{"id":"https://openalex.org/W2901790840","doi":"https://doi.org/10.1161/circgen.117.001907","title":"Tissue-Specific Differential Expression of Novel Genes and Long Intergenic Noncoding RNAs in Humans With Extreme Response to Evoked Endotoxemia","display_name":"Tissue-Specific Differential Expression of Novel Genes and Long Intergenic Noncoding RNAs in Humans With Extreme Response to Evoked Endotoxemia","publication_year":2018,"publication_date":"2018-11-01","ids":{"openalex":"https://openalex.org/W2901790840","doi":"https://doi.org/10.1161/circgen.117.001907","mag":"2901790840","pmid":"https://pubmed.ncbi.nlm.nih.gov/30571184","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6309423"},"language":"en","primary_location":{"id":"doi:10.1161/circgen.117.001907","doi":"https://doi.org/10.1161/circgen.117.001907","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circgen.117.001907","pdf_url":null,"source":{"id":"https://openalex.org/S4210202128","display_name":"Circulation Genomic and Precision Medicine","issn_l":"2574-8300","issn":["2574-8300"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation: Genomic and Precision Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6309423","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078392652","display_name":"Jane F. Ferguson","orcid":"https://orcid.org/0000-0001-6896-1025","observed_orcids":["https://orcid.org/0000-0001-6896-1025"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane F. Ferguson","raw_affiliation_strings":["Division of Cardiovascular Medicine, and Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC), Vanderbilt University Medical Center, Nashville, TN (J.F.F.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, and Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC), Vanderbilt University Medical Center, Nashville, TN (J.F.F.)","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022420096","display_name":"Chenyi Xue","orcid":"https://orcid.org/0000-0002-8829-7659","observed_orcids":["https://orcid.org/0000-0002-8829-7659"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenyi Xue","raw_affiliation_strings":["Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","Chenyi Xue Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Chenyi Xue Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101885519","display_name":"Yuanfeng Gao","orcid":"https://orcid.org/0000-0003-2130-2772","observed_orcids":["https://orcid.org/0000-0003-2130-2772"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I2800232565","display_name":"Beijing Chao-Yang Hospital, Capital Medical University","ror":"https://ror.org/01eff5662","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800232565","https://openalex.org/I4210110145","https://openalex.org/I4210135108"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yuanfeng Gao","raw_affiliation_strings":["Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","Department of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University, China (Y.G.)","Yuanfeng Gao Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.). Department of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University, China (Y.G.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Department of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University, China (Y.G.)","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2800232565"]},{"raw_affiliation_string":"Yuanfeng Gao Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.). Department of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University, China (Y.G.)","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2799503643","https://openalex.org/I2800232565"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tian Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118118575","display_name":"New Jersey Institute of Technology","ror":"https://ror.org/05e74xb87","country_code":"US","type":"education","lineage":["https://openalex.org/I118118575"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tian Tian","raw_affiliation_strings":["Department of Computer Science, New Jersey Institute of Technology, Newark (T.T., Z.W.)","Tian Tian Department of Computer Science, New Jersey Institute of Technology, Newark (T.T., Z.W.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, New Jersey Institute of Technology, Newark (T.T., Z.W.)","institution_ids":["https://openalex.org/I118118575"]},{"raw_affiliation_string":"Tian Tian Department of Computer Science, New Jersey Institute of Technology, Newark (T.T., Z.W.)","institution_ids":["https://openalex.org/I118118575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006789814","display_name":"Jianting Shi","orcid":"https://orcid.org/0000-0003-1558-7791","observed_orcids":["https://orcid.org/0000-0003-1558-7791"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianting Shi","raw_affiliation_strings":["Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","Jianting Shi Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Jianting Shi Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342886","display_name":"Xuan Zhang","orcid":"https://orcid.org/0000-0001-8775-1699","observed_orcids":["https://orcid.org/0000-0001-8775-1699"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuan Zhang","raw_affiliation_strings":["Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","Xuan Zhang Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Xuan Zhang Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100347228","display_name":"Ying Wang","orcid":"https://orcid.org/0000-0003-2873-7197","observed_orcids":["https://orcid.org/0000-0003-2873-7197"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","Ying Wang Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Ying Wang Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065229344","display_name":"Yuhuang D. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuhuang D. Li","raw_affiliation_strings":["Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","Yuhuang D. Li Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Yuhuang D. Li Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001916237","display_name":"Zhi Wei","orcid":"https://orcid.org/0000-0001-6059-4267","observed_orcids":["https://orcid.org/0000-0001-6059-4267"]},"institutions":[{"id":"https://openalex.org/I118118575","display_name":"New Jersey Institute of Technology","ror":"https://ror.org/05e74xb87","country_code":"US","type":"education","lineage":["https://openalex.org/I118118575"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhi Wei","raw_affiliation_strings":["Department of Computer Science, New Jersey Institute of Technology, Newark (T.T., Z.W.)","Zhi Wei Department of Computer Science, New Jersey Institute of Technology, Newark (T.T., Z.W.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, New Jersey Institute of Technology, Newark (T.T., Z.W.)","institution_ids":["https://openalex.org/I118118575"]},{"raw_affiliation_string":"Zhi Wei Department of Computer Science, New Jersey Institute of Technology, Newark (T.T., Z.W.)","institution_ids":["https://openalex.org/I118118575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001685590","display_name":"Mingyao Li","orcid":"https://orcid.org/0000-0003-2422-9494","observed_orcids":["https://orcid.org/0000-0003-2422-9494","https://orcid.org/0000-0001-8180-0621"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingyao Li","raw_affiliation_strings":["Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia (M.L.)","Mingyao Li Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia (M.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia (M.L.)","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Mingyao Li Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia (M.L.)","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036037952","display_name":"Hanrui Zhang","orcid":"https://orcid.org/0000-0001-8655-938X","observed_orcids":["https://orcid.org/0000-0001-8655-938X"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanrui Zhang","raw_affiliation_strings":["Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","Hanrui Zhang Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Hanrui Zhang Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026776682","display_name":"Muredach P. Reilly","orcid":"https://orcid.org/0000-0002-3035-9386","observed_orcids":["https://orcid.org/0000-0002-3035-9386"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muredach P. Reilly","raw_affiliation_strings":["Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.)","institution_ids":["https://openalex.org/I2799503643"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4293,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.58628043,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"11","first_page":"e001907","last_page":"e001907"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.6859999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.6859999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.07569999992847443,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lps-challenge","display_name":"lipopolysaccharide challenge","score":0.9580000042915344},{"id":"https://openalex.org/keywords/long-intergenic-noncoding-rna","display_name":"long intergenic non-coding RNA","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.8429999947547913},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.578000009059906},{"id":"https://openalex.org/keywords/cd14-monocytes","display_name":"CD14+ monocytes","score":0.8140000104904175},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.9559999704360962},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cardiometabolic-disease","display_name":"cardiometabolic disease","score":0.6629999876022339},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.3409999907016754}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8728140592575073},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7810683250427246},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6329572796821594},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5596418976783752},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5505573153495789},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.5399008393287659},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5042475461959839},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.47934064269065857},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.47333770990371704},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.46572965383529663},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4397476017475128},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43416187167167664},{"id":"https://openalex.org/C195139083","wikidata":"https://www.wikidata.org/wiki/Q3463539","display_name":"Intergenic region","level":4,"score":0.43414968252182007},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.40401044487953186},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.33473384380340576},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.17577487230300903},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12073755264282227}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1161/circgen.117.001907","doi":"https://doi.org/10.1161/circgen.117.001907","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circgen.117.001907","pdf_url":null,"source":{"id":"https://openalex.org/S4210202128","display_name":"Circulation Genomic and Precision Medicine","issn_l":"2574-8300","issn":["2574-8300"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation: Genomic and Precision Medicine","raw_type":"journal-article"},{"id":"pmid:30571184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30571184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation. Genomic and precision medicine","raw_type":"Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:6309423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6309423","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circ Genom Precis Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6309423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6309423","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circ Genom Precis Med","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G152020664","display_name":"Mentored Patient Oriented Research in Cardiometabolic Disease","funder_award_id":"K24HL107643","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2815439263","display_name":"Translational Studies of ADAMTS7 a Novel GWAS Locus for Coronary Atherosclerosis","funder_award_id":"R01HL111694","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4625334180","display_name":"Elucidation of Tissue-Specific Transcriptomic Profiles in Cardio-metabolic Disease","funder_award_id":"R01HL113147","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5359544430","display_name":"Institutional Clinical and Translational Science Award","funder_award_id":"UL1RR024134","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G742336583","display_name":"Lipids as Modulators of the Response to Vascular Injury","funder_award_id":"P50HL083799","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7895958283","display_name":"Macrophage-specific function of GWAS CAD-associated LIPA alleles in atherosclerosis","funder_award_id":"K99HL130574","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8566550471","display_name":null,"funder_award_id":"12POST11840017","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G8812780481","display_name":"Statistical Methods for Transcriptome Profiling Using RNA Sequencing","funder_award_id":"R01GM108600","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000878197","display_name":"University of Pennsylvania Diabetes Research Center","funder_award_id":"P30DK019525","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1597449789","https://openalex.org/W1978795069","https://openalex.org/W1979594866","https://openalex.org/W1986141384","https://openalex.org/W1996267694","https://openalex.org/W2005364235","https://openalex.org/W2040854989","https://openalex.org/W2044268463","https://openalex.org/W2076154138","https://openalex.org/W2079588819","https://openalex.org/W2092079568","https://openalex.org/W2097147259","https://openalex.org/W2113796986","https://openalex.org/W2116756227","https://openalex.org/W2128819433","https://openalex.org/W2130035132","https://openalex.org/W2133644362","https://openalex.org/W2133674589","https://openalex.org/W2135695964","https://openalex.org/W2136687565","https://openalex.org/W2154216508","https://openalex.org/W2154869618","https://openalex.org/W2156880688","https://openalex.org/W2159728803","https://openalex.org/W2160333540","https://openalex.org/W2162187760","https://openalex.org/W2162405407","https://openalex.org/W2279758515","https://openalex.org/W2320476296","https://openalex.org/W2338788418","https://openalex.org/W2401656403","https://openalex.org/W2409251372","https://openalex.org/W2423205648","https://openalex.org/W2511664109","https://openalex.org/W2532435486","https://openalex.org/W2538361155","https://openalex.org/W2556702335","https://openalex.org/W2570471359","https://openalex.org/W2571503386","https://openalex.org/W2593488635","https://openalex.org/W2605810679","https://openalex.org/W2768429801"],"related_works":["https://openalex.org/W2128819433","https://openalex.org/W111058280","https://openalex.org/W7064605763","https://openalex.org/W2604454241","https://openalex.org/W2128056463","https://openalex.org/W2016685400","https://openalex.org/W1861696557","https://openalex.org/W1196465514","https://openalex.org/W2162187760","https://openalex.org/W7097976349"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cytokine":[1],"responses":[2,86,150,293],"to":[3,54,91,169,179,265],"activation":[4],"of":[5,18,51,84,110,124,139,159,195,229,272,288],"innate":[6,289],"immunity":[7],"differ":[8],"between":[9,38,129,184],"individuals,":[10],"yet":[11],"the":[12,47,75,122,125,230],"genomic":[13],"and":[14,30,56,79,87,95,100,131,154,186,212,261,280,291],"tissue-specific":[15,28,160],"transcriptomic":[16],"determinants":[17],"inflammatory":[19,43,85,200,211],"responsiveness":[20],"are":[21],"not":[22,192,239],"well":[23],"understood.":[24],"We":[25,71,277],"hypothesized":[26],"that":[27,189,249,282],"mRNA":[29],"long":[31],"intergenic":[32],"noncoding":[33],"RNA":[34,89],"(lincRNA)":[35],"induction":[36],"differs":[37],"individuals":[39,73],"with":[40,134,198,210],"divergent":[41],"evoked":[42],"responses.":[44],"METHODS:":[45],"In":[46],"GENE":[48],"Study":[49],"(Genetics":[50],"Evoked":[52],"Response":[53],"Niacin":[55],"Endotoxemia),":[57],"we":[58,155,166,262],"performed":[59],"an":[60],"inpatient":[61],"endotoxin":[62],"challenge":[63],"(1":[64],"ng/kg":[65],"lipopolysaccharide":[66],"[LPS])":[67],"in":[68,74,121,145,215,236,240,245,259,294],"healthy":[69],"humans.":[70,295],"selected":[72],"top":[76,231],"(high":[77],"responders)":[78,82],"bottom":[80],"(low":[81],"extremes":[83],"applied":[88],"sequencing":[90],"CD14":[92],"monocytes":[93,247],"(N=15)":[94],"adipose":[96,241],"tissue":[97,149],"(N=25)":[98],"before":[99],"after":[101],"LPS":[102],"administration.":[103],"RESULTS:":[104],"Although":[105],"only":[106],"a":[107,135,157,193,223],"small":[108],"number":[109,138,158],"genes":[111,140,204],"were":[112,118,176,206],"differentially":[113,141,161,173],"expressed":[114,142,162,171,174,203],"at":[115],"baseline,":[116],"there":[117],"clear":[119],"differences":[120],"magnitude":[123],"transcriptional":[126],"response":[127],"post-LPS":[128],"high":[130,146],"low":[132],"responders,":[133],"far":[136],"greater":[137],"by":[143,234],"endotoxemia":[144,235],"responders.":[147],"Furthermore,":[148],"differed":[151],"during":[152],"inflammation,":[153],"found":[156],"lincRNAs":[163,175,196,232,281],"post-LPS,":[164],"which":[165],"validated.":[167],"Relative":[168],"nondifferentially":[170],"lincRNAs,":[172],"equally":[177],"likely":[178],"be":[180],"nonconserved":[181,224],"as":[182,267],"conserved":[183],"human":[185,199],"mouse,":[187],"indicating":[188],"conservation":[190],"is":[191,227],"predictor":[194],"associated":[197],"pathophysiology.":[201],"Differentially":[202],"also":[205],"enriched":[207],"for":[208,286],"signals":[209],"cardiometabolic":[213],"disease":[214],"published":[216],"genome-wide":[217],"association":[218],"studies.":[219],"CTB-41I6.2":[220],"(":[221,256,274],"AC002091.1),":[222],"human-specific":[225],"lincRNA,":[226],"one":[228],"regulated":[233],"monocytes,":[237,260],"but":[238],"tissue.":[242],"Knockdown":[243],"experiments":[244],"THP-1":[246],"suggest":[248],"this":[250,266],"lincRNA":[251,270],"enhances":[252],"LPS-induced":[253,269],"interleukin":[254],"6":[255],"IL6)":[257],"expression":[258],"now":[263],"refer":[264],"monocyte":[268],"regulator":[271],"IL6":[273],"MOLRIL6).":[275],"CONCLUSIONS:":[276],"highlight":[278],"mRNAs":[279],"represent":[283],"novel":[284],"candidates":[285],"modulation":[287],"immune":[290],"metabolic":[292],"CLINICAL":[296],"TRIAL":[297],"REGISTRATION:":[298],"URL:":[299],"https://www.clinicaltrials.gov":[300],".":[301],"Unique":[302],"identifier:":[303],"NCT00953667.":[304]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-11-29T00:00:00"}
