{"id":"https://openalex.org/W2901580201","doi":"https://doi.org/10.1161/str.48.suppl_1.197","title":"Abstract 197: Roles of Neutrophil Extracellular Trap in the Rupture of Intracranial Aneurysm","display_name":"Abstract 197: Roles of Neutrophil Extracellular Trap in the Rupture of Intracranial Aneurysm","publication_year":2017,"publication_date":"2017-02-01","ids":{"openalex":"https://openalex.org/W2901580201","doi":"https://doi.org/10.1161/str.48.suppl_1.197","mag":"2901580201"},"language":"en","primary_location":{"id":"doi:10.1161/str.48.suppl_1.197","doi":"https://doi.org/10.1161/str.48.suppl_1.197","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.48.suppl_1.197","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089115116","display_name":"Masaaki Korai","orcid":"https://orcid.org/0000-0002-5326-3467","observed_orcids":["https://orcid.org/0000-0002-5326-3467"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masaaki Korai","raw_affiliation_strings":["Univ of California, San Francisco, San Francisco, CA","Masaaki Korai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Masaaki Korai","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102154807","display_name":"Hajime Furukawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hajime Furukawa","raw_affiliation_strings":["Univ of California, San Francisco, San Francisco, CA","Hajime Furukawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Hajime Furukawa","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074420428","display_name":"Yoshinobu Kamio","orcid":"https://orcid.org/0000-0003-1072-796X","observed_orcids":["https://orcid.org/0000-0003-1072-796X","https://orcid.org/0000-0003-3118-807X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoshinobu Kamio","raw_affiliation_strings":["Univ of California, San Francisco, San Francisco, CA","Yoshinobu Kamio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Yoshinobu Kamio","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014046092","display_name":"Kazuha Mitsui","orcid":"https://orcid.org/0000-0002-3622-9371","observed_orcids":["https://orcid.org/0000-0002-3622-9371"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazuha Mitsui","raw_affiliation_strings":["Univ of California, San Francisco, San Francisco, CA","Kazuha Mitsui"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Kazuha Mitsui","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108383120","display_name":"Shinji Nagahiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Nagahiro","raw_affiliation_strings":["Tokushima Univ Graduate Sch, Tokushima, Japan","Shinji Nagahiro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Univ Graduate Sch, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Shinji Nagahiro","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014880968","display_name":"Tomoki N Hashimoto","orcid":"https://orcid.org/0000-0002-6046-9148","observed_orcids":["https://orcid.org/0000-0002-6046-9148"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomoki Hashimoto","raw_affiliation_strings":["Univ of California, San Francisco, San Francisco, CA","Tomoki Hashimoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Tomoki Hashimoto","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.031300000846385956,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-extracellular-traps","display_name":"neutrophil extracellular traps","score":0.996999979019165},{"id":"https://openalex.org/keywords/intracranial-aneurysm-rupture","display_name":"intracranial aneurysm rupture","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pad4","display_name":"PAD4","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cl-amidine","display_name":"Cl-amidine","score":0.7440000176429749},{"id":"https://openalex.org/keywords/granulocytes","display_name":"granulocytes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/elastase-induced-aneurysm","display_name":"elastase-induced aneurysm","score":0.8659999966621399},{"id":"https://openalex.org/keywords/doca-salt-hypertension","display_name":"DOCA-salt hypertension","score":0.8970000147819519},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5400000214576721},{"id":"https://openalex.org/keywords/dnase","display_name":"DNase","score":0.5979999899864197},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8799999952316284},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.9197062253952026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7711880207061768},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6816225051879883},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6140584349632263},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.5582968592643738},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5569757223129272},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5093628168106079},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.48428410291671753},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.47833940386772156},{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.4421824514865875},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40300849080085754},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3975822627544403},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3381273150444031},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15659373998641968},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1449504792690277},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13545459508895874},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11771455407142639}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/str.48.suppl_1.197","doi":"https://doi.org/10.1161/str.48.suppl_1.197","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.48.suppl_1.197","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3145470117","https://openalex.org/W3187928484","https://openalex.org/W3177400806","https://openalex.org/W4327607734","https://openalex.org/W3089608883","https://openalex.org/W2997349768","https://openalex.org/W3101988631","https://openalex.org/W4391607013","https://openalex.org/W4232020443","https://openalex.org/W3022144884"],"abstract_inverted_index":{"Introduction:":[0],"Neutrophil":[1],"extracellular":[2,14],"traps":[3],"(NETs)":[4],"are":[5],"originally":[6],"described":[7],"as":[8,50,138],"proinflammatory,":[9],"antimicrobial":[10],"structures":[11],"consisting":[12],"of":[13,24,54,57,77,86,93,133,151,188,193,216,229,262,265,282,290,304],"chromatin":[15],"decorated":[16],"with":[17,73],"granular":[18],"and":[19,63,75,103,122,136,190,199,219,246],"cytoplasmic":[20],"proteins.":[21],"The":[22],"formation":[23,74,85,192,264,281],"NETs":[25,35,87,194,266,283,293],"requires":[26],"peptidylarginine":[27],"deiminase":[28],"(PAD)":[29],"4.":[30],"Recent":[31],"studies":[32],"revealed":[33],"that":[34,83,228,279],"can":[36],"play":[37],"an":[38,165],"important":[39],"role":[40],"in":[41,44,106,221,240,253],"promoting":[42],"inflammation":[43],"vascular":[45],"diseases.":[46],"Inflammation":[47],"is":[48],"emerging":[49],"a":[51,131,160,297],"key":[52],"component":[53],"the":[55,84,91,156,171,181,186,191,206,210,222,235,241,247,254,263,272,280,288,302],"pathophysiology":[56],"intracranial":[58,78],"aneurysm.":[59],"In":[60,205],"both":[61,101],"human":[62],"mouse":[64],"studies,":[65],"activated":[66],"neutrophils":[67,189],"were":[68,225,238],"shown":[69],"to":[70,112],"be":[71,295],"associated":[72],"rupture":[76,172,236,273],"aneurysms.":[79],"Therefore,":[80],"we":[81,139],"hypothesized":[82],"by":[88,130,196,267,284],"PAD4":[89,118,124,243,249,286],"promotes":[90,287],"development":[92,289],"aneurysm":[94,291,305],"rupture.":[95,292,306],"We":[96,109,142],"tested":[97],"this":[98],"hypothesis":[99],"utilizing":[100],"pharmacological":[102],"genetic":[104],"approaches":[105],"mice.":[107,126,233],"Methods:":[108],"used":[110,143],"8-":[111],"10-week-old":[113],"male":[114],"C57BL/6J":[115],"mice,":[116,209],"global":[117,242],"knock":[119],"out":[120],"(KO)":[121],"granulocyte-specific":[123,248],"KO":[125,244,250],"Aneurysm":[127],"was":[128,153],"induced":[129],"combination":[132],"elastase":[134,152],"injection":[135],"hypertension":[137],"previously":[140],"describes.":[141],"deoxycorticosterone":[144],"acetate":[145],"(DOCA)-salt":[146],"hypertension.":[147],"A":[148],"single":[149],"dose":[150],"injected":[154],"into":[155],"cerebrospinal":[157],"fluid":[158],"using":[159],"stereotaxic":[161],"approach.":[162],"Results:":[163],"Cl-amidine,":[164],"inhibitor":[166,207],"for":[167,301],"PAD4,":[168],"significantly":[169],"decreased":[170,185,239],"rates":[173,237],"(92":[174],"vs":[175],"36%,":[176],"P":[177],"<":[178],"0.01).":[179],"At":[180],"same":[182],"time,":[183],"Cl-amidine":[184],"number":[187],"analyzed":[195],"Ly-6G":[197],"staining":[198],"citrullinated":[200],"histone":[201],"H3":[202],"staining,":[203],"respectively.":[204],"treated":[208,232],"messenger":[211],"ribonucleic":[212],"acid":[213],"(RNA)":[214],"level":[215],"ICAM-1,":[217],"MCP-1":[218],"TNF\u03b1":[220],"cerebral":[223],"arteries":[224],"lower":[226],"than":[227,252],"vehicle":[230],"control":[231],"Furthermore,":[234],"mice":[245,251,258],"corresponding":[255],"wild":[256],"type":[257],"groups.":[259],"Finally,":[260],"inhibition":[261],"DNase":[268],"treatment":[269],"also":[270],"reduced":[271],"rates.":[274],"Conclusions:":[275],"Our":[276],"data":[277],"indicate":[278],"granulocyte":[285],"may":[294],"represented":[296],"potential":[298],"therapeutic":[299],"target":[300],"prevention":[303]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-11-29T00:00:00"}
