{"id":"https://openalex.org/W2902019191","doi":"https://doi.org/10.1002/bmc.4452","title":"Analysis of sialic acid levels in Chinese intravenous immunoglobulins by high\u2010performance liquid chromatography with fluorescence detection","display_name":"Analysis of sialic acid levels in Chinese intravenous immunoglobulins by high\u2010performance liquid chromatography with fluorescence detection","publication_year":2018,"publication_date":"2018-12-04","ids":{"openalex":"https://openalex.org/W2902019191","doi":"https://doi.org/10.1002/bmc.4452","mag":"2902019191","pmid":"https://pubmed.ncbi.nlm.nih.gov/30513136"},"language":"en","primary_location":{"id":"doi:10.1002/bmc.4452","doi":"https://doi.org/10.1002/bmc.4452","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bmc.4452","pdf_url":null,"source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Li Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Ma","raw_affiliation_strings":["Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100631740","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0002-8583-3540","observed_orcids":["https://orcid.org/0000-0002-8583-3540"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mingxia Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingxia Hou","raw_affiliation_strings":["Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100407396","display_name":"Dong Li","orcid":"https://orcid.org/0000-0002-0331-6022","observed_orcids":["https://orcid.org/0000-0002-0331-6022"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Li","raw_affiliation_strings":["Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058685500","display_name":"Fengjuan Liu","orcid":"https://orcid.org/0000-0001-9187-3146","observed_orcids":["https://orcid.org/0000-0001-9187-3146"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengjuan Liu","raw_affiliation_strings":["Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103106858","display_name":"Xi Du","orcid":"https://orcid.org/0000-0002-4290-5460","observed_orcids":["https://orcid.org/0000-0002-4290-5460"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Du","raw_affiliation_strings":["Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050191122","display_name":"Peng Jiang","orcid":"https://orcid.org/0000-0001-6081-6288","observed_orcids":["https://orcid.org/0000-0001-6081-6288"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Jiang","raw_affiliation_strings":["Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022528379","display_name":"Zongkui Wang","orcid":"https://orcid.org/0000-0002-5764-7660","observed_orcids":["https://orcid.org/0000-0002-5764-7660"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zongkui Wang","raw_affiliation_strings":["Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034880722","display_name":"Rong Zhang","orcid":"https://orcid.org/0000-0003-4480-7191","observed_orcids":["https://orcid.org/0000-0003-4480-7191"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Zhang","raw_affiliation_strings":["Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101959925","display_name":"Haijun Cao","orcid":"https://orcid.org/0000-0003-1176-2468","observed_orcids":["https://orcid.org/0000-0003-1176-2468"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haijun Cao","raw_affiliation_strings":["Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015754392","display_name":"Shengliang Ye","orcid":"https://orcid.org/0000-0003-4477-3075","observed_orcids":["https://orcid.org/0000-0003-4477-3075"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shengliang Ye","raw_affiliation_strings":["Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China"],"raw_orcid":"https://orcid.org/0000-0003-4477-3075","affiliations":[{"raw_affiliation_string":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025012785","display_name":"Changqing Li","orcid":"https://orcid.org/0009-0004-2330-2228","observed_orcids":["https://orcid.org/0009-0004-2330-2228","https://orcid.org/0000-0002-9826-7744"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changqing Li","raw_affiliation_strings":["Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China","institution_ids":["https://openalex.org/I200296433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015754392","https://openalex.org/A5025012785"],"corresponding_institution_ids":["https://openalex.org/I200296433"],"apc_list":{"value":3710,"currency":"USD","value_usd":3710},"apc_paid":null,"fwci":0.0793,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.39032274,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"33","issue":"4","first_page":"e4452","last_page":"e4452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0406000018119812,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sialic-acid","display_name":"sialic acid","score":0.9800000190734863},{"id":"https://openalex.org/keywords/igg-sialylation","display_name":"IgG sialylation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/manufacturer-variation","display_name":"manufacturer variation","score":0.5260000228881836},{"id":"https://openalex.org/keywords/sialic-acid-release","display_name":"sialic acid release","score":0.7310000061988831},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.828000009059906},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2780115458","wikidata":"https://www.wikidata.org/wiki/Q419311","display_name":"Sialic acid","level":2,"score":0.9443972706794739},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.840249240398407},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.714036226272583},{"id":"https://openalex.org/C2779832904","wikidata":"https://www.wikidata.org/wiki/Q410420","display_name":"Papain","level":3,"score":0.5438748598098755},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.4926672577857971},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.47582224011421204},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.46273335814476013},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41819053888320923},{"id":"https://openalex.org/C2778671442","wikidata":"https://www.wikidata.org/wiki/Q310828","display_name":"N-Acetylneuraminic acid","level":3,"score":0.41287389397621155},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1939416527748108},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13044053316116333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08866432309150696}],"mesh":[{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016756","descriptor_name":"Immunoglobulins, Intravenous","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016756","descriptor_name":"Immunoglobulins, Intravenous","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D016756","descriptor_name":"Immunoglobulins, Intravenous","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019158","descriptor_name":"N-Acetylneuraminic Acid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/bmc.4452","doi":"https://doi.org/10.1002/bmc.4452","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bmc.4452","pdf_url":null,"source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},{"id":"pmid:30513136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30513136","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical chromatography : BMC","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323137","display_name":"Chinese Academy of Medical Sciences","ror":"https://ror.org/03cve4549"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W62151259","https://openalex.org/W1517709340","https://openalex.org/W1559576006","https://openalex.org/W1803163648","https://openalex.org/W1826144049","https://openalex.org/W1964112957","https://openalex.org/W1969600685","https://openalex.org/W1969892170","https://openalex.org/W1975345897","https://openalex.org/W1990225524","https://openalex.org/W2013842692","https://openalex.org/W2035433348","https://openalex.org/W2038079301","https://openalex.org/W2040373810","https://openalex.org/W2051118090","https://openalex.org/W2054139190","https://openalex.org/W2170456754","https://openalex.org/W2318324794","https://openalex.org/W2388731933","https://openalex.org/W2532518078","https://openalex.org/W2778963731","https://openalex.org/W2784158647","https://openalex.org/W4233238190"],"related_works":["https://openalex.org/W7096626868","https://openalex.org/W1969892170","https://openalex.org/W1538969863","https://openalex.org/W1975345897","https://openalex.org/W2017239895","https://openalex.org/W2144721017","https://openalex.org/W2032419556","https://openalex.org/W2178191916","https://openalex.org/W1559576006","https://openalex.org/W2160241845"],"abstract_inverted_index":{"Intravenous":[0],"immunoglobulin":[1],"(IVIg)":[2],"is":[3],"increasingly":[4],"used":[5],"for":[6],"the":[7,33,48,70,102,109,115,133,150,180,183],"treatment":[8],"of":[9,47,73,154,175],"autoimmune":[10],"and":[11,18,27,51,78,89,132,157,179,190],"systemic":[12],"inflammatory":[13],"diseases":[14],"with":[15,32,37,98],"both":[16],"licensed":[17],"off-label":[19],"indications.":[20],"Recent":[21],"studies":[22],"indicated":[23],"that":[24,114],"IVIg-mediated":[25],"immunomodulation":[26],"anti-inflammation":[28],"are":[29],"closely":[30],"associated":[31],"IgG":[34,38,49],"sialylation,":[35],"especially":[36],"crystallizable":[39],"fragment":[40],"(Fc)":[41],"sialylation.":[42],"The":[43,64,82,111],"sialic":[44,83,103,116,134,151,184],"acid":[45,84,104,117,135,152,185],"levels":[46,85,118,136,153,186],"molecules":[50],"Fc":[52,65,87,138,158],"fragments":[53,66,88,139,159],"in":[54,86,119,137,187,194],"12":[55],"IVIg":[56,90,121,155,177,188],"preparations":[57,91,122,156,178,189],"from":[58,69,108,124,141,160],"six":[59],"Chinese":[60,120,162,176],"manufacturers":[61],"were":[62,67,92,106,140,164],"evaluated.":[63],"derived":[68],"papain":[71],"digestion":[72],"IVIg,":[74],"followed":[75],"by":[76,94],"affinity":[77],"size":[79],"exclusion":[80],"chromatography.":[81],"determined":[93],"high-performance":[95],"liquid":[96],"chromatography":[97],"fluorescence":[99],"detection,":[100],"after":[101],"residues":[105],"released":[107],"proteins.":[110],"results":[112],"showed":[113],"ranged":[123],"0.875":[125],"(mol/mol":[126,130,143,147],"IgG)":[127],"to":[128,145,171],"1.085":[129],"IgG),":[131],"0.321":[142],"Fc)":[144],"0.361":[146],"Fc).":[148],"Furthermore,":[149],"different":[161],"manufactures":[163],"significantly":[165],"different.":[166],"These":[167],"findings":[168],"will":[169],"contribute":[170],"an":[172],"increased":[173],"understanding":[174],"relationship":[181],"between":[182],"their":[191],"clinical":[192,196],"efficacy":[193],"future":[195],"studies.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-12-11T00:00:00"}