{"id":"https://openalex.org/W2900575301","doi":"https://doi.org/10.1063/1.5045124","title":"Review: Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids","display_name":"Review: Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids","publication_year":2018,"publication_date":"2018-11-15","ids":{"openalex":"https://openalex.org/W2900575301","doi":"https://doi.org/10.1063/1.5045124","mag":"2900575301","pmid":"https://pubmed.ncbi.nlm.nih.gov/31069322","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6481728"},"language":"en","primary_location":{"id":"doi:10.1063/1.5045124","doi":"https://doi.org/10.1063/1.5045124","is_oa":true,"landing_page_url":"https://doi.org/10.1063/1.5045124","pdf_url":null,"source":{"id":"https://openalex.org/S4210206319","display_name":"APL Bioengineering","issn_l":"2473-2877","issn":["2473-2877"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320061","host_organization_name":"AIP Publishing","host_organization_lineage":["https://openalex.org/P4310320061","https://openalex.org/P4310320257"],"host_organization_lineage_names":["AIP Publishing","American Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APL Bioengineering","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1063/1.5045124","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048527821","display_name":"Mariana Oksdath","orcid":"https://orcid.org/0000-0001-6311-9170","observed_orcids":["https://orcid.org/0000-0001-6311-9170"]},"institutions":[{"id":"https://openalex.org/I107656453","display_name":"South Australia Pathology","ror":"https://ror.org/01kvtm035","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I107656453"]},{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I4210140852","display_name":"Centre for Cancer Biology","ror":"https://ror.org/03yg7hz06","country_code":"AU","type":"facility","lineage":["https://openalex.org/I107656453","https://openalex.org/I4210140852","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mariana Oksdath","raw_affiliation_strings":["Centre for Cancer Biology, South Australia Pathology and University of South Australia 1 , Adelaide 5001, Australia"],"raw_orcid":"https://orcid.org/0000-0001-6311-9170","affiliations":[{"raw_affiliation_string":"Centre for Cancer Biology, South Australia Pathology and University of South Australia 1 , Adelaide 5001, Australia","institution_ids":["https://openalex.org/I107656453","https://openalex.org/I170239107","https://openalex.org/I4210140852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055573736","display_name":"Sally L. Perrin","orcid":"https://orcid.org/0000-0001-9923-1383","observed_orcids":["https://orcid.org/0000-0001-9923-1383"]},"institutions":[{"id":"https://openalex.org/I107656453","display_name":"South Australia Pathology","ror":"https://ror.org/01kvtm035","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I107656453"]},{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I4210140852","display_name":"Centre for Cancer Biology","ror":"https://ror.org/03yg7hz06","country_code":"AU","type":"facility","lineage":["https://openalex.org/I107656453","https://openalex.org/I4210140852","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sally L. Perrin","raw_affiliation_strings":["Centre for Cancer Biology, South Australia Pathology and University of South Australia 1 , Adelaide 5001, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer Biology, South Australia Pathology and University of South Australia 1 , Adelaide 5001, Australia","institution_ids":["https://openalex.org/I107656453","https://openalex.org/I170239107","https://openalex.org/I4210140852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051105644","display_name":"C\u00e9dric Bardy","orcid":"https://orcid.org/0000-0001-8321-0852","observed_orcids":["https://orcid.org/0000-0001-8321-0852"]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]},{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Cedric Bardy","raw_affiliation_strings":["Flinders University, College of Medicine and Public Health 3 , Bedford Park 5042, Australia","South Australian Health and Medical Research Institute (SAHMRI) 2 , Adelaide 5000, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flinders University, College of Medicine and Public Health 3 , Bedford Park 5042, Australia","institution_ids":["https://openalex.org/I169541294"]},{"raw_affiliation_string":"South Australian Health and Medical Research Institute (SAHMRI) 2 , Adelaide 5000, Australia","institution_ids":["https://openalex.org/I4210137740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056416194","display_name":"Emily Frances Hilder","orcid":"https://orcid.org/0000-0002-4444-7870","observed_orcids":["https://orcid.org/0000-0002-4444-7870"]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Emily F. Hilder","raw_affiliation_strings":["Future Industries Institute, University of South Australia 4 , Mawson Lakes 5095, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Future Industries Institute, University of South Australia 4 , Mawson Lakes 5095, Australia","institution_ids":["https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030286069","display_name":"Cole A. DeForest","orcid":"https://orcid.org/0000-0003-0337-3577","observed_orcids":["https://orcid.org/0000-0003-0337-3577"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cole A. DeForest","raw_affiliation_strings":["Department of Chemical Engineering and Department of Bioengineering, University of Washington 5 , Seattle, Washington 98195-1750, USA"],"raw_orcid":"https://orcid.org/0000-0003-0337-3577","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Department of Bioengineering, University of Washington 5 , Seattle, Washington 98195-1750, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051165513","display_name":"Ruben Dario Arrua","orcid":"https://orcid.org/0000-0001-9057-294X","observed_orcids":["https://orcid.org/0000-0001-9057-294X"]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"R. Dario Arrua","raw_affiliation_strings":["Future Industries Institute, University of South Australia 4 , Mawson Lakes 5095, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Future Industries Institute, University of South Australia 4 , Mawson Lakes 5095, Australia","institution_ids":["https://openalex.org/I170239107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008963986","display_name":"Guillermo Alberto Gomez","orcid":"https://orcid.org/0000-0002-0494-2404","observed_orcids":["https://orcid.org/0000-0002-0494-2404"]},"institutions":[{"id":"https://openalex.org/I107656453","display_name":"South Australia Pathology","ror":"https://ror.org/01kvtm035","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I107656453"]},{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I4210140852","display_name":"Centre for Cancer Biology","ror":"https://ror.org/03yg7hz06","country_code":"AU","type":"facility","lineage":["https://openalex.org/I107656453","https://openalex.org/I4210140852","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Guillermo A. Gomez","raw_affiliation_strings":["Centre for Cancer Biology, South Australia Pathology and University of South Australia 1 , Adelaide 5001, Australia"],"raw_orcid":"https://orcid.org/0000-0002-0494-2404","affiliations":[{"raw_affiliation_string":"Centre for Cancer Biology, South Australia Pathology and University of South Australia 1 , Adelaide 5001, Australia","institution_ids":["https://openalex.org/I107656453","https://openalex.org/I170239107","https://openalex.org/I4210140852"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5008963986","https://openalex.org/A5051165513"],"corresponding_institution_ids":["https://openalex.org/I107656453","https://openalex.org/I170239107","https://openalex.org/I4210140852"],"apc_list":{"value":2200,"currency":"USD","value_usd":2200},"apc_paid":{"value":2200,"currency":"USD","value_usd":2200},"fwci":0.6292,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.56328452,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2","issue":"4","first_page":"041501","last_page":"041501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.10740000009536743,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.08190000057220459,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-organoids","display_name":"brain organoids","score":0.9670000076293945},{"id":"https://openalex.org/keywords/synthetic-scaffolds","display_name":"synthetic scaffolds","score":0.847000002861023},{"id":"https://openalex.org/keywords/stem-cell-derived-organoids","display_name":"stem cell-derived organoids","score":0.7919999957084656},{"id":"https://openalex.org/keywords/biomaterials","display_name":"biomaterials","score":0.968999981880188},{"id":"https://openalex.org/keywords/biomechanical-environment","display_name":"biomechanical environment","score":0.7300000190734863},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.9701765179634094},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6283483505249023},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.41166210174560547},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4051991105079651},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.37242162227630615},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3682304322719574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3640000820159912},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.359902024269104},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33062249422073364},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2946871221065521},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1564001441001892},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1524549126625061}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1063/1.5045124","doi":"https://doi.org/10.1063/1.5045124","is_oa":true,"landing_page_url":"https://doi.org/10.1063/1.5045124","pdf_url":null,"source":{"id":"https://openalex.org/S4210206319","display_name":"APL Bioengineering","issn_l":"2473-2877","issn":["2473-2877"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320061","host_organization_name":"AIP Publishing","host_organization_lineage":["https://openalex.org/P4310320061","https://openalex.org/P4310320257"],"host_organization_lineage_names":["AIP Publishing","American Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APL Bioengineering","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6481728","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6481728","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APL Bioeng","raw_type":"Text"},{"id":"pmid:31069322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31069322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APL bioengineering","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:dc23ad1d8a054c39b392371be4b9b762","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dc23ad1d8a054c39b392371be4b9b762","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"APL Bioengineering, Vol 2, Iss 4, Pp 041501-041501-19 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1063/1.5045124","doi":"https://doi.org/10.1063/1.5045124","is_oa":true,"landing_page_url":"https://doi.org/10.1063/1.5045124","pdf_url":null,"source":{"id":"https://openalex.org/S4210206319","display_name":"APL Bioengineering","issn_l":"2473-2877","issn":["2473-2877"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320061","host_organization_name":"AIP Publishing","host_organization_lineage":["https://openalex.org/P4310320061","https://openalex.org/P4310320257"],"host_organization_lineage_names":["AIP Publishing","American Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APL Bioengineering","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3058476572","display_name":null,"funder_award_id":"1067405 and 1123816","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G603132989","display_name":"CAREER:  User-Programmable Hydrogel Biomaterials to Probe and Direct 4D Stem Cell Fate","funder_award_id":"1652141","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6360440955","display_name":"The mechanochemical basis of cell polarity","funder_award_id":"FT160100366","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320977","display_name":"Flinders University","ror":"https://ror.org/01kpzv902"},{"id":"https://openalex.org/F4320320979","display_name":"University of South Australia","ror":"https://ror.org/01p93h210"},{"id":"https://openalex.org/F4320324006","display_name":"Cure Brain Cancer Foundation","ror":"https://ror.org/02db9yt31"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":159,"referenced_works":["https://openalex.org/W1531055064","https://openalex.org/W1532124327","https://openalex.org/W1534855572","https://openalex.org/W1645819625","https://openalex.org/W1911306676","https://openalex.org/W1944253530","https://openalex.org/W1969444872","https://openalex.org/W1971163936","https://openalex.org/W1974524647","https://openalex.org/W1975911274","https://openalex.org/W1985958520","https://openalex.org/W1986341797","https://openalex.org/W1991808150","https://openalex.org/W1993880792","https://openalex.org/W1997218140","https://openalex.org/W1998134697","https://openalex.org/W2001244335","https://openalex.org/W2003388415","https://openalex.org/W2008324315","https://openalex.org/W2009364907","https://openalex.org/W2009565629","https://openalex.org/W2009958353","https://openalex.org/W2010238215","https://openalex.org/W2014444260","https://openalex.org/W2018286352","https://openalex.org/W2018491726","https://openalex.org/W2023026872","https://openalex.org/W2028582107","https://openalex.org/W2032043292","https://openalex.org/W2044928246","https://openalex.org/W2045295282","https://openalex.org/W2047134067","https://openalex.org/W2056862690","https://openalex.org/W2058310958","https://openalex.org/W2060090147","https://openalex.org/W2060697891","https://openalex.org/W2067897176","https://openalex.org/W2068294198","https://openalex.org/W2069527111","https://openalex.org/W2069755236","https://openalex.org/W2073760372","https://openalex.org/W2073880678","https://openalex.org/W2074562018","https://openalex.org/W2088868630","https://openalex.org/W2088928924","https://openalex.org/W2099164785","https://openalex.org/W2099481325","https://openalex.org/W2110148884","https://openalex.org/W2115330640","https://openalex.org/W2122146362","https://openalex.org/W2127004672","https://openalex.org/W2127227914","https://openalex.org/W2127250954","https://openalex.org/W2128683756","https://openalex.org/W2130876797","https://openalex.org/W2132495128","https://openalex.org/W2132566055","https://openalex.org/W2134208433","https://openalex.org/W2137281934","https://openalex.org/W2142482716","https://openalex.org/W2142534205","https://openalex.org/W2146369085","https://openalex.org/W2154665940","https://openalex.org/W2158965201","https://openalex.org/W2163870773","https://openalex.org/W2174116726","https://openalex.org/W2195294260","https://openalex.org/W2213423782","https://openalex.org/W2256191215","https://openalex.org/W2257467030","https://openalex.org/W2259578665","https://openalex.org/W2286284214","https://openalex.org/W2290134975","https://openalex.org/W2296740725","https://openalex.org/W2317248635","https://openalex.org/W2333301394","https://openalex.org/W2335714831","https://openalex.org/W2341041396","https://openalex.org/W2343371293","https://openalex.org/W2369036439","https://openalex.org/W2409259228","https://openalex.org/W2424094044","https://openalex.org/W2463268415","https://openalex.org/W2464219688","https://openalex.org/W2469215989","https://openalex.org/W2490424988","https://openalex.org/W2501380663","https://openalex.org/W2503067859","https://openalex.org/W2507458667","https://openalex.org/W2510238988","https://openalex.org/W2510564348","https://openalex.org/W2512410982","https://openalex.org/W2519209219","https://openalex.org/W2527017317","https://openalex.org/W2531835077","https://openalex.org/W2552754421","https://openalex.org/W2562760503","https://openalex.org/W2563851889","https://openalex.org/W2564377385","https://openalex.org/W2564731929","https://openalex.org/W2585368338","https://openalex.org/W2587737921","https://openalex.org/W2588863856","https://openalex.org/W2590223143","https://openalex.org/W2592611994","https://openalex.org/W2596705496","https://openalex.org/W2599208276","https://openalex.org/W2602765053","https://openalex.org/W2607293416","https://openalex.org/W2609473806","https://openalex.org/W2609844460","https://openalex.org/W2610055642","https://openalex.org/W2616779259","https://openalex.org/W2618828505","https://openalex.org/W2624992840","https://openalex.org/W2727320713","https://openalex.org/W2731135089","https://openalex.org/W2735140255","https://openalex.org/W2737384616","https://openalex.org/W2739343374","https://openalex.org/W2741286864","https://openalex.org/W2742059672","https://openalex.org/W2742175163","https://openalex.org/W2744702298","https://openalex.org/W2746997939","https://openalex.org/W2750793262","https://openalex.org/W2753051071","https://openalex.org/W2753168648","https://openalex.org/W2763153129","https://openalex.org/W2766225693","https://openalex.org/W2766832099","https://openalex.org/W2767398790","https://openalex.org/W2767569544","https://openalex.org/W2767734597","https://openalex.org/W2768214603","https://openalex.org/W2768626269","https://openalex.org/W2769152375","https://openalex.org/W2773729171","https://openalex.org/W2775116549","https://openalex.org/W2780722747","https://openalex.org/W2781522649","https://openalex.org/W2782940950","https://openalex.org/W2783235643","https://openalex.org/W2783733655","https://openalex.org/W2784363986","https://openalex.org/W2786607693","https://openalex.org/W2788735115","https://openalex.org/W2789034055","https://openalex.org/W2790329053","https://openalex.org/W2790359280","https://openalex.org/W2791552546","https://openalex.org/W2791872135","https://openalex.org/W2792476159","https://openalex.org/W2792725988","https://openalex.org/W2793202580","https://openalex.org/W2800937816","https://openalex.org/W2885384332","https://openalex.org/W2898470719","https://openalex.org/W7096974372"],"related_works":["https://openalex.org/W7078411818","https://openalex.org/W4406518221","https://openalex.org/W7214935901","https://openalex.org/W7165542627","https://openalex.org/W3199358699","https://openalex.org/W2896873761","https://openalex.org/W7214660896","https://openalex.org/W4391100907","https://openalex.org/W7154984370","https://openalex.org/W3188744629"],"abstract_inverted_index":{"Stem":[0],"cell-derived":[1],"brain":[2,83],"organoids":[3],"provide":[4],"a":[5],"powerful":[6],"platform":[7],"for":[8,87],"systematic":[9],"studies":[10],"of":[11,18,29,64,81,90],"tissue":[12],"functional":[13],"architecture":[14],"and":[15,32,56,61,92],"the":[16,27,58,65,74,78],"development":[17],"personalized":[19],"therapies.":[20],"Here,":[21],"we":[22],"review":[23],"key":[24],"advances":[25],"at":[26],"interface":[28],"soft":[30],"matter":[31],"stem":[33],"cell":[34],"biology":[35],"on":[36],"synthetic":[37],"alternatives":[38],"to":[39,76],"extracellular":[40],"matrices.":[41],"We":[42,69],"emphasize":[43],"recent":[44],"biomaterial-based":[45],"strategies":[46],"that":[47,72],"have":[48,73],"been":[49],"proven":[50],"advantageous":[51],"towards":[52],"optimizing":[53],"organoid":[54,84],"growth":[55],"controlling":[57],"geometrical,":[59],"biomechanical,":[60],"biochemical":[62],"properties":[63],"organoid's":[66],"three-dimensional":[67],"environment.":[68],"highlight":[70],"systems":[71],"potential":[75],"increase":[77],"translational":[79],"value":[80],"region-specific":[82],"models":[85],"suitable":[86],"different":[88],"types":[89],"manipulations":[91],"high-throughput":[93],"applications.":[94]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-11-29T00:00:00"}