{"id":"https://openalex.org/W2901845656","doi":"https://doi.org/10.1002/dc.24118","title":"Cell block cellularity: A comparison of two fixatives and their impact on cellularity","display_name":"Cell block cellularity: A comparison of two fixatives and their impact on cellularity","publication_year":2018,"publication_date":"2018-11-23","ids":{"openalex":"https://openalex.org/W2901845656","doi":"https://doi.org/10.1002/dc.24118","mag":"2901845656","pmid":"https://pubmed.ncbi.nlm.nih.gov/30468311"},"language":"en","primary_location":{"id":"doi:10.1002/dc.24118","doi":"https://doi.org/10.1002/dc.24118","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dc.24118","pdf_url":null,"source":{"id":"https://openalex.org/S23314063","display_name":"Diagnostic Cytopathology","issn_l":"1097-0339","issn":["1097-0339","8755-1039"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diagnostic Cytopathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072814489","display_name":"Lester James Layfield","orcid":"https://orcid.org/0000-0003-1344-6506","observed_orcids":["https://orcid.org/0000-0003-1344-6506"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lester J. Layfield","raw_affiliation_strings":["Department of Pathology & Anatomical Sciences University of Missouri  Columbia Missouri"],"raw_orcid":"https://orcid.org/0000-0003-1344-6506","affiliations":[{"raw_affiliation_string":"Department of Pathology & Anatomical Sciences University of Missouri  Columbia Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084117084","display_name":"Magda Esebua","orcid":"https://orcid.org/0000-0001-5884-9603","observed_orcids":["https://orcid.org/0000-0001-5884-9603"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Magda Esebua","raw_affiliation_strings":["Department of Pathology & Anatomical Sciences University of Missouri  Columbia Missouri"],"raw_orcid":"https://orcid.org/0000-0001-5884-9603","affiliations":[{"raw_affiliation_string":"Department of Pathology & Anatomical Sciences University of Missouri  Columbia Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009419995","display_name":"Jonathan Ross Ang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Ang","raw_affiliation_strings":["Department of Internal Medicine, Division of Pulmonology University of Missouri  Columbia Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Pulmonology University of Missouri  Columbia Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030802266","display_name":"Mohammed M. Alnijoumi","orcid":"https://orcid.org/0000-0003-1135-2282","observed_orcids":["https://orcid.org/0000-0003-1135-2282"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammed M. Alnijoumi","raw_affiliation_strings":["Department of Internal Medicine, Division of Pulmonology University of Missouri  Columbia Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Pulmonology University of Missouri  Columbia Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042114500","display_name":"Harijyot S. Sohal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harijyot S. Sohal","raw_affiliation_strings":["Department of Internal Medicine, Division of Pulmonology University of Missouri  Columbia Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Pulmonology University of Missouri  Columbia Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028252532","display_name":"Richard Hammer","orcid":"https://orcid.org/0000-0002-7173-9414","observed_orcids":["https://orcid.org/0000-0002-7173-9414"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Hammer","raw_affiliation_strings":["Department of Pathology & Anatomical Sciences University of Missouri  Columbia Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Anatomical Sciences University of Missouri  Columbia Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004215937","display_name":"Nitya Prabhakaran","orcid":"https://orcid.org/0000-0001-6589-9422","observed_orcids":["https://orcid.org/0000-0001-6589-9422"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitya Prabhakaran","raw_affiliation_strings":["Department of Pathology & Anatomical Sciences University of Missouri  Columbia Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Anatomical Sciences University of Missouri  Columbia Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084151216","display_name":"Robert L. Schmidt","orcid":"https://orcid.org/0000-0003-4414-0139","observed_orcids":["https://orcid.org/0000-0003-4414-0139"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I61474668","display_name":"ARUP Laboratories (United States)","ror":"https://ror.org/00c2tyx86","country_code":"US","type":"company","lineage":["https://openalex.org/I61474668"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Schmidt","raw_affiliation_strings":["University of Utah and ARUP Laboratories  Salt Lake City Utah"],"raw_orcid":"https://orcid.org/0000-0003-4414-0139","affiliations":[{"raw_affiliation_string":"University of Utah and ARUP Laboratories  Salt Lake City Utah","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I61474668"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072814489"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":3920,"currency":"USD","value_usd":3920},"apc_paid":null,"fwci":0.5146,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.67444091,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"47","issue":"5","first_page":"417","last_page":"420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.5756999850273132,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.5756999850273132,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.10779999941587448,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.1006999984383583,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-block","display_name":"cell block","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cellularity","display_name":"cellularity","score":0.9710000157356262},{"id":"https://openalex.org/keywords/formalin-fixation","display_name":"formalin fixation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ancillary-testing","display_name":"ancillary testing","score":0.9089999794960022},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.847000002861023},{"id":"https://openalex.org/keywords/inter-rater-reliability","display_name":"inter-rater reliability","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cytological-specimens","display_name":"cytology specimens","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8045320510864258},{"id":"https://openalex.org/C2780848204","wikidata":"https://www.wikidata.org/wiki/Q3127040","display_name":"Fixative","level":3,"score":0.673876166343689},{"id":"https://openalex.org/C146249460","wikidata":"https://www.wikidata.org/wiki/Q2914991","display_name":"Fixation (population genetics)","level":3,"score":0.507902204990387},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.46283721923828125},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.44985848665237427},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.12245234847068787},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08909463882446289},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D005404","descriptor_name":"Fixatives","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005404","descriptor_name":"Fixatives","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D005557","descriptor_name":"Formaldehyde","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005557","descriptor_name":"Formaldehyde","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016707","descriptor_name":"Tissue Fixation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016707","descriptor_name":"Tissue Fixation","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/dc.24118","doi":"https://doi.org/10.1002/dc.24118","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dc.24118","pdf_url":null,"source":{"id":"https://openalex.org/S23314063","display_name":"Diagnostic Cytopathology","issn_l":"1097-0339","issn":["1097-0339","8755-1039"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diagnostic Cytopathology","raw_type":"journal-article"},{"id":"pmid:30468311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30468311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diagnostic cytopathology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W127198751","https://openalex.org/W1905773750","https://openalex.org/W1978236936","https://openalex.org/W1988804401","https://openalex.org/W2002036865","https://openalex.org/W2012208883","https://openalex.org/W2024997816","https://openalex.org/W2060784863","https://openalex.org/W2072412185","https://openalex.org/W2083344543","https://openalex.org/W2100038149","https://openalex.org/W2105022277","https://openalex.org/W2313456284","https://openalex.org/W2329111121","https://openalex.org/W2329165562","https://openalex.org/W2412547462","https://openalex.org/W2517713776","https://openalex.org/W2737532239","https://openalex.org/W2760846286","https://openalex.org/W2784956588"],"related_works":["https://openalex.org/W7055254110","https://openalex.org/W7169819567","https://openalex.org/W2888955968","https://openalex.org/W7090061423","https://openalex.org/W7131810314","https://openalex.org/W2518363449","https://openalex.org/W3099571043","https://openalex.org/W1514899824","https://openalex.org/W2006727908","https://openalex.org/W4309568846"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ancillary":[1,20],"testing":[2,21,56],"including":[3],"immunohistochemistry":[4],"and":[5,32,51,71,110,132,137],"molecular":[6],"diagnostics":[7],"has":[8],"become":[9],"an":[10],"increasingly":[11],"important":[12,23],"component":[13],"for":[14,26,30,42,79,93,98,107,123,134,189],"the":[15,52,105,115,135,144,157,176],"evaluation":[16],"of":[17,38,54,64,90,128,150,185],"cytologic":[18],"specimens.":[19],"is":[22],"not":[24],"only":[25],"diagnosis":[27],"but":[28],"also":[29],"predictive":[31],"prognostic":[33],"evaluation.":[34],"While":[35],"a":[36,165],"number":[37],"substrates":[39],"are":[40,48],"appropriate":[41],"ancillary":[43,55,190],"testing,":[44],"cell":[45,91,153,186],"block":[46],"specimens":[47],"commonly":[49],"utilized":[50],"success":[53],"depends":[57],"on":[58],"cell-block":[59],"cellularity.":[60,81],"METHODS:":[61],"Forty-six":[62],"pairs":[63],"cases":[65],"each":[66,74,94,99,108],"fixed":[67],"in":[68],"both":[69,124],"formalin":[70,138,158,166],"CytoLyt":[72,136,145,177],"were":[73,101],"analyzed":[75],"by":[76,103,156,175],"two":[77],"evaluators":[78],"overall":[80],"Linear":[82],"regression":[83],"was":[84,112,120,130],"used":[85],"to":[86,182],"assess":[87],"inter-rater":[88],"reliability":[89],"counts":[92],"method.":[95,159,178],"Cellularity":[96],"scores":[97,106],"case":[100],"obtained":[102],"averaging":[104],"rater":[109],"cellularity":[111,151,171,184],"compared":[113],"between":[114],"methods.":[116,125],"RESULTS:":[117],"Inter-rater":[118],"agreement":[119],"very":[121],"good":[122],"The":[126],"coefficient":[127],"determination":[129],"1.0":[131],"0.99":[133],"methods":[139],"respectively.":[140],"Cell":[141,161],"blocks":[142,154,162,187],"using":[143,164],"method":[146],"have":[147],"lower":[148],"levels":[149],"than":[152,172],"performed":[155],"CONCLUSIONS:":[160],"prepared":[163],"fixative":[167],"yield":[168],"significantly":[169],"greater":[170],"those":[173],"produced":[174],"Formalin":[179],"fixation":[180],"appears":[181],"optimize":[183],"useful":[188],"testing.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-11-29T00:00:00"}