{"id":"https://openalex.org/W2901739227","doi":"https://doi.org/10.1093/ofid/ofy210.525","title":"516. Implementation of a Probiotic for the Primary Prevention of Hospital-Onset Clostridium difficile Infection","display_name":"516. Implementation of a Probiotic for the Primary Prevention of Hospital-Onset Clostridium difficile Infection","publication_year":2018,"publication_date":"2018-11-01","ids":{"openalex":"https://openalex.org/W2901739227","doi":"https://doi.org/10.1093/ofid/ofy210.525","mag":"2901739227"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofy210.525","doi":"https://doi.org/10.1093/ofid/ofy210.525","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofy210.525","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/ofid/ofy210.525","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000005791","display_name":"Kati Shihadeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801983979","display_name":"Denver Health Medical Center","ror":"https://ror.org/01fbz6h17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801983979"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kati Shihadeh","raw_affiliation_strings":["Acute Care Pharmacy, Denver Health Medical Center, Denver, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acute Care Pharmacy, Denver Health Medical Center, Denver, Colorado","institution_ids":["https://openalex.org/I2801983979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103132917","display_name":"Heather L. Young","orcid":"https://orcid.org/0000-0002-0706-5777","observed_orcids":["https://orcid.org/0000-0002-0706-5777"]},"institutions":[{"id":"https://openalex.org/I2801983979","display_name":"Denver Health Medical Center","ror":"https://ror.org/01fbz6h17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801983979"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Young","raw_affiliation_strings":["Infectious Diseases, Denver Health Medical Center, Denver, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Denver Health Medical Center, Denver, Colorado","institution_ids":["https://openalex.org/I2801983979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062751081","display_name":"Bryan C. Knepper","orcid":"https://orcid.org/0000-0002-4073-5955","observed_orcids":["https://orcid.org/0000-0002-4073-5955"]},"institutions":[{"id":"https://openalex.org/I2801983979","display_name":"Denver Health Medical Center","ror":"https://ror.org/01fbz6h17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801983979"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan Knepper","raw_affiliation_strings":["Patient Safety and Quality, Denver Health Medical Center, Denver, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Patient Safety and Quality, Denver Health Medical Center, Denver, Colorado","institution_ids":["https://openalex.org/I2801983979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064348185","display_name":"Robert Tapia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801983979","display_name":"Denver Health Medical Center","ror":"https://ror.org/01fbz6h17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801983979"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Tapia","raw_affiliation_strings":["Denver Health, Denver, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Denver Health, Denver, Colorado","institution_ids":["https://openalex.org/I2801983979"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088165121","display_name":"Timothy C Jenkins","orcid":"https://orcid.org/0000-0002-1029-7085","observed_orcids":["https://orcid.org/0000-0002-1029-7085"]},"institutions":[{"id":"https://openalex.org/I2801983979","display_name":"Denver Health Medical Center","ror":"https://ror.org/01fbz6h17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801983979"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy C Jenkins","raw_affiliation_strings":["Denver Health, Denver, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Denver Health, Denver, Colorado","institution_ids":["https://openalex.org/I2801983979"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801983979"],"apc_list":{"value":4053,"currency":"USD","value_usd":4053},"apc_paid":{"value":4053,"currency":"USD","value_usd":4053},"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"suppl_1","first_page":"S191","last_page":"S191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11000","display_name":"Infection Control in Healthcare","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clostridium-difficile-infection","display_name":"Clostridium difficile infection","score":0.9190000295639038},{"id":"https://openalex.org/keywords/hospital-onset-infection","display_name":"hospital-onset infection","score":0.8629999756813049},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.9210000038146973},{"id":"https://openalex.org/keywords/lactobacillus-acidophilus","display_name":"Lactobacillus acidophilus","score":0.8949999809265137},{"id":"https://openalex.org/keywords/lacticaseibacillus-casei","display_name":"Lactobacillus casei","score":0.9679999947547913},{"id":"https://openalex.org/keywords/lacticaseibacillus-rhamnosus","display_name":"Lactobacillus rhamnosus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/primary-prevention","display_name":"primary prevention","score":0.746999979019165},{"id":"https://openalex.org/keywords/antibiotic-associated-diarrhea","display_name":"antibiotic-associated diarrhea","score":0.6740000247955322},{"id":"https://openalex.org/keywords/best-practice-advisory","display_name":"best practice advisory","score":0.8349999785423279},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7549999952316284},{"id":"https://openalex.org/keywords/hospitalized-patients","display_name":"hospitalized patients","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9400793313980103},{"id":"https://openalex.org/C2994496256","wikidata":"https://www.wikidata.org/wiki/Q27031090","display_name":"Clostridium difficile","level":3,"score":0.814262330532074},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.6429184675216675},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5912021994590759},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5569333434104919},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5127571821212769},{"id":"https://openalex.org/C2779915187","wikidata":"https://www.wikidata.org/wiki/Q574891","display_name":"Antibiotic-associated diarrhea","level":4,"score":0.4276609420776367},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4166330099105835},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.41524410247802734},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.11771014332771301},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/ofid/ofy210.525","doi":"https://doi.org/10.1093/ofid/ofy210.525","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofy210.525","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5239188","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6255073","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6255073","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6255073","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofy210.525","doi":"https://doi.org/10.1093/ofid/ofy210.525","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofy210.525","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416997514","https://openalex.org/W2981402359","https://openalex.org/W4389565080","https://openalex.org/W2800004127","https://openalex.org/W2290844537","https://openalex.org/W1970561648","https://openalex.org/W3161965511","https://openalex.org/W3094959168","https://openalex.org/W4389545982","https://openalex.org/W2904801241"],"abstract_inverted_index":{"Hospital-onset":[0],"Clostridium":[1],"difficile":[2],"infection":[3],"(HO-CDI)":[4],"affects":[5],"over":[6],"100,000":[7],"patients":[8,128,149,193,214,251,275],"in":[9,127,155,181,188,247,274],"the":[10,45,50,67,117,121,146,156,167,278,284],"United":[11],"States":[12],"each":[13],"year.":[14,158],"Due":[15],"to":[16,43,74,87,90,113,134,255],"a":[17,25,34,55,80,106,174,196,216,298,303,311],"rising":[18],"rate":[19],"of":[20,39,49,58,69,148,190,208,219,286,297,314],"HO-CDI":[21,223],"at":[22,200],"Denver":[23],"Health,":[24],"multifaceted":[26,299],"CDI":[27,70,162,287,300],"prevention":[28,285],"plan":[29],"was":[30,42,85,125,145,153,186,245,306],"implemented":[31,86,288],"which":[32],"included":[33],"probiotic":[35,51,118,281,304],"intervention.":[36,52],"The":[37,109,123,142,178,222,257],"purpose":[38],"this":[40],"study":[41,57],"describe":[44],"implementation":[46],"and":[47,97,165,169,184,229,233,265,309],"uptake":[48],"This":[53],"is":[54],"retrospective":[56],"adult":[59],"inpatients":[60],"who":[61,129,194,276],"received":[62,195,252,277,308],"antibiotics":[63],"considered":[64],"high-risk":[65,107,197],"for":[66,105,150,199,211,215,225,283],"development":[68],"from":[71,120,261],"March":[72,75,78],"2017":[73],"2018.":[76],"In":[77],"2017,":[79],"Best":[81],"Practice":[82],"Advisory":[83],"(BPA)":[84],"advise":[88],"providers":[89,112],"order":[91,104,114],"Bio-K+":[92,152,185,209,253],"(L.":[93],"acidophilus,":[94],"L.":[95,98],"casei,":[96],"rhamnosus)":[99],"when":[100],"they":[101],"signed":[102],"an":[103],"antibiotic.":[108],"BPA":[110,124,179,290],"allowed":[111],"or":[115,138],"decline":[116],"directly":[119],"BPA.":[122],"suppressed":[126],"were":[130,205,231,260,269],"pregnant,":[131],"immunocompromised,":[132],"unable":[133],"take":[135],"oral":[136],"medications,":[137],"had":[139,291,310],"active":[140],"CDI.":[141],"primary":[143],"outcome":[144],"proportion":[147],"whom":[151],"prescribed":[154,210],"first":[157],"Secondary":[159],"outcomes":[160],"include":[161],"rates":[163,224],"before":[164],"after":[166],"intervention":[168,282,305],"adverse":[170,316],"events":[171],"defined":[172],"as":[173],"positive":[175,258,271],"Lactobacillus":[176,244],"culture.":[177,256],"fired":[180],"3,840":[182],"cases,":[183],"ordered":[187],"94.8%":[189],"these.":[191],"For":[192],"antibiotic":[198],"least":[201],"24":[202],"hours,":[203],"there":[204],"2,636":[206],"courses":[207],"2,324":[212],"unique":[213],"median":[217],"duration":[218],"3":[220],"days.":[221],"1":[226],"year":[227],"pre-":[228],"postintervention":[230],"0.75":[232],"0.60":[234],"cases":[235],"per":[236],"1,000":[237],"patient":[238],"days,":[239],"respectively":[240],"(P":[241],"=":[242],"0.16).":[243],"cultured":[246],"11":[248],"patients;":[249],"five":[250],"prior":[254],"cultures":[259,273],"abdominal":[262],"fluid":[263],"(4)":[264],"sputum":[266],"(1).":[267],"There":[268],"no":[270],"blood":[272],"probiotic.":[279],"A":[280],"via":[289],"excellent":[292],"provider":[293],"uptake.":[294],"As":[295],"part":[296],"action":[301],"plan,":[302],"well":[307],"low":[312],"risk":[313],"serious":[315],"events.":[317],"Figure":[318,322],"1.":[319,321],"Table":[320],"2.":[323],"All":[324],"authors:":[325],"No":[326],"reported":[327],"disclosures.":[328]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2018-11-29T00:00:00"}