{"id":"https://openalex.org/W2901216688","doi":null,"title":"The Wilms\u2019 tumor suppressor protein1 activates anti-proliferative and apoptotic pathways resulting in growth arrest and apoptosis in a cellular system","display_name":"The Wilms\u2019 tumor suppressor protein1 activates anti-proliferative and apoptotic pathways resulting in growth arrest and apoptosis in a cellular system","publication_year":2004,"publication_date":"2004-04-01","ids":{"openalex":"https://openalex.org/W2901216688","mag":"2901216688"},"language":"en","primary_location":{"id":"mag:2901216688","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/64/7_Supplement/410.4","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057233429","display_name":"Debra J. Birn-Morrison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra J. Birn-Morrison","raw_affiliation_strings":["Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009372910","display_name":"Jacqueline M. Mason","orcid":"https://orcid.org/0009-0009-6151-3444","observed_orcids":["https://orcid.org/0009-0009-6151-3444"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline M. Mason","raw_affiliation_strings":["Mount Sinai School of Medicine, New York, NY"],"raw_orcid":"https://orcid.org/0009-0009-6151-3444","affiliations":[{"raw_affiliation_string":"Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088924793","display_name":"Milton A. English","orcid":"https://orcid.org/0009-0001-0146-8049","observed_orcids":["https://orcid.org/0009-0001-0146-8049"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milton A. English","raw_affiliation_strings":["Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032412371","display_name":"Windy Berkofsky\u2010Fessler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Windy Berkofsky\u2010Fessler","raw_affiliation_strings":["Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034992183","display_name":"Jonathan D. Licht","orcid":"https://orcid.org/0000-0002-3942-1369","observed_orcids":["https://orcid.org/0000-0002-3942-1369"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan D. Licht","raw_affiliation_strings":["Mount Sinai School of Medicine, New York, NY"],"raw_orcid":"https://orcid.org/0000-0002-3942-1369","affiliations":[{"raw_affiliation_string":"Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43263317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"64","issue":null,"first_page":"410","last_page":"411"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.7728999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.7728999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.14489999413490295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.04580000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wt1","display_name":"WT1","score":0.8199999928474426},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.550000011920929},{"id":"https://openalex.org/keywords/growth-arrest","display_name":"growth arrest","score":0.5989999771118164},{"id":"https://openalex.org/keywords/bak","display_name":"Bak","score":0.7210000157356262},{"id":"https://openalex.org/keywords/foxo1","display_name":"FOXO1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mkp-3","display_name":"MKP-3","score":0.8989999890327454},{"id":"https://openalex.org/keywords/sprouty1","display_name":"Sprouty1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/erk1-2-dephosphorylation","display_name":"ERK1/2 dephosphorylation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/ras-mapk-pathway","display_name":"RAS/MAPK pathway","score":0.7369999885559082},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.9300000071525574},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.765999972820282},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.6549999713897705},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6722697019577026},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5926891565322876},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5627583265304565},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5546702146530151},{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.547454833984375},{"id":"https://openalex.org/C140149449","wikidata":"https://www.wikidata.org/wiki/Q17928793","display_name":"FOXO1","level":4,"score":0.5455949902534485},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5379126667976379},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.49475234746932983},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4763258099555969},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46860870718955994},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4338177442550659},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.40070289373397827},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37770161032676697},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20529165863990784},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.1733272671699524},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09957772493362427}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2901216688","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/64/7_Supplement/410.4","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2053772791","https://openalex.org/W2051069729","https://openalex.org/W7100505808","https://openalex.org/W1563992487","https://openalex.org/W2913141021","https://openalex.org/W1997203379","https://openalex.org/W2324980317","https://openalex.org/W1509056501","https://openalex.org/W2164885953","https://openalex.org/W2377747302"],"abstract_inverted_index":{"1787":[0],"The":[2,124,254],"Wilms\u2019":[3,21],"tumor":[4,30],"suppressor":[5,31],"protein":[6,39,114],"(WT1),":[7],"a":[8,29,41,52,214,346],"transcription":[9,147,190],"factor":[10,226],"critical":[11],"for":[12,55,182],"normal":[13],"kidney":[14],"development,":[15],"is":[16,152,175,212,258],"mutated":[17],"in":[18,34,43,63,106,184,209,298],"10-15%":[19],"of":[20,103,119,121,148,162,191,201,205,286,310,317],"tumors.":[22],"Genetic":[23],"data":[24,257],"originally":[25],"identified":[26],"WT1":[27,61,70,113,177,236,247,273,297,304,323,351],"as":[28],"and":[32,47,58,76,82,90,109,137,168,196,222,243,267,291,312,315,326,332,334,341],"experiments":[33],"vitro":[35],"showed":[36],"that":[37,87,126,217,235,276,322],"the":[38,128,146,159,180,189,199,206,288,336],"plays":[40],"role":[42],"both":[44,88],"growth":[45,107,210,225],"suppression":[46],"apoptosis.":[48,79],"We":[49],"recently":[50],"established":[51],"tetracycline-repressible":[53],"system":[54],"expressing":[56],"wild-type":[57],"tumor-derived":[59],"mutant":[60],"proteins":[62],"Saos2":[64],"cells.":[65],"Wild-type,":[66],"but":[67],"not":[68,116],"mutant,":[69],"blocks":[71,335],"cellular":[72,249],"proliferation,":[73],"DNA":[74],"synthesis":[75,200],"rapidly":[77,270],"induces":[78],"Caspases":[80],"8":[81],"9":[83],"are":[84,94,131,171,269,278,294],"cleaved,":[85],"indicating":[86,275],"intrinsic":[89,325],"extrinsic":[91,327],"apoptotic":[92,129,328],"pathways":[93],"activated.":[95],"Using":[96],"microarray":[97],"analysis,":[98],"we":[99,343],"defined":[100,345],"two":[101,185],"sets":[102],"genes":[104,125,207],"involved":[105,208],"control":[108,211],"apoptosis,":[110],"respectively.":[111],"Mutant":[112],"does":[115],"induce":[117],"expression":[118,314],"any":[120],"these":[122],"genes.":[123],"comprise":[127],"subset":[130],"Bak,":[132,265,289],"Bik,":[133],"Foxo1,":[134,333],"Fas":[135,149,169,202],"ligand":[136,170],"Akt.":[138,318],"Foxo1":[139,151,167,266,290],"mediates":[140],"programmed":[141],"cell":[142],"death":[143],"by":[144,154,187,197,251,260,282,296,320,349],"inducing":[145],"ligand.":[150,203],"inactivated":[153],"AKT-dependent":[155],"phosphorylation,":[156],"which":[157,350],"promotes":[158],"nuclear":[160],"export":[161],"Foxo1.":[163],"In":[164,284],"our":[165,231],"system,":[166],"induced":[172,271],"whereas":[173],"AKT":[174],"inhibited.":[176],"may":[178,244],"reset":[179],"threshold":[181],"apoptosis":[183],"ways,":[186],"activating":[188,198],"pro-apoptotic":[192],"Bcl-2":[193],"family":[194],"members":[195],"One":[204],"MKP3,":[213],"dual-specificity":[215],"phosphatase":[216],"specifically":[218],"dephosphorylates":[219],"activated":[220,252,295],"ERK1/2":[221,311],"down-regulates":[223],"Ras-mediated":[224],"signaling.":[227],"This":[228],"correlates":[229],"with":[230],"recent":[232],"study":[233],"demonstrating":[234,321],"directly":[237,280],"activates":[238,324],"Sprouty1,":[239,342],"another":[240],"Ras/MAPK":[241,337],"inhibitor,":[242],"explain":[245],"why":[246],"prevents":[248],"transformation":[250],"Ras.":[253],"gene":[255],"array":[256],"confirmed":[259],"real":[261],"time":[262],"PCR":[263],"analysis.":[264],"MKP3":[268,292,340],"upon":[272],"expression,":[274],"they":[277],"probably":[279],"regulated":[281],"WT1.":[283],"support":[285],"this,":[287],"promoters":[293],"transient":[299],"transfection":[300],"assays.":[301],"As":[302],"predicted,":[303],"induction":[305],"leads":[306],"to":[307],"decreased":[308,313],"phosphorylation":[309,316],"Altogether,":[319],"signals":[329],"through":[330,339],"Bak":[331],"pathway":[338],"have":[344],"novel":[347],"mechanism":[348],"can":[352],"limit":[353],"growth.":[354]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2018-11-29T00:00:00"}
