,248,440],"revealed":[236],"most":[240,273],"sensitive":[241],"an":[246],"isobologram":[247,436],"demonstrated":[249],"presence":[252],"more":[254],"than":[255],"one":[256,346],"deficiencies":[259],"redundant":[261],"effect.":[264],"proposed":[267,372,406],"influential":[274],"(in":[290],"INR)":[294],"may":[295],"improve":[296],"response.\\n\\nA":[302],"VII-based":[304],"method":[305,329,447,459,490],"heuristic":[319,444],"model-order":[320,445],"reduction":[321,446],"shown":[331],"associated":[334],"with":[335],"minimal":[336],"bias":[337],"its":[339],"illustrated":[342],"using":[343],"data":[344],"typical":[347],"simulated":[348],"patient":[349],"two":[351],"real":[352],"supporting":[354],"proof-of-principle.\\n\\nFinally,":[356],"framework":[358,524,541,557],"systematic":[360,526],"evaluation":[361,527],"assumptions":[364,375,387,529],"developed.":[366],"In":[367],"particular,":[368],"flowchart":[370],"evaluate":[374],"impact":[379],"probability":[382],"assumption":[384],"violation.":[385],"analyses":[391,416],"presented":[392],"evaluated":[397],"used":[399],"illustrate":[401],"utility":[403,552],"framework.\\n\\nIn":[407],"thesis,":[409],"both":[410],"top-down":[412],"bottom-up":[414],"applied":[418],"explore":[420,550],"Standard":[428],"such":[430],"population":[432],"analysis,":[433,437],"simulations,":[435],"employed.":[442],"experimented":[449],"seemed":[451],"work":[453,466],"well":[454],"although":[455],"generalisation":[456],"other":[461,546],"settings":[462,547],"requires":[463],"prospective":[464],"testing.\\n\\nThe":[465],"conducted":[467],"offered":[471],"next":[482],"step":[483,535],"would":[484,499,536],"extend":[487],"current":[489],"dose.":[497],"This":[498],"require":[500],"setting":[501],"up":[502],"evaluating":[504],"individualisation":[507],"algorithm":[508],"(perhaps":[509],"Bayesian)":[510],"incorporates":[512],"VII-INR":[515],"bivariate":[516],"variable.":[518],"Last":[519],"but":[520],"least,":[522],"proposed.":[531],"An":[532],"important":[533],"series":[544],"fully":[549],"robustness":[554],"model-building":[560],"processes":[561],"settings.":[565]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2018-12-11T00:00:00"}