{"id":"https://openalex.org/W2901219686","doi":"https://doi.org/10.1039/c8nr05933k","title":"Polymer nanoparticles for the intravenous delivery of anticancer drugs: the checkpoints on the road from the synthesis to clinical translation","display_name":"Polymer nanoparticles for the intravenous delivery of anticancer drugs: the checkpoints on the road from the synthesis to clinical translation","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2901219686","doi":"https://doi.org/10.1039/c8nr05933k","mag":"2901219686","pmid":"https://pubmed.ncbi.nlm.nih.gov/30512025"},"language":"en","primary_location":{"id":"doi:10.1039/c8nr05933k","doi":"https://doi.org/10.1039/c8nr05933k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8nr05933k","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011192228","display_name":"Raffaele Ferrari","orcid":"https://orcid.org/0000-0001-9319-5449","observed_orcids":["https://orcid.org/0000-0001-9319-5449"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257618","display_name":"Institute for Chemical and Bioengineering","ror":"https://ror.org/05fhwqj89","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257618"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"R. Ferrari","raw_affiliation_strings":["Department of Chemistry and Applied Biosciences","ETH Zurich","Institute for Chemical and Bioengineering","Switzerland","Zurich","Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-9319-5449","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Applied Biosciences","institution_ids":[]},{"raw_affiliation_string":"ETH Zurich","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Institute for Chemical and Bioengineering","institution_ids":["https://openalex.org/I4405257618"]},{"raw_affiliation_string":"Switzerland","institution_ids":[]},{"raw_affiliation_string":"Zurich","institution_ids":[]},{"raw_affiliation_string":"Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080488300","display_name":"Mattia Sponchioni","orcid":"https://orcid.org/0000-0002-8130-6495","observed_orcids":["https://orcid.org/0000-0002-8130-6495"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257618","display_name":"Institute for Chemical and Bioengineering","ror":"https://ror.org/05fhwqj89","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257618"]},{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["CH","IT"],"is_corresponding":true,"raw_author_name":"M. Sponchioni","raw_affiliation_strings":["Department of Chemistry and Applied Biosciences","ETH Zurich","Institute for Chemical and Bioengineering","Switzerland","Zurich","Department of Chemistry, Materials and Chemical Engineering \"Giulio Natta\", Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy","Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-8130-6495","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Applied Biosciences","institution_ids":[]},{"raw_affiliation_string":"ETH Zurich","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Institute for Chemical and Bioengineering","institution_ids":["https://openalex.org/I4405257618"]},{"raw_affiliation_string":"Switzerland","institution_ids":[]},{"raw_affiliation_string":"Zurich","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Materials and Chemical Engineering \"Giulio Natta\", Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy","institution_ids":["https://openalex.org/I93860229"]},{"raw_affiliation_string":"Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049334550","display_name":"Massimo Morbidelli","orcid":"https://orcid.org/0000-0002-0112-414X","observed_orcids":["https://orcid.org/0000-0002-0112-414X"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257618","display_name":"Institute for Chemical and Bioengineering","ror":"https://ror.org/05fhwqj89","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257618"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M. Morbidelli","raw_affiliation_strings":["Department of Chemistry and Applied Biosciences","ETH Zurich","Institute for Chemical and Bioengineering","Switzerland","Zurich","Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Applied Biosciences","institution_ids":[]},{"raw_affiliation_string":"ETH Zurich","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Institute for Chemical and Bioengineering","institution_ids":["https://openalex.org/I4405257618"]},{"raw_affiliation_string":"Switzerland","institution_ids":[]},{"raw_affiliation_string":"Zurich","institution_ids":[]},{"raw_affiliation_string":"Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034349404","display_name":"Davide Moscatelli","orcid":"https://orcid.org/0000-0003-2759-9781","observed_orcids":["https://orcid.org/0000-0003-2759-9781"]},"institutions":[{"id":"https://openalex.org/I4403928382","display_name":"Istituto di Scienze e Tecnologie Chimiche \"Giulio Natta\"","ror":"https://ror.org/04r43k021","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4403928382"]},{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D. Moscatelli","raw_affiliation_strings":["20131 Milano","Department of Chemistry","Italy","Materials and Chemical Engineering \u201cGiulio Natta\u201d","Politecnico di Milano","Department of Chemistry, Materials and Chemical Engineering \"Giulio Natta\", Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy"],"raw_orcid":"https://orcid.org/0000-0003-2759-9781","affiliations":[{"raw_affiliation_string":"20131 Milano","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Italy","institution_ids":[]},{"raw_affiliation_string":"Materials and Chemical Engineering \u201cGiulio Natta\u201d","institution_ids":["https://openalex.org/I4403928382"]},{"raw_affiliation_string":"Politecnico di Milano","institution_ids":["https://openalex.org/I93860229"]},{"raw_affiliation_string":"Department of Chemistry, Materials and Chemical Engineering \"Giulio Natta\", Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy","institution_ids":["https://openalex.org/I93860229"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5080488300"],"corresponding_institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257618","https://openalex.org/I93860229"],"apc_list":null,"apc_paid":null,"fwci":1.3888,"has_fulltext":false,"cited_by_count":191,"citation_normalized_percentile":{"value":0.80379747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"10","issue":"48","first_page":"22701","last_page":"22719"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polymeric-nanoparticles","display_name":"polymeric nanoparticles","score":0.9919999837875366},{"id":"https://openalex.org/keywords/intravenous-drug-delivery","display_name":"intravenous drug delivery","score":0.9850000143051147},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.9559999704360962},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.949999988079071},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.8370000123977661},{"id":"https://openalex.org/keywords/toxicity","display_name":"toxicity","score":0.8460000157356262},{"id":"https://openalex.org/keywords/drug-loading-and-release","display_name":"drug loading and release","score":0.9599999785423279},{"id":"https://openalex.org/keywords/nanoparticle-stability","display_name":"nanoparticle stability","score":0.9309999942779541},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.6389999985694885},{"id":"https://openalex.org/keywords/cellular-internalization","display_name":"cellular internalization","score":0.9020000100135803},{"id":"https://openalex.org/keywords/biodegradability","display_name":"biodegradability","score":0.9800000190734863},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/lipophilic-drugs","display_name":"lipophilic drugs","score":0.7649999856948853},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.47876039147377014},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.45264625549316406},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.42354047298431396},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4000627100467682},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3418174088001251},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3280024528503418},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18608427047729492},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D061605","descriptor_name":"Administration, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1039/c8nr05933k","doi":"https://doi.org/10.1039/c8nr05933k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8nr05933k","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},{"id":"pmid:30512025","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30512025","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"Journal Article"},{"id":"pmh:oai:re.public.polimi.it:11311/1076592","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11311/1076592","pdf_url":null,"source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":209,"referenced_works":["https://openalex.org/W202574349","https://openalex.org/W277563343","https://openalex.org/W328972456","https://openalex.org/W606839851","https://openalex.org/W629102554","https://openalex.org/W1516954147","https://openalex.org/W1543155074","https://openalex.org/W1564553363","https://openalex.org/W1564577751","https://openalex.org/W1664986234","https://openalex.org/W1718641735","https://openalex.org/W1823544132","https://openalex.org/W1871308790","https://openalex.org/W1963675633","https://openalex.org/W1964185052","https://openalex.org/W1967440516","https://openalex.org/W1969457012","https://openalex.org/W1970375274","https://openalex.org/W1971429865","https://openalex.org/W1972154409","https://openalex.org/W1972180606","https://openalex.org/W1973250793","https://openalex.org/W1977467418","https://openalex.org/W1979849149","https://openalex.org/W1981412372","https://openalex.org/W1981710947","https://openalex.org/W1984811676","https://openalex.org/W1986387253","https://openalex.org/W1987117221","https://openalex.org/W1987205432","https://openalex.org/W1987270443","https://openalex.org/W1990061716","https://openalex.org/W1990182718","https://openalex.org/W1990796256","https://openalex.org/W1992542552","https://openalex.org/W1993456710","https://openalex.org/W1993969840","https://openalex.org/W1996170794","https://openalex.org/W1996275708","https://openalex.org/W1998380582","https://openalex.org/W1999627128","https://openalex.org/W2000950571","https://openalex.org/W2001397660","https://openalex.org/W2003275588","https://openalex.org/W2004589810","https://openalex.org/W2009887707","https://openalex.org/W2010384454","https://openalex.org/W2010908849","https://openalex.org/W2011352246","https://openalex.org/W2013765163","https://openalex.org/W2014668585","https://openalex.org/W2015006203","https://openalex.org/W2015168077","https://openalex.org/W2015403265","https://openalex.org/W2017315930","https://openalex.org/W2017333482","https://openalex.org/W2019592267","https://openalex.org/W2020535635","https://openalex.org/W2020747873","https://openalex.org/W2024315050","https://openalex.org/W2025292917","https://openalex.org/W2025326642","https://openalex.org/W2025343509","https://openalex.org/W2025919388","https://openalex.org/W2026319736","https://openalex.org/W2026734776","https://openalex.org/W2026735896","https://openalex.org/W2027432937","https://openalex.org/W2028179436","https://openalex.org/W2029041094","https://openalex.org/W2029352881","https://openalex.org/W2029987677","https://openalex.org/W2030094610","https://openalex.org/W2030498396","https://openalex.org/W2030855909","https://openalex.org/W2031406458","https://openalex.org/W2032760352","https://openalex.org/W2032815757","https://openalex.org/W2032965857","https://openalex.org/W2033857478","https://openalex.org/W2035950049","https://openalex.org/W2038426489","https://openalex.org/W2041105700","https://openalex.org/W2041480715","https://openalex.org/W2045400542","https://openalex.org/W2045499291","https://openalex.org/W2045561438","https://openalex.org/W2049293202","https://openalex.org/W2049336362","https://openalex.org/W2053422722","https://openalex.org/W2055574464","https://openalex.org/W2055631278","https://openalex.org/W2056347214","https://openalex.org/W2056853730","https://openalex.org/W2059503044","https://openalex.org/W2059766794","https://openalex.org/W2060497431","https://openalex.org/W2060721901","https://openalex.org/W2061575731","https://openalex.org/W2063403344","https://openalex.org/W2063751734","https://openalex.org/W2066467291","https://openalex.org/W2067796149","https://openalex.org/W2067934965","https://openalex.org/W2068572014","https://openalex.org/W2069145078","https://openalex.org/W2070928975","https://openalex.org/W2071423096","https://openalex.org/W2072266745","https://openalex.org/W2072997205","https://openalex.org/W2074049796","https://openalex.org/W2077850064","https://openalex.org/W2080774028","https://openalex.org/W2081279947","https://openalex.org/W2082972185","https://openalex.org/W2083349615","https://openalex.org/W2083733712","https://openalex.org/W2088236945","https://openalex.org/W2091010508","https://openalex.org/W2091299256","https://openalex.org/W2091357955","https://openalex.org/W2091697975","https://openalex.org/W2091982741","https://openalex.org/W2093758237","https://openalex.org/W2094399039","https://openalex.org/W2094587125","https://openalex.org/W2098509550","https://openalex.org/W2099344825","https://openalex.org/W2099797949","https://openalex.org/W2100807658","https://openalex.org/W2104808978","https://openalex.org/W2105310619","https://openalex.org/W2105804200","https://openalex.org/W2107092681","https://openalex.org/W2107910518","https://openalex.org/W2108882170","https://openalex.org/W2108890560","https://openalex.org/W2110270192","https://openalex.org/W2110568975","https://openalex.org/W2114369412","https://openalex.org/W2118561606","https://openalex.org/W2120826143","https://openalex.org/W2121215860","https://openalex.org/W2121429936","https://openalex.org/W2122993090","https://openalex.org/W2125359528","https://openalex.org/W2126622563","https://openalex.org/W2126846737","https://openalex.org/W2126979011","https://openalex.org/W2127410754","https://openalex.org/W2130166533","https://openalex.org/W2130946050","https://openalex.org/W2132491645","https://openalex.org/W2134726513","https://openalex.org/W2135486162","https://openalex.org/W2135782311","https://openalex.org/W2136226057","https://openalex.org/W2136502605","https://openalex.org/W2139001148","https://openalex.org/W2139549149","https://openalex.org/W2140699578","https://openalex.org/W2141395077","https://openalex.org/W2142897044","https://openalex.org/W2143131755","https://openalex.org/W2146738959","https://openalex.org/W2147219712","https://openalex.org/W2148018018","https://openalex.org/W2150086428","https://openalex.org/W2150647921","https://openalex.org/W2153028101","https://openalex.org/W2153771870","https://openalex.org/W2156969927","https://openalex.org/W2158018814","https://openalex.org/W2158558808","https://openalex.org/W2159206613","https://openalex.org/W2160239222","https://openalex.org/W2167534105","https://openalex.org/W2169498622","https://openalex.org/W2171346702","https://openalex.org/W2171757680","https://openalex.org/W2172226098","https://openalex.org/W2194343859","https://openalex.org/W2253332708","https://openalex.org/W2286836085","https://openalex.org/W2316771598","https://openalex.org/W2318675757","https://openalex.org/W2321443970","https://openalex.org/W2321525475","https://openalex.org/W2323149868","https://openalex.org/W2324961323","https://openalex.org/W2333082611","https://openalex.org/W2333769757","https://openalex.org/W2415404013","https://openalex.org/W2462297714","https://openalex.org/W2546724040","https://openalex.org/W2557455617","https://openalex.org/W2762576253","https://openalex.org/W2766205420","https://openalex.org/W2766729511","https://openalex.org/W2790999516","https://openalex.org/W2791565941","https://openalex.org/W2796781998","https://openalex.org/W2801293072","https://openalex.org/W2891586359","https://openalex.org/W3000387663","https://openalex.org/W4232680877","https://openalex.org/W4254288502","https://openalex.org/W4255378812","https://openalex.org/W4256245095"],"related_works":["https://openalex.org/W7212309351","https://openalex.org/W4408495836","https://openalex.org/W7218237730","https://openalex.org/W2791448019","https://openalex.org/W6888803649","https://openalex.org/W1816730954","https://openalex.org/W7203666576","https://openalex.org/W1966322461","https://openalex.org/W2310644527","https://openalex.org/W7148704548"],"abstract_inverted_index":{"In":[0],"this":[1,92],"review":[2,93],"article":[3],"we":[4],"discuss":[5],"some":[6,133],"of":[7,14,106,116,132,147],"the":[8,12,37,49,67,79,103,113,130,139,145],"key":[9],"aspects":[10],"concerning":[11],"development":[13,105],"a":[15,41,84,107],"polymer-based":[16,85,117],"nanoparticle":[17,60],"formulation":[18,86],"for":[19],"intravenous":[20],"drug":[21,56],"delivery.":[22],"Since":[23],"numerous":[24],"preparations":[25],"fail":[26],"before":[27],"and":[28,54,58,62,75,89,125,141],"during":[29],"clinical":[30,120],"trials,":[31],"our":[32],"aim":[33],"is":[34,94],"to":[35,44,82,96,99,110,144],"emphasize":[36],"main":[38,80],"issues":[39],"that":[40],"nanocarrier":[42],"has":[43],"face":[45],"once":[46],"injected":[47],"into":[48],"body.":[50],"These":[51],"include":[52],"biocompatibility":[53],"toxicity,":[55],"loading":[57],"release,":[59],"storage":[61],"stability,":[63],"biodistribution,":[64],"selectivity":[65],"towards":[66],"target":[68],"organs":[69],"or":[70],"tissues,":[71],"internalization":[72],"in":[73,102,129],"cells":[74],"biodegradability.":[76],"They":[77],"represent":[78],"checkpoints":[81],"define":[83],"as":[87],"safe":[88],"effective.":[90],"Indeed,":[91],"intended":[95],"provide":[97],"guidelines":[98],"be":[100],"followed":[101],"early":[104],"new":[108],"nanotherapeutic":[109],"hopefully":[111],"increase":[112],"success":[114],"rate":[115],"formulations":[118],"entering":[119],"trials.":[121],"The":[122],"corresponding":[123],"requirements":[124],"characteristics":[126],"are":[127],"discussed":[128],"context":[131],"relevant":[134],"case":[135],"studies":[136],"taken":[137],"from":[138],"literature":[140],"mainly":[142],"related":[143],"delivery":[146],"lipophilic":[148],"anticancer":[149],"therapeutics.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":37},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":36},{"year":2020,"cited_by_count":37},{"year":2019,"cited_by_count":11},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-11-29T00:00:00"}