{"id":"https://openalex.org/W2900596992","doi":"https://doi.org/10.1007/s00401-018-1933-9","title":"Inflammation in ALS/FTD pathogenesis","display_name":"Inflammation in ALS/FTD pathogenesis","publication_year":2018,"publication_date":"2018-11-21","ids":{"openalex":"https://openalex.org/W2900596992","doi":"https://doi.org/10.1007/s00401-018-1933-9","mag":"2900596992","pmid":"https://pubmed.ncbi.nlm.nih.gov/30465257"},"language":"en","primary_location":{"id":"doi:10.1007/s00401-018-1933-9","doi":"https://doi.org/10.1007/s00401-018-1933-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00401-018-1933-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00401-018-1933-9.pdf","source":{"id":"https://openalex.org/S198620474","display_name":"Acta Neuropathologica","issn_l":"0001-6322","issn":["0001-6322","1432-0533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00401-018-1933-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082876071","display_name":"Madelyn E. McCauley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madelyn E. McCauley","raw_affiliation_strings":["Board of Governors Regenerative Medicine Institute, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Board of Governors Regenerative Medicine Institute, Los Angeles, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084599209","display_name":"Robert H. Baloh","orcid":"https://orcid.org/0000-0002-0100-8376","observed_orcids":["https://orcid.org/0000-0002-0100-8376"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert H. Baloh","raw_affiliation_strings":["Board of Governors Regenerative Medicine Institute, Los Angeles, USA. robert.baloh@csmc.edu","Department of Neurology, Center for Neural Science and Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA. robert.baloh@csmc.edu","Board of Governors Regenerative Medicine Institute, Los Angeles, USA","Department of Neurology, Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":"https://orcid.org/0000-0002-0100-8376","affiliations":[{"raw_affiliation_string":"Board of Governors Regenerative Medicine Institute, Los Angeles, USA. robert.baloh@csmc.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, Center for Neural Science and Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA. robert.baloh@csmc.edu","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Board of Governors Regenerative Medicine Institute, Los Angeles, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084599209"],"corresponding_institution_ids":["https://openalex.org/I1282927834"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":14.9626,"has_fulltext":true,"cited_by_count":321,"citation_normalized_percentile":{"value":0.99511038,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"137","issue":"5","first_page":"715","last_page":"730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.06809999793767929,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/frontotemporal-dementia","display_name":"frontotemporal dementia","score":1.0},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6570000052452087},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8610000014305115},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.8610000014305115},{"id":"https://openalex.org/keywords/circulating-immune-cells","display_name":"circulating immune cells","score":0.753000020980835},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9779999852180481},{"id":"https://openalex.org/keywords/autoinflammation","display_name":"autoinflammation","score":0.953000009059906},{"id":"https://openalex.org/keywords/c9orf72","display_name":"C9orf72","score":0.9330000281333923},{"id":"https://openalex.org/keywords/tbk1","display_name":"TBK1","score":0.996999979019165},{"id":"https://openalex.org/keywords/optineurin","display_name":"optineurin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neurodegenerative-disease-pathogenesis","display_name":"neurodegeneration pathogenesis","score":0.5519999861717224},{"id":"https://openalex.org/keywords/immune-cell-function","display_name":"immune cell function","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7973889112472534},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6192361116409302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.526847243309021},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3979854881763458},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20466318726539612}],"mesh":[{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00401-018-1933-9","doi":"https://doi.org/10.1007/s00401-018-1933-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00401-018-1933-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00401-018-1933-9.pdf","source":{"id":"https://openalex.org/S198620474","display_name":"Acta Neuropathologica","issn_l":"0001-6322","issn":["0001-6322","1432-0533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathologica","raw_type":"journal-article"},{"id":"pmid:30465257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30465257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta neuropathologica","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6482122","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6482122","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Neuropathol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s00401-018-1933-9","doi":"https://doi.org/10.1007/s00401-018-1933-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00401-018-1933-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00401-018-1933-9.pdf","source":{"id":"https://openalex.org/S198620474","display_name":"Acta Neuropathologica","issn_l":"0001-6322","issn":["0001-6322","1432-0533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathologica","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G408100375","display_name":null,"funder_award_id":"NS097545","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4863667881","display_name":null,"funder_award_id":"T32 GM118288","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6036924141","display_name":null,"funder_award_id":"R01 NS097545","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6300123391","display_name":null,"funder_award_id":"352536","funder_id":"https://openalex.org/F4320308306","funder_display_name":"Muscular Dystrophy Association"},{"id":"https://openalex.org/G690395421","display_name":null,"funder_award_id":"R01 NS069669","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000184776","display_name":null,"funder_award_id":"NS069669","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000349544","display_name":null,"funder_award_id":"NS097545","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308306","display_name":"Muscular Dystrophy Association","ror":"https://ror.org/01frxsf98"},{"id":"https://openalex.org/F4320313996","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2900596992.pdf","grobid_xml":"https://content.openalex.org/works/W2900596992.grobid-xml"},"referenced_works_count":174,"referenced_works":["https://openalex.org/W18768637","https://openalex.org/W31801189","https://openalex.org/W52558577","https://openalex.org/W199671778","https://openalex.org/W239648239","https://openalex.org/W1552106782","https://openalex.org/W1575263086","https://openalex.org/W1619082318","https://openalex.org/W1680107906","https://openalex.org/W1787406445","https://openalex.org/W1926674024","https://openalex.org/W1963961512","https://openalex.org/W1965975446","https://openalex.org/W1967086577","https://openalex.org/W1967118636","https://openalex.org/W1970380641","https://openalex.org/W1970433280","https://openalex.org/W1974485241","https://openalex.org/W1977099733","https://openalex.org/W1978866898","https://openalex.org/W1979375317","https://openalex.org/W1980918455","https://openalex.org/W1981329326","https://openalex.org/W1982739794","https://openalex.org/W1983541649","https://openalex.org/W1983633543","https://openalex.org/W1984538960","https://openalex.org/W1987138690","https://openalex.org/W1987705857","https://openalex.org/W1988917755","https://openalex.org/W1993813911","https://openalex.org/W1995810781","https://openalex.org/W1996024251","https://openalex.org/W1998975866","https://openalex.org/W1999419270","https://openalex.org/W2000177767","https://openalex.org/W2003618511","https://openalex.org/W2003674452","https://openalex.org/W2005945296","https://openalex.org/W2007478642","https://openalex.org/W2008267385","https://openalex.org/W2012006815","https://openalex.org/W2012851706","https://openalex.org/W2016462453","https://openalex.org/W2017916137","https://openalex.org/W2019338768","https://openalex.org/W2019706623","https://openalex.org/W2021359548","https://openalex.org/W2022367303","https://openalex.org/W2023233358","https://openalex.org/W2026211597","https://openalex.org/W2027047473","https://openalex.org/W2028097575","https://openalex.org/W2028803746","https://openalex.org/W2029636921","https://openalex.org/W2032463921","https://openalex.org/W2033158384","https://openalex.org/W2033682903","https://openalex.org/W2035368043","https://openalex.org/W2039659387","https://openalex.org/W2040578796","https://openalex.org/W2047517574","https://openalex.org/W2048259921","https://openalex.org/W2051387942","https://openalex.org/W2052888134","https://openalex.org/W2054068057","https://openalex.org/W2054637685","https://openalex.org/W2054876142","https://openalex.org/W2057310829","https://openalex.org/W2058094550","https://openalex.org/W2058742494","https://openalex.org/W2061194981","https://openalex.org/W2062769365","https://openalex.org/W2063996210","https://openalex.org/W2066874059","https://openalex.org/W2067897311","https://openalex.org/W2068874043","https://openalex.org/W2069781018","https://openalex.org/W2071117491","https://openalex.org/W2072853625","https://openalex.org/W2074726646","https://openalex.org/W2075691498","https://openalex.org/W2077331144","https://openalex.org/W2080757088","https://openalex.org/W2084343282","https://openalex.org/W2085717208","https://openalex.org/W2086639871","https://openalex.org/W2092145129","https://openalex.org/W2094798020","https://openalex.org/W2095685454","https://openalex.org/W2101321540","https://openalex.org/W2102327538","https://openalex.org/W2105846299","https://openalex.org/W2106914633","https://openalex.org/W2107768418","https://openalex.org/W2109759840","https://openalex.org/W2111917577","https://openalex.org/W2112608285","https://openalex.org/W2113290014","https://openalex.org/W2115235607","https://openalex.org/W2117453887","https://openalex.org/W2119149099","https://openalex.org/W2123586959","https://openalex.org/W2124976615","https://openalex.org/W2127861463","https://openalex.org/W2131026449","https://openalex.org/W2132259121","https://openalex.org/W2132924600","https://openalex.org/W2135522980","https://openalex.org/W2135607950","https://openalex.org/W2139264742","https://openalex.org/W2140447941","https://openalex.org/W2144787399","https://openalex.org/W2150523249","https://openalex.org/W2151003930","https://openalex.org/W2154415802","https://openalex.org/W2154945114","https://openalex.org/W2156054547","https://openalex.org/W2158003396","https://openalex.org/W2158949580","https://openalex.org/W2167295920","https://openalex.org/W2167912995","https://openalex.org/W2213215651","https://openalex.org/W2215667136","https://openalex.org/W2225188179","https://openalex.org/W2280077905","https://openalex.org/W2283963041","https://openalex.org/W2297261057","https://openalex.org/W2304886140","https://openalex.org/W2336528486","https://openalex.org/W2337901090","https://openalex.org/W2339719520","https://openalex.org/W2345745180","https://openalex.org/W2378497488","https://openalex.org/W2398423404","https://openalex.org/W2398515656","https://openalex.org/W2406553940","https://openalex.org/W2415775274","https://openalex.org/W2460035459","https://openalex.org/W2468501494","https://openalex.org/W2497241389","https://openalex.org/W2500850723","https://openalex.org/W2518003787","https://openalex.org/W2533941196","https://openalex.org/W2540127583","https://openalex.org/W2552399604","https://openalex.org/W2558485988","https://openalex.org/W2577452028","https://openalex.org/W2585432400","https://openalex.org/W2594565722","https://openalex.org/W2600881183","https://openalex.org/W2608367614","https://openalex.org/W2615290258","https://openalex.org/W2615586845","https://openalex.org/W2622807556","https://openalex.org/W2720849841","https://openalex.org/W2732599352","https://openalex.org/W2743037209","https://openalex.org/W2751865550","https://openalex.org/W2761403361","https://openalex.org/W2761726094","https://openalex.org/W2770562947","https://openalex.org/W2779851534","https://openalex.org/W2783582599","https://openalex.org/W2787234767","https://openalex.org/W2788797941","https://openalex.org/W2789764978","https://openalex.org/W2793084066","https://openalex.org/W2795507797","https://openalex.org/W2800772770","https://openalex.org/W2803272141","https://openalex.org/W3194791349","https://openalex.org/W4210735407","https://openalex.org/W4252979096"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Amyotrophic":[0],"lateral":[1],"sclerosis":[2],"(ALS)":[3],"and":[4,18,20,48,52,70,77,92,97,137,160,162],"frontotemporal":[5],"dementia":[6],"(FTD)":[7],"are":[8,72],"neurodegenerative":[9],"diseases":[10],"that":[11,56,102],"overlap":[12],"in":[13,60,65,74,95,100,122,131,133,154,175],"their":[14],"clinical":[15],"presentation,":[16],"pathology":[17],"genetics,":[19],"likely":[21],"represent":[22],"a":[23],"spectrum":[24],"of":[25,38,90,129],"one":[26],"underlying":[27],"disease.":[28],"In":[29],"ALS/FTD":[30,75,132,155],"patients,":[31,76],"neuroinflammation":[32,57],"characterized":[33],"by":[34,152],"innate":[35,170],"immune":[36,67,139,149,171],"responses":[37],"tissue-resident":[39],"glial":[40],"cells":[41],"is":[42,79],"uniformly":[43],"present":[44],"on":[45,148],"end-stage":[46],"pathology,":[47,108],"human":[49],"imaging":[50],"studies":[51],"rodent":[53],"models":[54],"support":[55],"begins":[58],"early":[59],"disease":[61,120],"pathogenesis.":[62],"Additionally,":[63],"changes":[64],"circulating":[66],"cell":[68,150],"populations":[69],"cytokines":[71],"found":[73],"there":[78],"evidence":[80,99,144],"for":[81,145],"an":[82],"autoinflammatory":[83],"state.":[84],"However,":[85],"despite":[86],"the":[87,127,135,168],"prominent":[88],"role":[89],"neuro-":[91],"systemic":[93],"inflammation":[94,113,130],"ALS/FTD,":[96],"experimental":[98],"rodents":[101],"altering":[103],"microglial":[104],"function":[105,151],"can":[106],"mitigate":[107],"therapeutic":[109],"approaches":[110],"to":[111,118,167],"decrease":[112],"have":[114],"thus":[115],"far":[116],"failed":[117],"alter":[119],"course":[121],"humans.":[123],"Here,":[124],"we":[125],"review":[126],"characteristics":[128],"both":[134],"nervous":[136],"peripheral":[138],"systems.":[140],"We":[141],"further":[142],"discuss":[143],"direct":[146],"influence":[147],"mutations":[153],"genes":[156],"including":[157],"C9orf72,":[158],"TBK1":[159],"OPTN,":[161],"how":[163],"this":[164],"could":[165],"lead":[166],"altered":[169],"system":[172],"\"tone\"":[173],"observed":[174],"these":[176],"patients.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":45},{"year":2024,"cited_by_count":54},{"year":2023,"cited_by_count":53},{"year":2022,"cited_by_count":45},{"year":2021,"cited_by_count":40},{"year":2020,"cited_by_count":45},{"year":2019,"cited_by_count":16}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}