{"id":"https://openalex.org/W2901037775","doi":"https://doi.org/10.1161/circ.136.suppl_1.21327","title":"Abstract 21327: In vivo Reduction of Mitochondrial Oxidative Stress Abolishes Arrhythmic Sudden Cardiac Death (SCD) in Non-Ischemic Heart Failure","display_name":"Abstract 21327: In vivo Reduction of Mitochondrial Oxidative Stress Abolishes Arrhythmic Sudden Cardiac Death (SCD) in Non-Ischemic Heart Failure","publication_year":2017,"publication_date":"2017-11-14","ids":{"openalex":"https://openalex.org/W2901037775","doi":"https://doi.org/10.1161/circ.136.suppl_1.21327","mag":"2901037775"},"language":"en","primary_location":{"id":"doi:10.1161/circ.136.suppl_1.21327","doi":"https://doi.org/10.1161/circ.136.suppl_1.21327","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.136.suppl_1.21327","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103201441","display_name":"Swati Dey","orcid":"https://orcid.org/0000-0003-4692-6848","observed_orcids":["https://orcid.org/0000-0003-4692-6848"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swati Dey","raw_affiliation_strings":["Medicine-Cardiology, Johns Hopkins Univ, Baltimore, MD","Swati Dey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine-Cardiology, Johns Hopkins Univ, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Swati Dey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040823719","display_name":"Deeptankar DeMazumder","orcid":"https://orcid.org/0000-0002-9322-8009","observed_orcids":["https://orcid.org/0000-0002-9322-8009"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deeptankar DeMazumder","raw_affiliation_strings":["Medicine-Cardiology, Univ of Cincinnati/ Johns Hopkins Univ, Baltimore, MD","Deeptankar DeMazumder"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine-Cardiology, Univ of Cincinnati/ Johns Hopkins Univ, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Deeptankar DeMazumder","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080198568","display_name":"Brian P O'Rourke","orcid":"https://orcid.org/0000-0002-5548-4853","observed_orcids":["https://orcid.org/0000-0002-5548-4853"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian O'Rourke","raw_affiliation_strings":["Medicine-Cardiology, Johns Hopkins Univ, Baltimore, MD","Brian O'Rourke"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine-Cardiology, Johns Hopkins Univ, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Brian O'Rourke","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"136","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.05939999967813492,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.05620000138878822,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.9340000152587891},{"id":"https://openalex.org/keywords/non-ischemic-heart-failure","display_name":"non-ischemic heart failure","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.9399999976158142},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.878000020980835},{"id":"https://openalex.org/keywords/mitotempo","display_name":"MitoTEMPO","score":0.996999979019165},{"id":"https://openalex.org/keywords/ventricular-arrhythmias","display_name":"ventricular arrhythmias","score":0.7649999856948853},{"id":"https://openalex.org/keywords/dispersion-of-repolarization","display_name":"dispersion of repolarization","score":0.8130000233650208},{"id":"https://openalex.org/keywords/mitochondrial-antioxidant-enzymes","display_name":"mitochondrial antioxidant enzymes","score":0.5630000233650208},{"id":"https://openalex.org/keywords/left-ventricular-dysfunction","display_name":"left ventricular dysfunction","score":0.656000018119812},{"id":"https://openalex.org/keywords/phosphoproteome","display_name":"phosphoproteome","score":0.6919999718666077},{"id":"https://openalex.org/keywords/contractile-dysfunction","display_name":"contractile dysfunction","score":0.7279999852180481},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.6380000114440918},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.5809999704360962},{"id":"https://openalex.org/keywords/gene-transfer","display_name":"gene transfer","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7031849026679993},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6646130084991455},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5911390781402588},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5857980847358704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5373173952102661},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.48957547545433044},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.48340359330177307},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.41722628474235535},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.12087589502334595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11940324306488037}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.136.suppl_1.21327","doi":"https://doi.org/10.1161/circ.136.suppl_1.21327","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.136.suppl_1.21327","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2765234773","https://openalex.org/W2918796114","https://openalex.org/W2807803570","https://openalex.org/W4254395692","https://openalex.org/W4388833297","https://openalex.org/W2001594709","https://openalex.org/W2337551063","https://openalex.org/W4403947286","https://openalex.org/W2777029951","https://openalex.org/W41338640"],"abstract_inverted_index":{"Intro:":[0],"Reactive":[1],"oxygen":[2],"species":[3],"(ROS)":[4],"are":[5,19,280,294],"central":[6],"to":[7,117,167,186,231,306,310],"SCD":[8,60,162,171,183,332],"pathophysiology,":[9],"but":[10,263,292],"their":[11],"effects":[12],"depend":[13],"on":[14],"where":[15],"and":[16,53,94,163,172,209,228,235,250,314],"how":[17],"ROS":[18,44,133,258],"generated.":[20],"Insight":[21],"into":[22],"this":[23],"has":[24],"been":[25],"limited":[26],"by":[27,322],"the":[28,39,99,118,142,154,176,223,295],"lack":[29],"of":[30,50,57,82,91,123,146,153,189,207,222,240,274,284,298],"adequate":[31],"experimental":[32],"methods.":[33],"Employing":[34],"innovative":[35],"approaches,":[36],"we":[37,84,103,131],"tested":[38],"hypothesis":[40],"that":[41,73,199],"elevated":[42],"mitochondrial":[43,275],"(mROS)":[45],"is":[46],"a":[47,68,79,86,281],"principal":[48,282],"source":[49,283],"oxidative":[51,286,312],"stress":[52,287,313],"in":[54,61,105,141,213,225,259,288,334],"vivo":[55,106],"reduction":[56],"mROS":[58,249,264,301,324],"mitigates":[59],"non-ischemic":[62,76],"heart":[63],"failure":[64],"(HF).":[65],"Methods:":[66],"In":[67,98,125,237],"unique":[69],"guinea":[70],"pig":[71],"model":[72],"mimics":[74],"human":[75],"HF":[77,101,155,180],"with":[78,109,272],"high":[80],"incidence":[81],"SCD,":[83],"performed":[85,104],"randomized":[87],"2x2":[88],"crossover":[89],"study":[90],"vehicle":[92],"(v)":[93],"MitoTEMPO":[95,159,168,200,217,244],"therapies":[96],"(vM/Mv).":[97],"untreated":[100],"model,":[102],"gene":[107],"transfer":[108],"novel,":[110],"genetically":[111],"encoded":[112],"ratiometric":[113],"redox":[114,320],"sensors":[115],"targeted":[116],"cytosol":[119],"(cROS)":[120],"or":[121,144],"mitochondria":[122],"cardiomyocytes.":[124],"isolated":[126],"left":[127],"ventricular":[128],"(LV)":[129],"myocytes,":[130,242],"quantified":[132],"dynamics":[134],"during":[135],"field":[136],"stimulation":[137],"(1":[138],"Hz,":[139],"37\u00b0C)":[140],"presence":[143],"absence":[145],"MitoTEMPO.":[147],"Results:":[148],"Over":[149],"4":[150],"weeks,":[151],"65%":[152],"animals":[156],"experienced":[157],"SCD.":[158,236,317],"therapy":[160,201,218,333],"abolished":[161],"LV":[164,174,241],"dysfunction.":[165],"Crossover":[166],"(vM)":[169],"prevented":[170,220],"improved":[173],"function;":[175],"converse":[177],"(Mv)":[178],"worsened":[179],"without":[181],"increasing":[182],"for":[184,331],"up":[185],"5":[187],"weeks":[188],"follow":[190],"up,":[191],"suggesting":[192],"distinct":[193],"underlying":[194],"mechanisms.":[195],"EKG":[196],"analysis":[197],"revealed":[198],"decreased":[202,210],"PVC":[203],"burden,":[204],"reduced":[205],"dispersion":[206],"repolarization":[208],"QT":[211],"variability":[212],"arrhythmogenic":[214,290],"failing":[215,289,304],"hearts.":[216],"also":[219,293],"many":[221],"changes":[224],"expression":[226],"proteome":[227],"phosphoproteome":[229],"leading":[230],"contractile":[232],"dysfunction,":[233],"arrhythmia":[234],"subcellular":[238],"studies":[239],"acute":[243],"exposure":[245],"strongly":[246],"suppressed":[247],"both":[248],"cROS.":[251],"Exogenous":[252],"H":[253],"2":[254,256],"O":[255],"increased":[257],"all":[260],"intracellular":[261],"compartments,":[262],"scavenging":[265,302,325],"was":[266],"impaired":[267],"more":[268,308],"than":[269],"cROS,":[270],"consistent":[271],"downregulation":[273],"antioxidant":[276],"enzymes.":[277],"Conclusions:":[278],"Mitochondria":[279],"cellular":[285],"hearts,":[291],"major":[296],"sink":[297],"ROS.":[299],"Impaired":[300],"cause":[303],"hearts":[305],"become":[307],"vulnerable":[309],"demand-induced":[311],"promote":[315],"arrhythmic":[316],"Maintaining":[318],"global":[319],"balance":[321],"enhanced":[323],"may":[326],"be":[327],"an":[328],"effective":[329],"strategy":[330],"HF.":[335]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-11-29T00:00:00"}
