{"id":"https://openalex.org/W2901737279","doi":"https://doi.org/10.1111/jgs.15577","title":"Association Between Functional Performance and Alzheimer's Disease Biomarkers in Individuals Without Dementia","display_name":"Association Between Functional Performance and Alzheimer's Disease Biomarkers in Individuals Without Dementia","publication_year":2018,"publication_date":"2018-11-21","ids":{"openalex":"https://openalex.org/W2901737279","doi":"https://doi.org/10.1111/jgs.15577","mag":"2901737279","pmid":"https://pubmed.ncbi.nlm.nih.gov/30462843","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6391872"},"language":"en","primary_location":{"id":"doi:10.1111/jgs.15577","doi":"https://doi.org/10.1111/jgs.15577","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jgs.15577","pdf_url":null,"source":{"id":"https://openalex.org/S204183829","display_name":"Journal of the American Geriatrics Society","issn_l":"0002-8614","issn":["0002-8614","1532-5415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6391872","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007016271","display_name":"Maria E. Vassilaki","orcid":"https://orcid.org/0000-0001-8328-136X","observed_orcids":["https://orcid.org/0000-0001-8328-136X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maria Vassilaki","raw_affiliation_strings":["Departments of Health Sciences Research Mayo Clinic Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Health Sciences Research Mayo Clinic Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103229553","display_name":"Jeremiah A. Aakre","orcid":"https://orcid.org/0000-0002-3517-4153","observed_orcids":["https://orcid.org/0000-0002-3517-4153"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremiah A. Aakre","raw_affiliation_strings":["Departments of Health Sciences Research Mayo Clinic Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Health Sciences Research Mayo Clinic Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055499310","display_name":"Walter K. Kremers","orcid":"https://orcid.org/0000-0001-5714-3473","observed_orcids":["https://orcid.org/0000-0001-5714-3473"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter K. Kremers","raw_affiliation_strings":["Departments of Health Sciences Research Mayo Clinic Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Health Sciences Research Mayo Clinic Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090710393","display_name":"Michelle M. Mielke","orcid":"https://orcid.org/0000-0001-7177-1185","observed_orcids":["https://orcid.org/0000-0001-7177-1185"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle M. Mielke","raw_affiliation_strings":["Departments of Health Sciences Research Mayo Clinic Mayo Clinic Rochester Minnesota","Departments of Neurology Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Health Sciences Research Mayo Clinic Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Departments of Neurology Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058106909","display_name":"Yonas E. Geda","orcid":"https://orcid.org/0000-0003-1187-7230","observed_orcids":["https://orcid.org/0000-0003-1187-7230"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yonas E. Geda","raw_affiliation_strings":["Department of Psychiatry and Psychology and Department of Neurology Mayo Clinic Scottsdale Arizona","Departments of Health Sciences Research Mayo Clinic Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychology and Department of Neurology Mayo Clinic Scottsdale Arizona","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"Departments of Health Sciences Research Mayo Clinic Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032297807","display_name":"Mary M. Machulda","orcid":"https://orcid.org/0000-0003-4834-5967","observed_orcids":["https://orcid.org/0000-0003-4834-5967"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary M. Machulda","raw_affiliation_strings":["Departments of Psychiatry and Psychology Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Psychology Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059027860","display_name":"David S. Knopman","orcid":"https://orcid.org/0000-0002-6544-066X","observed_orcids":["https://orcid.org/0000-0002-6544-066X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Knopman","raw_affiliation_strings":["Departments of Neurology Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087002297","display_name":"Preciosa M. Coloma","orcid":"https://orcid.org/0009-0002-8996-1811","observed_orcids":["https://orcid.org/0009-0002-8996-1811"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Preciosa M. Coloma","raw_affiliation_strings":["Real World Data Science Basel Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Real World Data Science Basel Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023280553","display_name":"Barbara Sch\u00e4uble","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Barbara Schauble","raw_affiliation_strings":["Medical Affairs F. Hoffmann-La Roche Ltd Basel Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs F. Hoffmann-La Roche Ltd Basel Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043921358","display_name":"Prashanthi Vemuri","orcid":"https://orcid.org/0000-0003-4286-0589","observed_orcids":["https://orcid.org/0000-0003-4286-0589"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prashanthi Vemuri","raw_affiliation_strings":["Department of Radiology Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001313680","display_name":"Val J. Lowe","orcid":"https://orcid.org/0000-0002-5612-1667","observed_orcids":["https://orcid.org/0000-0002-5612-1667"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Val J. Lowe","raw_affiliation_strings":["Department of Radiology Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005099850","display_name":"Clifford R. Jack","orcid":"https://orcid.org/0000-0001-7916-622X","observed_orcids":["https://orcid.org/0000-0001-7916-622X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford R. Jack","raw_affiliation_strings":["Department of Radiology Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110342810","display_name":"Ronald Carl Petersen","orcid":"https://orcid.org/0000-0002-8178-6601","observed_orcids":["https://orcid.org/0000-0002-8178-6601"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald C. Petersen","raw_affiliation_strings":["Departments of Health Sciences Research Mayo Clinic Mayo Clinic Rochester Minnesota","Departments of Neurology Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Health Sciences Research Mayo Clinic Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Departments of Neurology Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112116344","display_name":"Rosebud O. Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosebud O. Roberts","raw_affiliation_strings":["Departments of Health Sciences Research Mayo Clinic Mayo Clinic Rochester Minnesota","Departments of Neurology Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Health Sciences Research Mayo Clinic Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Departments of Neurology Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007016271"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":1.8734,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.85081498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"66","issue":"12","first_page":"2274","last_page":"2281"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8960000276565552},{"id":"https://openalex.org/keywords/functional-performance","display_name":"functional performance","score":0.9599999785423279},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cognitively-unimpaired-older-adults","display_name":"cognitively unimpaired older adults","score":0.8510000109672546},{"id":"https://openalex.org/keywords/amyloid-pet","display_name":"amyloid PET","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cortical-thickness","display_name":"cortical thickness","score":0.902999997138977},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.925000011920929},{"id":"https://openalex.org/keywords/clinical-dementia-rating","display_name":"Clinical Dementia Rating","score":0.7710000276565552},{"id":"https://openalex.org/keywords/functional-activities-questionnaire","display_name":"Functional Activities Questionnaire","score":0.9819999933242798},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.9010000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8082830905914307},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7289616465568542},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6383380889892578},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.572101891040802},{"id":"https://openalex.org/C2780906993","wikidata":"https://www.wikidata.org/wiki/Q5133756","display_name":"Clinical Dementia Rating","level":4,"score":0.5521433353424072},{"id":"https://openalex.org/C2781073650","wikidata":"https://www.wikidata.org/wiki/Q4047010","display_name":"Pittsburgh compound B","level":4,"score":0.5464984774589539},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5311089158058167},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5297535061836243},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.468009352684021},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.4461306035518646},{"id":"https://openalex.org/C199374082","wikidata":"https://www.wikidata.org/wiki/Q907080","display_name":"Standardized uptake value","level":3,"score":0.43916356563568115},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42907238006591797},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.32945680618286133},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.32873862981796265},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3267199993133545},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.15115222334861755},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076604","descriptor_name":"Physical Functional Performance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008910","descriptor_name":"Minnesota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/jgs.15577","doi":"https://doi.org/10.1111/jgs.15577","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jgs.15577","pdf_url":null,"source":{"id":"https://openalex.org/S204183829","display_name":"Journal of the American Geriatrics Society","issn_l":"0002-8614","issn":["0002-8614","1532-5415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"journal-article"},{"id":"pmid:30462843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30462843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5843297","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6391872","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6391872","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6391872","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Geriatr Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5843297","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6391872","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1062948755","display_name":"Multimorbidity and Aging: Rochester Epidemiology Project","funder_award_id":"R01AG034676","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G388381678","display_name":"Alzheimers Disease Patient Registry","funder_award_id":"U01AG006786","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G517245306","display_name":"Evaluating and Extending Our Hypothetical Model of Alzheimer's Biomarkers","funder_award_id":"R01AG011378","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7027563359","display_name":"Development, Validation, and Application of an Imaging based CVD Scale","funder_award_id":"R01NS097495","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8251536870","display_name":"Brain Aging and Alzheimer's Biomarker Classification Using Amyloid PET, tau PET, and Neurodegeneration on MRI: Developing the ATN system","funder_award_id":"R01AG041851","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000863370","display_name":"Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkers","funder_award_id":"R37AG011378","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000878665","display_name":"Investigating Resistance and Resilience Mechanisms in Alzheimer\u2019s Disease","funder_award_id":"R01AG056366","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G95754455","display_name":"Mayo Alzheimer's Disease Research Center","funder_award_id":"P50AG016574","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320309464","display_name":"Mayo Foundation for Medical Education and Research","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320315931","display_name":"GHR Foundation","ror":"https://ror.org/05ahavf04"},{"id":"https://openalex.org/F4320316501","display_name":"Elsie and Marvin Dekelboum Family Foundation","ror":"https://ror.org/01qsat610"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W74130876","https://openalex.org/W1604841733","https://openalex.org/W1991952617","https://openalex.org/W2000555003","https://openalex.org/W2010814238","https://openalex.org/W2011195206","https://openalex.org/W2020780341","https://openalex.org/W2028436804","https://openalex.org/W2028902253","https://openalex.org/W2039391011","https://openalex.org/W2039678292","https://openalex.org/W2040434160","https://openalex.org/W2041695997","https://openalex.org/W2041892844","https://openalex.org/W2050006425","https://openalex.org/W2057771377","https://openalex.org/W2059481988","https://openalex.org/W2061090644","https://openalex.org/W2085870059","https://openalex.org/W2110703451","https://openalex.org/W2111399612","https://openalex.org/W2112882050","https://openalex.org/W2116232912","https://openalex.org/W2123940611","https://openalex.org/W2125045513","https://openalex.org/W2129168200","https://openalex.org/W2129497119","https://openalex.org/W2129745845","https://openalex.org/W2144480211","https://openalex.org/W2148079076","https://openalex.org/W2155277084","https://openalex.org/W2160137225","https://openalex.org/W2167840686","https://openalex.org/W2187760945","https://openalex.org/W2194493703","https://openalex.org/W2220409079","https://openalex.org/W2323058690","https://openalex.org/W2529649944","https://openalex.org/W2750063464","https://openalex.org/W2773500119","https://openalex.org/W2799379448"],"related_works":["https://openalex.org/W4389440614","https://openalex.org/W3017173131","https://openalex.org/W7117294049","https://openalex.org/W2908739504","https://openalex.org/W3049006468","https://openalex.org/W4224303242","https://openalex.org/W4402543485","https://openalex.org/W2603527380","https://openalex.org/W2915228783","https://openalex.org/W2551126960"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"examine":[2],"the":[3,78,96,109,219],"cross-sectional":[4,199],"association":[5,208],"between":[6,209],"functional":[7,106,210],"performance":[8,92,211],"and":[9,22,73,88,108,149,155,188,212],"Alzheimer's":[10],"disease":[11],"(AD)":[12],"neuroimaging":[13,214],"biomarkers":[14,215],"in":[15,191,218,227],"individuals":[16],"without":[17],"dementia":[18,220],"(cognitively":[19],"unimpaired":[20],"(CU),":[21],"those":[23,156],"with":[24,116,157,182],"mild":[25],"cognitive":[26,147],"impairment":[27],"(MCI)).":[28],"DESIGN:":[29],"Cross-sectional.":[30],"SETTING:":[31],"Olmsted":[32],"County,":[33],"Minnesota.":[34],"PARTICIPANTS:":[35],"C-PiB)":[36],"positron":[37],"emission":[38],"tomography":[39],"(PET)":[40],"(N=1,782).":[41],"MEASUREMENTS:":[42],"C-PiB-PET":[43],"retention":[44],"ratio":[45,51,135],"as":[46,66,128,167],"a":[47,117,158],"standardized":[48],"uptake":[49],"value":[50],"greater":[52,121,161,183],"than":[53,68,122,162],"1.42":[54],"(high":[55],"amyloid;":[56],"A+),":[57],"abnormal":[58],"(reduced)":[59],"AD":[60,213],"signature":[61],"cortical":[62],"thickness":[63],"(neurodegeneration;":[64],"N+)":[65],"less":[67],"2.67":[69],"mm":[70],"(MRI":[71],"measurement),":[72],"biomarker":[74],"groups":[75],"according":[76],"to":[77,130,169],"combination":[79],"of":[80,102,185,197],"abnormality":[81],"(or":[82],"not)":[83],"for":[84,105,142],"amyloid":[85],"accumulation":[86],"(A+/A-)":[87],"neurodegeneration":[89],"(N+/N-).":[90],"Functional":[91,110],"was":[93],"assessed":[94],"using":[95],"Clinical":[97],"Dementia":[98],"Rating":[99],"(CDR)":[100],"Sum":[101],"Boxes":[103],"(SOB)":[104],"domains":[107],"Activities":[111],"Questionnaire":[112],"(FAQ).":[113],"RESULTS:":[114],"Participants":[115],"CDR-SOB":[118],"(functional)":[119],"score":[120,160],"0":[123,163],"were":[124,164,180],"almost":[125],"4":[126],"times":[127,166],"likely":[129,168],"have":[131,170],"N":[132],"+":[133,172,187,190],"(odds":[134],"(OR)=3.92,":[136],"95%":[137,174],"confidence":[138],"interval":[139],"(CI)=1.77-8.67,":[140],"adjusting":[141],"age,":[143],"sex,":[144],"education,":[145],"global":[146],"z-score,":[148],"APOE":[150],"\u03b54":[151],"allele":[152],"status;":[153],"p<.001)":[154],"FAQ":[159,178],"1.5":[165],"A":[171],"(OR=1.48,":[173],"CI=1.04-2.11,":[175],"p=.03).":[176],"Higher":[177],"scores":[179],"associated":[181],"odds":[184],"A+N":[186],"A-N":[189],"CU":[192],"participants.":[193],"CONCLUSION:":[194],"The":[195,222],"findings":[196],"this":[198],"study":[200],"supplement":[201],"limited":[202],"available":[203],"information":[204],"that":[205],"supports":[206],"an":[207],"very":[216],"early":[217],"pathophysiology.":[221],"associations":[223],"should":[224],"be":[225],"validated":[226],"longitudinal":[228],"studies.":[229],"J":[230],"Am":[231],"Geriatr":[232],"Soc":[233],"66:2274-2281,":[234],"2018.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-11-29T00:00:00"}
