{"id":"https://openalex.org/W2901255143","doi":"https://doi.org/10.1038/s41592-018-0212-y","title":"Efficient scarless genome editing in human pluripotent stem cells","display_name":"Efficient scarless genome editing in human pluripotent stem cells","publication_year":2018,"publication_date":"2018-11-19","ids":{"openalex":"https://openalex.org/W2901255143","doi":"https://doi.org/10.1038/s41592-018-0212-y","mag":"2901255143","pmid":"https://pubmed.ncbi.nlm.nih.gov/30504872"},"language":"en","primary_location":{"id":"doi:10.1038/s41592-018-0212-y","doi":"https://doi.org/10.1038/s41592-018-0212-y","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41592-018-0212-y","pdf_url":null,"source":{"id":"https://openalex.org/S127827428","display_name":"Nature Methods","issn_l":"1548-7091","issn":["1548-7091","1548-7105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Methods","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042092033","display_name":"Kazuya Ikeda","orcid":"https://orcid.org/0000-0003-3671-5940","observed_orcids":["https://orcid.org/0000-0003-3671-5940"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazuya Ikeda","raw_affiliation_strings":["Department of Pediatrics, Stanford University, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-3671-5940","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109348318","display_name":"Nobuko Uchida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuko Uchida","raw_affiliation_strings":["ReGen Med Division, BOCO Silicon Valley, Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ReGen Med Division, BOCO Silicon Valley, Palo Alto, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084586140","display_name":"Toshinobu Nishimura","orcid":"https://orcid.org/0000-0002-5425-1708","observed_orcids":["https://orcid.org/0000-0002-5425-1708"]},"institutions":[{"id":"https://openalex.org/I4394709089","display_name":"Institute for Stem Cell Biology and Regenerative Medicine","ror":"https://ror.org/02vbab064","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4394709089","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toshinobu Nishimura","raw_affiliation_strings":["Department of Genetics, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I4394709089","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Joseph White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709089","display_name":"Institute for Stem Cell Biology and Regenerative Medicine","ror":"https://ror.org/02vbab064","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4394709089","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph White","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I4394709089","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062116896","display_name":"Renata M. Martin","orcid":"https://orcid.org/0000-0003-2996-4260","observed_orcids":["https://orcid.org/0000-0003-2996-4260"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renata M. Martin","raw_affiliation_strings":["Department of Pediatrics, Stanford University, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-2996-4260","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059937255","display_name":"Hiromitsu Nakauchi","orcid":"https://orcid.org/0000-0002-9841-6973","observed_orcids":["https://orcid.org/0000-0002-9841-6973","https://orcid.org/0000-0002-8122-2566"]},"institutions":[{"id":"https://openalex.org/I4394709089","display_name":"Institute for Stem Cell Biology and Regenerative Medicine","ror":"https://ror.org/02vbab064","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4394709089","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiromitsu Nakauchi","raw_affiliation_strings":["Department of Genetics, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I4394709089","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012862996","display_name":"Vittorio Sebastiano","orcid":"https://orcid.org/0000-0002-8498-8655","observed_orcids":["https://orcid.org/0000-0002-8498-8655"]},"institutions":[{"id":"https://openalex.org/I4394709089","display_name":"Institute for Stem Cell Biology and Regenerative Medicine","ror":"https://ror.org/02vbab064","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4394709089","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vittorio Sebastiano","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I4394709089","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046180673","display_name":"Kenneth I. Weinberg","orcid":"https://orcid.org/0000-0003-1922-9131","observed_orcids":["https://orcid.org/0000-0003-1922-9131"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth I. Weinberg","raw_affiliation_strings":["Department of Pediatrics, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007644395","display_name":"Matthew Hebden Porteus","orcid":"https://orcid.org/0000-0002-3850-4648","observed_orcids":["https://orcid.org/0000-0002-3850-4648"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew H. Porteus","raw_affiliation_strings":["Department of Pediatrics, Stanford University, Stanford, CA, USA. mporteus@stanford.edu","Department of Pediatrics, Stanford University, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3850-4648","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Stanford University, Stanford, CA, USA. mporteus@stanford.edu","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pediatrics, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007644395"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":0.8732,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.7165768,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"15","issue":"12","first_page":"1045","last_page":"1047"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-pluripotent-stem-cells","display_name":"human pluripotent stem cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/crispr-cas9","display_name":"CRISPR/Cas9","score":0.9819999933242798},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9980000257492065},{"id":"https://openalex.org/keywords/positive-and-negative-selection","display_name":"positive and negative selection","score":0.925000011920929},{"id":"https://openalex.org/keywords/shrna","display_name":"shRNA","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.8462851643562317},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.7880438566207886},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7857540845870972},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.7641141414642334},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.7373161315917969},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6052912473678589},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.597924530506134},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5406020283699036},{"id":"https://openalex.org/C2910924664","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Human Induced Pluripotent Stem Cells","level":5,"score":0.501011848449707},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4625731110572815},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.4350022077560425},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.4269666373729706},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4179842472076416},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.37463247776031494},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32140928506851196},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21638891100883484},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.07665273547172546},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059765","descriptor_name":"Homologous Recombination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/s41592-018-0212-y","doi":"https://doi.org/10.1038/s41592-018-0212-y","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41592-018-0212-y","pdf_url":null,"source":{"id":"https://openalex.org/S127827428","display_name":"Nature Methods","issn_l":"1548-7091","issn":["1548-7091","1548-7105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Methods","raw_type":"journal-article"},{"id":"pmid:30504872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30504872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature methods","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2003418092","https://openalex.org/W2053763799","https://openalex.org/W2058864686","https://openalex.org/W2091140839","https://openalex.org/W2102098190","https://openalex.org/W2109427914","https://openalex.org/W2157304951","https://openalex.org/W2159714953","https://openalex.org/W2179681966","https://openalex.org/W2343876552","https://openalex.org/W2545491855","https://openalex.org/W2781815848","https://openalex.org/W2793671517"],"related_works":["https://openalex.org/W2781815848","https://openalex.org/W2942076130","https://openalex.org/W2790739701","https://openalex.org/W4398240517","https://openalex.org/W2793671517","https://openalex.org/W2572003722","https://openalex.org/W3173198734","https://openalex.org/W2898236698","https://openalex.org/W2514410885","https://openalex.org/W4285086646"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-11-29T00:00:00"}
