{"id":"https://openalex.org/W2902307291","doi":"https://doi.org/10.1093/ofid/ofy210.962","title":"1129. Targeted Voriconazole Prophylaxis in Heart Transplantation Recipients","display_name":"1129. Targeted Voriconazole Prophylaxis in Heart Transplantation Recipients","publication_year":2018,"publication_date":"2018-11-01","ids":{"openalex":"https://openalex.org/W2902307291","doi":"https://doi.org/10.1093/ofid/ofy210.962","mag":"2902307291"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofy210.962","doi":"https://doi.org/10.1093/ofid/ofy210.962","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofy210.962","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/ofid/ofy210.962","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101758357","display_name":"Michael Lin","orcid":"https://orcid.org/0000-0003-2992-6221","observed_orcids":["https://orcid.org/0000-0003-2992-6221","https://orcid.org/0000-0002-8275-7140"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Lin","raw_affiliation_strings":["Northwestern University Feinberg School of Medicine, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University Feinberg School of Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010714967","display_name":"Ignacio A. Echenique","orcid":"https://orcid.org/0000-0002-6301-0121","observed_orcids":["https://orcid.org/0000-0002-6301-0121"]},"institutions":[{"id":"https://openalex.org/I4210108700","display_name":"Cleveland Clinic Florida","ror":"https://ror.org/0155k7414","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4210108700"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ignacio Echenique","raw_affiliation_strings":["Infectious Diseases, Cleveland Clinic Florida, Weston, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Cleveland Clinic Florida, Weston, Florida","institution_ids":["https://openalex.org/I4210108700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046385947","display_name":"Michael Angarone","orcid":"https://orcid.org/0000-0002-3728-7864","observed_orcids":["https://orcid.org/0000-0002-3728-7864"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Angarone","raw_affiliation_strings":["Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003749205","display_name":"Allen S. Anderson","orcid":"https://orcid.org/0000-0001-7216-2613","observed_orcids":["https://orcid.org/0000-0001-7216-2613"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen Anderson","raw_affiliation_strings":["Cardiology, Northwestern University Feinberg School of Medicine and Bloom Cardiovascular Institute, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Northwestern University Feinberg School of Medicine and Bloom Cardiovascular Institute, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011913674","display_name":"Valentina Stosor","orcid":"https://orcid.org/0000-0002-0388-5460","observed_orcids":["https://orcid.org/0000-0002-0388-5460"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valentina Stosor","raw_affiliation_strings":["Infectious Diseases & Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases & Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4053,"currency":"USD","value_usd":4053},"apc_paid":{"value":4053,"currency":"USD","value_usd":4053},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"suppl_1","first_page":"S338","last_page":"S338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.05739999935030937,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voriconazole","display_name":"voriconazole","score":0.9179999828338623},{"id":"https://openalex.org/keywords/antifungal-prophylaxis","display_name":"antifungal prophylaxis","score":0.902999997138977},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/invasive-fungal-infections","display_name":"invasive fungal infections","score":0.9549999833106995},{"id":"https://openalex.org/keywords/thymoglobulin","display_name":"thymoglobulin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/basiliximab","display_name":"basiliximab","score":0.7990000247955322},{"id":"https://openalex.org/keywords/aspergillosis","display_name":"aspergillosis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/candidemia","display_name":"candidemia","score":0.8610000014305115},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6200000047683716},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.923429012298584},{"id":"https://openalex.org/C2777630719","wikidata":"https://www.wikidata.org/wiki/Q21006907","display_name":"Thymoglobulin","level":4,"score":0.741480827331543},{"id":"https://openalex.org/C2780690907","wikidata":"https://www.wikidata.org/wiki/Q412236","display_name":"Voriconazole","level":3,"score":0.612729549407959},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5419110059738159},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.49140918254852295},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4666459560394287},{"id":"https://openalex.org/C2776391196","wikidata":"https://www.wikidata.org/wiki/Q259626","display_name":"Aspergillosis","level":2,"score":0.4464697241783142},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.4354020953178406},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3467538356781006},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17988768219947815},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.13576728105545044},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.12687453627586365},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.08742266893386841},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/ofid/ofy210.962","doi":"https://doi.org/10.1093/ofid/ofy210.962","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofy210.962","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5239369","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6255345","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6255345","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6255345","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofy210.962","doi":"https://doi.org/10.1093/ofid/ofy210.962","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofy210.962","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2944232261","https://openalex.org/W2549715886","https://openalex.org/W2016311899","https://openalex.org/W3120396853","https://openalex.org/W2993957157","https://openalex.org/W2753911458","https://openalex.org/W2078306357","https://openalex.org/W3196045486","https://openalex.org/W2018323473","https://openalex.org/W4311793978"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,14,247],"use":[3,126,248],"of":[4,16,24,31,49,65,102,127,132,143,153,210,235,249],"antifungal":[5,250],"prophylaxis,":[6],"targeted":[7,25,68],"or":[8,135],"universal,":[9],"remains":[10],"controversial":[11],"and":[12,63,94,112,117,198,213,241,261],"unstudied.":[13],"goal":[15],"this":[17,219,227,264],"study":[18,48],"is":[19],"to":[20,56,59,258],"determine":[21,259],"the":[22,61,130],"role":[23],"voriconazole":[26],"prophylaxis":[27,251],"(VORI)":[28],"in":[29,71,129,162,207,263],"prevention":[30],"invasive":[32,183],"fungal":[33],"infections":[34],"(IFI)":[35],"after":[36,179,216],"heart":[37],"transplantation":[38],"(HT).":[39],"Methods":[40],"We":[41],"conducted":[42],"a":[43,150,232],"single-center,":[44],"prospective,":[45],"observational":[46],"cohort":[47],"276":[50],"HT":[51,74,217,253],"recipients":[52,75,164],"from":[53],"June":[54,72],"2005":[55],"April":[57],"2017":[58],"characterize":[60],"incidence":[62],"outcome":[64],"IFI":[66,86,215],"following":[67,125,237,252],"VORI.":[69],"Starting":[70],"2013,":[73],"with":[76,186],"thymoglobulin":[77,118],"(ATG)":[78],"treatment":[79],"received":[80,115,123],"VORI":[81,138,180,205,238],"for":[82,149],"3":[83],"months.":[84],"Probable/proven":[85],"were":[87,97,244],"defined":[88],"by":[89],"EORTC/MSG":[90],"criteria.":[91],"Descriptive":[92],"frequencies":[93],"univariate":[95],"analyses":[96],"performed.":[98],"Results":[99],"Mean":[100],"duration":[101,152],"follow-up":[103],"post-HT":[104,148,170],"was":[105,139],"1,165":[106],"days":[107,145,155,169],"(0\u20133,152":[108],"days).":[109,157],"149":[110],"(54%)":[111],"70":[113],"(25%)":[114],"basiliximab":[116],"induction,":[119],"respectively.":[120],"Thirty-one":[121],"(11%)":[122],"VORI,":[124],"ATG":[128],"setting":[131],"induction":[133],"(68%)":[134],"rejection":[136],"(32%).":[137],"started":[140],"at":[141,166],"median":[142],"6":[144],"(0\u20131,008":[146],"days)":[147],"mean":[151,167],"97":[154],"(5\u2013251":[156],"Overall,":[158],"23":[159,163],"IFIs":[160],"occurred":[161],"(8%)":[165],"283":[168],"(range":[171],"2\u20131,579":[172],"days),":[173],"including":[174],"seven":[175,182],"Aspergillus":[176],"(one":[177],"occurring":[178],"completion),":[181],"Candida":[184],"(five":[185],"candidemia),":[187],"two":[188,192,194],"Rhizopus,":[189],"one":[190,196,199],"Cunninghamella,":[191],"histoplasma,":[193],"blastomyces,":[195],"Cryptococcus,":[197],"multifocal":[200],"cutaneous":[201],"Alternaria.":[202],"Conclusion":[203],"Targeted":[204],"resulted":[206],"reduced":[208],"incidences":[209],"both":[211,257],"early":[212],"overall":[214],"although":[218],"did":[220],"not":[221,245],"reach":[222],"statistical":[223],"significance.":[224],"Since":[225],"instituting":[226],"strategy,":[228],"we":[229],"have":[230],"observed":[231],"single":[233],"case":[234],"aspergillosis":[236],"discontinuation.":[239],"Overall":[240],"1-year":[242],"mortality":[243],"impacted.":[246],"requires":[254],"continued":[255],"investigation":[256],"efficacy":[260],"toxicity":[262],"patient":[265],"population.":[266],"Disclosures":[267],"All":[268],"authors:":[269],"No":[270],"reported":[271],"disclosures.":[272]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2018-12-11T00:00:00"}
