{"id":"https://openalex.org/W2900701040","doi":null,"title":"The Systemic Quantification Of Immune Cell Populations In Various Murine Models: How Age, Tumor Burden, and Immunotherapy Affect the Immune Response","display_name":"The Systemic Quantification Of Immune Cell Populations In Various Murine Models: How Age, Tumor Burden, and Immunotherapy Affect the Immune Response","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2900701040","mag":"2900701040"},"language":"en","primary_location":{"id":"pmh:oai:opencommons.uconn.edu:srhonors_theses-1582","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/srhonors_theses/572","pdf_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=1582&context=srhonors_theses","source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Honors Scholar Theses","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=1582&context=srhonors_theses","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kavita Sinha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kavita Sinha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.9419999718666077},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anti-ctla-4-antibody","display_name":"anti-CTLA-4 antibody","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.7820000052452087},{"id":"https://openalex.org/keywords/immune-cell-quantification","display_name":"immune cell quantification","score":0.7260000109672546},{"id":"https://openalex.org/keywords/tumor-burden","display_name":"tumor burden","score":0.6029999852180481},{"id":"https://openalex.org/keywords/mouse-strain-differences","display_name":"mouse strain differences","score":0.7680000066757202},{"id":"https://openalex.org/keywords/balb-cj","display_name":"BALB/cJ","score":0.8180000185966492},{"id":"https://openalex.org/keywords/mouse-age","display_name":"mouse age","score":0.4819999933242798},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.6890000104904175},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.7823865413665771},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7475038170814514},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6139273047447205},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5458919405937195},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4267251491546631},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36730819940567017},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.21598362922668457},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.09489321708679199}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:opencommons.uconn.edu:srhonors_theses-1582","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/srhonors_theses/572","pdf_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=1582&context=srhonors_theses","source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Honors Scholar Theses","raw_type":"text"},{"id":"pmh:oai:digitalcommons.lib.uconn.edu:srhonors_theses-1582","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/srhonors_theses/572","pdf_url":null,"source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Honors Scholar Theses","raw_type":"text"},{"id":"mag:2900701040","doi":null,"is_oa":false,"landing_page_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=1582&context=srhonors_theses","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:opencommons.uconn.edu:srhonors_theses-1582","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/srhonors_theses/572","pdf_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=1582&context=srhonors_theses","source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Honors Scholar Theses","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2900701040.pdf","grobid_xml":"https://content.openalex.org/works/W2900701040.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W120970592","https://openalex.org/W615426413","https://openalex.org/W1483124841","https://openalex.org/W1517279365","https://openalex.org/W1520434148","https://openalex.org/W1587403680","https://openalex.org/W1592224632","https://openalex.org/W1971595657","https://openalex.org/W1974139477","https://openalex.org/W1978103330","https://openalex.org/W2010121426","https://openalex.org/W2023568503","https://openalex.org/W2034269086","https://openalex.org/W2045360275","https://openalex.org/W2049725546","https://openalex.org/W2060888966","https://openalex.org/W2062961963","https://openalex.org/W2066671159","https://openalex.org/W2068347036","https://openalex.org/W2087304127","https://openalex.org/W2094366129","https://openalex.org/W2097995306","https://openalex.org/W2122495232","https://openalex.org/W2124116262","https://openalex.org/W2133483909","https://openalex.org/W2140235037","https://openalex.org/W2155784894","https://openalex.org/W2160166896","https://openalex.org/W2162085901","https://openalex.org/W2163175900","https://openalex.org/W2166329890","https://openalex.org/W2167167418","https://openalex.org/W2172170289","https://openalex.org/W2172466148","https://openalex.org/W2185075416","https://openalex.org/W2263759961","https://openalex.org/W2401861683","https://openalex.org/W2595236036"],"related_works":["https://openalex.org/W2783072793","https://openalex.org/W3203689851","https://openalex.org/W2810745690","https://openalex.org/W2999583889","https://openalex.org/W4221045907","https://openalex.org/W2169794517","https://openalex.org/W3100501502","https://openalex.org/W4324018006","https://openalex.org/W7212161602","https://openalex.org/W2956029463"],"abstract_inverted_index":{"Immunotherapy":[0],"as":[1,52,191,193,245],"a":[2,69],"form":[3],"of":[4,63,83,86,115,117,130,143,162,169,205,221],"cancer":[5,39],"treatment":[6],"has":[7,45,78],"become":[8],"increasingly":[9],"popular":[10],"in":[11,56,106,148,213,266],"the":[12,26,31,43,60,64,74,81,112,132,144,231,246],"past":[13],"few":[14],"decades.":[15],"Researchers":[16],"have":[17,226],"worked":[18,134],"to":[19,23,34,47,58,73,80,126,215],"figure":[20],"out":[21],"how":[22,131,230,236,250],"best":[24],"use":[25],"body\u2019s":[27],"natural":[28],"defense":[29],"mechanism,":[30],"immune":[32,65,71,145,217,232,257],"system,":[33,66],"fight":[35],"off":[36,62],"and":[37,54,91,95,135,155,166,174,179,186,195,235,252,260],"destroy":[38],"cells.":[40],"In":[41],"particular,":[42],"goal":[44],"been":[46],"manipulate":[48],"checkpoint":[49],"blockades":[50],"such":[51],"CTLA-4":[53],"PD-1":[55],"order":[57],"take":[59],"breaks":[61],"allowing":[67],"for":[68,248],"prolonged":[70],"response":[72],"cancer.":[75],"This":[76],"work":[77],"led":[79],"development":[82],"human":[84],"versions":[85],"anti-CTLA4":[87,251],"antibodies":[88,93],"(ipilimumab,":[89],"tremelimumab)":[90],"anti-PD1":[92,253],"(pembrolizumab":[94],"Nivolumab)":[96],"that":[97,208],"are":[98,210],"currently":[99],"either":[100],"FDA":[101],"approved":[102],"or":[103,198],"being":[104],"used":[105],"clinical":[107],"trials.":[108],"Despite":[109],"this":[110,267],"progress,":[111],"true":[113],"mechanism":[114],"action":[116],"these":[118,203],"therapeutics":[119,254],"is":[120],"not":[121],"fully":[122],"understood.":[123],"To":[124],"begin":[125],"gain":[127],"an":[128,140,227],"idea":[129],"treatments":[133],"differed":[136],"from":[137,202],"one":[138],"another,":[139],"immunological":[141],"snapshot":[142],"cell":[146,258],"populations":[147,259],"mice":[149,161,168,178,182,187,220,242],"under":[150],"various":[151,256],"conditions":[152],"was":[153],"analyzed":[154],"compared.":[156],"Comparisons":[157],"were":[158],"done":[159],"between":[160,219],"different":[163,170,222],"strains":[164],"(BALB/cJ":[165],"BL/6),":[167],"ages":[171],"(6-8":[172],"weeks":[173],"8-12":[175],"months),":[176],"na\u00efve":[177],"tumor-bearing":[180],"mice,":[181],"with":[183,188],"early":[184],"tumors":[185],"late":[189],"tumors,":[190],"well":[192],"untreated":[194],"treated":[196],"(anti-CTLA4":[197],"anti-PD1)":[199],"mice.":[200],"Results":[201],"sets":[204],"experiments":[206],"showed":[207],"there":[209],"significant":[211],"variations":[212],"regards":[214],"some":[216],"cells":[218],"groups,":[223],"which":[224],"may":[225],"impact":[228],"on":[229],"system":[233],"functions":[234],"effectively":[237],"tumor":[238],"regression":[239],"occurs.":[240],"These":[241],"models":[243],"serve":[244],"basis":[247],"understanding":[249],"affect":[255],"will":[261],"help":[262],"guide":[263],"further":[264],"research":[265],"area.":[268]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-11-29T00:00:00"}
