{"id":"https://openalex.org/W2902199239","doi":"https://doi.org/10.1515/cclm-2018-1111","title":"Making new biomarkers a reality: the case of serum human epididymis protein 4","display_name":"Making new biomarkers a reality: the case of serum human epididymis protein 4","publication_year":2018,"publication_date":"2018-12-04","ids":{"openalex":"https://openalex.org/W2902199239","doi":"https://doi.org/10.1515/cclm-2018-1111","mag":"2902199239","pmid":"https://pubmed.ncbi.nlm.nih.gov/30511925"},"language":"en","primary_location":{"id":"doi:10.1515/cclm-2018-1111","doi":"https://doi.org/10.1515/cclm-2018-1111","is_oa":true,"landing_page_url":"https://doi.org/10.1515/cclm-2018-1111","pdf_url":"https://www.degruyter.com/downloadpdf/journals/cclm/57/9/article-p1284.pdf","source":{"id":"https://openalex.org/S124948411","display_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","issn_l":"1434-6621","issn":["1434-6621","1437-4331"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.degruyter.com/downloadpdf/journals/cclm/57/9/article-p1284.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007224605","display_name":"Simona Ferraro","orcid":"https://orcid.org/0000-0002-6733-4166","observed_orcids":["https://orcid.org/0000-0002-6733-4166"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210087773","display_name":"Luigi Sacco Hospital","ror":"https://ror.org/0025g8755","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087773","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Simona Ferraro","raw_affiliation_strings":["Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d , University of Milan , Milan , Italy","UOC Patologia Clinica, Ospedale \u201cLuigi Sacco\u201d , Via GB Grassi 74 , 20157 Milano , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d , University of Milan , Milan , Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"UOC Patologia Clinica, Ospedale \u201cLuigi Sacco\u201d , Via GB Grassi 74 , 20157 Milano , Italy","institution_ids":["https://openalex.org/I4210087773"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085613233","display_name":"Mauro Panteghini","orcid":"https://orcid.org/0000-0002-7147-3433","observed_orcids":["https://orcid.org/0000-0002-7147-3433","https://orcid.org/0000-0002-0078-5026"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mauro Panteghini","raw_affiliation_strings":["Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d , University of Milan , Milan , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d , University of Milan , Milan , Italy","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007224605"],"corresponding_institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210087773"],"apc_list":{"value":2400,"currency":"EUR","value_usd":2712},"apc_paid":null,"fwci":0.4119,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.42878533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"57","issue":"9","first_page":"1284","last_page":"1294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/he4","display_name":"HE4","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9459999799728394},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.906000018119812},{"id":"https://openalex.org/keywords/ca125","display_name":"CA125","score":0.8529999852180481},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.8790000081062317},{"id":"https://openalex.org/keywords/diagnostic-performance","display_name":"diagnostic performance","score":0.6269999742507935},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.8960000276565552},{"id":"https://openalex.org/keywords/reference-change-value","display_name":"reference change value","score":0.7549999952316284},{"id":"https://openalex.org/keywords/assay-harmonization","display_name":"assay harmonization","score":0.656000018119812},{"id":"https://openalex.org/keywords/biomarker-implementation","display_name":"biomarker implementation","score":0.5649999976158142},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2781254305","wikidata":"https://www.wikidata.org/wiki/Q1973610","display_name":"Epididymis","level":3,"score":0.8395485877990723},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4419613480567932},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.28459078073501587},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.06434297561645508}],"mesh":[{"descriptor_ui":"D000081102","descriptor_name":"WAP Four-Disulfide Core Domain Protein 2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000081102","descriptor_name":"WAP Four-Disulfide Core Domain Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018394","descriptor_name":"CA-125 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018394","descriptor_name":"CA-125 Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1515/cclm-2018-1111","doi":"https://doi.org/10.1515/cclm-2018-1111","is_oa":true,"landing_page_url":"https://doi.org/10.1515/cclm-2018-1111","pdf_url":"https://www.degruyter.com/downloadpdf/journals/cclm/57/9/article-p1284.pdf","source":{"id":"https://openalex.org/S124948411","display_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","issn_l":"1434-6621","issn":["1434-6621","1437-4331"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","raw_type":"journal-article"},{"id":"pmid:30511925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30511925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry and laboratory medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1515/cclm-2018-1111","doi":"https://doi.org/10.1515/cclm-2018-1111","is_oa":true,"landing_page_url":"https://doi.org/10.1515/cclm-2018-1111","pdf_url":"https://www.degruyter.com/downloadpdf/journals/cclm/57/9/article-p1284.pdf","source":{"id":"https://openalex.org/S124948411","display_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","issn_l":"1434-6621","issn":["1434-6621","1437-4331"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2902199239.pdf","grobid_xml":"https://content.openalex.org/works/W2902199239.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W97046790","https://openalex.org/W106756114","https://openalex.org/W1524991052","https://openalex.org/W1596171810","https://openalex.org/W1824917436","https://openalex.org/W1952350108","https://openalex.org/W1963767225","https://openalex.org/W1967696143","https://openalex.org/W1967743734","https://openalex.org/W1983275362","https://openalex.org/W1987603108","https://openalex.org/W1991253654","https://openalex.org/W1993609204","https://openalex.org/W1995011038","https://openalex.org/W1998142983","https://openalex.org/W2002852242","https://openalex.org/W2013607579","https://openalex.org/W2023428885","https://openalex.org/W2026288233","https://openalex.org/W2028632016","https://openalex.org/W2036740908","https://openalex.org/W2037412915","https://openalex.org/W2050643656","https://openalex.org/W2056357003","https://openalex.org/W2063913275","https://openalex.org/W2071020286","https://openalex.org/W2071165397","https://openalex.org/W2071541869","https://openalex.org/W2072102325","https://openalex.org/W2072676529","https://openalex.org/W2072942199","https://openalex.org/W2078985953","https://openalex.org/W2086250674","https://openalex.org/W2086757750","https://openalex.org/W2090081190","https://openalex.org/W2091903670","https://openalex.org/W2095385418","https://openalex.org/W2099745794","https://openalex.org/W2102518179","https://openalex.org/W2103333940","https://openalex.org/W2117275438","https://openalex.org/W2118672901","https://openalex.org/W2124345906","https://openalex.org/W2125498283","https://openalex.org/W2127162013","https://openalex.org/W2127936928","https://openalex.org/W2128104740","https://openalex.org/W2129355295","https://openalex.org/W2131627402","https://openalex.org/W2132244795","https://openalex.org/W2135844005","https://openalex.org/W2135936215","https://openalex.org/W2150523860","https://openalex.org/W2152261493","https://openalex.org/W2153190986","https://openalex.org/W2153392280","https://openalex.org/W2160061958","https://openalex.org/W2163298590","https://openalex.org/W2164890175","https://openalex.org/W2274101897","https://openalex.org/W2318467812","https://openalex.org/W2326951125","https://openalex.org/W2327006789","https://openalex.org/W2330621998","https://openalex.org/W2336126572","https://openalex.org/W2475260219","https://openalex.org/W2528072415","https://openalex.org/W2740404645","https://openalex.org/W2759661650","https://openalex.org/W2885715636","https://openalex.org/W3035130918","https://openalex.org/W4210987384","https://openalex.org/W6649691557","https://openalex.org/W6807962703","https://openalex.org/W7073640948"],"related_works":["https://openalex.org/W1963767225","https://openalex.org/W2612952911","https://openalex.org/W2365661089","https://openalex.org/W1015835296","https://openalex.org/W2885715636","https://openalex.org/W1983275362","https://openalex.org/W2035325680","https://openalex.org/W4286265307","https://openalex.org/W2350933529","https://openalex.org/W2351779927"],"abstract_inverted_index":{"Background":[0],"Measurement":[1],"of":[2,20,44,55,83,91,100,107,130,134,152,162],"human":[3],"epididymis":[4],"protein":[5],"4":[6],"(HE4)":[7],"in":[8,17,69,87,211],"serum":[9],"has":[10,111,156],"recently":[11],"been":[12],"proposed":[13],"for":[14,120,145,183,190],"clinical":[15,33,38,222],"use":[16],"the":[18,28,32,42,48,88,108,125,128,131,150,159,163,168,185,198,205],"framework":[19],"ovarian":[21],"cancer":[22],"(OvCa).":[23],"We":[24,177],"sought":[25],"to":[26,78,167,219],"retrace":[27],"translational":[29],"phase":[30],"and":[31,40,50,97,102,187,197,204],"implementation":[34],"steps":[35],"boosting":[36],"HE4's":[37,121,153],"value":[39,171],"discuss":[41],"effects":[43],"its":[45,217],"introduction":[46],"on":[47],"diagnostic":[49,85,94,122,146],"management":[51],"pathways.":[52],"Methods":[53],"Meta-analyses":[54],"running":[56],"evidence":[57],"have":[58],"preliminarily":[59],"suggested":[60],"that":[61,76,113,158,200,207],"HE4":[62,179],"may":[63],"overcome":[64],"carbohydrate":[65],"antigen":[66],"125":[67],"(CA125)":[68],"identifying":[70],"OvCa,":[71,92],"showing":[72],"however":[73],"several":[74],"gaps":[75],"need":[77],"be":[79,173,202,209],"considered,":[80],"i.e.":[81],"definition":[82],"biomarker":[84,164,194,215],"performance":[86],"early":[89],"detection":[90],"added":[93],"value,":[95],"biological":[96,154],"lifestyle":[98],"factors":[99,110],"variation,":[101],"optimal":[103],"interpretative":[104],"criteria.":[105],"Investigation":[106],"influencing":[109],"shown":[112],"renal":[114],"impairment":[115],"represents":[116],"a":[117,192,195,213],"major":[118],"limitation":[119],"power.":[123],"On":[124],"other":[126],"hand,":[127],"demonstration":[129],"substantial":[132],"equivalence":[133],"results":[135],"obtained":[136],"by":[137],"commercially":[138],"available":[139],"assays":[140],"allows":[141],"recommending":[142],"harmonized":[143],"thresholds":[144],"purpose,":[147],"even":[148],"if":[149],"study":[151],"variation":[155],"clarified":[157],"longitudinal":[160],"interpretation":[161],"changes":[165],"according":[166],"reference":[169],"change":[170],"could":[172],"more":[174],"appropriate.":[175],"Summary":[176],"used":[178],"as":[180],"an":[181,220],"example":[182],"describing":[184],"long":[186],"bumpy":[188],"road":[189],"making":[191],"new":[193],"reality,":[196],"issues":[199],"should":[201,208],"checked":[203],"information":[206],"provided":[210],"moving":[212],"novel":[214],"from":[216],"discovery":[218],"effective":[221],"adoption.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-12-11T00:00:00"}