{"id":"https://openalex.org/W2901264140","doi":null,"title":"Flux balance analysis of Plasmodium falciparum growth and energy metabolism","display_name":"Flux balance analysis of Plasmodium falciparum growth and energy metabolism","publication_year":2017,"publication_date":"2017-12-01","ids":{"openalex":"https://openalex.org/W2901264140","mag":"2901264140"},"language":"en","primary_location":{"id":"pmh:oai:scholar.sun.ac.za:10019.1/102598","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10019.1/102598","pdf_url":"http://hdl.handle.net/10019.1/102598","source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10019.1/102598","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016680650","display_name":"Robert William Burger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Robert William Burger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016680650"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":1.0},{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"flux balance analysis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/genome-scale-metabolic-models","display_name":"genome-scale metabolic models","score":0.7289999723434448},{"id":"https://openalex.org/keywords/parasite-growth","display_name":"parasite growth","score":0.8510000109672546},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.9089999794960022},{"id":"https://openalex.org/keywords/biomass-production","display_name":"biomass production","score":0.8109999895095825},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.7310000061988831},{"id":"https://openalex.org/keywords/atovaquone","display_name":"atovaquone","score":0.9459999799728394},{"id":"https://openalex.org/keywords/metabolic-network-simulation","display_name":"metabolic network simulation","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.6241335868835449},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.6104081273078918},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.5727542638778687},{"id":"https://openalex.org/C2777423268","wikidata":"https://www.wikidata.org/wiki/Q3663116","display_name":"Energy balance","level":2,"score":0.5482412576675415},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.48606017231941223},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.4389423131942749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36817896366119385},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2649756669998169},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2293568253517151},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.21919304132461548},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.17397662997245789},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13231024146080017},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.09225103259086609},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.059635281562805176},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholar.sun.ac.za:10019.1/102598","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10019.1/102598","pdf_url":"http://hdl.handle.net/10019.1/102598","source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2901264140","doi":null,"is_oa":false,"landing_page_url":"https://scholar.sun.ac.za/handle/10019.1/102598","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholar.sun.ac.za:10019.1/102598","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10019.1/102598","pdf_url":"http://hdl.handle.net/10019.1/102598","source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5343157487","display_name":null,"funder_award_id":"82813","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2901264140.pdf","grobid_xml":"https://content.openalex.org/works/W2901264140.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W9841291","https://openalex.org/W1845019034","https://openalex.org/W1965418384","https://openalex.org/W1967225297","https://openalex.org/W1969680376","https://openalex.org/W1971403296","https://openalex.org/W1976730633","https://openalex.org/W1977041255","https://openalex.org/W2004857711","https://openalex.org/W2007745105","https://openalex.org/W2012439378","https://openalex.org/W2015796769","https://openalex.org/W2021747008","https://openalex.org/W2032920633","https://openalex.org/W2033591223","https://openalex.org/W2052137707","https://openalex.org/W2052859950","https://openalex.org/W2059535228","https://openalex.org/W2059546521","https://openalex.org/W2094491295","https://openalex.org/W2104108767","https://openalex.org/W2106907365","https://openalex.org/W2107062718","https://openalex.org/W2109104657","https://openalex.org/W2118846793","https://openalex.org/W2120167281","https://openalex.org/W2122150697","https://openalex.org/W2130962879","https://openalex.org/W2132218677","https://openalex.org/W2136623181","https://openalex.org/W2142338182","https://openalex.org/W2142469205","https://openalex.org/W2144856591","https://openalex.org/W2148292884","https://openalex.org/W2153373497","https://openalex.org/W2154367381","https://openalex.org/W2155049977","https://openalex.org/W2156779720","https://openalex.org/W2158293950","https://openalex.org/W2160751597","https://openalex.org/W2165943792","https://openalex.org/W2169038227","https://openalex.org/W2313084985","https://openalex.org/W2337717688","https://openalex.org/W2419380513","https://openalex.org/W4298267312","https://openalex.org/W4323915027","https://openalex.org/W7073557482"],"related_works":["https://openalex.org/W7210527678","https://openalex.org/W1933985894","https://openalex.org/W2753736157","https://openalex.org/W2156522652","https://openalex.org/W2955227195","https://openalex.org/W2603639392","https://openalex.org/W1514203218","https://openalex.org/W564170918","https://openalex.org/W2741275442","https://openalex.org/W2214475354"],"abstract_inverted_index":{"Genome-scale":[0],"network":[1],"reconstructions":[2],"serve":[3],"as":[4],"an":[5,87],"ideal":[6],"tool":[7],"for":[8,42,66],"the":[9,43,61,70,73,78,81,84],"modeling":[10],"of":[11,28,46,57,63,72,80,86],"large,":[12],"complex":[13],"metabolic":[14],"networks.In":[15],"this":[16],"study":[17],"we":[18,75],"use":[19],"flux-balance":[20],"analysis":[21],"to":[22,35,50,83],"investigate":[23],"key":[24],"amino":[25],"acid":[26],"dependencies":[27],"Plasmodium":[29],"falciparum":[30],"growth.Our":[31],"model":[32,74,82],"was":[33],"able":[34,49],"produce":[36],"a":[37,55],"realistic":[38],"flux":[39],"distribution":[40],"geared":[41],"optimal":[44,67],"production":[45],"biomass.We":[47],"were":[48],"simulate":[51,77],"parasite":[52],"growth":[53],"in":[54],"variety":[56],"conditions":[58,65],"and":[59],"assess":[60],"favourability":[62],"these":[64],"growth.To":[68],"demonstrate":[69],"applicability":[71],"additionally":[76],"response":[79],"introduction":[85],"antimalarial":[88],"agent,":[89],"atovaquone.":[90]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-11-29T00:00:00"}