{"id":"https://openalex.org/W2900546348","doi":"https://doi.org/10.25258/ijddt.v8i2.13877","title":"The Optimization of Maltodextrin and Arabic Gum in the Microencapsulation of Aqueous Fraction of Clinacanthus nutans Using Simplex Lattice Design","display_name":"The Optimization of Maltodextrin and Arabic Gum in the Microencapsulation of Aqueous Fraction of Clinacanthus nutans Using Simplex Lattice Design","publication_year":2018,"publication_date":"2018-11-02","ids":{"openalex":"https://openalex.org/W2900546348","doi":"https://doi.org/10.25258/ijddt.v8i2.13877","mag":"2900546348"},"language":"en","primary_location":{"id":"doi:10.25258/ijddt.v8i2.13877","doi":"https://doi.org/10.25258/ijddt.v8i2.13877","is_oa":false,"landing_page_url":"https://doi.org/10.25258/ijddt.v8i2.13877","pdf_url":null,"source":{"id":"https://openalex.org/S4210211336","display_name":"International Journal of Drug Delivery Technology","issn_l":"0975-4415","issn":["0975-4415"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Drug Delivery Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026566441","display_name":"Intan Martha Cahyani","orcid":"https://orcid.org/0000-0001-9870-1048","observed_orcids":["https://orcid.org/0000-0001-9870-1048"]},"institutions":[{"id":"https://openalex.org/I4405276636","display_name":"Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi Semarang","ror":"https://ror.org/05smz3977","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405276636"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Intan Martha Cahyani","raw_affiliation_strings":["Sekolah Tinggi Ilmu Farmasi \u201cYayasan Pharmasi\u201d Semarang, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sekolah Tinggi Ilmu Farmasi \u201cYayasan Pharmasi\u201d Semarang, Indonesia","institution_ids":["https://openalex.org/I4405276636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082794777","display_name":"Ebta Narasukma Anggraeny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405276636","display_name":"Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi Semarang","ror":"https://ror.org/05smz3977","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405276636"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Ebta Narasukma Anggraeny","raw_affiliation_strings":["Sekolah Tinggi Ilmu Farmasi \u201cYayasan Pharmasi\u201d Semarang, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sekolah Tinggi Ilmu Farmasi \u201cYayasan Pharmasi\u201d Semarang, Indonesia","institution_ids":["https://openalex.org/I4405276636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012916902","display_name":"Bekti Nugraheni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405276636","display_name":"Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi Semarang","ror":"https://ror.org/05smz3977","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405276636"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Bekti Nugraheni","raw_affiliation_strings":["Sekolah Tinggi Ilmu Farmasi \u201cYayasan Pharmasi\u201d Semarang, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sekolah Tinggi Ilmu Farmasi \u201cYayasan Pharmasi\u201d Semarang, Indonesia","institution_ids":["https://openalex.org/I4405276636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113856207","display_name":"Christiana Retnaningsih","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I147439693","display_name":"Soegijapranata Catholic University","ror":"https://ror.org/039t4sn90","country_code":"ID","type":"education","lineage":["https://openalex.org/I147439693"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Christiana Retnaningsih","raw_affiliation_strings":["Universitas Katolik Soegijapranata Semarang, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Katolik Soegijapranata Semarang, Indonesia","institution_ids":["https://openalex.org/I147439693"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084757170","display_name":"Victoria Kristina Ananingsih","orcid":"https://orcid.org/0000-0003-2366-4937","observed_orcids":["https://orcid.org/0000-0003-2366-4937"]},"institutions":[{"id":"https://openalex.org/I147439693","display_name":"Soegijapranata Catholic University","ror":"https://ror.org/039t4sn90","country_code":"ID","type":"education","lineage":["https://openalex.org/I147439693"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"V Kristina Ananingsih","raw_affiliation_strings":["2Universitas Katolik Soegijapranata Semarang, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Universitas Katolik Soegijapranata Semarang, Indonesia","institution_ids":["https://openalex.org/I147439693"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1881,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.49634017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"8","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12048","display_name":"Microencapsulation and Drying Processes","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12048","display_name":"Microencapsulation and Drying Processes","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14461","display_name":"Medicinal Plant Studies","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clinacanthus-nutans","display_name":"Clinacanthus nutans","score":0.9470000267028809},{"id":"https://openalex.org/keywords/microencapsulation","display_name":"microencapsulation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/maltodextrin","display_name":"maltodextrin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gum-arabic","display_name":"gum arabic","score":0.9850000143051147},{"id":"https://openalex.org/keywords/aqueous-leaf-extract","display_name":"aqueous leaf extract","score":0.781000018119812},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9670000076293945},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.7319999933242798},{"id":"https://openalex.org/keywords/moisture-content","display_name":"moisture content","score":0.8029999732971191},{"id":"https://openalex.org/keywords/flow-rate","display_name":"flow rate","score":0.8759999871253967},{"id":"https://openalex.org/keywords/simplex-lattice-design","display_name":"simplex lattice design","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2777846834","wikidata":"https://www.wikidata.org/wiki/Q177570","display_name":"Maltodextrin","level":3,"score":0.9705613851547241},{"id":"https://openalex.org/C2780054349","wikidata":"https://www.wikidata.org/wiki/Q535814","display_name":"Gum arabic","level":2,"score":0.8445916175842285},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.5768480896949768},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5024728775024414},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.45359107851982117},{"id":"https://openalex.org/C24939127","wikidata":"https://www.wikidata.org/wiki/Q373499","display_name":"Water content","level":2,"score":0.452815443277359},{"id":"https://openalex.org/C64248961","wikidata":"https://www.wikidata.org/wiki/Q791576","display_name":"Water activity","level":3,"score":0.4342171549797058},{"id":"https://openalex.org/C96455323","wikidata":"https://www.wikidata.org/wiki/Q13955","display_name":"Arabic","level":2,"score":0.4339362382888794},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.39035123586654663},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.36732280254364014},{"id":"https://openalex.org/C2779587474","wikidata":"https://www.wikidata.org/wiki/Q1066303","display_name":"Spray drying","level":2,"score":0.34718430042266846},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3117719888687134},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13979819416999817},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11390936374664307},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.25258/ijddt.v8i2.13877","doi":"https://doi.org/10.25258/ijddt.v8i2.13877","is_oa":false,"landing_page_url":"https://doi.org/10.25258/ijddt.v8i2.13877","pdf_url":null,"source":{"id":"https://openalex.org/S4210211336","display_name":"International Journal of Drug Delivery Technology","issn_l":"0975-4415","issn":["0975-4415"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Drug Delivery Technology","raw_type":"journal-article"},{"id":"pmh:oai:repository.unika.ac.id:17771","doi":null,"is_oa":false,"landing_page_url":"http://repository.unika.ac.id/17771/1/58119951852017G2_IJDDT%2CVol8%2CIssue2%2CArticle12%20%28international%20journal%29.pdf","pdf_url":"http://repository.unika.ac.id/17771/1/58119951852017G2_IJDDT%2CVol8%2CIssue2%2CArticle12%20%28international%20journal%29.pdf","source":{"id":"https://openalex.org/S4306401887","display_name":"Unika Repositor (Unika)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102140","host_organization_name":"Universitas Katolik Santo Thomas","host_organization_lineage":["https://openalex.org/I4210102140"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:repository.unika.ac.id:18060","doi":null,"is_oa":false,"landing_page_url":"http://repository.unika.ac.id/18060/1/58119951852017G2_IJDDT%2CVol8%2CIssue2%2CArticle12%20%28international%20journal%29%20%281%29.pdf","pdf_url":"http://repository.unika.ac.id/18060/1/58119951852017G2_IJDDT%2CVol8%2CIssue2%2CArticle12%20%28international%20journal%29%20%281%29.pdf","source":{"id":"https://openalex.org/S4306401887","display_name":"Unika Repositor (Unika)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102140","host_organization_name":"Universitas Katolik Santo Thomas","host_organization_lineage":["https://openalex.org/I4210102140"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:repository.unika.ac.id:21868","doi":null,"is_oa":false,"landing_page_url":"http://repository.unika.ac.id/21868/1/IJDDT%2CVol8%2CIssue2%2CArticle12.pdf","pdf_url":"http://repository.unika.ac.id/21868/1/IJDDT%2CVol8%2CIssue2%2CArticle12.pdf","source":{"id":"https://openalex.org/S4306401887","display_name":"Unika Repositor (Unika)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102140","host_organization_name":"Universitas Katolik Santo Thomas","host_organization_lineage":["https://openalex.org/I4210102140"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:repository.unika.ac.id:23757","doi":null,"is_oa":false,"landing_page_url":"http://repository.unika.ac.id/23757/1/58119951852017G2_IJDDT%2CVol8%2CIssue2%2CArticle12%20%28international%20journal%29.pdf","pdf_url":"http://repository.unika.ac.id/23757/1/58119951852017G2_IJDDT%2CVol8%2CIssue2%2CArticle12%20%28international%20journal%29.pdf","source":{"id":"https://openalex.org/S4306401887","display_name":"Unika Repositor (Unika)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102140","host_organization_name":"Universitas Katolik Santo Thomas","host_organization_lineage":["https://openalex.org/I4210102140"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:repository.unika.ac.id:23770","doi":null,"is_oa":false,"landing_page_url":"http://repository.unika.ac.id/23770/1/58119951852018G1_IJDDT%2CVol8%2CIssue2%2CArticle12.pdf","pdf_url":"http://repository.unika.ac.id/23770/1/58119951852018G1_IJDDT%2CVol8%2CIssue2%2CArticle12.pdf","source":{"id":"https://openalex.org/S4306401887","display_name":"Unika Repositor (Unika)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102140","host_organization_name":"Universitas Katolik Santo Thomas","host_organization_lineage":["https://openalex.org/I4210102140"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2152947300","https://openalex.org/W2160779215","https://openalex.org/W2228979552"],"related_works":["https://openalex.org/W7032898533","https://openalex.org/W7042476255","https://openalex.org/W7154852431","https://openalex.org/W4415155859","https://openalex.org/W4400205348","https://openalex.org/W6981187483","https://openalex.org/W2348821792","https://openalex.org/W3113118730","https://openalex.org/W2997767534","https://openalex.org/W4285509484"],"abstract_inverted_index":{"The":[0,69,85,114],"aqueous":[1,22],"fraction":[2,23],"of":[3,38,62,88,111,116,124],"Clinacanthus":[4],"nutans":[5],"leaf":[6],"extracts":[7],"contains":[8],"flavonoids":[9],"which":[10],"known":[11],"had":[12],"antioxidative":[13],"properties.":[14],"To":[15],"improve":[16],"acceptability,":[17],"this":[18],"viscous":[19],"and":[20,28,40,43,67,82,90,105],"bitter":[21],"was":[24,51,93,139,145],"microencapsulated":[25],"using":[26,53],"maltodextrin":[27,39,89],"Arabic":[29,41,91],"gum.":[30],"This":[31],"research":[32],"aims":[33],"to":[34,72],"discover":[35],"the":[36,44,73,109,121,132,136,142],"effectivity":[37],"gum":[42,92],"concentrations":[45],"for":[46],"optimum":[47,86],"microencapsulation.":[48],"Optimization":[49],"design":[50,59],"done":[52,71],"Design":[54,125],"Expert":[55,126],"with":[56,60,97],"simplex":[57],"lattice":[58],"ratios":[61],"1:0;":[63],"0.75:0.25;":[64],"0.5:0.5;":[65],"0.25:0.75":[66],"0:1.":[68],"evaluations":[70],"results":[74],"were":[75],"microcapsule":[76],"yield,":[77],"moisture":[78,99],"content,":[79,100],"flow":[80,101],"rate,":[81],"antioxidant":[83,106],"activity.":[84],"ratio":[87],"obtained":[94],"at":[95,108],"0.806:0.194":[96],"1.49%":[98],"rate":[102],"4.375":[103],"g/s":[104],"activity":[107],"value":[110],"842,499":[112],"ppm.":[113],"result":[115,123],"one-sample":[117],"T-test":[118],"showed":[119],"that":[120,141],"prediction":[122],"did":[127],"not":[128],"differ":[129],"significantly":[130],"from":[131],"experiment":[133],"result.":[134],"From":[135],"data,":[137],"it":[138],"concluded":[140],"resulting":[143],"equation":[144],"valid":[146]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-11-29T00:00:00"}