{"id":"https://openalex.org/W2901836693","doi":"https://doi.org/10.1038/s41368-018-0037-7","title":"Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses","display_name":"Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses","publication_year":2018,"publication_date":"2018-11-12","ids":{"openalex":"https://openalex.org/W2901836693","doi":"https://doi.org/10.1038/s41368-018-0037-7","mag":"2901836693","pmid":"https://pubmed.ncbi.nlm.nih.gov/30420594","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6232154"},"language":"en","primary_location":{"id":"doi:10.1038/s41368-018-0037-7","doi":"https://doi.org/10.1038/s41368-018-0037-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41368-018-0037-7","pdf_url":"https://www.nature.com/articles/s41368-018-0037-7.pdf","source":{"id":"https://openalex.org/S44743489","display_name":"International Journal of Oral Science","issn_l":"1674-2818","issn":["1674-2818","2049-3169"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oral Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41368-018-0037-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081339318","display_name":"Susan Connolly Yost","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268108","display_name":"The Forsyth Institute","ror":"https://ror.org/05tr9gt18","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405268108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Yost","raw_affiliation_strings":["Forsyth Institute, 245 First Street, Cambridge, MA, 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Forsyth Institute, 245 First Street, Cambridge, MA, 02142, USA","institution_ids":["https://openalex.org/I4405268108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111539668","display_name":"Philip Stashenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Stashenko","raw_affiliation_strings":["Boston University Henry M. Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA, 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Henry M. Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA, 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082251851","display_name":"Yoon\u2010Hee Choi","orcid":"https://orcid.org/0000-0001-6651-7908","observed_orcids":["https://orcid.org/0000-0001-6651-7908"]},"institutions":[{"id":"https://openalex.org/I4405268108","display_name":"The Forsyth Institute","ror":"https://ror.org/05tr9gt18","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405268108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoonhee Choi","raw_affiliation_strings":["Forsyth Institute, 245 First Street, Cambridge, MA, 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Forsyth Institute, 245 First Street, Cambridge, MA, 02142, USA","institution_ids":["https://openalex.org/I4405268108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056842287","display_name":"Maria A. Kukuruzinska","orcid":"https://orcid.org/0000-0001-5314-1454","observed_orcids":["https://orcid.org/0000-0001-5314-1454"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Kukuruzinska","raw_affiliation_strings":["Boston University Henry M. Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA, 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Henry M. Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA, 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078229572","display_name":"Caroline Attardo Genco","orcid":"https://orcid.org/0000-0001-7772-4216","observed_orcids":["https://orcid.org/0000-0001-7772-4216"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline A. Genco","raw_affiliation_strings":["Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, 02111, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090831790","display_name":"Andrew Salama","orcid":"https://orcid.org/0000-0001-9712-3418","observed_orcids":["https://orcid.org/0000-0001-9712-3418"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Salama","raw_affiliation_strings":["Boston University Henry M. Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA, 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Henry M. Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA, 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061160552","display_name":"Ellen O. Weinberg","orcid":"https://orcid.org/0000-0002-6937-0371","observed_orcids":["https://orcid.org/0000-0002-6937-0371"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen O. Weinberg","raw_affiliation_strings":["Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, 02111, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044547146","display_name":"Carolyn D. Kramer","orcid":"https://orcid.org/0000-0002-0804-7407","observed_orcids":["https://orcid.org/0000-0002-0804-7407"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn D. Kramer","raw_affiliation_strings":["Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, 02111, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005883524","display_name":"Jorge Frias\u2010Lopez","orcid":"https://orcid.org/0000-0002-2097-3171","observed_orcids":["https://orcid.org/0000-0002-2097-3171"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jorge Frias-Lopez","raw_affiliation_strings":["Department of Oral Biology, College of Dentistry, University of Florida, 1395 Center Drive, Gainesville, FL, 32610-0424, USA. jfrias-lopez@dental.ufl.edu","Department of Oral Biology, College of Dentistry, University of Florida, 1395 Center Drive, Gainesville, FL, 32610-0424, USA"],"raw_orcid":"https://orcid.org/0000-0002-2097-3171","affiliations":[{"raw_affiliation_string":"Department of Oral Biology, College of Dentistry, University of Florida, 1395 Center Drive, Gainesville, FL, 32610-0424, USA. jfrias-lopez@dental.ufl.edu","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Oral Biology, College of Dentistry, University of Florida, 1395 Center Drive, Gainesville, FL, 32610-0424, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5005883524"],"corresponding_institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":7.9224,"has_fulltext":true,"cited_by_count":145,"citation_normalized_percentile":{"value":0.98292641,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"10","issue":"4","first_page":"32","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oral-microbiota","display_name":"oral microbiota","score":1.0},{"id":"https://openalex.org/keywords/metatranscriptomics","display_name":"metatranscriptomics","score":0.8289999961853027},{"id":"https://openalex.org/keywords/fusobacteria","display_name":"Fusobacteria","score":0.9229999780654907},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.8029999732971191},{"id":"https://openalex.org/keywords/microbial-gene-expression","display_name":"microbial gene expression","score":0.7269999980926514},{"id":"https://openalex.org/keywords/iron-transport","display_name":"iron transport","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tryptophanase","display_name":"tryptophanase","score":0.8399999737739563},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.8610000014305115},{"id":"https://openalex.org/keywords/capsule-biosynthesis","display_name":"capsule biosynthesis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/flagellar-biosynthesis","display_name":"flagellar biosynthesis","score":0.6990000009536743},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hemolysin","display_name":"hemolysin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/adhesins","display_name":"adhesins","score":0.9390000104904175},{"id":"https://openalex.org/keywords/reactive-nitrogen-intermediates","display_name":"reactive nitrogen intermediates","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.7802652716636658},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.7770761251449585},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.7071517705917358},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.579615592956543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5588245391845703},{"id":"https://openalex.org/C2910160754","wikidata":"https://www.wikidata.org/wiki/Q1500347","display_name":"Oral Microbiome","level":3,"score":0.5157013535499573},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.462518572807312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3319319486618042},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2512081265449524},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1796014904975891},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16989529132843018},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12672752141952515}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41368-018-0037-7","doi":"https://doi.org/10.1038/s41368-018-0037-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41368-018-0037-7","pdf_url":"https://www.nature.com/articles/s41368-018-0037-7.pdf","source":{"id":"https://openalex.org/S44743489","display_name":"International Journal of Oral Science","issn_l":"1674-2818","issn":["1674-2818","2049-3169"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oral Science","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5178822","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6232154","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6232154","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6232154","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Oral Sci","raw_type":"Text"},{"id":"pmid:30420594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30420594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oral science","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2418ee6abeb347adbe1b3b1c0379b9c1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2418ee6abeb347adbe1b3b1c0379b9c1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Oral Science, Vol 10, Iss 4, Pp 1-10 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41368-018-0037-7","doi":"https://doi.org/10.1038/s41368-018-0037-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41368-018-0037-7","pdf_url":"https://www.nature.com/articles/s41368-018-0037-7.pdf","source":{"id":"https://openalex.org/S44743489","display_name":"International Journal of Oral Science","issn_l":"1674-2818","issn":["1674-2818","2049-3169"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oral Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G8987244470","display_name":"Dysbiosis of the subgingival microbiome: host-microbial metatranscriptomic analysis during periodontal disease progression and post periodontal treatment","funder_award_id":"R01DE021553","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320309565","display_name":"Boston University","ror":"https://ror.org/05qwgg493"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2901836693.pdf","grobid_xml":"https://content.openalex.org/works/W2901836693.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W46714953","https://openalex.org/W656059578","https://openalex.org/W1479801019","https://openalex.org/W1757407923","https://openalex.org/W1787888625","https://openalex.org/W1819796515","https://openalex.org/W1862711637","https://openalex.org/W1909329119","https://openalex.org/W1941180513","https://openalex.org/W1968391680","https://openalex.org/W1969353942","https://openalex.org/W1969425863","https://openalex.org/W1974116356","https://openalex.org/W1991008356","https://openalex.org/W1996068858","https://openalex.org/W1996613294","https://openalex.org/W1998674591","https://openalex.org/W2003472128","https://openalex.org/W2006292369","https://openalex.org/W2010592372","https://openalex.org/W2015872545","https://openalex.org/W2016853666","https://openalex.org/W2019094601","https://openalex.org/W2021183792","https://openalex.org/W2025141680","https://openalex.org/W2033167804","https://openalex.org/W2035386751","https://openalex.org/W2044577523","https://openalex.org/W2058212785","https://openalex.org/W2062107099","https://openalex.org/W2063053479","https://openalex.org/W2065418645","https://openalex.org/W2072346832","https://openalex.org/W2072967720","https://openalex.org/W2080559907","https://openalex.org/W2080580603","https://openalex.org/W2088258525","https://openalex.org/W2096401930","https://openalex.org/W2102619694","https://openalex.org/W2102746137","https://openalex.org/W2106272164","https://openalex.org/W2107060225","https://openalex.org/W2107097628","https://openalex.org/W2108234281","https://openalex.org/W2110065044","https://openalex.org/W2115510752","https://openalex.org/W2120335773","https://openalex.org/W2121748291","https://openalex.org/W2133856765","https://openalex.org/W2140679462","https://openalex.org/W2143587740","https://openalex.org/W2144656526","https://openalex.org/W2146975236","https://openalex.org/W2148395963","https://openalex.org/W2148510247","https://openalex.org/W2151269016","https://openalex.org/W2155839154","https://openalex.org/W2156536854","https://openalex.org/W2157408188","https://openalex.org/W2157710407","https://openalex.org/W2159675211","https://openalex.org/W2161106528","https://openalex.org/W2171961740","https://openalex.org/W2191953568","https://openalex.org/W2235523093","https://openalex.org/W2236822143","https://openalex.org/W2239043016","https://openalex.org/W2327808934","https://openalex.org/W2342962563","https://openalex.org/W2386783987","https://openalex.org/W2524463122","https://openalex.org/W2524671679","https://openalex.org/W2534350753"],"related_works":["https://openalex.org/W3097218373","https://openalex.org/W2624171766","https://openalex.org/W3039126934","https://openalex.org/W2999829053","https://openalex.org/W2801050647","https://openalex.org/W4317786928","https://openalex.org/W4306879654","https://openalex.org/W2937753868","https://openalex.org/W4400214467","https://openalex.org/W4410595647"],"abstract_inverted_index":{"Oral":[0,269],"squamous":[1,270],"cell":[2,271],"carcinoma":[3,272],"(OSCC)":[4,273],"is":[5,17],"the":[6,21,24,32,47,70,104,110,144,154,217,223,231,240,252,287,300,303,308,320,336],"most":[7,10,253,337],"prevalent":[8],"and":[9,38,96,131,138,169,175,193,259,279,295,313,326,353],"commonly":[11],"studied":[12],"oral":[13,25,72,155,232,241,257],"cancer.":[14,370],"However,":[15],"there":[16],"a":[18,57,86,245,264,331],"void":[19],"regarding":[20],"role":[22,265,288],"that":[23,161,213,365],"microbiome":[26,49,73,233,242],"may":[27,215,262],"play":[28,263,291],"in":[29,50,69,74,119,136,153,199,225,230,266,286,292,307,324,345,355],"OSCC.":[30,358],"Although":[31,205],"relationship":[33],"between":[34],"microbial":[35,44,347,363],"community":[36,111],"composition":[37],"OSCC":[39,75,159,235],"has":[40,243,274],"been":[41,275],"thoroughly":[42],"investigated,":[43],"profiles":[45],"of":[46,61,91,99,109,149,202,227,234,239,247,256,302,310,322],"human":[48],"cancer":[51,100,203],"are":[52,207],"understudied.":[53],"Here":[54],"we":[55],"performed":[56],"small":[58],"pilot":[59],"study":[60],"community-wide":[62],"metatranscriptome":[63,332],"analysis":[64],"to":[65,76,103,143,164,277],"profile":[66],"mRNA":[67],"expression":[68,148,226],"entire":[71],"reveal":[77],"molecular":[78],"functions":[79],"associated":[80,157,184,250,368],"with":[81,158,185,251,315,349,357,369],"this":[82],"disease.":[83,120],"Fusobacteria":[84,214],"showed":[85,160],"statistically":[87],"significantly":[88],"higher":[89],"number":[90],"transcripts":[92],"at":[93,179,319],"tumour":[94,137,180],"sites":[95,98,201],"tumour-adjacent":[97,139],"patients":[101,356],"compared":[102,142],"healthy":[105,145,311],"controls":[106],"analysed.":[107],"Regardless":[108],"composition,":[112],"specific":[113],"metabolic":[114],"signatures":[115],"were":[116,134,177,196,366],"consistently":[117,367],"found":[118],"Activities":[121],"such":[122],"as":[123],"iron":[124,172],"ion":[125],"transport,":[126,173],"tryptophanase":[127],"activity,":[128],"peptidase":[129],"activities":[130,162,183,364],"superoxide":[132],"dismutase":[133],"over-represented":[135],"samples":[140],"when":[141],"controls.":[146],"The":[147,359],"putative":[150],"virulence":[151,228],"factors":[152,229],"communities":[156],"related":[163],"capsule":[165,194],"biosynthesis,":[166],"flagellum":[167],"synthesis":[168],"assembly,":[170],"chemotaxis,":[171,191],"haemolysins":[174],"adhesins":[176],"upregulated":[178,198],"sites.":[181],"Moreover,":[182],"protection":[186],"against":[187],"reactive":[188],"nitrogen":[189],"intermediates,":[190],"flagellar":[192],"biosynthesis":[195],"also":[197,361],"non-tumour":[200],"patients.":[204,236],"they":[206],"preliminary,":[208],"our":[209],"results":[210],"further":[211],"suggest":[212],"be":[216],"leading":[218],"phylogenetic":[219],"group":[220,246],"responsible":[221],"for":[222],"increase":[224],"A":[237],"search":[238],"revealed":[244,342],"bacteria":[248,289],"closely":[249],"common":[254],"type":[255],"cancer,":[258],"whose":[260],"activity":[261],"its":[267,293],"development.":[268],"linked":[276],"tobacco":[278],"alcohol":[280],"consumption,":[281],"but":[282],"there\u2019s":[283],"increasing":[284],"interest":[285],"might":[290],"initiation":[294],"growth.":[296],"To":[297],"better":[298],"understand":[299],"behaviour":[301],"various":[304],"microbes":[305],"present":[306],"mouths":[309],"people":[312],"those":[314],"OSCC,":[316],"Jorge":[317],"Frias-Lopez":[318],"University":[321],"Florida":[323],"Gainesville":[325],"his":[327],"colleagues":[328],"carried":[329],"out":[330],"analysis,":[333],"which":[334],"identifies":[335],"actively":[338],"expressed":[339],"genes.":[340],"This":[341],"significant":[343],"differences":[344],"their":[346],"communities,":[348],"Fusidobacteria":[350],"particularly":[351],"enriched":[352],"hyperactive":[354],"team":[360],"identified":[362]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-11-29T00:00:00"}
