{"id":"https://openalex.org/W2900567433","doi":"https://doi.org/10.1038/s41467-018-06843-5","title":"A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation","display_name":"A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation","publication_year":2018,"publication_date":"2018-11-12","ids":{"openalex":"https://openalex.org/W2900567433","doi":"https://doi.org/10.1038/s41467-018-06843-5","mag":"2900567433","pmid":"https://pubmed.ncbi.nlm.nih.gov/30446650","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6240116"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-018-06843-5","doi":"https://doi.org/10.1038/s41467-018-06843-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-06843-5","pdf_url":"https://www.nature.com/articles/s41467-018-06843-5.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-018-06843-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087521111","display_name":"Daniel B. Reeves","orcid":"https://orcid.org/0000-0001-5684-9538","observed_orcids":["https://orcid.org/0000-0001-5684-9538"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel B. Reeves","raw_affiliation_strings":["Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., Seattle, WA, 98122, USA"],"raw_orcid":"https://orcid.org/0000-0001-5684-9538","affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., Seattle, WA, 98122, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023984917","display_name":"Elizabeth R. Duke","orcid":"https://orcid.org/0000-0002-3348-9039","observed_orcids":["https://orcid.org/0000-0002-3348-9039"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth R. Duke","raw_affiliation_strings":["Department of Medicine, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA","Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., Seattle, WA, 98122, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., Seattle, WA, 98122, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033119708","display_name":"Thor A. Wagner","orcid":"https://orcid.org/0000-0002-1520-268X","observed_orcids":["https://orcid.org/0000-0002-1520-268X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thor A. Wagner","raw_affiliation_strings":["Center for Global Infectious Disease Research, Seattle Children's Research Institute, 1900 9th Ave., Seattle, WA, 98101, USA","Department of Pediatrics, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, 1900 9th Ave., Seattle, WA, 98101, USA","institution_ids":["https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Department of Pediatrics, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103224778","display_name":"Sarah Palmer","orcid":"https://orcid.org/0000-0002-9195-3805","observed_orcids":["https://orcid.org/0000-0002-9195-3805"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I4210145422","display_name":"Westmead Institute for Medical Research","ror":"https://ror.org/04zj3ra44","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210145422"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sarah E. Palmer","raw_affiliation_strings":["Centre for Virus Research, The Westmead Institute for Medical Research, University of Sydney, 176 Hawkesbury Rd., Sydney, NSW, 2145, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Virus Research, The Westmead Institute for Medical Research, University of Sydney, 176 Hawkesbury Rd., Sydney, NSW, 2145, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I4210145422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036762753","display_name":"Adam M. Spivak","orcid":"https://orcid.org/0000-0003-1815-7893","observed_orcids":["https://orcid.org/0000-0003-1815-7893"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam M. Spivak","raw_affiliation_strings":["Department of Medicine, University of Utah, 30N 1900 E, Salt Lake City, UT, 84132, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Utah, 30N 1900 E, Salt Lake City, UT, 84132, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086574482","display_name":"Joshua Tisdell Schiffer","orcid":"https://orcid.org/0000-0002-2598-1621","observed_orcids":["https://orcid.org/0000-0002-2598-1621"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua T. Schiffer","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., Seattle, WA, 98122, USA. jschiffe@fhcrc.org","Department of Medicine, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA. jschiffe@fhcrc.org","Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., Seattle, WA, 98122, USA. jschiffe@fhcrc.org","Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., Seattle, WA, 98122, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., Seattle, WA, 98122, USA. jschiffe@fhcrc.org","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA. jschiffe@fhcrc.org","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., Seattle, WA, 98122, USA. jschiffe@fhcrc.org","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., Seattle, WA, 98122, USA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5086574482"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":9.0359,"has_fulltext":true,"cited_by_count":143,"citation_normalized_percentile":{"value":0.98993007,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"9","issue":"1","first_page":"4811","last_page":"4811"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-persistence","display_name":"HIV persistence","score":0.9200000166893005},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.906000018119812},{"id":"https://openalex.org/keywords/hiv-reservoir","display_name":"HIV reservoir","score":0.5910000205039978},{"id":"https://openalex.org/keywords/clonal-populations","display_name":"clonal populations","score":0.7570000290870667},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"viral evolution","score":0.7070000171661377},{"id":"https://openalex.org/keywords/functional-cure","display_name":"functional cure","score":0.6370000243186951},{"id":"https://openalex.org/keywords/hiv-latency","display_name":"HIV latency","score":0.4580000042915344},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.820537805557251},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.7873876094818115},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6270653605461121},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5857658982276917},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4321445822715759},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42347991466522217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42129209637641907},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35311946272850037},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.3322829008102417},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15130963921546936},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41467-018-06843-5","doi":"https://doi.org/10.1038/s41467-018-06843-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-06843-5","pdf_url":"https://www.nature.com/articles/s41467-018-06843-5.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5203981","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6240116","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6240116","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6240116","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:30446650","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30446650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06843-5","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-018-06843-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:23a1b16278b148bf86674b641b9e2165","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/23a1b16278b148bf86674b641b9e2165","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:d3e708e779664bdfbeec752fe51d1be0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d3e708e779664bdfbeec752fe51d1be0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-018-06843-5","doi":"https://doi.org/10.1038/s41467-018-06843-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-06843-5","pdf_url":"https://www.nature.com/articles/s41467-018-06843-5.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1150034057","display_name":null,"funder_award_id":"UM1AI068635","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G1153707119","display_name":null,"funder_award_id":"1UM1AI126611-01","funder_id":"https://openalex.org/F4320309010","funder_display_name":"Delaney AIDS Research Enterprise"},{"id":"https://openalex.org/G1437275154","display_name":null,"funder_award_id":"P01 AI030371-24, U19 AI113173-02, R01 AI121129-01, UM1 AI126623, UM1 AI068635","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1729714301","display_name":null,"funder_award_id":"P01 AI030371-24","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G1909522847","display_name":"Immunoprotective Properties of Tissue-resident Memory T Cells in Mice and Humans within Mucosal Sites","funder_award_id":"R01AI121129","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2584361871","display_name":null,"funder_award_id":"1U19AI096109","funder_id":"https://openalex.org/F4320309010","funder_display_name":"Delaney AIDS Research Enterprise"},{"id":"https://openalex.org/G2910143918","display_name":null,"funder_award_id":"U19 AI113173-02","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G3357657595","display_name":"DARE: Delaney AIDS Research Enterprise to find a cure.","funder_award_id":"U19AI096109","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3462701734","display_name":null,"funder_award_id":"UM1 AI126623","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G3930483489","display_name":"University of Washington Sexually Transmitted Infections Cooperative Research Cen","funder_award_id":"U19AI113173","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4925349168","display_name":null,"funder_award_id":"R01 AI121129-01","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G536165561","display_name":"Delaney AIDS Research Enterprise to Cure HIV","funder_award_id":"UM1AI126611","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5809992656","display_name":null,"funder_award_id":"KL2TR002317","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G6305753049","display_name":"Cell and Gene Therapy for HIV Cure","funder_award_id":"UM1AI126623","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6329780409","display_name":null,"funder_award_id":"TR002317","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G6627372601","display_name":null,"funder_award_id":"AAP1061681","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G822542702","display_name":"Simulating persistence and elimination of the HIV reservoir","funder_award_id":"K25AI155224","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000028484","display_name":null,"funder_award_id":"AI068635","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000858468","display_name":"NRSA Training Core","funder_award_id":"TL1TR002318","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000866158","display_name":"SDMC: HIV Vaccine Trials Network","funder_award_id":"UM1AI068635","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000868680","display_name":"University of Washington/Fred Hutch Center for AIDS Research","funder_award_id":"P30AI027757","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000891566","display_name":"Host Defense Training in Allergy and Infectious Diseases","funder_award_id":"T32AI007044","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000893862","display_name":"Institutional Career Development Core","funder_award_id":"KL2TR002317","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320306854","display_name":"Washington Research Foundation","ror":"https://ror.org/00hasdx88"},{"id":"https://openalex.org/F4320309010","display_name":"Delaney AIDS Research Enterprise","ror":"https://ror.org/040gxv777"},{"id":"https://openalex.org/F4320311531","display_name":"Australian Centre for HIV and Hepatitis Virology Research","ror":"https://ror.org/02he67h29"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2900567433.pdf","grobid_xml":"https://content.openalex.org/works/W2900567433.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1497870368","https://openalex.org/W1520782722","https://openalex.org/W1964380294","https://openalex.org/W1969276189","https://openalex.org/W1975699571","https://openalex.org/W1980223851","https://openalex.org/W1981636515","https://openalex.org/W1982448824","https://openalex.org/W1982728956","https://openalex.org/W1993803315","https://openalex.org/W2000042664","https://openalex.org/W2005674407","https://openalex.org/W2006765654","https://openalex.org/W2007607803","https://openalex.org/W2016168268","https://openalex.org/W2020102996","https://openalex.org/W2022098233","https://openalex.org/W2028840312","https://openalex.org/W2031182775","https://openalex.org/W2034659049","https://openalex.org/W2041457600","https://openalex.org/W2046159404","https://openalex.org/W2051269276","https://openalex.org/W2054614777","https://openalex.org/W2055796578","https://openalex.org/W2064140898","https://openalex.org/W2064416623","https://openalex.org/W2065148379","https://openalex.org/W2072164469","https://openalex.org/W2081622536","https://openalex.org/W2084513007","https://openalex.org/W2101466217","https://openalex.org/W2101516953","https://openalex.org/W2105538746","https://openalex.org/W2111642815","https://openalex.org/W2114538357","https://openalex.org/W2114705914","https://openalex.org/W2115023808","https://openalex.org/W2115580899","https://openalex.org/W2120915945","https://openalex.org/W2124114936","https://openalex.org/W2125170595","https://openalex.org/W2126515754","https://openalex.org/W2126603527","https://openalex.org/W2127012498","https://openalex.org/W2129136949","https://openalex.org/W2130719514","https://openalex.org/W2139250164","https://openalex.org/W2140505465","https://openalex.org/W2140573695","https://openalex.org/W2143763222","https://openalex.org/W2144549163","https://openalex.org/W2149233928","https://openalex.org/W2151758275","https://openalex.org/W2163515030","https://openalex.org/W2164734631","https://openalex.org/W2168736565","https://openalex.org/W2169033726","https://openalex.org/W2170614926","https://openalex.org/W2172144516","https://openalex.org/W2231521459","https://openalex.org/W2263584512","https://openalex.org/W2272185077","https://openalex.org/W2396421546","https://openalex.org/W2461540377","https://openalex.org/W2473738987","https://openalex.org/W2477260699","https://openalex.org/W2504810550","https://openalex.org/W2512878063","https://openalex.org/W2598871150","https://openalex.org/W2626171259","https://openalex.org/W2626844631","https://openalex.org/W2734230971","https://openalex.org/W2755874731","https://openalex.org/W2793229524","https://openalex.org/W2952062677","https://openalex.org/W2982328647","https://openalex.org/W3103362336"],"related_works":["https://openalex.org/W2560383746","https://openalex.org/W3136921086","https://openalex.org/W2522164855","https://openalex.org/W4200346605","https://openalex.org/W4411028673","https://openalex.org/W2609975224","https://openalex.org/W2064416623","https://openalex.org/W2975857794","https://openalex.org/W2896724624","https://openalex.org/W2418599563"],"abstract_inverted_index":{"Antiretroviral":[0],"therapy":[1],"(ART)":[2],"suppresses":[3],"viral":[4,31,91],"replication":[5,32,88],"in":[6,33],"people":[7],"living":[8],"with":[9,71],"HIV.":[10],"Yet,":[11],"infected":[12,42,55,97,112],"cells":[13,56,98,113],"persist":[14],"for":[15],"decades":[16],"on":[17],"ART":[18,23,35],"and":[19,37,47,127],"viremia":[20],"returns":[21],"if":[22],"is":[24],"stopped.":[25],"Persistence":[26],"has":[27],"been":[28],"attributed":[29],"to":[30],"an":[34],"sanctuary":[36],"long-lived":[38],"and/or":[39],"proliferating":[40],"latently":[41],"cells.":[43],"Using":[44],"ecological":[45],"methods":[46],"existing":[48],"data,":[49],"we":[50],"infer":[51],"that":[52],">99%":[53],"of":[54,59,65,77,85,111,123],"are":[57],"members":[58],"clonal":[60],"populations":[61],"after":[62],"one":[63],"year":[64],"ART.":[66,115],"We":[67],"reconcile":[68],"our":[69,103],"results":[70,104],"observations":[72],"from":[73,100],"the":[74,121,124],"first":[75],"months":[76],"ART,":[78],"demonstrating":[79],"mathematically":[80],"how":[81],"a":[82,109,130],"fossil":[83],"record":[84],"historic":[86],"HIV":[87,125],"permits":[89],"observed":[90],"evolution":[92],"even":[93],"while":[94],"most":[95],"new":[96],"arise":[99],"proliferation.":[101],"Together,":[102],"imply":[105],"cellular":[106],"proliferation":[107,118],"generates":[108],"majority":[110],"during":[114],"Therefore,":[116],"reducing":[117],"could":[119],"decrease":[120],"size":[122],"reservoir":[126],"help":[128],"achieve":[129],"functional":[131],"cure.":[132]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":26},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-11-29T00:00:00"}