{"id":"https://openalex.org/W2901650786","doi":"https://doi.org/10.1002/chem.201804488","title":"Characterization of PEGylated Asparaginase: New Opportunities from NMR Analysis of Large PEGylated Therapeutics","display_name":"Characterization of PEGylated Asparaginase: New Opportunities from NMR Analysis of Large PEGylated Therapeutics","publication_year":2018,"publication_date":"2018-11-21","ids":{"openalex":"https://openalex.org/W2901650786","doi":"https://doi.org/10.1002/chem.201804488","mag":"2901650786","pmid":"https://pubmed.ncbi.nlm.nih.gov/30462348"},"language":"en","primary_location":{"id":"doi:10.1002/chem.201804488","doi":"https://doi.org/10.1002/chem.201804488","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chem.201804488","pdf_url":null,"source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://flore.unifi.it/bitstream/2158/1148112/5/Chemistry_Eur_J_PEG_Asparaginase_2019.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069642187","display_name":"Linda Cerofolini","orcid":"https://orcid.org/0000-0002-0795-9594","observed_orcids":["https://orcid.org/0000-0002-0795-9594"]},"institutions":[{"id":"https://openalex.org/I4210144939","display_name":"Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine","ror":"https://ror.org/04v403p80","country_code":"IT","type":"education","lineage":["https://openalex.org/I4210144939"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Linda Cerofolini","raw_affiliation_strings":["Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy"],"raw_orcid":"https://orcid.org/0000-0002-0795-9594","affiliations":[{"raw_affiliation_string":"Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy","institution_ids":["https://openalex.org/I4210144939","https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071760085","display_name":"Stefano Giuntini","orcid":"https://orcid.org/0000-0002-2292-8163","observed_orcids":["https://orcid.org/0000-0002-2292-8163"]},"institutions":[{"id":"https://openalex.org/I4210144939","display_name":"Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine","ror":"https://ror.org/04v403p80","country_code":"IT","type":"education","lineage":["https://openalex.org/I4210144939"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Giuntini","raw_affiliation_strings":["Department of Chemistry University of Florence Via della Lastruccia 3 50019 Sesto Fiorentino Italy","Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy"],"raw_orcid":"https://orcid.org/0000-0002-2292-8163","affiliations":[{"raw_affiliation_string":"Department of Chemistry University of Florence Via della Lastruccia 3 50019 Sesto Fiorentino Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy","institution_ids":["https://openalex.org/I4210144939","https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007385615","display_name":"Azzurra Carlon","orcid":"https://orcid.org/0000-0002-0806-4266","observed_orcids":["https://orcid.org/0000-0002-0806-4266"]},"institutions":[{"id":"https://openalex.org/I4210144939","display_name":"Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine","ror":"https://ror.org/04v403p80","country_code":"IT","type":"education","lineage":["https://openalex.org/I4210144939"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Azzurra Carlon","raw_affiliation_strings":["Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy","institution_ids":["https://openalex.org/I4210144939","https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082753420","display_name":"Enrico Ravera","orcid":"https://orcid.org/0000-0001-7708-9208","observed_orcids":["https://orcid.org/0000-0001-7708-9208"]},"institutions":[{"id":"https://openalex.org/I4210144939","display_name":"Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine","ror":"https://ror.org/04v403p80","country_code":"IT","type":"education","lineage":["https://openalex.org/I4210144939"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Enrico Ravera","raw_affiliation_strings":["Department of Chemistry University of Florence Via della Lastruccia 3 50019 Sesto Fiorentino Italy","Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy"],"raw_orcid":"https://orcid.org/0000-0001-7708-9208","affiliations":[{"raw_affiliation_string":"Department of Chemistry University of Florence Via della Lastruccia 3 50019 Sesto Fiorentino Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy","institution_ids":["https://openalex.org/I4210144939","https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050857426","display_name":"V. Calderone","orcid":"https://orcid.org/0000-0002-7963-6241","observed_orcids":["https://orcid.org/0000-0002-7963-6241"]},"institutions":[{"id":"https://openalex.org/I4210144939","display_name":"Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine","ror":"https://ror.org/04v403p80","country_code":"IT","type":"education","lineage":["https://openalex.org/I4210144939"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vito Calderone","raw_affiliation_strings":["Department of Chemistry University of Florence Via della Lastruccia 3 50019 Sesto Fiorentino Italy","Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy"],"raw_orcid":"https://orcid.org/0000-0002-7963-6241","affiliations":[{"raw_affiliation_string":"Department of Chemistry University of Florence Via della Lastruccia 3 50019 Sesto Fiorentino Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy","institution_ids":["https://openalex.org/I4210144939","https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072329968","display_name":"Marco Fragai","orcid":"https://orcid.org/0000-0002-8440-1690","observed_orcids":["https://orcid.org/0000-0002-8440-1690"]},"institutions":[{"id":"https://openalex.org/I4210144939","display_name":"Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine","ror":"https://ror.org/04v403p80","country_code":"IT","type":"education","lineage":["https://openalex.org/I4210144939"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Marco Fragai","raw_affiliation_strings":["Department of Chemistry University of Florence Via della Lastruccia 3 50019 Sesto Fiorentino Italy","Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy"],"raw_orcid":"https://orcid.org/0000-0002-8440-1690","affiliations":[{"raw_affiliation_string":"Department of Chemistry University of Florence Via della Lastruccia 3 50019 Sesto Fiorentino Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy","institution_ids":["https://openalex.org/I4210144939","https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082086847","display_name":"Giacomo Parigi","orcid":"https://orcid.org/0000-0002-1989-4644","observed_orcids":["https://orcid.org/0000-0002-1989-4644"]},"institutions":[{"id":"https://openalex.org/I4210144939","display_name":"Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine","ror":"https://ror.org/04v403p80","country_code":"IT","type":"education","lineage":["https://openalex.org/I4210144939"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giacomo Parigi","raw_affiliation_strings":["Department of Chemistry University of Florence Via della Lastruccia 3 50019 Sesto Fiorentino Italy","Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy"],"raw_orcid":"https://orcid.org/0000-0002-1989-4644","affiliations":[{"raw_affiliation_string":"Department of Chemistry University of Florence Via della Lastruccia 3 50019 Sesto Fiorentino Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy","institution_ids":["https://openalex.org/I4210144939","https://openalex.org/I45084792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050056049","display_name":"Claudio Luchinat","orcid":"https://orcid.org/0000-0003-2271-8921","observed_orcids":["https://orcid.org/0000-0003-2271-8921"]},"institutions":[{"id":"https://openalex.org/I4210144939","display_name":"Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine","ror":"https://ror.org/04v403p80","country_code":"IT","type":"education","lineage":["https://openalex.org/I4210144939"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Claudio Luchinat","raw_affiliation_strings":["Department of Chemistry University of Florence Via della Lastruccia 3 50019 Sesto Fiorentino Italy","Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy"],"raw_orcid":"https://orcid.org/0000-0003-2271-8921","affiliations":[{"raw_affiliation_string":"Department of Chemistry University of Florence Via della Lastruccia 3 50019 Sesto Fiorentino Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Magnetic Resonance Center (CERM) University of Florence and Consorzio Interuniversitario Risonanze Magnetiche di, Metallo Proteine (CIRMMP) Via L. Sacconi 6 50019 Sesto Fiorentino Italy","institution_ids":["https://openalex.org/I4210144939","https://openalex.org/I45084792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050056049","https://openalex.org/A5072329968","https://openalex.org/A5082753420"],"corresponding_institution_ids":["https://openalex.org/I4210144939","https://openalex.org/I45084792"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":2.1538,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.89940414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"25","issue":"8","first_page":"1984","last_page":"1991"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.14880000054836273,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.08150000125169754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pegylated-asparaginase","display_name":"pegylated asparaginase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.7319999933242798},{"id":"https://openalex.org/keywords/pegylation","display_name":"PEGylation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/resonance-assignment","display_name":"chemical shift assignment","score":0.7379999756813049},{"id":"https://openalex.org/keywords/structural-characterization","display_name":"structural characterization","score":0.6940000057220459},{"id":"https://openalex.org/keywords/x-ray-crystallography","display_name":"X-ray crystallography","score":0.8299999833106995},{"id":"https://openalex.org/keywords/protein-conformation","display_name":"protein conformation","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C2779149719","wikidata":"https://www.wikidata.org/wiki/Q682252","display_name":"PEGylation","level":3,"score":0.6825249195098877},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.49148881435394287},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.45273464918136597},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42664116621017456},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35557711124420166},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.33257240056991577},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27879226207733154},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2723793387413025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21419209241867065},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.07012906670570374}],"mesh":[{"descriptor_ui":"D001215","descriptor_name":"Asparaginase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001215","descriptor_name":"Asparaginase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020099","descriptor_name":"Coated Materials, Biocompatible","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/chem.201804488","doi":"https://doi.org/10.1002/chem.201804488","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chem.201804488","pdf_url":null,"source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},{"id":"pmid:30462348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30462348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry (Weinheim an der Bergstrasse, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:flore.unifi.it:2158/1148112","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2158/1148112","pdf_url":"https://flore.unifi.it/bitstream/2158/1148112/5/Chemistry_Eur_J_PEG_Asparaginase_2019.pdf","source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:flore.unifi.it:2158/1148112","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2158/1148112","pdf_url":"https://flore.unifi.it/bitstream/2158/1148112/5/Chemistry_Eur_J_PEG_Asparaginase_2019.pdf","source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1982653369","display_name":null,"funder_award_id":"675858","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G292265402","display_name":"World-wide E-infrastructure for structural biology","funder_award_id":"675858","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3026024081","display_name":"Metodologie chimiche innovative per strategie molecolari avanzate in biomedicina","funder_award_id":"2012SK7ASN","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G6997527528","display_name":null,"funder_award_id":"2012SK7ASN","funder_id":"https://openalex.org/F4320329094","funder_display_name":"Fondazione Cassa di Risparmio di Firenze"},{"id":"https://openalex.org/G735744980","display_name":null,"funder_award_id":"PRIN 2012SK7ASN","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G7439577669","display_name":"A worldwide e-Infrastructure for NMR and structural biology","funder_award_id":"261572","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G823774000","display_name":null,"funder_award_id":"653706","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320322648","display_name":"Universit\u00e0 degli Studi di Firenze","ror":"https://ror.org/04jr1s763"},{"id":"https://openalex.org/F4320329094","display_name":"Fondazione Cassa di Risparmio di Firenze","ror":"https://ror.org/049wkn258"},{"id":"https://openalex.org/F4320330797","display_name":"Instituto de F\u00edsica de Cantabria","ror":"https://ror.org/040kx1j83"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2901650786.pdf","grobid_xml":"https://content.openalex.org/works/W2901650786.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1424849964","https://openalex.org/W1519975928","https://openalex.org/W1538658196","https://openalex.org/W1971014721","https://openalex.org/W1971317954","https://openalex.org/W1972913960","https://openalex.org/W1981331687","https://openalex.org/W1984349476","https://openalex.org/W1989800988","https://openalex.org/W1994328955","https://openalex.org/W1996898871","https://openalex.org/W1998417052","https://openalex.org/W2000157905","https://openalex.org/W2007406685","https://openalex.org/W2007512075","https://openalex.org/W2030728145","https://openalex.org/W2034331226","https://openalex.org/W2042939393","https://openalex.org/W2043833150","https://openalex.org/W2058094839","https://openalex.org/W2066496977","https://openalex.org/W2068125497","https://openalex.org/W2089156647","https://openalex.org/W2092370721","https://openalex.org/W2097897519","https://openalex.org/W2104060281","https://openalex.org/W2120127018","https://openalex.org/W2125181056","https://openalex.org/W2154225627","https://openalex.org/W2155930838","https://openalex.org/W2161587364","https://openalex.org/W2165115873","https://openalex.org/W2165337638","https://openalex.org/W2169821755","https://openalex.org/W2185126691","https://openalex.org/W2236763222","https://openalex.org/W2239069384","https://openalex.org/W2277366394","https://openalex.org/W2320134096","https://openalex.org/W2343568188","https://openalex.org/W2413072608","https://openalex.org/W2588550827","https://openalex.org/W2606049010","https://openalex.org/W2621120495","https://openalex.org/W2763824119","https://openalex.org/W2773030141","https://openalex.org/W2801446087","https://openalex.org/W4234454654","https://openalex.org/W4241710088","https://openalex.org/W4242156983","https://openalex.org/W4243536486"],"related_works":["https://openalex.org/W4242156983","https://openalex.org/W2588550827","https://openalex.org/W2165115873","https://openalex.org/W1969488119","https://openalex.org/W2606899509","https://openalex.org/W2768473564","https://openalex.org/W2901439506","https://openalex.org/W2979071108","https://openalex.org/W7167447869","https://openalex.org/W1557416798"],"abstract_inverted_index":{"Resonance":[0],"assignment":[1,55],"and":[2,13,56,71],"structural":[3,41,59],"characterization":[4],"of":[5,15,61],"pharmacologically":[6],"relevant":[7],"proteins":[8,17,64],"promise":[9],"to":[10,28,37,51],"improve":[11],"understanding":[12],"safety":[14],"these":[16,35],"by":[18],"rational":[19],"design.":[20],"However,":[21],"the":[22,30,39,53],"PEG":[23],"coating":[24],"that":[25,47],"is":[26,49],"used":[27],"evade":[29],"immune":[31],"system":[32],"also":[33],"causes":[34],"molecules":[36],"\"evade\"":[38],"standard":[40],"biology":[42],"methodologies.":[43],"We":[44],"here":[45],"demonstrate":[46],"it":[48],"possible":[50],"obtain":[52],"resonance":[54],"a":[57],"reliable":[58],"model":[60],"large":[62],"PEGylated":[63],"through":[65],"an":[66],"integrated":[67],"approach":[68],"encompassing":[69],"NMR":[70],"X-ray":[72],"crystallography.":[73]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2018-11-29T00:00:00"}