{"id":"https://openalex.org/W2901449986","doi":"https://doi.org/10.3171/2018.4.jns172652","title":"In vivo histotripsy brain treatment","display_name":"In vivo histotripsy brain treatment","publication_year":2018,"publication_date":"2018-11-15","ids":{"openalex":"https://openalex.org/W2901449986","doi":"https://doi.org/10.3171/2018.4.jns172652","mag":"2901449986","pmid":"https://pubmed.ncbi.nlm.nih.gov/30485186","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6925659"},"language":"en","primary_location":{"id":"doi:10.3171/2018.4.jns172652","doi":"https://doi.org/10.3171/2018.4.jns172652","is_oa":true,"landing_page_url":"https://doi.org/10.3171/2018.4.jns172652","pdf_url":"https://thejns.org/downloadpdf/journals/j-neurosurg/131/4/article-p1331.pdf","source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://thejns.org/downloadpdf/journals/j-neurosurg/131/4/article-p1331.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033982782","display_name":"Jonathan R. Sukovich","orcid":"https://orcid.org/0000-0002-5650-991X","observed_orcids":["https://orcid.org/0000-0002-5650-991X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan R. Sukovich","raw_affiliation_strings":["Departments of Biomedical Engineering,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical Engineering,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113028792","display_name":"Charles A. Cain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles A. Cain","raw_affiliation_strings":["Departments of Biomedical Engineering,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical Engineering,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062190152","display_name":"Aditya Swarup Pandey","orcid":"https://orcid.org/0000-0003-0789-4273","observed_orcids":["https://orcid.org/0000-0003-0789-4273"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aditya S. Pandey","raw_affiliation_strings":["Neurosurgery,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgery,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045874363","display_name":"Neeraj Chaudhary","orcid":"https://orcid.org/0000-0003-0630-2547","observed_orcids":["https://orcid.org/0000-0003-0630-2547"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neeraj Chaudhary","raw_affiliation_strings":["Radiology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112903833","display_name":"Sandra Ines Camelo-Piragua","orcid":"https://orcid.org/0000-0002-9606-9402","observed_orcids":["https://orcid.org/0000-0002-9606-9402"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Camelo-Piragua","raw_affiliation_strings":["Pathology, University of Michigan, Ann Arbor, Michigan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, University of Michigan, Ann Arbor, Michigan;","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008723274","display_name":"Steven P. Allen","orcid":"https://orcid.org/0000-0003-4778-8168","observed_orcids":["https://orcid.org/0000-0003-4778-8168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven P. Allen","raw_affiliation_strings":["Departments of Biomedical Engineering,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical Engineering,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046270398","display_name":"Timothy L. Hall","orcid":"https://orcid.org/0000-0002-4867-2856","observed_orcids":["https://orcid.org/0000-0002-4867-2856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy L. Hall","raw_affiliation_strings":["Departments of Biomedical Engineering,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical Engineering,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010807952","display_name":"John Snell","orcid":"https://orcid.org/0000-0003-2683-6108","observed_orcids":["https://orcid.org/0000-0003-2683-6108","https://orcid.org/0009-0006-2508-8442"]},"institutions":[{"id":"https://openalex.org/I311903142","display_name":"Focused Ultrasound Foundation","ror":"https://ror.org/04qjbd269","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I311903142"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Snell","raw_affiliation_strings":["Focused Ultrasound Foundation, Charlottesville, Virginia;","University of Virginia, Department of Neurosurgery, Charlottesville, Virginia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Focused Ultrasound Foundation, Charlottesville, Virginia;","institution_ids":["https://openalex.org/I311903142"]},{"raw_affiliation_string":"University of Virginia, Department of Neurosurgery, Charlottesville, Virginia; and","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068443720","display_name":"Zhiyuan Xu","orcid":"https://orcid.org/0000-0002-7257-6856","observed_orcids":["https://orcid.org/0000-0002-7257-6856"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiyuan Xu","raw_affiliation_strings":["Departments of Biomedical Engineering,","University of Virginia, Department of Neurosurgery, Charlottesville, Virginia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical Engineering,","institution_ids":[]},{"raw_affiliation_string":"University of Virginia, Department of Neurosurgery, Charlottesville, Virginia; and","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111978193","display_name":"Jonathan M. Cannata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267956","display_name":"HistoSonics, Inc. (United States)","ror":"https://ror.org/055k8fy81","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267956"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan M. Cannata","raw_affiliation_strings":["HistoSonics, Inc., Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HistoSonics, Inc., Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4405267956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088045561","display_name":"Dejan Teofilovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267956","display_name":"HistoSonics, Inc. (United States)","ror":"https://ror.org/055k8fy81","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267956"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dejan Teofilovic","raw_affiliation_strings":["HistoSonics, Inc., Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HistoSonics, Inc., Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4405267956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080820094","display_name":"James A. Bertolina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267956","display_name":"HistoSonics, Inc. (United States)","ror":"https://ror.org/055k8fy81","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267956"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Bertolina","raw_affiliation_strings":["HistoSonics, Inc., Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HistoSonics, Inc., Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4405267956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078044974","display_name":"Neal F. Kassell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I311903142","display_name":"Focused Ultrasound Foundation","ror":"https://ror.org/04qjbd269","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I311903142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal Kassell","raw_affiliation_strings":["Focused Ultrasound Foundation, Charlottesville, Virginia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Focused Ultrasound Foundation, Charlottesville, Virginia;","institution_ids":["https://openalex.org/I311903142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017355711","display_name":"Zhen Xu","orcid":"https://orcid.org/0000-0003-0262-3044","observed_orcids":["https://orcid.org/0000-0003-0262-3044"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhen Xu","raw_affiliation_strings":["Departments of Biomedical Engineering,","University of Virginia, Department of Neurosurgery, Charlottesville, Virginia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical Engineering,","institution_ids":[]},{"raw_affiliation_string":"University of Virginia, Department of Neurosurgery, Charlottesville, Virginia; and","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3105,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.88492711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"131","issue":"4","first_page":"1331","last_page":"1338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histotripsy","display_name":"histotripsy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acoustic-cavitation","display_name":"acoustic cavitation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.5239999890327454},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.7210000157356262},{"id":"https://openalex.org/keywords/edema","display_name":"edema","score":0.7390000224113464},{"id":"https://openalex.org/keywords/mri-outcomes","display_name":"MRI outcomes","score":0.3720000088214874},{"id":"https://openalex.org/keywords/histological-outcomes","display_name":"histological outcomes","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.907654881477356},{"id":"https://openalex.org/C2985948822","wikidata":"https://www.wikidata.org/wiki/Q564897","display_name":"Focused ultrasound","level":3,"score":0.5852974653244019},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.561290442943573},{"id":"https://openalex.org/C2779727089","wikidata":"https://www.wikidata.org/wiki/Q564875","display_name":"Therapeutic ultrasound","level":3,"score":0.5415816903114319},{"id":"https://openalex.org/C2779369059","wikidata":"https://www.wikidata.org/wiki/Q1758383","display_name":"Gyrus","level":2,"score":0.5216448903083801},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5190792083740234},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.490688681602478},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4771246910095215},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4361970126628876},{"id":"https://openalex.org/C64012434","wikidata":"https://www.wikidata.org/wiki/Q6839290","display_name":"Microbubbles","level":3,"score":0.4236384928226471},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34980058670043945},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.10862967371940613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3171/2018.4.jns172652","doi":"https://doi.org/10.3171/2018.4.jns172652","is_oa":true,"landing_page_url":"https://doi.org/10.3171/2018.4.jns172652","pdf_url":"https://thejns.org/downloadpdf/journals/j-neurosurg/131/4/article-p1331.pdf","source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},{"id":"pmid:30485186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30485186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurosurgery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6925659","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6925659/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurosurg","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3171/2018.4.jns172652","doi":"https://doi.org/10.3171/2018.4.jns172652","is_oa":true,"landing_page_url":"https://doi.org/10.3171/2018.4.jns172652","pdf_url":"https://thejns.org/downloadpdf/journals/j-neurosurg/131/4/article-p1331.pdf","source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1289837697","display_name":"Novel Ultrasonic Technique for the Treatment of Hemorrhagic Stroke","funder_award_id":"R01NS108042","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3410636693","display_name":null,"funder_award_id":"S10 RR022425","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3473813510","display_name":"Image-guided Non-invasive Ultrasonic Thrombolysis Using Histotripsy","funder_award_id":"R01EB008998","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G6233059157","display_name":"High-Speed Optical Imaging for Medical Diagnosis and Therapy","funder_award_id":"S10RR022425","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8434819420","display_name":"Imaging Feedback to Guide Ultrasonic Tissue Fractionation for Cancer Therapy","funder_award_id":"R01CA134579","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309171","display_name":"Focused Ultrasound Foundation","ror":"https://ror.org/04qjbd269"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2901449986.pdf","grobid_xml":"https://content.openalex.org/works/W2901449986.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W195308866","https://openalex.org/W1516414236","https://openalex.org/W1603542412","https://openalex.org/W1895781480","https://openalex.org/W1935507357","https://openalex.org/W1971385195","https://openalex.org/W1973281923","https://openalex.org/W1974897995","https://openalex.org/W1978432461","https://openalex.org/W1980154864","https://openalex.org/W1985962834","https://openalex.org/W1987931700","https://openalex.org/W1988950556","https://openalex.org/W2002532476","https://openalex.org/W2017741298","https://openalex.org/W2022843396","https://openalex.org/W2025191689","https://openalex.org/W2029011692","https://openalex.org/W2035773301","https://openalex.org/W2039255009","https://openalex.org/W2040883398","https://openalex.org/W2055007518","https://openalex.org/W2061048404","https://openalex.org/W2066755143","https://openalex.org/W2071890828","https://openalex.org/W2073956340","https://openalex.org/W2076274585","https://openalex.org/W2085889654","https://openalex.org/W2088499309","https://openalex.org/W2090230042","https://openalex.org/W2090904570","https://openalex.org/W2091580446","https://openalex.org/W2093245095","https://openalex.org/W2098816456","https://openalex.org/W2114677264","https://openalex.org/W2119791583","https://openalex.org/W2127980347","https://openalex.org/W2143507292","https://openalex.org/W2144352085","https://openalex.org/W2145705662","https://openalex.org/W2165510365","https://openalex.org/W2169057357","https://openalex.org/W2277983862","https://openalex.org/W2279215614","https://openalex.org/W2346361841","https://openalex.org/W2735195563"],"related_works":["https://openalex.org/W3153844049","https://openalex.org/W2118213324","https://openalex.org/W3048132535","https://openalex.org/W1973281923","https://openalex.org/W2279215614","https://openalex.org/W2009497118","https://openalex.org/W2552065445","https://openalex.org/W3203660391","https://openalex.org/W3164951014","https://openalex.org/W2934683812"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Histotripsy":[1,147,165,248],"is":[2],"an":[3,56],"ultrasound-based":[4],"treatment":[5,212,283],"modality":[6],"relying":[7],"on":[8],"the":[9,23,29,44,60,70,88,94,133,163,202,232,238,263,270,282,286],"generation":[10],"of":[11,22,38,79,90,144,157,184,228,257],"targeted":[12,115],"cavitation":[13],"bubble":[14],"clouds,":[15],"which":[16],"mechanically":[17],"fractionate":[18],"tissue.":[19],"The":[20],"purpose":[21],"current":[24],"study":[25],"was":[26,148],"to":[27,54,59,66,81,86,109,150,159,169,201,221,241,244,252,268,275],"investigate":[28],"in":[30,69,93,132,162,193,231,262,285],"vivo":[31],"feasibility,":[32],"including":[33],"dosage":[34],"requirements":[35],"and":[36,104,116,127,138,178,224,260],"safety,":[37],"generating":[39],"well-confined":[40],"destructive":[41],"lesions":[42,68,74,97,152,166,199,240,256],"within":[43,118,269],"porcine":[45,71],"brain":[46],"utilizing":[47],"histotripsy":[48,62,91,239],"technology.":[49],"METHODS:":[50],"Following":[51],"a":[52,76,154],"craniectomy":[53],"open":[55],"acoustic":[57],"window":[58],"brain,":[61],"pulses":[63],"were":[64,84,98,113,130,167,213],"delivered":[65],"generate":[67,151,253],"cortex.":[72,164,265],"Large":[73],"with":[75,153,173,181,198],"major":[77,155,205],"dimension":[78,156],"up":[80,158],"1":[82,160],"cm":[83,161],"generated":[85,99],"demonstrate":[87],"efficacy":[89],"lesioning":[92],"brain.":[95],"Gyrus-confined":[96],"at":[100,281],"different":[101],"applied":[102],"dosages":[103],"under":[105],"ultrasound":[106],"imaging":[107],"guidance":[108],"ensure":[110],"that":[111],"they":[112],"accurately":[114],"contained":[117],"individual":[119],"gyri.":[120],"Clinical":[121],"evaluation":[122,236],"as":[123,125],"well":[124,171],"MRI":[126,218],"histological":[128,182],"outcomes":[129],"assessed":[131],"acute":[134,287],"(\u2264":[135,140],"6":[136],"hours)":[137,142],"subacute":[139,245,289],"72":[141,216],"phases":[143],"recovery.":[145],"RESULTS:":[146],"able":[149],"seen":[168],"be":[170,242,250],"demarcated":[172],"sharp":[174],"boundaries":[175,192],"between":[176],"treated":[177],"untreated":[179],"tissues,":[180],"evidence":[183,227],"injuries":[185],"extending":[186],"\u2264":[187],"200":[188],"\u00b5m":[189],"from":[190,211],"their":[191],"all":[194],"cases.":[195],"In":[196],"animals":[197],"confined":[200,267],"gyrus,":[203],"no":[204,222,225],"hemorrhage":[206,277],"or":[207,278,288],"other":[208],"complications":[209],"resulting":[210],"observed.":[214],"At":[215],"hours,":[217],"revealed":[219,237],"minimal":[220],"edema":[223,279],"radiographic":[226],"inflammatory":[229],"changes":[230],"perilesional":[233],"area.":[234],"Histological":[235],"similar":[243],"infarcts.":[246],"CONCLUSIONS:":[247],"can":[249],"used":[251],"sharply":[254],"defined":[255],"arbitrary":[258],"shapes":[259],"sizes":[261],"swine":[264],"Lesions":[266],"gyri":[271],"did":[272],"not":[273],"lead":[274],"significant":[276],"responses":[280],"site":[284],"time":[290],"intervals.":[291]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-11-29T00:00:00"}