{"id":"https://openalex.org/W2902139089","doi":"https://doi.org/10.1016/j.phrs.2018.11.038","title":"Clinical evidence on the effects of saffron (Crocus sativus L.) on cardiovascular risk factors: A systematic review meta-analysis","display_name":"Clinical evidence on the effects of saffron (Crocus sativus L.) on cardiovascular risk factors: A systematic review meta-analysis","publication_year":2018,"publication_date":"2018-11-28","ids":{"openalex":"https://openalex.org/W2902139089","doi":"https://doi.org/10.1016/j.phrs.2018.11.038","mag":"2902139089","pmid":"https://pubmed.ncbi.nlm.nih.gov/30502528"},"language":"en","primary_location":{"id":"doi:10.1016/j.phrs.2018.11.038","doi":"https://doi.org/10.1016/j.phrs.2018.11.038","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phrs.2018.11.038","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084345017","display_name":"Makan Pourmasoumi","orcid":"https://orcid.org/0000-0001-9335-7276","observed_orcids":["https://orcid.org/0000-0001-9335-7276"]},"institutions":[{"id":"https://openalex.org/I204331812","display_name":"Guilan University of Medical Sciences","ror":"https://ror.org/04ptbrd12","country_code":"IR","type":"education","lineage":["https://openalex.org/I204331812","https://openalex.org/I4210110574"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Makan Pourmasoumi","raw_affiliation_strings":["Gastrointestinal & Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Rasht, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal & Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Rasht, Iran","institution_ids":["https://openalex.org/I204331812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000739995","display_name":"Amir Hadi","orcid":"https://orcid.org/0000-0001-9952-6579","observed_orcids":["https://orcid.org/0000-0001-9952-6579"]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Amir Hadi","raw_affiliation_strings":["Halal Research Center of IRI, FDA, Tehran, Iran; School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: amirhadi.vnt@gmail.com","Halal Research Center of IRI, FDA, Tehran, Iran","School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Halal Research Center of IRI, FDA, Tehran, Iran; School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: amirhadi.vnt@gmail.com","institution_ids":["https://openalex.org/I114982161"]},{"raw_affiliation_string":"Halal Research Center of IRI, FDA, Tehran, Iran","institution_ids":[]},{"raw_affiliation_string":"School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000295058","display_name":"Ameneh Najafgholizadeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799282979","display_name":"Islamic Azad University, Isfahan","ror":"https://ror.org/039zhhm92","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I2799282979"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ameneh Najafgholizadeh","raw_affiliation_strings":["Department of Microbiology, Naein Branch, Islamic Azad University Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Naein Branch, Islamic Azad University Isfahan, Iran","institution_ids":["https://openalex.org/I2799282979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057189417","display_name":"Marzieh Kafeshani","orcid":"https://orcid.org/0000-0002-2564-3999","observed_orcids":["https://orcid.org/0000-0002-2564-3999"]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Marzieh Kafeshani","raw_affiliation_strings":["School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036163332","display_name":"Amirhossein Sahebkar","orcid":"https://orcid.org/0000-0002-8656-1444","observed_orcids":["https://orcid.org/0000-0002-8656-1444","https://orcid.org/0000-0003-1747-8353"]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Amirhossein Sahebkar","raw_affiliation_strings":["Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: sahebkara@mums.ac.ir","Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran","Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran","School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: sahebkara@mums.ac.ir","institution_ids":["https://openalex.org/I165560825"]},{"raw_affiliation_string":"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]},{"raw_affiliation_string":"Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]},{"raw_affiliation_string":"School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000739995","https://openalex.org/A5036163332"],"corresponding_institution_ids":["https://openalex.org/I114982161","https://openalex.org/I165560825"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":null,"fwci":0.8188,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.68516162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"139","issue":null,"first_page":"348","last_page":"359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12742","display_name":"Sunflower and Safflower Cultivation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saffron","display_name":"saffron","score":1.0},{"id":"https://openalex.org/keywords/crocin","display_name":"crocin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.9860000014305115},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.9070000052452087},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.6639999747276306},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.7789999842643738},{"id":"https://openalex.org/keywords/fasting-insulin","display_name":"fasting insulin","score":0.6869999766349792},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.8759999871253967},{"id":"https://openalex.org/keywords/waist-circumference","display_name":"waist circumference","score":0.972000002861023},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2779571273","wikidata":"https://www.wikidata.org/wiki/Q15041677","display_name":"Crocus sativus","level":2,"score":0.8185229301452637},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8029016852378845},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6643102169036865},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6071678400039673},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.6039197444915771},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.5668092370033264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5632421374320984},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.5501410365104675},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.46838217973709106},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.44635307788848877},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.42448654770851135},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.4154992997646332},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.25779300928115845},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2268458604812622}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027622","descriptor_name":"Crocus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phrs.2018.11.038","doi":"https://doi.org/10.1016/j.phrs.2018.11.038","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phrs.2018.11.038","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},{"id":"pmid:30502528","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30502528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W93767886","https://openalex.org/W877877802","https://openalex.org/W1483936248","https://openalex.org/W1523272844","https://openalex.org/W1551506091","https://openalex.org/W1572968453","https://openalex.org/W1579760457","https://openalex.org/W1598602811","https://openalex.org/W1929294451","https://openalex.org/W1979710076","https://openalex.org/W1980753124","https://openalex.org/W1980911687","https://openalex.org/W1982258148","https://openalex.org/W1983531446","https://openalex.org/W1988595128","https://openalex.org/W2010408706","https://openalex.org/W2017979197","https://openalex.org/W2032612125","https://openalex.org/W2032737645","https://openalex.org/W2033623725","https://openalex.org/W2042123130","https://openalex.org/W2053164513","https://openalex.org/W2060032799","https://openalex.org/W2077623476","https://openalex.org/W2087604724","https://openalex.org/W2098923148","https://openalex.org/W2107328434","https://openalex.org/W2113082026","https://openalex.org/W2116343833","https://openalex.org/W2117247600","https://openalex.org/W2121541511","https://openalex.org/W2133712260","https://openalex.org/W2152804188","https://openalex.org/W2157823046","https://openalex.org/W2158102204","https://openalex.org/W2161356218","https://openalex.org/W2163933399","https://openalex.org/W2212528403","https://openalex.org/W2236919306","https://openalex.org/W2310963599","https://openalex.org/W2323094312","https://openalex.org/W2589191583","https://openalex.org/W2603623680","https://openalex.org/W2607124959","https://openalex.org/W2734761617","https://openalex.org/W2741443301","https://openalex.org/W2742824155","https://openalex.org/W2743820880","https://openalex.org/W2751846068","https://openalex.org/W2766786287","https://openalex.org/W2767339377","https://openalex.org/W2767375938","https://openalex.org/W2778535823","https://openalex.org/W2782827488","https://openalex.org/W2783131083","https://openalex.org/W2789012263","https://openalex.org/W2790606056","https://openalex.org/W2790671378","https://openalex.org/W2792738479","https://openalex.org/W2794052542","https://openalex.org/W2810309731","https://openalex.org/W2886383626","https://openalex.org/W2894894696","https://openalex.org/W2991792334","https://openalex.org/W4212792302","https://openalex.org/W4294215472","https://openalex.org/W4362504902","https://openalex.org/W6701080054"],"related_works":["https://openalex.org/W4311937971","https://openalex.org/W3195930115","https://openalex.org/W3024296281","https://openalex.org/W4289730974","https://openalex.org/W2898691375","https://openalex.org/W2955531293","https://openalex.org/W2555392920","https://openalex.org/W3005204519","https://openalex.org/W2999116155","https://openalex.org/W3132310069"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-12-11T00:00:00"}