{"id":"https://openalex.org/W2901423402","doi":null,"title":"Early chronology of heat stress-induced alterations in skeletal muscle","display_name":"Early chronology of heat stress-induced alterations in skeletal muscle","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2901423402","mag":"2901423402"},"language":"en","primary_location":{"id":"pmh:oai:lib.dr.iastate.edu:etd-7537","doi":null,"is_oa":true,"landing_page_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=7537&context=etd","pdf_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=7537&context=etd","source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},"parent_works":[],"lineage":["https://openalex.org/W2901423402"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=7537&context=etd","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021604565","display_name":"Olga Volodina","orcid":"https://orcid.org/0000-0001-7086-2288","observed_orcids":["https://orcid.org/0000-0001-7086-2288"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Olga Volodina","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7086-2288","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5021604565"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12365","display_name":"Effects of Environmental Stressors on Livestock","score":0.1965000033378601,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.09799999743700027,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heat-stress","display_name":"heat stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.8450000286102295},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7870000004768372},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.7649999856948853},{"id":"https://openalex.org/keywords/mitochondrial-electron-transport-chain","display_name":"mitochondrial electron transport chain","score":0.8289999961853027},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8289999961853027},{"id":"https://openalex.org/keywords/inflammatory-signaling-pathways","display_name":"inflammatory signaling","score":0.7269999980926514},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9240000247955322},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.9039999842643738},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9179999828338623},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.843999981880188},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.968999981880188},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.7099999785423279},{"id":"https://openalex.org/keywords/thermoneutrality","display_name":"thermoneutrality","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C181536285","wikidata":"https://www.wikidata.org/wiki/Q130788","display_name":"Chronology","level":2,"score":0.6204931735992432},{"id":"https://openalex.org/C2987418964","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Heat stress","level":2,"score":0.6080603003501892},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5944951772689819},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2597543001174927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24020916223526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23380526900291443},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.09876355528831482},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:lib.dr.iastate.edu:etd-7537","doi":null,"is_oa":true,"landing_page_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=7537&context=etd","pdf_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=7537&context=etd","source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},{"id":"mag:2901423402","doi":null,"is_oa":false,"landing_page_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=7537&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:lib.dr.iastate.edu:etd-7537","doi":null,"is_oa":true,"landing_page_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=7537&context=etd","pdf_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=7537&context=etd","source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2901423402.pdf","grobid_xml":"https://content.openalex.org/works/W2901423402.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2315601282"],"related_works":["https://openalex.org/W2608943605","https://openalex.org/W2315601282","https://openalex.org/W2749195354","https://openalex.org/W2308927362","https://openalex.org/W2610483367","https://openalex.org/W2902758626","https://openalex.org/W3171622260","https://openalex.org/W2992885345","https://openalex.org/W4393304379"],"abstract_inverted_index":{"Prolonged":[0],"exposure":[1,115],"to":[2,28,82,94,116,120,138,183,209,274,278,300,310],"elevated":[3,117,301],"environmental":[4],"temperature":[5,118,302],"can":[6],"result":[7],"in":[8,73,85,89,109,135,155,161,200,211,291,294],"heat":[9,35,43,71,110,149,162,184,197,240,253,281,319],"stress.":[10,147,254],"Heat":[11],"stress":[12,36,72,111,150,163,185,198,205,282,320],"has":[13,99,329],"negative":[14],"effects":[15],"on":[16,332],"human":[17],"health,":[18],"animal":[19],"health":[20],"and":[21,23,49,76,145,221,286,324],"wellbeing,":[22],"brings":[24],"economic":[25],"losses":[26],"related":[27],"agricultural":[29],"production.":[30],"While":[31],"clinical":[32],"symptoms":[33],"of":[34,42,54,57,65,126,141,203,218,232,239,245,252,264],"are":[37,50],"well":[38],"studied,":[39],"intracellular":[40],"mechanisms":[41],"stress-induced":[44],"injury":[45,112],"require":[46],"further":[47],"investigation":[48],"essential":[51],"for":[52,186,303],"development":[53],"etiological":[55],"treatment":[56],"heal":[58],"illness.":[59],"Skeletal":[60],"muscle":[61,92],"dysfunction":[62,123],"is":[63],"one":[64],"the":[66,90,127,225,268,276],"major":[67,86],"pathologies":[68],"associated":[69,259],"with":[70,260],"both":[74],"humans":[75],"animals.":[77],"This":[78],"thesis":[79,167],"was":[80,168,258],"aimed":[81,273],"determine":[83,159,275],"changes":[84,160,215],"pathways":[87,154],"involved":[88],"skeletal":[91,156,296],"response":[93],"short-term":[95,280,318],"hyperthermic":[96],"exposure.":[97],"It":[98],"been":[100],"established":[101],"that":[102,196],"redox":[103,292,322],"balance":[104,293,323],"plays":[105],"a":[106,288],"crucial":[107],"role":[108],"as":[113],"an":[114],"leads":[119,137],"mitochondrial":[121,128,133,219,222,284,307,333],"respiratory":[122],"via":[124],"disruption":[125],"electron":[129],"transport":[130],"chain.":[131],"Dysfunctional":[132],"respiration,":[134],"turn,":[136],"increased":[139],"production":[140],"reactive":[142],"oxygen":[143],"species":[144],"oxidative":[146,204],"Further,":[148],"activates":[151,325],"inflammatory":[152,326],"signaling":[153,234,256,327],"muscle.":[157,297],"To":[158],"sensitive":[164],"pathways,":[165],"this":[166],"divided":[169],"into":[170],"three":[171],"research":[172,176,227,270],"chapters.":[173],"The":[174],"first":[175],"chapter":[177,228,271],"includes":[178],"results":[179],"from":[180],"pigs":[181],"exposed":[182,299],"2":[187],"h,":[188,190],"4":[189,237],"or":[191,336],"6":[192,250,304],"h.":[193],"We":[194],"found":[195,230],"resulted":[199],"decreased":[201,261],"abundance":[202,263],"indicators":[206],"likely":[207],"due":[208],"elevations":[210],"antioxidant":[212],"activity.":[213],"These":[214],"were":[216],"independent":[217],"content":[220],"biogenesis.":[223],"In":[224,267,316],"second":[226],"we":[229,272],"activation":[231,247,257],"AP-1":[233],"pathway":[235],"following":[236,249],"h":[238,251,305],"stress,":[241],"while":[242],"initial":[243],"signs":[244],"NF-\u03baB":[246],"occurred":[248],"Inflammatory":[255],"protein":[262],"cytokine":[265],"IL-6.":[266],"final":[269],"extent":[277],"which":[279],"altered":[283],"function":[285,308],"confirm":[287],"reductive":[289],"shift":[290],"murine":[295],"Mice":[298],"had":[306],"similar":[309],"animals":[311],"kept":[312],"under":[313],"thermoneutral":[314],"conditions.":[315],"conclusion,":[317],"shifts":[321],"but":[328],"little":[330],"effect":[331],"content,":[334],"biogenesis,":[335],"function.":[337]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2018-11-29T00:00:00"}
