{"id":"https://openalex.org/W2901006087","doi":"https://doi.org/10.3389/fpsyt.2018.00595","title":"Drug Addiction: From Neuroscience to Ethics","display_name":"Drug Addiction: From Neuroscience to Ethics","publication_year":2018,"publication_date":"2018-11-19","ids":{"openalex":"https://openalex.org/W2901006087","doi":"https://doi.org/10.3389/fpsyt.2018.00595","mag":"2901006087","pmid":"https://pubmed.ncbi.nlm.nih.gov/30524319","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6262362"},"language":"en","primary_location":{"id":"doi:10.3389/fpsyt.2018.00595","doi":"https://doi.org/10.3389/fpsyt.2018.00595","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2018.00595","pdf_url":"https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00595/pdf","source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00595/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083499645","display_name":"Michele Farisco","orcid":"https://orcid.org/0000-0002-3298-7829","observed_orcids":["https://orcid.org/0000-0002-3298-7829"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I4210115745","display_name":"Biogem","ror":"https://ror.org/01ymr5447","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I2801626668","https://openalex.org/I4210115745"]}],"countries":["IT","SE"],"is_corresponding":true,"raw_author_name":"Michele Farisco","raw_affiliation_strings":["Centre for Research Ethics and Bioethics, Uppsala University, Uppsala, Sweden","Science and Society Unit, Biogem, Biology and Molecular Genetics Institute, Ariano Irpino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Research Ethics and Bioethics, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Science and Society Unit, Biogem, Biology and Molecular Genetics Institute, Ariano Irpino, Italy","institution_ids":["https://openalex.org/I4210115745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011911477","display_name":"Kathinka Evers","orcid":"https://orcid.org/0000-0002-9180-1190","observed_orcids":["https://orcid.org/0000-0002-9180-1190"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kathinka Evers","raw_affiliation_strings":["Centre for Research Ethics and Bioethics, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Research Ethics and Bioethics, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056074308","display_name":"Jean\u2010Pierre Changeux","orcid":"https://orcid.org/0000-0003-0297-1583","observed_orcids":["https://orcid.org/0000-0003-0297-1583"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I187986737","display_name":"Coll\u00e8ge de France","ror":"https://ror.org/04ex24z53","country_code":"FR","type":"education","lineage":["https://openalex.org/I187986737"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Changeux","raw_affiliation_strings":["Coll\u00e8ge de France and Institut Pasteur CNRS, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coll\u00e8ge de France and Institut Pasteur CNRS, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I157536573","https://openalex.org/I187986737"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5083499645"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I4210115745"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":1741,"currency":"EUR","value_usd":1877},"fwci":2.0995,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.86164117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":null,"first_page":"595","last_page":"595"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.5195000171661377,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.5195000171661377,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.30709999799728394,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11953","display_name":"Neuroethics, Human Enhancement, Biomedical Innovations","score":0.09030000120401382,"subfield":{"id":"https://openalex.org/subfields/1211","display_name":"Philosophy"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-addiction","display_name":"drug addiction","score":0.9649999737739563},{"id":"https://openalex.org/keywords/opioid-crisis","display_name":"opioid epidemic","score":0.7480000257492065},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.7590000033378601},{"id":"https://openalex.org/keywords/socioeconomic-status","display_name":"socioeconomic status","score":0.8560000061988831},{"id":"https://openalex.org/keywords/addiction-prevention","display_name":"addiction prevention","score":0.7080000042915344},{"id":"https://openalex.org/keywords/social-responsibility","display_name":"social responsibility","score":0.5189999938011169},{"id":"https://openalex.org/keywords/reward","display_name":"reward","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.7679623365402222},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5380752682685852},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.49172642827033997},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.46147820353507996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3868371844291687},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.38458797335624695},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.3216992914676666}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fpsyt.2018.00595","doi":"https://doi.org/10.3389/fpsyt.2018.00595","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2018.00595","pdf_url":"https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00595/pdf","source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5250966","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6262362","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30524319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30524319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6262362","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6262362/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Psychiatry","raw_type":"Text"},{"id":"pmh:oai:DiVA.org:uu-364429","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-364429","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:78087a1551ca4806ae955e83d933ec6c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/78087a1551ca4806ae955e83d933ec6c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Psychiatry, Vol 9 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fpsyt.2018.00595","doi":"https://doi.org/10.3389/fpsyt.2018.00595","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2018.00595","pdf_url":"https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00595/pdf","source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5766349579","display_name":"Human Brain Project Specific Grant Agreement 2","funder_award_id":"785907","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6607577419","display_name":null,"funder_award_id":"785907","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2901006087.pdf","grobid_xml":"https://content.openalex.org/works/W2901006087.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W639939759","https://openalex.org/W1266238005","https://openalex.org/W1422125843","https://openalex.org/W1593376394","https://openalex.org/W1607328275","https://openalex.org/W1978983866","https://openalex.org/W1985874257","https://openalex.org/W1986225748","https://openalex.org/W2009074065","https://openalex.org/W2014016697","https://openalex.org/W2015303758","https://openalex.org/W2022644200","https://openalex.org/W2025097580","https://openalex.org/W2027022038","https://openalex.org/W2031977354","https://openalex.org/W2035540305","https://openalex.org/W2056317365","https://openalex.org/W2072272954","https://openalex.org/W2079126110","https://openalex.org/W2102773298","https://openalex.org/W2103251342","https://openalex.org/W2118310282","https://openalex.org/W2121244078","https://openalex.org/W2141977597","https://openalex.org/W2142823391","https://openalex.org/W2146969099","https://openalex.org/W2147731450","https://openalex.org/W2157383890","https://openalex.org/W2167549042","https://openalex.org/W2283026346","https://openalex.org/W2329316201","https://openalex.org/W2339137991","https://openalex.org/W2519077384","https://openalex.org/W2562670863","https://openalex.org/W2579583215","https://openalex.org/W2766648178","https://openalex.org/W2793501104","https://openalex.org/W2802668337","https://openalex.org/W2884550519","https://openalex.org/W2890391604","https://openalex.org/W2950410030","https://openalex.org/W2981136699","https://openalex.org/W4244091328"],"related_works":["https://openalex.org/W1493935387","https://openalex.org/W37952882","https://openalex.org/W3193162160","https://openalex.org/W60062141","https://openalex.org/W2479533556","https://openalex.org/W1999274123","https://openalex.org/W2773323246","https://openalex.org/W2148297672","https://openalex.org/W7073574683","https://openalex.org/W2339137991"],"abstract_inverted_index":{"In":[0],"the":[1,15,23,27,30,52,76,87,93],"present":[2],"paper,":[3],"we":[4],"suggest":[5],"a":[6,36,45,80,97,101],"potential":[7],"new":[8],"ethical":[9,48,53],"analysis":[10],"of":[11,29,38,104],"addiction":[12,110],"focusing":[13],"on":[14],"relationship":[16],"between":[17],"aware":[18,40],"and":[19,41,108],"unaware":[20,42],"processing":[21,43],"in":[22,63,92],"brain.":[24,94],"We":[25],"take":[26],"case":[28],"opioids":[31],"epidemics":[32],"to":[33,50,65,73],"argue":[34],"that":[35,62],"consideration":[37],"both":[39],"provides":[44,96],"more":[46],"comprehensive":[47],"framework":[49],"discuss":[51],"issues":[54],"raised":[55],"by":[56],"addiction.":[57],"Finally,":[58],"our":[59],"hypothesis":[60],"is":[61],"addition":[64],"identified":[66],"Central":[67],"Nervous":[68],"System's":[69],"neuronal/neurochemical":[70],"factors":[71],"contributing":[72],"addictive":[74],"dynamics,":[75],"socio-economic":[77],"status":[78],"plays":[79],"causal":[81],"role":[82],"through":[83],"epigenetic":[84],"processes,":[85],"originating":[86],"need":[88],"for":[89,100,106],"additional":[90],"reward":[91],"This":[95],"strong":[98],"base":[99],"socio-political":[102],"form":[103],"responsibility":[105],"preventing":[107],"managing":[109],"crisis.":[111]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-11-29T00:00:00"}
