{"id":"https://openalex.org/W2901549754","doi":"https://doi.org/10.1038/s41467-018-07521-2","title":"Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds","display_name":"Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds","publication_year":2018,"publication_date":"2018-11-20","ids":{"openalex":"https://openalex.org/W2901549754","doi":"https://doi.org/10.1038/s41467-018-07521-2","mag":"2901549754","pmid":"https://pubmed.ncbi.nlm.nih.gov/30478283","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6255838"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-018-07521-2","doi":"https://doi.org/10.1038/s41467-018-07521-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-07521-2","pdf_url":"https://www.nature.com/articles/s41467-018-07521-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-018-07521-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029283240","display_name":"Vunnam Srinivasulu","orcid":"https://orcid.org/0000-0003-4940-835X","observed_orcids":["https://orcid.org/0000-0003-4940-835X"]},"institutions":[{"id":"https://openalex.org/I29891158","display_name":"University of Sharjah","ror":"https://ror.org/00engpz63","country_code":"AE","type":"education","lineage":["https://openalex.org/I29891158"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Vunnam Srinivasulu","raw_affiliation_strings":["Sharjah Institute for Medical Research, University of Sharjah, P.O. Box 27272, Sharjah, UAE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharjah Institute for Medical Research, University of Sharjah, P.O. Box 27272, Sharjah, UAE","institution_ids":["https://openalex.org/I29891158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042346979","display_name":"Paul Schilf","orcid":"https://orcid.org/0000-0003-3015-656X","observed_orcids":["https://orcid.org/0000-0003-3015-656X"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Paul Schilf","raw_affiliation_strings":["L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck, Ratzeburger Allee 160 23538, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck, Ratzeburger Allee 160 23538, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030928316","display_name":"Saleh Mohamed Ibrahim","orcid":"https://orcid.org/0000-0001-7827-2290","observed_orcids":["https://orcid.org/0000-0001-7827-2290"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Saleh Ibrahim","raw_affiliation_strings":["L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck, Ratzeburger Allee 160 23538, L\u00fcbeck, Germany. Saleh.Ibrahim@uksh.de","L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck, Ratzeburger Allee 160 23538, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck, Ratzeburger Allee 160 23538, L\u00fcbeck, Germany. Saleh.Ibrahim@uksh.de","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck, Ratzeburger Allee 160 23538, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042763400","display_name":"Monther A. Khanfar","orcid":"https://orcid.org/0000-0003-4718-4006","observed_orcids":["https://orcid.org/0000-0003-4718-4006"]},"institutions":[{"id":"https://openalex.org/I114972647","display_name":"University of Jordan","ror":"https://ror.org/05k89ew48","country_code":"JO","type":"education","lineage":["https://openalex.org/I114972647"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Monther A. Khanfar","raw_affiliation_strings":["Department of Chemistry, University of Jordan, 11942, Amman, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Jordan, 11942, Amman, Jordan","institution_ids":["https://openalex.org/I114972647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027900649","display_name":"Scott McN. Sieburth","orcid":"https://orcid.org/0000-0003-1075-0772","observed_orcids":["https://orcid.org/0000-0003-1075-0772"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott McN Sieburth","raw_affiliation_strings":["Department of Chemistry, Temple University, 201 Beury Hall, Philadelphia, PA, 19122, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Temple University, 201 Beury Hall, Philadelphia, PA, 19122, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087612178","display_name":"Hany A. Omar","orcid":"https://orcid.org/0000-0002-4670-8149","observed_orcids":["https://orcid.org/0000-0002-4670-8149"]},"institutions":[{"id":"https://openalex.org/I113643904","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70","country_code":"EG","type":"education","lineage":["https://openalex.org/I113643904"]},{"id":"https://openalex.org/I29891158","display_name":"University of Sharjah","ror":"https://ror.org/00engpz63","country_code":"AE","type":"education","lineage":["https://openalex.org/I29891158"]}],"countries":["AE","EG"],"is_corresponding":false,"raw_author_name":"Hany Omar","raw_affiliation_strings":["College of Pharmacy, University of Sharjah, P.O. Box, 27272, Sharjah, UAE","Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt","Sharjah Institute for Medical Research, University of Sharjah, P.O. Box 27272, Sharjah, UAE"],"raw_orcid":"https://orcid.org/0000-0002-4670-8149","affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Sharjah, P.O. Box, 27272, Sharjah, UAE","institution_ids":["https://openalex.org/I29891158"]},{"raw_affiliation_string":"Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt","institution_ids":["https://openalex.org/I113643904"]},{"raw_affiliation_string":"Sharjah Institute for Medical Research, University of Sharjah, P.O. Box 27272, Sharjah, UAE","institution_ids":["https://openalex.org/I29891158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026444408","display_name":"Anusha Sebastian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29891158","display_name":"University of Sharjah","ror":"https://ror.org/00engpz63","country_code":"AE","type":"education","lineage":["https://openalex.org/I29891158"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Anusha Sebastian","raw_affiliation_strings":["Sharjah Institute for Medical Research, University of Sharjah, P.O. Box 27272, Sharjah, UAE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharjah Institute for Medical Research, University of Sharjah, P.O. Box 27272, Sharjah, UAE","institution_ids":["https://openalex.org/I29891158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033013954","display_name":"Raed A. Al\u2010Qawasmeh","orcid":"https://orcid.org/0000-0002-9325-6229","observed_orcids":["https://orcid.org/0000-0002-9325-6229"]},"institutions":[{"id":"https://openalex.org/I114972647","display_name":"University of Jordan","ror":"https://ror.org/05k89ew48","country_code":"JO","type":"education","lineage":["https://openalex.org/I114972647"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Raed A. AlQawasmeh","raw_affiliation_strings":["Department of Chemistry, University of Jordan, 11942, Amman, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Jordan, 11942, Amman, Jordan","institution_ids":["https://openalex.org/I114972647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101838367","display_name":"Matthew John O\u2019Connor","orcid":"https://orcid.org/0009-0006-6383-2404","observed_orcids":["https://orcid.org/0009-0006-6383-2404"]},"institutions":[{"id":"https://openalex.org/I120250893","display_name":"New York University Abu Dhabi","ror":"https://ror.org/00e5k0821","country_code":"AE","type":"education","lineage":["https://openalex.org/I120250893","https://openalex.org/I57206974"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Matthew John O\u2019Connor","raw_affiliation_strings":["New York University, Abu Dhabi, P.O. Box 129188, Saadiyat Island, Abu Dhabi, UAE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University, Abu Dhabi, P.O. Box 129188, Saadiyat Island, Abu Dhabi, UAE","institution_ids":["https://openalex.org/I120250893"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113658738","display_name":"Taleb H. Al\u2010Tel","orcid":"https://orcid.org/0000-0003-4914-9677","observed_orcids":["https://orcid.org/0000-0003-4914-9677"]},"institutions":[{"id":"https://openalex.org/I29891158","display_name":"University of Sharjah","ror":"https://ror.org/00engpz63","country_code":"AE","type":"education","lineage":["https://openalex.org/I29891158"]}],"countries":["AE"],"is_corresponding":true,"raw_author_name":"Taleb H. Al-Tel","raw_affiliation_strings":["College of Pharmacy, University of Sharjah, P.O. Box, 27272, Sharjah, UAE. taltal@sharjah.ac.ae","Sharjah Institute for Medical Research, University of Sharjah, P.O. Box 27272, Sharjah, UAE. taltal@sharjah.ac.ae","College of Pharmacy, University of Sharjah, P.O. Box, 27272, Sharjah, UAE"],"raw_orcid":"https://orcid.org/0000-0003-4914-9677","affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Sharjah, P.O. Box, 27272, Sharjah, UAE. taltal@sharjah.ac.ae","institution_ids":["https://openalex.org/I29891158"]},{"raw_affiliation_string":"Sharjah Institute for Medical Research, University of Sharjah, P.O. Box 27272, Sharjah, UAE. taltal@sharjah.ac.ae","institution_ids":["https://openalex.org/I29891158"]},{"raw_affiliation_string":"College of Pharmacy, University of Sharjah, P.O. Box, 27272, Sharjah, UAE","institution_ids":["https://openalex.org/I29891158"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5030928316","https://openalex.org/A5113658738"],"corresponding_institution_ids":["https://openalex.org/I29891158","https://openalex.org/I9341345"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":1.4687,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.78228155,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"4989","last_page":"4989"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.4602000117301941,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.4602000117301941,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12973","display_name":"Synthesis of Indole Derivatives","score":0.22470000386238098,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.10019999742507935,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/desymmetrization","display_name":"desymmetrization","score":0.9390000104904175},{"id":"https://openalex.org/keywords/diastereoselective-synthesis","display_name":"diastereoselective synthesis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/oxidative-dearomatization","display_name":"oxidative dearomatization","score":0.7110000252723694},{"id":"https://openalex.org/keywords/phenols","display_name":"phenols","score":0.7250000238418579},{"id":"https://openalex.org/keywords/piperazinone","display_name":"piperazinone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/natural-product-scaffolds","display_name":"natural product scaffolds","score":0.7990000247955322},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.6790000200271606},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hepatoma-cells","display_name":"hepatoma cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C2777190055","wikidata":"https://www.wikidata.org/wiki/Q3045251","display_name":"Desymmetrization","level":4,"score":0.8199230432510376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5573310256004333},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.49483722448349},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.45385512709617615},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3840579092502594},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.3461433947086334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24424609541893005},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12834471464157104},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.12607669830322266}],"mesh":[{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1038/s41467-018-07521-2","doi":"https://doi.org/10.1038/s41467-018-07521-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-07521-2","pdf_url":"https://www.nature.com/articles/s41467-018-07521-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5239731","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6255838","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30478283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30478283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6255838","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6255838/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07521-2","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-018-07521-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:a23eadb10c13483abe4733c23c443b09","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a23eadb10c13483abe4733c23c443b09","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:fe4e0908a13b4e04b9750d85006dd424","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fe4e0908a13b4e04b9750d85006dd424","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)","raw_type":"article"},{"id":"pmh:oai:null:20.500.12613/4373","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12613/4373","pdf_url":null,"source":{"id":"https://openalex.org/S4306402624","display_name":"TUScholarShare (Temple University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84392919","host_organization_name":"Temple University","host_organization_lineage":["https://openalex.org/I84392919"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41467-018-07521-2","doi":"https://doi.org/10.1038/s41467-018-07521-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-07521-2","pdf_url":"https://www.nature.com/articles/s41467-018-07521-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2901549754.pdf","grobid_xml":"https://content.openalex.org/works/W2901549754.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W581624223","https://openalex.org/W1499643633","https://openalex.org/W1558022610","https://openalex.org/W1963825663","https://openalex.org/W1973758809","https://openalex.org/W1976635219","https://openalex.org/W1978203691","https://openalex.org/W1986581600","https://openalex.org/W1995824328","https://openalex.org/W2004607992","https://openalex.org/W2010587448","https://openalex.org/W2016079332","https://openalex.org/W2019625094","https://openalex.org/W2021947577","https://openalex.org/W2045528361","https://openalex.org/W2048068073","https://openalex.org/W2052543023","https://openalex.org/W2060145168","https://openalex.org/W2066880469","https://openalex.org/W2073824176","https://openalex.org/W2074847845","https://openalex.org/W2085897253","https://openalex.org/W2086034778","https://openalex.org/W2095987251","https://openalex.org/W2102395935","https://openalex.org/W2111139603","https://openalex.org/W2136351224","https://openalex.org/W2142595462","https://openalex.org/W2144277227","https://openalex.org/W2148141656","https://openalex.org/W2154428193","https://openalex.org/W2169303530","https://openalex.org/W2314047519","https://openalex.org/W2331458772","https://openalex.org/W2334926942","https://openalex.org/W2345105659","https://openalex.org/W2485399056","https://openalex.org/W2518316928","https://openalex.org/W2606546819","https://openalex.org/W2610842989","https://openalex.org/W2659015911","https://openalex.org/W2729327121","https://openalex.org/W2740740572","https://openalex.org/W2755773200","https://openalex.org/W2770746786","https://openalex.org/W2773927148","https://openalex.org/W2784282439","https://openalex.org/W2949236218","https://openalex.org/W2949876845","https://openalex.org/W2951389949","https://openalex.org/W2951659335","https://openalex.org/W4211018043","https://openalex.org/W4256402233"],"related_works":["https://openalex.org/W3019842501","https://openalex.org/W4392925299","https://openalex.org/W3184521366","https://openalex.org/W2901962603","https://openalex.org/W2085897253","https://openalex.org/W2783926069","https://openalex.org/W2518410786","https://openalex.org/W2040851060","https://openalex.org/W2145795749","https://openalex.org/W2133800019"],"abstract_inverted_index":{"Octahydroindolo[2,3-a]quinolizine":[0],"ring":[1],"system":[2],"forms":[3],"the":[4,19,70,81,98,109,126,135],"basic":[5],"framework":[6],"comprised":[7],"of":[8,15,22,64,69,73,100,108,140],"more":[9,55],"than":[10,56],"2000":[11],"distinct":[12],"family":[13],"members":[14],"natural":[16],"products.":[17],"Despite":[18],"potential":[20],"applications":[21],"this":[23],"privileged":[24],"substructure":[25],"in":[26,129],"drug":[27],"discovery,":[28],"efficient,":[29],"atom-economic":[30],"and":[31,61,80,102,124,142],"modular":[32],"strategies":[33],"for":[34,97],"its":[35],"assembly,":[36],"is":[37,104],"underdeveloped.":[38],"Here":[39],"we":[40],"show":[41],"a":[42,144],"one-step":[43],"build/couple/pair":[44],"strategy":[45],"that":[46,116],"uniquely":[47],"allows":[48],"access":[49],"to":[50,147],"diverse":[51],"octahydroindolo[2,3-a]quinolizine":[52,110],"scaffolds":[53],"with":[54],"three":[57],"contiguous":[58],"chiral":[59,91],"centers":[60],"broad":[62],"distribution":[63],"molecular":[65],"shapes":[66],"via":[67],"desymmetrization":[68],"oxidative-dearomatization":[71],"products":[72],"phenols.":[74],"The":[75],"cascade":[76],"demonstrates":[77],"excellent":[78],"diastereoselectivity,":[79],"enantioselectivity":[82],"exceeded":[83],"99%":[84],"when":[85],"amino":[86],"acids":[87],"are":[88],"used":[89],"as":[90],"reagents.":[92],"Furthermore,":[93],"two":[94],"diastereoselective":[95],"reactions":[96],"synthesis":[99],"oxocanes":[101],"piperazinones,":[103],"reported.":[105],"Phenotypic":[106],"screening":[107],"library":[111],"identifies":[112],"small":[113],"molecule":[114],"probes":[115],"selectively":[117],"suppress":[118],"mitochondrial":[119],"membrane":[120],"potential,":[121],"ATP":[122],"contents":[123,128],"elevate":[125],"ROS":[127],"hepatoma":[130],"cells":[131],"(Hepa1-6)":[132],"without":[133],"altering":[134],"immunological":[136],"activation":[137],"or":[138],"reprogramming":[139],"T-":[141],"B-cells,":[143],"promising":[145],"approach":[146],"cancer":[148],"therapy.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-11-29T00:00:00"}
