{"id":"https://openalex.org/W2901543139","doi":"https://doi.org/10.7554/elife.37059","title":"Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation","display_name":"Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation","publication_year":2018,"publication_date":"2018-10-10","ids":{"openalex":"https://openalex.org/W2901543139","doi":"https://doi.org/10.7554/elife.37059","mag":"2901543139","pmid":"https://pubmed.ncbi.nlm.nih.gov/30303482","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6179386"},"language":"en","primary_location":{"id":"doi:10.7554/elife.37059","doi":"https://doi.org/10.7554/elife.37059","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.37059","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.37059","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021369042","display_name":"Arda Halu","orcid":"https://orcid.org/0000-0001-6217-790X","observed_orcids":["https://orcid.org/0000-0001-6217-790X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arda Halu","raw_affiliation_strings":["Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States","Channing Division of Network Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States"],"raw_orcid":"https://orcid.org/0000-0001-6217-790X","affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Channing Division of Network Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336344","display_name":"Jianguo Wang","orcid":"https://orcid.org/0000-0003-1826-9924","observed_orcids":["https://orcid.org/0000-0003-1826-9924"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian-Guo Wang","raw_affiliation_strings":["Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000117746","display_name":"Hiroshi Iwata","orcid":"https://orcid.org/0000-0001-7098-9406","observed_orcids":["https://orcid.org/0000-0001-7098-9406"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroshi Iwata","raw_affiliation_strings":["Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037601612","display_name":"Alexander Mojcher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Mojcher","raw_affiliation_strings":["Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081666063","display_name":"Ana Luisa Abib","orcid":"https://orcid.org/0000-0002-3434-0316","observed_orcids":["https://orcid.org/0000-0002-3434-0316"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Luisa Abib","raw_affiliation_strings":["Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015707475","display_name":"Sasha A. Singh","orcid":"https://orcid.org/0000-0003-0929-3164","observed_orcids":["https://orcid.org/0000-0003-0929-3164"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sasha A Singh","raw_affiliation_strings":["Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064861833","display_name":"Masanori Aikawa","orcid":"https://orcid.org/0000-0002-9275-2079","observed_orcids":["https://orcid.org/0000-0002-9275-2079"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Masanori Aikawa","raw_affiliation_strings":["Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States"],"raw_orcid":"https://orcid.org/0000-0002-9275-2079","affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048563533","display_name":"Amitabh Sharma","orcid":"https://orcid.org/0000-0003-0632-4690","observed_orcids":["https://orcid.org/0000-0003-0632-4690"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amitabh Sharma","raw_affiliation_strings":["Channing Division of Network Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States"],"raw_orcid":"https://orcid.org/0000-0003-0632-4690","affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048563533","https://openalex.org/A5064861833"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":0.5554,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.61459425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.781000018119812},{"id":"https://openalex.org/keywords/co-abundance-networks","display_name":"co-abundance networks","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8679999709129333},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/macrophage-like-cells","display_name":"macrophage-like cells","score":0.7440000176429749},{"id":"https://openalex.org/keywords/proinflammatory-signaling","display_name":"pro-inflammatory signaling","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.9705190658569336},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.7138478755950928},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6462357044219971},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5847260355949402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5384291410446167},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.48470616340637207},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4248961806297302},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4215339422225952},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3487943708896637},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1772545874118805},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12743273377418518},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09279313683509827},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0799606442451477},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.7554/elife.37059","doi":"https://doi.org/10.7554/elife.37059","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.37059","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5136478","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6179386","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6179386","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6179386","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:30303482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30303482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8c3933a92d4f4b0fb82541c154f0f2f1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8c3933a92d4f4b0fb82541c154f0f2f1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 7 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.37059","doi":"https://doi.org/10.7554/elife.37059","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.37059","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W1544009106","https://openalex.org/W1609483177","https://openalex.org/W1611787727","https://openalex.org/W1650965741","https://openalex.org/W1838945435","https://openalex.org/W1964064254","https://openalex.org/W1966675141","https://openalex.org/W1971661335","https://openalex.org/W1984996259","https://openalex.org/W1988688237","https://openalex.org/W1991838517","https://openalex.org/W1994803330","https://openalex.org/W1999670119","https://openalex.org/W2001088980","https://openalex.org/W2006402375","https://openalex.org/W2007069550","https://openalex.org/W2009019945","https://openalex.org/W2009405916","https://openalex.org/W2009497794","https://openalex.org/W2010707723","https://openalex.org/W2012953300","https://openalex.org/W2016726091","https://openalex.org/W2017138237","https://openalex.org/W2020259352","https://openalex.org/W2023455126","https://openalex.org/W2026465178","https://openalex.org/W2027876496","https://openalex.org/W2031218556","https://openalex.org/W2033208312","https://openalex.org/W2034316376","https://openalex.org/W2035273201","https://openalex.org/W2035610050","https://openalex.org/W2045134556","https://openalex.org/W2047951064","https://openalex.org/W2052706283","https://openalex.org/W2056710301","https://openalex.org/W2056782561","https://openalex.org/W2062533676","https://openalex.org/W2064631610","https://openalex.org/W2066531004","https://openalex.org/W2067305633","https://openalex.org/W2067803871","https://openalex.org/W2069231540","https://openalex.org/W2073054137","https://openalex.org/W2079724669","https://openalex.org/W2080549540","https://openalex.org/W2081375228","https://openalex.org/W2081810806","https://openalex.org/W2083045667","https://openalex.org/W2087470992","https://openalex.org/W2097690822","https://openalex.org/W2101181377","https://openalex.org/W2103368657","https://openalex.org/W2104042033","https://openalex.org/W2104549677","https://openalex.org/W2106966651","https://openalex.org/W2110336366","https://openalex.org/W2112098540","https://openalex.org/W2113072832","https://openalex.org/W2118568491","https://openalex.org/W2118607021","https://openalex.org/W2119220491","https://openalex.org/W2120280233","https://openalex.org/W2122863289","https://openalex.org/W2124757426","https://openalex.org/W2125910575","https://openalex.org/W2130495917","https://openalex.org/W2130940389","https://openalex.org/W2132022337","https://openalex.org/W2135030836","https://openalex.org/W2140883620","https://openalex.org/W2147068611","https://openalex.org/W2148043260","https://openalex.org/W2150350943","https://openalex.org/W2157658519","https://openalex.org/W2157997136","https://openalex.org/W2159560463","https://openalex.org/W2159861185","https://openalex.org/W2160378233","https://openalex.org/W2162166699","https://openalex.org/W2162405407","https://openalex.org/W2163783674","https://openalex.org/W2166010463","https://openalex.org/W2170146596","https://openalex.org/W2214256683","https://openalex.org/W2263739890","https://openalex.org/W2294302252","https://openalex.org/W2300203480","https://openalex.org/W2332016763","https://openalex.org/W2336735556","https://openalex.org/W2340761255","https://openalex.org/W2505661818","https://openalex.org/W2536301196","https://openalex.org/W2539985226","https://openalex.org/W2540759005","https://openalex.org/W2551996271","https://openalex.org/W2558366645","https://openalex.org/W2599029890","https://openalex.org/W2612713581","https://openalex.org/W2624282460","https://openalex.org/W2747290830","https://openalex.org/W2748400555","https://openalex.org/W2915108429","https://openalex.org/W2916767477","https://openalex.org/W2917375902","https://openalex.org/W4255114028","https://openalex.org/W4294329053"],"related_works":["https://openalex.org/W6957834151","https://openalex.org/W2886722574","https://openalex.org/W2162166699","https://openalex.org/W4388537248","https://openalex.org/W2410122609","https://openalex.org/W3128163146","https://openalex.org/W2275728963","https://openalex.org/W4285368365","https://openalex.org/W4223902443","https://openalex.org/W4360989842"],"abstract_inverted_index":{"The":[0],"role":[1,143],"of":[2,27,81,98,108,134,144],"pro-inflammatory":[3,148],"macrophage":[4,75,99],"activation":[5],"in":[6,36,147],"cardiovascular":[7],"disease":[8,51],"(CVD)":[9],"is":[10,34,41],"a":[11,85],"complex":[12,28],"one":[13],"amenable":[14],"to":[15,44,56,78],"network":[16,86,124],"approaches.":[17],"While":[18],"an":[19],"indispensible":[20],"tool":[21],"for":[22],"elucidating":[23],"the":[24,32,57,82,91,106,112,122,141],"molecular":[25],"underpinnings":[26],"diseases":[29],"including":[30],"CVD,":[31],"interactome":[33,58],"limited":[35],"its":[37],"utility":[38],"as":[39],"it":[40,61],"not":[42],"specific":[43],"any":[45],"cell":[46],"type,":[47],"experimental":[48],"condition":[49],"or":[50],"state.":[52],"We":[53],"introduced":[54],"context-specificity":[55],"by":[59],"combining":[60],"with":[62,105,126],"co-abundance":[63,109],"networks":[64],"derived":[65],"from":[66,70],"unbiased":[67],"proteomics":[68,129],"measurements":[69],"activated":[71],"macrophage-like":[72],"cells.":[73],"Each":[74],"phenotype":[76],"contributed":[77],"certain":[79],"regions":[80],"interactome.":[83],"Using":[84],"proximity-based":[87],"prioritization":[88],"method":[89],"on":[90],"combined":[92],"network,":[93],"we":[94],"predicted":[95],"potential":[96],"regulators":[97],"activation.":[100],"Prediction":[101],"performance":[102],"significantly":[103],"increased":[104],"addition":[107],"edges,":[110],"and":[111,118,128],"prioritized":[113],"candidates":[114],"captured":[115],"inflammation,":[116],"immunity":[117],"CVD":[119],"signatures.":[120],"Integrating":[121],"novel":[123],"topology":[125],"transcriptomics":[127],"revealed":[130],"top":[131],"candidate":[132],"drivers":[133],"inflammation.":[135],"In":[136],"vitro":[137],"loss-of-function":[138],"experiments":[139],"demonstrated":[140],"regulatory":[142],"these":[145],"proteins":[146],"signaling.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-11-29T00:00:00"}
