{"id":"https://openalex.org/W2902377348","doi":"https://doi.org/10.1038/s41467-018-07685-x","title":"CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages","display_name":"CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages","publication_year":2018,"publication_date":"2018-12-05","ids":{"openalex":"https://openalex.org/W2902377348","doi":"https://doi.org/10.1038/s41467-018-07685-x","mag":"2902377348","pmid":"https://pubmed.ncbi.nlm.nih.gov/30538245","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6290072"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-018-07685-x","doi":"https://doi.org/10.1038/s41467-018-07685-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-07685-x","pdf_url":"https://www.nature.com/articles/s41467-018-07685-x.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-018-07685-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038220662","display_name":"G\u00fclce It\u0131r Per\u00e7in","orcid":"https://orcid.org/0000-0002-3515-0434","observed_orcids":["https://orcid.org/0000-0002-3515-0434"]},"institutions":[{"id":"https://openalex.org/I4210127789","display_name":"Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)","ror":"https://ror.org/039a53269","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210127789"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gulce Itir Percin","raw_affiliation_strings":["Regeneration in Hematopoiesis and Animal Models in Hematopoiesis, Institute for Immunology, Fetscherstr. 74, 01307, Dresden, Germany","Regeneration in Hematopoiesis, Leibniz-Institute on Aging - Fritz-Lipmann-Institute (FLI), Beutenbergstrasse 11, 07745, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneration in Hematopoiesis and Animal Models in Hematopoiesis, Institute for Immunology, Fetscherstr. 74, 01307, Dresden, Germany","institution_ids":[]},{"raw_affiliation_string":"Regeneration in Hematopoiesis, Leibniz-Institute on Aging - Fritz-Lipmann-Institute (FLI), Beutenbergstrasse 11, 07745, Jena, Germany","institution_ids":["https://openalex.org/I4210127789"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055665904","display_name":"Ji\u0159\u00ed Eitler","orcid":"https://orcid.org/0000-0002-3175-2438","observed_orcids":["https://orcid.org/0000-0002-3175-2438"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiri Eitler","raw_affiliation_strings":["Regeneration in Hematopoiesis and Animal Models in Hematopoiesis, Institute for Immunology, Fetscherstr. 74, 01307, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneration in Hematopoiesis and Animal Models in Hematopoiesis, Institute for Immunology, Fetscherstr. 74, 01307, Dresden, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005157412","display_name":"Andrea Kranz","orcid":"https://orcid.org/0000-0002-7481-0220","observed_orcids":["https://orcid.org/0000-0002-7481-0220"]},"institutions":[{"id":"https://openalex.org/I4405272450","display_name":"Biotechnologisches Zentrum","ror":"https://ror.org/046b28292","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405272450","https://openalex.org/I4405279746","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrea Kranz","raw_affiliation_strings":["Genomics, Biotechnology Center, TU Dresden, BioInnovationsZentrum, Tatzberg 47-49, 01307, Dresden, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7481-0220","affiliations":[{"raw_affiliation_string":"Genomics, Biotechnology Center, TU Dresden, BioInnovationsZentrum, Tatzberg 47-49, 01307, Dresden, Germany","institution_ids":["https://openalex.org/I4405272450","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007296593","display_name":"Jun Fu","orcid":"https://orcid.org/0000-0002-5120-4674","observed_orcids":["https://orcid.org/0000-0002-5120-4674"]},"institutions":[{"id":"https://openalex.org/I4405272450","display_name":"Biotechnologisches Zentrum","ror":"https://ror.org/046b28292","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405272450","https://openalex.org/I4405279746","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jun Fu","raw_affiliation_strings":["Genomics, Biotechnology Center, TU Dresden, BioInnovationsZentrum, Tatzberg 47-49, 01307, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics, Biotechnology Center, TU Dresden, BioInnovationsZentrum, Tatzberg 47-49, 01307, Dresden, Germany","institution_ids":["https://openalex.org/I4405272450","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073221843","display_name":"Jeffrey W. Pollard","orcid":"https://orcid.org/0000-0003-4579-0053","observed_orcids":["https://orcid.org/0000-0003-4579-0053"]},"institutions":[{"id":"https://openalex.org/I2802581871","display_name":"Edinburgh Cancer Research","ror":"https://ror.org/05a7t9b67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I2802581871","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4210116174","display_name":"MRC Centre for Reproductive Health","ror":"https://ror.org/02f4tsf92","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210116174","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4210164624","display_name":"The Queen's Medical Research Institute","ror":"https://ror.org/059zxg644","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jeffrey W. Pollard","raw_affiliation_strings":["Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road S, Edinburgh, EH16 4TJ, Scotland, UK","MRC and University of Edinburgh Centre for Reproductive Health, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK"],"raw_orcid":"https://orcid.org/0000-0003-4579-0053","affiliations":[{"raw_affiliation_string":"Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road S, Edinburgh, EH16 4TJ, Scotland, UK","institution_ids":["https://openalex.org/I2802581871","https://openalex.org/I4210158898","https://openalex.org/I98677209"]},{"raw_affiliation_string":"MRC and University of Edinburgh Centre for Reproductive Health, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK","institution_ids":["https://openalex.org/I4210116174","https://openalex.org/I4210164624","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037975255","display_name":"Ronald Naumann","orcid":"https://orcid.org/0000-0003-2084-5150","observed_orcids":["https://orcid.org/0000-0003-2084-5150"]},"institutions":[{"id":"https://openalex.org/I4210159854","display_name":"Max Planck Institute of Molecular Cell Biology and Genetics","ror":"https://ror.org/05b8d3w18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210159854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ronald Naumann","raw_affiliation_strings":["Max Planck Institute of Molecular Cell Biology and Genetics, Transgenic Core Facility, Pfotenhauerstr. 108, 01307, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Molecular Cell Biology and Genetics, Transgenic Core Facility, Pfotenhauerstr. 108, 01307, Dresden, Germany","institution_ids":["https://openalex.org/I4210159854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091669415","display_name":"Claudia Waskow","orcid":"https://orcid.org/0000-0003-3261-0922","observed_orcids":["https://orcid.org/0000-0003-3261-0922"]},"institutions":[{"id":"https://openalex.org/I4210127789","display_name":"Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)","ror":"https://ror.org/039a53269","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210127789"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Claudia Waskow","raw_affiliation_strings":["Department of Medicine III, Faculty of Medicine, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. Claudia.Waskow@leibniz-fli.de","Faculty of Biological Sciences, Friedrich-Schiller University, F\u00fcrstengraben 1, 07743, Jena, Germany. Claudia.Waskow@leibniz-fli.de","Regeneration in Hematopoiesis and Animal Models in Hematopoiesis, Institute for Immunology, Fetscherstr. 74, 01307, Dresden, Germany. Claudia.Waskow@leibniz-fli.de","Regeneration in Hematopoiesis, Leibniz-Institute on Aging - Fritz-Lipmann-Institute (FLI), Beutenbergstrasse 11, 07745, Jena, Germany. Claudia.Waskow@leibniz-fli.de","Regeneration in Hematopoiesis, Leibniz-Institute on Aging \u2013 Fritz-Lipmann\u2212Institute (FLI), Beutenbergstrasse 11, 07745, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, Faculty of Medicine, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. Claudia.Waskow@leibniz-fli.de","institution_ids":["https://openalex.org/I78650965"]},{"raw_affiliation_string":"Faculty of Biological Sciences, Friedrich-Schiller University, F\u00fcrstengraben 1, 07743, Jena, Germany. Claudia.Waskow@leibniz-fli.de","institution_ids":["https://openalex.org/I76198965"]},{"raw_affiliation_string":"Regeneration in Hematopoiesis and Animal Models in Hematopoiesis, Institute for Immunology, Fetscherstr. 74, 01307, Dresden, Germany. Claudia.Waskow@leibniz-fli.de","institution_ids":[]},{"raw_affiliation_string":"Regeneration in Hematopoiesis, Leibniz-Institute on Aging - Fritz-Lipmann-Institute (FLI), Beutenbergstrasse 11, 07745, Jena, Germany. Claudia.Waskow@leibniz-fli.de","institution_ids":["https://openalex.org/I4210127789"]},{"raw_affiliation_string":"Regeneration in Hematopoiesis, Leibniz-Institute on Aging \u2013 Fritz-Lipmann\u2212Institute (FLI), Beutenbergstrasse 11, 07745, Jena, Germany","institution_ids":["https://openalex.org/I4210127789"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5091669415"],"corresponding_institution_ids":["https://openalex.org/I4210127789","https://openalex.org/I76198965","https://openalex.org/I78650965"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":0.9334,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.6960596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"5279","last_page":"5279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.524399995803833,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.524399995803833,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.18359999358654022,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.06239999830722809,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/csf1r","display_name":"CSF1R","score":0.9810000061988831},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.7549999952316284},{"id":"https://openalex.org/keywords/tissue-resident-macrophages","display_name":"tissue-resident macrophages","score":0.8349999785423279},{"id":"https://openalex.org/keywords/embryonic-macrophages","display_name":"embryonic macrophages","score":0.859000027179718},{"id":"https://openalex.org/keywords/flt3","display_name":"FLT3","score":0.7279999852180481},{"id":"https://openalex.org/keywords/macrophage-depletion","display_name":"macrophage depletion","score":0.6710000038146973},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.7760000228881836},{"id":"https://openalex.org/keywords/macrophage-differentiation","display_name":"macrophage differentiation","score":0.6570000052452087},{"id":"https://openalex.org/keywords/hematopoietic-differentiation","display_name":"hematopoietic differentiation","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.8249539732933044},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.7583616971969604},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7475378513336182},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5890031456947327},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.5847241878509521},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5825752019882202},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5415712594985962},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5179075598716736},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.45034828782081604},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4275052547454834},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3331281244754791},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24395433068275452},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.14869236946105957},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06640222668647766},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016187","descriptor_name":"Receptors, Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016187","descriptor_name":"Receptors, Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1038/s41467-018-07685-x","doi":"https://doi.org/10.1038/s41467-018-07685-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-07685-x","pdf_url":"https://www.nature.com/articles/s41467-018-07685-x.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5260818","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6290072","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30538245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30538245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6290072","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6290072/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07685-x","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-018-07685-x","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:26aa34f35e234e4680c9e47817ebef45","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/26aa34f35e234e4680c9e47817ebef45","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f4bcbee8645e4fb7bdd759d52c6660e9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f4bcbee8645e4fb7bdd759d52c6660e9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)","raw_type":"article"},{"id":"pmh:oai:frl.publisso.de:frl:6416107","doi":null,"is_oa":true,"landing_page_url":"https://www.nature.com/articles/s41467-018-07685-x#Sec17","pdf_url":null,"source":{"id":"https://openalex.org/S4306402606","display_name":"Informationszentrum Lebenswissenschaften (ZB MED)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210112663","host_organization_name":"ZB MED - Information Centre for Life Sciences","host_organization_lineage":["https://openalex.org/I4210112663"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, 9:5279","raw_type":"Zeitschriftenartikel"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/63ad267e-5ab5-4dd3-a334-4ae8560bc73d","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/files/77921741/s41467_018_07685_x.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Percin, G I, Eitler, J, Kranz, A, Fu, J, Pollard, J W, Naumann, R & Waskow, C 2018, 'CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages', Nature Communications, vol. 9, 5279. https://doi.org/10.1038/s41467-018-07685-x","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_3058740","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0003-F661-A","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature communications","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41467-018-07685-x","doi":"https://doi.org/10.1038/s41467-018-07685-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-07685-x","pdf_url":"https://www.nature.com/articles/s41467-018-07685-x.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.766700029373169}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1087379496","display_name":null,"funder_award_id":"FOR2033","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1510773004","display_name":null,"funder_award_id":"TRR127-A5","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1643668384","display_name":"The Metastatic Cascade: Macrophages Lead the Way.","funder_award_id":"101067","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G1957150380","display_name":"Integrated multi-dimensional molecular organ imaging","funder_award_id":"MR/K015710/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2646326828","display_name":"The Metastatic Cascade: Macrophages Lead the Way.","funder_award_id":"101067/Z/13/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3659755382","display_name":null,"funder_award_id":"WA2837/6-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4041648523","display_name":null,"funder_award_id":"TRR127","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5256814435","display_name":null,"funder_award_id":"FOR2033-A03","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6054008368","display_name":null,"funder_award_id":"WA2837","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7149438675","display_name":"MRC Centre for Reproductive Health at the University of Edinburgh","funder_award_id":"MR/N022556/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8109457359","display_name":null,"funder_award_id":"WA2837/7-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2902377348.pdf","grobid_xml":"https://content.openalex.org/works/W2902377348.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W78744612","https://openalex.org/W81291701","https://openalex.org/W1444346221","https://openalex.org/W1505372769","https://openalex.org/W1588611448","https://openalex.org/W1643834408","https://openalex.org/W1859780204","https://openalex.org/W1948478725","https://openalex.org/W1971833736","https://openalex.org/W1975820522","https://openalex.org/W2004207939","https://openalex.org/W2010876644","https://openalex.org/W2014035331","https://openalex.org/W2023666964","https://openalex.org/W2029275169","https://openalex.org/W2031603575","https://openalex.org/W2033242304","https://openalex.org/W2035213168","https://openalex.org/W2044224359","https://openalex.org/W2054581136","https://openalex.org/W2054843370","https://openalex.org/W2065338876","https://openalex.org/W2066707761","https://openalex.org/W2069891658","https://openalex.org/W2079822769","https://openalex.org/W2087101282","https://openalex.org/W2089477918","https://openalex.org/W2090685407","https://openalex.org/W2092743770","https://openalex.org/W2096692079","https://openalex.org/W2100820895","https://openalex.org/W2102857621","https://openalex.org/W2114675972","https://openalex.org/W2117276705","https://openalex.org/W2121004230","https://openalex.org/W2125403801","https://openalex.org/W2133351125","https://openalex.org/W2141778874","https://openalex.org/W2142084466","https://openalex.org/W2142242761","https://openalex.org/W2145169299","https://openalex.org/W2161472648"],"related_works":["https://openalex.org/W2746360004","https://openalex.org/W2090685407","https://openalex.org/W1643834408","https://openalex.org/W2068824600","https://openalex.org/W2004207939","https://openalex.org/W2100067750","https://openalex.org/W1512832024","https://openalex.org/W7166123634","https://openalex.org/W2287335854","https://openalex.org/W2767952784"],"abstract_inverted_index":{"Regulatory":[0],"mechanisms":[1],"controlling":[2],"the":[3,71,80,101,116,141],"pool":[4,63],"size":[5,64],"of":[6,29,46,67,73,76,93,104,118,143],"spleen":[7,30,47,74,127],"dendritic":[8],"cells":[9],"(DC)":[10],"remain":[11],"incompletely":[12],"understood.":[13],"DCs":[14,48],"are":[15,98],"continuously":[16],"replenished":[17],"from":[18],"hematopoietic":[19,145],"stem":[20],"cells,":[21],"and":[22,38,43,58,79,120],"FLT3-mediated":[23],"signals":[24,69],"cell-intrinsically":[25],"regulate":[26],"homeostatic":[27],"expansion":[28],"DCs.":[31,94],"Here":[32],"we":[33,113],"show":[34,114],"that":[35,115,135],"combining":[36],"FLT3":[37],"CSF1R-deficiencies":[39],"results":[40,90],"in":[41,49,87,91,109],"specific":[42],"complete":[44],"abrogation":[45],"vivo.":[50],"Spatiotemporally":[51],"controlled":[52],"CSF1R":[53],"depletion":[54,83,108],"reveals":[55],"a":[56,131],"cell-extrinsic":[57],"non-hematopoietic":[59],"mechanism":[60],"for":[61,100,140],"DC":[62,105,119],"regulation.":[65],"Lack":[66],"CSF1R-mediated":[68],"impedes":[70],"differentiation":[72,117,142],"macrophages":[75,97],"embryonic":[77],"origin,":[78],"resulted":[81],"macrophage":[82],"during":[84],"development":[85],"or":[86],"adult":[88],"mice":[89],"loss":[92],"Moreover,":[95],"embryo-derived":[96],"important":[99,139],"physiologic":[102],"regeneration":[103,122],"after":[106],"activation-induced":[107],"situ.":[110],"In":[111],"summary,":[112],"their":[121],"relies":[123],"on":[124],"ontogenetically":[125],"distinct":[126],"macrophages,":[128],"thereby":[129],"providing":[130],"novel":[132],"regulatory":[133],"principle":[134],"may":[136],"also":[137],"be":[138],"other":[144],"cell":[146],"types.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-12-11T00:00:00"}