{"id":"https://openalex.org/W2901229709","doi":"https://doi.org/10.31138/mjr.28.4.174","title":"Dkk1: A key molecule in joint remodelling and fibrosis","display_name":"Dkk1: A key molecule in joint remodelling and fibrosis","publication_year":2017,"publication_date":"2017-10-01","ids":{"openalex":"https://openalex.org/W2901229709","doi":"https://doi.org/10.31138/mjr.28.4.174","mag":"2901229709","pmid":"https://pubmed.ncbi.nlm.nih.gov/32185280","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7045998"},"language":"en","primary_location":{"id":"doi:10.31138/mjr.28.4.174","doi":"https://doi.org/10.31138/mjr.28.4.174","is_oa":true,"landing_page_url":"https://doi.org/10.31138/mjr.28.4.174","pdf_url":"https://www.mjrheum.org/assets/files/792/file99_886.pdf","source":{"id":"https://openalex.org/S4210235892","display_name":"Mediterranean Journal of Rheumatology","issn_l":"2529-198X","issn":["2529-198X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","poland-20","russia-white-list-4","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean Journal of Rheumatology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.mjrheum.org/assets/files/792/file99_886.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002807035","display_name":"Kalliopi Klavdianou","orcid":"https://orcid.org/0000-0002-1267-1106","observed_orcids":["https://orcid.org/0000-0002-1267-1106"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Kalliopi Klavdianou","raw_affiliation_strings":["Department of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece","Assistant Professor of Medicine/Rheumatology Medical University of Patras University Department of Internal Medicine, Rheumatology Department Rheumatology Research Laboratory March 25 26504 K. Kastritsi Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]},{"raw_affiliation_string":"Assistant Professor of Medicine/Rheumatology Medical University of Patras University Department of Internal Medicine, Rheumatology Department Rheumatology Research Laboratory March 25 26504 K. Kastritsi Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062248231","display_name":"Stamatis\u2010Nick C. Liossis","orcid":"https://orcid.org/0000-0003-2511-8083","observed_orcids":["https://orcid.org/0000-0003-2511-8083"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Stamatis-Nick Liossis","raw_affiliation_strings":["Department of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece","Assistant Professor of Medicine/Rheumatology Medical University of Patras University Department of Internal Medicine, Rheumatology Department Rheumatology Research Laboratory March 25 26504 K. Kastritsi Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]},{"raw_affiliation_string":"Assistant Professor of Medicine/Rheumatology Medical University of Patras University Department of Internal Medicine, Rheumatology Department Rheumatology Research Laboratory March 25 26504 K. Kastritsi Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039944418","display_name":"Dimitrios Daoussis","orcid":"https://orcid.org/0000-0001-8027-3655","observed_orcids":["https://orcid.org/0000-0001-8027-3655"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Dimitrios Daoussis","raw_affiliation_strings":["Department of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece","Assistant Professor of Medicine/Rheumatology Medical University of Patras University Department of Internal Medicine, Rheumatology Department Rheumatology Research Laboratory March 25 26504 K. Kastritsi Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]},{"raw_affiliation_string":"Assistant Professor of Medicine/Rheumatology Medical University of Patras University Department of Internal Medicine, Rheumatology Department Rheumatology Research Laboratory March 25 26504 K. Kastritsi Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039944418"],"corresponding_institution_ids":["https://openalex.org/I174878644"],"apc_list":null,"apc_paid":null,"fwci":0.0413,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.04463643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"28","issue":"4","first_page":"174","last_page":"182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.32030001282691956,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.32030001282691956,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.12630000710487366,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.1071000024676323,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dkk1","display_name":"DKK1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/wnt-signaling-inhibition","display_name":"Wnt signaling inhibition","score":0.7960000038146973},{"id":"https://openalex.org/keywords/joint-remodeling","display_name":"joint remodeling","score":0.9440000057220459},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.847000002861023},{"id":"https://openalex.org/keywords/ankylosing-spondylitis","display_name":"ankylosing spondylitis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/arthritis","display_name":"arthritis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.5559999942779541},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6349999904632568},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8220000267028809},{"id":"https://openalex.org/keywords/skin-fibrosis","display_name":"skin fibrosis","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.7166990637779236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6141002178192139},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5697198510169983},{"id":"https://openalex.org/C2777402515","wikidata":"https://www.wikidata.org/wiki/Q52849","display_name":"Ankylosing spondylitis","level":2,"score":0.4632619023323059},{"id":"https://openalex.org/C2777491412","wikidata":"https://www.wikidata.org/wiki/Q18036610","display_name":"DKK1","level":4,"score":0.4495231509208679},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.44334739446640015},{"id":"https://openalex.org/C2779967694","wikidata":"https://www.wikidata.org/wiki/Q1383511","display_name":"Scleroderma (fungus)","level":3,"score":0.44093868136405945},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.4153684377670288},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.41420888900756836},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3589659631252289},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35121023654937744},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3417547643184662},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21374750137329102},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2101818323135376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1837913990020752},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1102806031703949},{"id":"https://openalex.org/C180032290","wikidata":"https://www.wikidata.org/wiki/Q1664296","display_name":"Inoculation","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.31138/mjr.28.4.174","doi":"https://doi.org/10.31138/mjr.28.4.174","is_oa":true,"landing_page_url":"https://doi.org/10.31138/mjr.28.4.174","pdf_url":"https://www.mjrheum.org/assets/files/792/file99_886.pdf","source":{"id":"https://openalex.org/S4210235892","display_name":"Mediterranean Journal of Rheumatology","issn_l":"2529-198X","issn":["2529-198X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","poland-20","russia-white-list-4","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean Journal of Rheumatology","raw_type":"journal-article"},{"id":"pmid:32185280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32185280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean journal of rheumatology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7045998","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7045998/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterr J Rheumatol","raw_type":"Text"},{"id":"pmh:https://cyberleninka.ru/article/n/dkk1-a-key-molecule-in-joint-remodelling-and-fibrosis","doi":null,"is_oa":true,"landing_page_url":"https://cyberleninka.ru/article/n/dkk1-a-key-molecule-in-joint-remodelling-and-fibrosis","pdf_url":null,"source":{"id":"https://openalex.org/S4306401404","display_name":"CyberLeninK (CyberLeninka)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:e5d7f2da5fe6434cb32f566ec3eb5f64","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e5d7f2da5fe6434cb32f566ec3eb5f64","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mediterranean Journal of Rheumatology, Vol 28, Iss 4, Pp 174-182 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.31138/mjr.28.4.174","doi":"https://doi.org/10.31138/mjr.28.4.174","is_oa":true,"landing_page_url":"https://doi.org/10.31138/mjr.28.4.174","pdf_url":"https://www.mjrheum.org/assets/files/792/file99_886.pdf","source":{"id":"https://openalex.org/S4210235892","display_name":"Mediterranean Journal of Rheumatology","issn_l":"2529-198X","issn":["2529-198X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","poland-20","russia-white-list-4","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean Journal of Rheumatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2901229709.pdf","grobid_xml":"https://content.openalex.org/works/W2901229709.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W201653061","https://openalex.org/W981460048","https://openalex.org/W1778447872","https://openalex.org/W1831059025","https://openalex.org/W1907562818","https://openalex.org/W1918709511","https://openalex.org/W1918718462","https://openalex.org/W1967131493","https://openalex.org/W1968593380","https://openalex.org/W1973613422","https://openalex.org/W1974619242","https://openalex.org/W1978270439","https://openalex.org/W1982804269","https://openalex.org/W1987104810","https://openalex.org/W1993126740","https://openalex.org/W1994928797","https://openalex.org/W2003999827","https://openalex.org/W2005403632","https://openalex.org/W2007791827","https://openalex.org/W2012884263","https://openalex.org/W2018575064","https://openalex.org/W2020674681","https://openalex.org/W2028914771","https://openalex.org/W2031509868","https://openalex.org/W2037930731","https://openalex.org/W2043691868","https://openalex.org/W2045977996","https://openalex.org/W2052998950","https://openalex.org/W2056202684","https://openalex.org/W2057339670","https://openalex.org/W2059114286","https://openalex.org/W2060290432","https://openalex.org/W2064912275","https://openalex.org/W2069543462","https://openalex.org/W2070150094","https://openalex.org/W2070567106","https://openalex.org/W2074496483","https://openalex.org/W2075282559","https://openalex.org/W2083141507","https://openalex.org/W2085748055","https://openalex.org/W2086694435","https://openalex.org/W2089781422","https://openalex.org/W2095813219","https://openalex.org/W2095930129","https://openalex.org/W2095975942","https://openalex.org/W2100274551","https://openalex.org/W2100835225","https://openalex.org/W2102859558","https://openalex.org/W2106544674","https://openalex.org/W2110495233","https://openalex.org/W2111888125","https://openalex.org/W2117156715","https://openalex.org/W2119284420","https://openalex.org/W2119413986","https://openalex.org/W2135084900","https://openalex.org/W2141520345","https://openalex.org/W2143227567","https://openalex.org/W2147225264","https://openalex.org/W2156105259","https://openalex.org/W2157101382","https://openalex.org/W2157881774","https://openalex.org/W2158734690","https://openalex.org/W2164113977","https://openalex.org/W2165992621","https://openalex.org/W2169453638","https://openalex.org/W2169869729","https://openalex.org/W2176368777","https://openalex.org/W2255771722","https://openalex.org/W2312561295","https://openalex.org/W2340806795","https://openalex.org/W2397597082","https://openalex.org/W2404673691","https://openalex.org/W2473230786","https://openalex.org/W2482825522","https://openalex.org/W2531669554","https://openalex.org/W4233627166","https://openalex.org/W6683421388"],"related_works":["https://openalex.org/W2507731631","https://openalex.org/W1983687614","https://openalex.org/W2079764599","https://openalex.org/W2158734690","https://openalex.org/W2110495233","https://openalex.org/W2909615353","https://openalex.org/W3160924636","https://openalex.org/W3007726211","https://openalex.org/W2314160648","https://openalex.org/W2330239429"],"abstract_inverted_index":{"Dickkopf-1":[0,71],"(Dkk-1)":[1],"is":[2,34,114,123,194,207],"a":[3,173,216,229,240],"Wnt":[4],"signaling":[5],"pathway":[6],"inhibitor":[7],"that":[8,31,129,145,180],"has":[9],"been":[10],"shown":[11],"to":[12,93],"play":[13],"an":[14,98,109,185],"important":[15],"role":[16,52,218],"in":[17,20,26,36,55,64,83,134,151,155,188,197,201,219,231,244],"joint":[18,56,77,105,220,236],"remodeling,":[19,78],"experimental":[21],"models":[22,143],"of":[23,53,97,104,170],"arthritis":[24],"and":[25,58,163,222,224],"humans.":[27],"Recent":[28],"data":[29,49,140],"suggest":[30],"this":[32,181],"molecule":[33,182],"involved":[35,150],"the":[37,47,51,69,84,95,102,152,160,198,211],"fibrotic":[38,153,189,245],"process":[39,103,154],"as":[40,159,227,239],"well.":[41],"OBJECTIVES:":[42],"This":[43],"review":[44],"summarizes":[45],"all":[46],"available":[48],"regarding":[50],"Dkk-1":[54,130,146,171,193,206,214],"remodeling":[57,221,237],"fibrosis.":[59],"METHODS:":[60],"An":[61],"electronic":[62],"search":[63],"literature":[65],"was":[66],"performed":[67],"using":[68],"terms":[70],"(Dkk-1),":[72],"fibrosis,":[73],"Systemic":[74],"Sclerosis":[75],"(Scleroderma),":[76],"Ankylosing":[79],"Spondylitis.":[80],"Moreover,":[81,139],"references":[82],"retrieved":[85],"articles":[86],"were":[87],"reviewed.":[88],"RESULTS:":[89],"Dkk1":[90,113],"expression":[91,122,169],"seems":[92],"determine":[94],"fate":[96],"arthritic":[99],"joint,":[100],"shifting":[101],"remodelling":[106],"towards":[107],"either":[108,228],"erosive/destructive":[110],"phenotype,":[111],"when":[112,120],"overexpressed":[115],"or":[116,238],"new":[117],"bone":[118],"formation":[119],"its":[121],"decreased.":[124],"In":[125,165,191],"humans,":[126,192],"evidence":[127],"suggests":[128],"may":[131,147],"be":[132,148,184],"dysfunctional":[133],"patients":[135,202],"with":[136,203],"ankylosing":[137],"spondylitis.":[138],"from":[141,210],"animal":[142,166],"indicate":[144],"crucially":[149],"several":[156],"organs":[157],"such":[158],"liver,":[161],"lungs":[162],"kidneys.":[164],"models,":[167],"enhanced":[168],"had":[172],"clear":[174],"suppressive":[175],"effect":[176],"on":[177],"fibrosis":[178,223],"suggesting":[179],"could":[183,225],"attractive":[186],"target":[187,243],"diseases.":[190,246],"clearly":[195],"expressed":[196],"skin.":[199,212],"However,":[200],"systemic":[204],"sclerosis":[205],"strikingly":[208],"absent":[209],"CONCLUSION:":[213],"plays":[215],"critical":[217],"serve":[226],"biomarker":[230],"diseases":[232],"characterized":[233],"by":[234],"pathological":[235],"potential":[241],"therapeutic":[242]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-11-29T00:00:00"}