{"id":"https://openalex.org/W2902018992","doi":"https://doi.org/10.3389/fendo.2018.00739","title":"Bioactivity of Thyroid Hormone Analogs at Cancer Cells","display_name":"Bioactivity of Thyroid Hormone Analogs at Cancer Cells","publication_year":2018,"publication_date":"2018-12-04","ids":{"openalex":"https://openalex.org/W2902018992","doi":"https://doi.org/10.3389/fendo.2018.00739","mag":"2902018992","pmid":"https://pubmed.ncbi.nlm.nih.gov/30564196","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6288194"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2018.00739","doi":"https://doi.org/10.3389/fendo.2018.00739","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2018.00739","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2018.00739/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fendo.2018.00739/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064680897","display_name":"Paul J. Davis","orcid":"https://orcid.org/0000-0002-6794-4917","observed_orcids":["https://orcid.org/0000-0002-6794-4917"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul J. Davis","raw_affiliation_strings":["Department of Medicine, Albany Medical College, Albany, NY, United States","Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Albany Medical College, Albany, NY, United States","institution_ids":["https://openalex.org/I4405260259"]},{"raw_affiliation_string":"Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, United States","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040532034","display_name":"Heng\u2010Yuan Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heng-Yuan Tang","raw_affiliation_strings":["Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, United States","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015342768","display_name":"Aleck A. Hercbergs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleck Hercbergs","raw_affiliation_strings":["Department of Radiation Oncology, The Cleveland Clinic, Cleveland, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The Cleveland Clinic, Cleveland, OH, United States","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067497938","display_name":"Hung\u2010Yun Lin","orcid":"https://orcid.org/0000-0003-2824-6419","observed_orcids":["https://orcid.org/0000-0003-2824-6419"]},"institutions":[{"id":"https://openalex.org/I2802331550","display_name":"Taipei Medical University Hospital","ror":"https://ror.org/03k0md330","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802331550"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hung-Yun Lin","raw_affiliation_strings":["PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan","TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan","Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan","Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I2802331550","https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058454020","display_name":"Kelly A. Keating","orcid":"https://orcid.org/0000-0002-1767-6379","observed_orcids":["https://orcid.org/0000-0002-1767-6379"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly A. Keating","raw_affiliation_strings":["Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, United States","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032045966","display_name":"Shaker A. Mousa","orcid":"https://orcid.org/0000-0002-9294-015X","observed_orcids":["https://orcid.org/0000-0002-9294-015X"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaker A. Mousa","raw_affiliation_strings":["Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, United States","institution_ids":["https://openalex.org/I365282"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5064680897"],"corresponding_institution_ids":["https://openalex.org/I365282","https://openalex.org/I4405260259"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.6341,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.55135952,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"739","last_page":"739"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.7827000021934509,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.7827000021934509,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.05299999937415123,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.05079999938607216,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-hormone-analogs","display_name":"thyroid hormone analogs","score":0.996999979019165},{"id":"https://openalex.org/keywords/thyroid-hormone-receptor","display_name":"thyroid hormone receptor","score":0.7580000162124634},{"id":"https://openalex.org/keywords/levothyroxine","display_name":"levothyroxine","score":0.7749999761581421},{"id":"https://openalex.org/keywords/reverse-t3","display_name":"reverse T3","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tetraiodothyroacetic-acid","display_name":"tetraiodothyroacetic acid","score":0.8970000147819519},{"id":"https://openalex.org/keywords/triiodothyroacetic-acid","display_name":"triiodothyroacetic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/integrin-alphavbeta3","display_name":"integrin \u03b1v\u03b23","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/anti-apoptotic-effects","display_name":"anti-apoptotic effects","score":0.8690000176429749},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.5759999752044678},{"id":"https://openalex.org/keywords/deiodination","display_name":"deiodination","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C109115496","wikidata":"https://www.wikidata.org/wiki/Q2539644","display_name":"Thyroid hormone receptor","level":3,"score":0.7560245394706726},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6658645272254944},{"id":"https://openalex.org/C2779074563","wikidata":"https://www.wikidata.org/wiki/Q3052031","display_name":"Thyronine","level":4,"score":0.6390013694763184},{"id":"https://openalex.org/C149574134","wikidata":"https://www.wikidata.org/wiki/Q18031987","display_name":"Thyroid hormone receptor beta","level":5,"score":0.62017822265625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6184834241867065},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5773240923881531},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5466492772102356},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5001187324523926},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.47526758909225464},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.455163836479187},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.45462632179260254},{"id":"https://openalex.org/C160860887","wikidata":"https://www.wikidata.org/wiki/Q18031986","display_name":"Thyroid hormone receptor alpha","level":5,"score":0.4390407204627991},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4376782178878784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4185987412929535},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.41520100831985474},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34416961669921875},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25304847955703735},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2478092908859253},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.2247341275215149},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12708312273025513},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0945512056350708},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.08248040080070496},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fendo.2018.00739","doi":"https://doi.org/10.3389/fendo.2018.00739","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2018.00739","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2018.00739/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5266652","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6288194","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6288194","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6288194","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmid:30564196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30564196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:dba30e9c711e43fcbc6dbc1d9a39b863","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dba30e9c711e43fcbc6dbc1d9a39b863","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 9 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2018.00739","doi":"https://doi.org/10.3389/fendo.2018.00739","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2018.00739","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2018.00739/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309500","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2902018992.pdf","grobid_xml":"https://content.openalex.org/works/W2902018992.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W183472924","https://openalex.org/W1987475341","https://openalex.org/W1991934428","https://openalex.org/W1999970915","https://openalex.org/W2004880381","https://openalex.org/W2017851065","https://openalex.org/W2021507484","https://openalex.org/W2021932599","https://openalex.org/W2022157317","https://openalex.org/W2023407585","https://openalex.org/W2026220243","https://openalex.org/W2026713030","https://openalex.org/W2036204980","https://openalex.org/W2048388145","https://openalex.org/W2052516480","https://openalex.org/W2073791430","https://openalex.org/W2076727003","https://openalex.org/W2080658243","https://openalex.org/W2107608192","https://openalex.org/W2110363029","https://openalex.org/W2123110143","https://openalex.org/W2132519082","https://openalex.org/W2147000598","https://openalex.org/W2153024016","https://openalex.org/W2153251628","https://openalex.org/W2158549224","https://openalex.org/W2162589718","https://openalex.org/W2286191259","https://openalex.org/W2477082431","https://openalex.org/W2512508208","https://openalex.org/W2593889687","https://openalex.org/W2606042615","https://openalex.org/W2621151172","https://openalex.org/W2768204243","https://openalex.org/W2792032047","https://openalex.org/W2795803098","https://openalex.org/W2888685985","https://openalex.org/W2905443703","https://openalex.org/W6607440475","https://openalex.org/W6713156166"],"related_works":["https://openalex.org/W3037068683","https://openalex.org/W3039108202","https://openalex.org/W35454281","https://openalex.org/W2979761477","https://openalex.org/W2132519082","https://openalex.org/W3176366999","https://openalex.org/W2888685985","https://openalex.org/W2106156583","https://openalex.org/W2997658791","https://openalex.org/W1996476040"],"abstract_inverted_index":{"In":[0,32,86,156],"the":[1,42,76,89,145,182],"context":[2],"of":[3,34,70,80,102,126,163,178,184],"genomic":[4,59],"thyroid":[5,18,94,103,129],"hormone":[6,19,95,104,130,142],"actions":[7,101],"in":[8,110],"normal":[9],"(noncancer)":[10],"cells":[11,115,119],"that":[12,175],"involve":[13],"primary":[14,146],"interactions":[15],"with":[16],"nuclear":[17,44],"receptors":[20],"(TRs),":[21],"L-thyroxine":[22],"(T4),":[23],"and":[24,54,116,120,140,143,159],"3,3',5'-triiodo-L-thyronine":[25],"(reverse":[26],"T3,":[27,81],"rT3)":[28],"have":[29,57,169],"little":[30],"bioactivity.":[31],"terms":[33],"TRs,":[35],"T4":[36,53,134,164],"is":[37,48,64,108,135,144],"a":[38,65,122,136],"prohormone":[39],"from":[40],"which":[41],"active":[43],"ligand,":[45],"3,5,3'-triido-L-thyronine":[46],"(T3),":[47],"generated":[49],"by":[50,113],"deiodination.":[51],"Deaminated":[52],"T3":[55],"metabolites":[56],"different":[58,124],"effects:":[60],"tetraiodothyroacetic":[61],"acid":[62,74,78],"(tetrac)":[63],"low":[66],"grade":[67],"thyromimetic":[68,84],"derivative":[69],"T4,":[71],"whereas":[72],"triiodothyroacetic":[73],"(triac),":[75],"acetic":[77],"metabolite":[79],"has":[82,121],"substantial":[83],"activity.":[85],"cancer":[87,114],"cells,":[88],"cell":[90],"surface":[91],"receptor":[92],"for":[93],"on":[96,181],"integrin":[97,107],"\u03b1v\u03b23":[98],"mediates":[99],"non-genomic":[100],"analogs.":[105,131],"The":[106],"expressed":[109],"large":[111],"measure":[112],"dividing":[117],"endothelial":[118],"substantially":[123],"panel":[125],"responses":[127],"to":[128],"At":[132],"\u03b1v\u03b23,":[133,166],"potent":[137],"proliferative,":[138],"anti-apoptotic":[139],"pro-angiogenic":[141],"ligand.":[147],"rT3":[148],"may":[149],"also":[150,168],"be":[151],"proliferative":[152],"at":[153,165,172],"this":[154,173],"site.":[155],"contrast,":[157],"tetrac":[158],"triac":[160],"are":[161,176],"antagonists":[162],"but":[167],"anticancer":[170],"properties":[171],"site":[174],"independent":[177],"their":[179],"effects":[180],"binding":[183],"T4.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-12-11T00:00:00"}