{"id":"https://openalex.org/W2901028131","doi":"https://doi.org/10.1021/acsami.8b11071","title":"Off-the-Shelf Biomimetic Graphene Oxide\u2013Collagen Hybrid Scaffolds Wrapped with Osteoinductive Extracellular Matrix for the Repair of Cranial Defects in Rats","display_name":"Off-the-Shelf Biomimetic Graphene Oxide\u2013Collagen Hybrid Scaffolds Wrapped with Osteoinductive Extracellular Matrix for the Repair of Cranial Defects in Rats","publication_year":2018,"publication_date":"2018-11-13","ids":{"openalex":"https://openalex.org/W2901028131","doi":"https://doi.org/10.1021/acsami.8b11071","mag":"2901028131","pmid":"https://pubmed.ncbi.nlm.nih.gov/30421913"},"language":"en","primary_location":{"id":"doi:10.1021/acsami.8b11071","doi":"https://doi.org/10.1021/acsami.8b11071","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.8b11071","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials & Interfaces","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003686872","display_name":"Shaokai Liu","orcid":"https://orcid.org/0000-0002-2948-1798","observed_orcids":["https://orcid.org/0000-0002-2948-1798"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaokai Liu","raw_affiliation_strings":["Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075362347","display_name":"Shan Mou","orcid":"https://orcid.org/0000-0003-0056-5477","observed_orcids":["https://orcid.org/0000-0003-0056-5477"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Mou","raw_affiliation_strings":["Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025306901","display_name":"Chuchao Zhou","orcid":"https://orcid.org/0000-0002-4115-6277","observed_orcids":["https://orcid.org/0000-0002-4115-6277","https://orcid.org/0009-0005-7904-8465"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuchao Zhou","raw_affiliation_strings":["Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043662036","display_name":"Liang Guo","orcid":"https://orcid.org/0009-0003-9601-3390","observed_orcids":["https://orcid.org/0009-0003-9601-3390","https://orcid.org/0000-0002-1585-7889"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Guo","raw_affiliation_strings":["Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086249677","display_name":"Aimei Zhong","orcid":"https://orcid.org/0000-0003-1508-4633","observed_orcids":["https://orcid.org/0000-0003-1508-4633","https://orcid.org/0000-0002-1441-0938"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aimei Zhong","raw_affiliation_strings":["Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115590906","display_name":"Jie Yang","orcid":"https://orcid.org/0000-0003-0423-4157","observed_orcids":["https://orcid.org/0000-0003-0423-4157","https://orcid.org/0009-0008-6594-7111","https://orcid.org/0000-0001-8394-4303"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Yang","raw_affiliation_strings":["Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045136980","display_name":"Quan Yuan","orcid":"https://orcid.org/0000-0002-2836-1081","observed_orcids":["https://orcid.org/0000-0002-2836-1081"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quan Yuan","raw_affiliation_strings":["Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012922632","display_name":"Jiecong Wang","orcid":"https://orcid.org/0000-0002-7041-7325","observed_orcids":["https://orcid.org/0000-0002-7041-7325"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiecong Wang","raw_affiliation_strings":["Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081564639","display_name":"Jiaming Sun","orcid":"https://orcid.org/0000-0003-4973-6636","observed_orcids":["https://orcid.org/0000-0003-4973-6636"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiaming Sun","raw_affiliation_strings":["Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100402732","display_name":"Zhenxing Wang","orcid":"https://orcid.org/0000-0002-2436-0372","observed_orcids":["https://orcid.org/0000-0002-2436-0372","https://orcid.org/0009-0009-9871-0425"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenxing Wang","raw_affiliation_strings":["Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":"https://orcid.org/0000-0002-2436-0372","affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081564639","https://openalex.org/A5100402732"],"corresponding_institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.0214,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.92308084,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"49","first_page":"42948","last_page":"42958"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graphene-oxide","display_name":"graphene oxide","score":0.9649999737739563},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.9610000252723694},{"id":"https://openalex.org/keywords/hybrid-hydrogels","display_name":"hybrid hydrogels","score":0.7639999985694885},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6740000247955322},{"id":"https://openalex.org/keywords/osteoinduction","display_name":"osteoinduction","score":0.7670000195503235},{"id":"https://openalex.org/keywords/bone-marrow-mesenchymal-stem-cells","display_name":"bone marrow mesenchymal stem cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cranial-defect-reconstruction","display_name":"cranial defect repair","score":0.7580000162124634},{"id":"https://openalex.org/keywords/bone-tissue-engineering","display_name":"bone tissue engineering","score":0.7990000247955322},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.656000018119812},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.7997387647628784},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7793046236038208},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7171558141708374},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.6943566799163818},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6771281957626343},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.593174397945404},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5828850269317627},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4824426770210266},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4424852132797241},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.4349867105484009},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3505942225456238},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.32728710770606995},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1339234709739685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1125434935092926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09161874651908875},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006108","descriptor_name":"Graphite","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006108","descriptor_name":"Graphite","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040761","descriptor_name":"Biomimetic Materials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D040761","descriptor_name":"Biomimetic Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsami.8b11071","doi":"https://doi.org/10.1021/acsami.8b11071","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.8b11071","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials & Interfaces","raw_type":"journal-article"},{"id":"pmid:30421913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30421913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied materials & interfaces","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4488260531","display_name":null,"funder_award_id":"81601701","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5022208737","display_name":null,"funder_award_id":"2017CFB263","funder_id":"https://openalex.org/F4320322186","funder_display_name":"Natural Science Foundation of Hubei Province"},{"id":"https://openalex.org/G5929385254","display_name":null,"funder_award_id":"81501688","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8965059920","display_name":null,"funder_award_id":"81701922","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322186","display_name":"Natural Science Foundation of Hubei Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1148919984","https://openalex.org/W1512370406","https://openalex.org/W1536601781","https://openalex.org/W1584346353","https://openalex.org/W1845637683","https://openalex.org/W1895844182","https://openalex.org/W1958152583","https://openalex.org/W1979133141","https://openalex.org/W1987813151","https://openalex.org/W1991981437","https://openalex.org/W2005200593","https://openalex.org/W2007661784","https://openalex.org/W2017018731","https://openalex.org/W2028495064","https://openalex.org/W2029959239","https://openalex.org/W2041048532","https://openalex.org/W2044592690","https://openalex.org/W2056894710","https://openalex.org/W2068230961","https://openalex.org/W2099858530","https://openalex.org/W2125203621","https://openalex.org/W2127774872","https://openalex.org/W2134888071","https://openalex.org/W2135479172","https://openalex.org/W2170258102","https://openalex.org/W2210134551","https://openalex.org/W2214919522","https://openalex.org/W2225513920","https://openalex.org/W2235324276","https://openalex.org/W2262304198","https://openalex.org/W2313165248","https://openalex.org/W2321248347","https://openalex.org/W2322982413","https://openalex.org/W2323445201","https://openalex.org/W2325429418","https://openalex.org/W2328855252","https://openalex.org/W2329984659","https://openalex.org/W2330420417","https://openalex.org/W2397554520","https://openalex.org/W2400493280","https://openalex.org/W2409248716","https://openalex.org/W2521929517","https://openalex.org/W2530528982","https://openalex.org/W2531888908","https://openalex.org/W2539575122","https://openalex.org/W2540661720","https://openalex.org/W2557649156","https://openalex.org/W2571338677","https://openalex.org/W2573288927","https://openalex.org/W2576858833","https://openalex.org/W2581509008","https://openalex.org/W2590316073","https://openalex.org/W2600939806","https://openalex.org/W2602768144","https://openalex.org/W2605251842","https://openalex.org/W2620435339","https://openalex.org/W2739744022","https://openalex.org/W2748186533","https://openalex.org/W2751682718","https://openalex.org/W2753216485","https://openalex.org/W2770411658","https://openalex.org/W2794627938","https://openalex.org/W2807291660","https://openalex.org/W4230240787","https://openalex.org/W4233194460"],"related_works":["https://openalex.org/W2993914030","https://openalex.org/W3023463432","https://openalex.org/W4386831837","https://openalex.org/W2214919522","https://openalex.org/W7054475785","https://openalex.org/W3195449307","https://openalex.org/W4402198888","https://openalex.org/W4402980033","https://openalex.org/W4206509262","https://openalex.org/W3003931519"],"abstract_inverted_index":{"Hydrogels":[0],"such":[1],"as":[2,262],"type":[3],"I":[4],"collagen":[5],"(COL)":[6],"have":[7,32],"been":[8],"widely":[9],"studied":[10],"in":[11,161,164,214,224,257],"bone":[12,46,121,222,267],"tissue":[13,268],"repair,":[14],"whereas":[15,221],"their":[16,22],"weak":[17],"mechanical":[18,36],"strength":[19],"has":[20],"limited":[21],"clinical":[23],"application.":[24],"By":[25],"adding":[26],"graphene":[27],"oxide":[28],"(GO)":[29],"nanosheets,":[30],"researchers":[31],"successfully":[33],"improved":[34],"the":[35,41,48,55,86,94,131,138,142,156,181,197,207,238,244,248],"properties":[37],"and":[38,50,81,89,152,163,175,192,241,252],"biocompatibility":[39,242],"of":[40,54,96,155,243,250],"hydrogels.":[42],"However,":[43],"for":[44,127,145,266],"large":[45],"defects,":[47],"osteoinductive":[49,112],"cell":[51,65,87,176],"adhesion":[52],"ability":[53,194,240],"GO":[56,245],"hybrid":[57,100],"hydrogels":[58,246],"need":[59],"to":[60,140,196],"be":[61],"improved.":[62],"Mesenchymal":[63],"stem":[64,124],"(MSC)":[66],"secreted":[67],"extracellular":[68,113],"matrix":[69,114],"(ECM),":[70],"which":[71,235],"is":[72],"an":[73,111,263],"intricate":[74],"network,":[75],"could":[76],"provide":[77],"a":[78,104,188,215,232],"biomimetic":[79],"microenvironment":[80],"functional":[82],"molecules":[83],"that":[84,180,206],"enhance":[85],"proliferation":[88,190],"survival":[90],"rate.":[91],"To":[92],"synergize":[93],"advantages":[95],"MSC-ECM":[97],"with":[98,137],"GO-COL":[99,132,200],"implants,":[101],"we":[102],"developed":[103],"novel":[105],"ECM":[106],"scaffold":[107,133],"construction":[108],"method.":[109],"First,":[110],"(OiECM)":[115],"was":[116,134,227],"created":[117],"by":[118],"culturing":[119,253],"osteodifferentiated":[120],"marrow":[122],"mesenchymal":[123],"cells":[125],"(BMSCs)":[126],"21":[128],"days.":[129],"Then,":[130],"fully":[135],"wrapped":[136],"OiECM":[139],"construct":[141],"OiECM-GO-COL":[143,157,185,208],"composite":[144],"implantation.":[146],"The":[147],"morphology,":[148],"physical":[149],"properties,":[150],"biocompatibility,":[151],"osteogenic":[153,193,239],"performance":[154],"implants":[158,186,209],"were":[159],"assessed":[160],"vitro":[162],"vivo":[165,203],"(5":[166],"mm":[167],"rat":[168,216],"cranial":[169,218],"defect":[170,219],"model).":[171],"Both":[172],"gene":[173],"expression":[174],"level":[177],"assessments":[178],"suggested":[179],"BMSCs":[182],"cultured":[183],"on":[184,255],"had":[187],"higher":[189],"rate":[191],"compared":[195],"COL":[198],"or":[199],"groups.":[201],"In":[202],"results":[204],"showed":[205],"achieved":[210],"better":[211],"repair":[212],"effects":[213],"critical":[217],"model,":[220],"formation":[223],"other":[225],"groups":[226],"limited.":[228],"This":[229],"study":[230],"provides":[231],"promising":[233],"strategy,":[234],"greatly":[236],"improves":[237],"without":[247],"procedure":[249],"seeding":[251],"MSCs":[254],"scaffolds":[256],"vitro,":[258],"demonstrating":[259],"its":[260],"potential":[261],"off-the-shelf":[264],"method":[265],"engineering.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2018-11-29T00:00:00"}