{"id":"https://openalex.org/W2900529828","doi":"https://doi.org/10.1097/ico.0000000000001808","title":"Bilateral Ulcerative Keratitis Associated With Afatinib Treatment for Non\u2013Small-cell Lung Carcinoma","display_name":"Bilateral Ulcerative Keratitis Associated With Afatinib Treatment for Non\u2013Small-cell Lung Carcinoma","publication_year":2018,"publication_date":"2018-11-08","ids":{"openalex":"https://openalex.org/W2900529828","doi":"https://doi.org/10.1097/ico.0000000000001808","mag":"2900529828","pmid":"https://pubmed.ncbi.nlm.nih.gov/30418275"},"language":"en","primary_location":{"id":"doi:10.1097/ico.0000000000001808","doi":"https://doi.org/10.1097/ico.0000000000001808","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ico.0000000000001808","pdf_url":null,"source":{"id":"https://openalex.org/S145806103","display_name":"Cornea","issn_l":"0277-3740","issn":["0277-3740","1536-4798"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cornea","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010530818","display_name":"James McKelvie","orcid":"https://orcid.org/0000-0002-6460-4175","observed_orcids":["https://orcid.org/0000-0002-6460-4175"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I2802146118","display_name":"Queen Victoria Hospital","ror":"https://ror.org/01ywpxj09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802146118","https://openalex.org/I4210138177"]}],"countries":["GB","NZ"],"is_corresponding":true,"raw_author_name":"James McKelvie","raw_affiliation_strings":["Corneoplastic Unit and Eye Bank, Queen Victoria Hospital, NHS Trust, East Grinstead, West Sussex, United Kingdom;","Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corneoplastic Unit and Eye Bank, Queen Victoria Hospital, NHS Trust, East Grinstead, West Sussex, United Kingdom;","institution_ids":["https://openalex.org/I2802146118"]},{"raw_affiliation_string":"Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; and","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077763058","display_name":"Cameron McLintock","orcid":"https://orcid.org/0000-0001-8513-9324","observed_orcids":["https://orcid.org/0000-0001-8513-9324"]},"institutions":[{"id":"https://openalex.org/I2802146118","display_name":"Queen Victoria Hospital","ror":"https://ror.org/01ywpxj09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802146118","https://openalex.org/I4210138177"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Cameron McLintock","raw_affiliation_strings":["Corneoplastic Unit and Eye Bank, Queen Victoria Hospital, NHS Trust, East Grinstead, West Sussex, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corneoplastic Unit and Eye Bank, Queen Victoria Hospital, NHS Trust, East Grinstead, West Sussex, United Kingdom;","institution_ids":["https://openalex.org/I2802146118"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077178210","display_name":"Mohamed Elalfy","orcid":"https://orcid.org/0000-0001-6796-9340","observed_orcids":["https://orcid.org/0000-0001-6796-9340"]},"institutions":[{"id":"https://openalex.org/I2802146118","display_name":"Queen Victoria Hospital","ror":"https://ror.org/01ywpxj09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802146118","https://openalex.org/I4210138177"]},{"id":"https://openalex.org/I4210108806","display_name":"Research Institute of Ophthalmology","ror":"https://ror.org/01h0ca774","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210108806"]}],"countries":["EG","GB"],"is_corresponding":true,"raw_author_name":"Mohamed Elalfy","raw_affiliation_strings":["Corneoplastic Unit and Eye Bank, Queen Victoria Hospital, NHS Trust, East Grinstead, West Sussex, United Kingdom;","The Research Institute of Ophthalmology, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corneoplastic Unit and Eye Bank, Queen Victoria Hospital, NHS Trust, East Grinstead, West Sussex, United Kingdom;","institution_ids":["https://openalex.org/I2802146118"]},{"raw_affiliation_string":"The Research Institute of Ophthalmology, Cairo, Egypt","institution_ids":["https://openalex.org/I4210108806"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010530818","https://openalex.org/A5077178210","https://openalex.org/A5077763058"],"corresponding_institution_ids":["https://openalex.org/I154130895","https://openalex.org/I2802146118","https://openalex.org/I4210108806"],"apc_list":null,"apc_paid":null,"fwci":0.9816,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.7194282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"38","issue":"3","first_page":"384","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/afatinib","display_name":"afatinib","score":0.9670000076293945},{"id":"https://openalex.org/keywords/corneal-ulcer","display_name":"corneal ulcer","score":0.9160000085830688},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8690000176429749},{"id":"https://openalex.org/keywords/drug-induced-ocular-toxicity","display_name":"drug-induced ocular toxicity","score":0.8349999785423279},{"id":"https://openalex.org/keywords/corneal-stromal-thinning","display_name":"corneal stromal thinning","score":0.8920000195503235},{"id":"https://openalex.org/keywords/epithelial-defect","display_name":"epithelial defect","score":0.8289999961853027},{"id":"https://openalex.org/keywords/ocular-side-effects","display_name":"ocular adverse effects","score":0.753000020980835},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9001661539077759},{"id":"https://openalex.org/C2780586478","wikidata":"https://www.wikidata.org/wiki/Q4688818","display_name":"Afatinib","level":5,"score":0.8614448308944702},{"id":"https://openalex.org/C2778560704","wikidata":"https://www.wikidata.org/wiki/Q757838","display_name":"Keratitis","level":2,"score":0.568361759185791},{"id":"https://openalex.org/C2780608754","wikidata":"https://www.wikidata.org/wiki/Q5171111","display_name":"Corneal perforation","level":3,"score":0.4997131824493408},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4901140630245209},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.43233487010002136},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4249858856201172},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38004618883132935},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.37615329027175903},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3610052466392517},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23539766669273376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.219760924577713},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1410246193408966},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.08253851532936096},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.08048686385154724}],"mesh":[{"descriptor_ui":"D000077716","descriptor_name":"Afatinib","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003320","descriptor_name":"Corneal Ulcer","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/ico.0000000000001808","doi":"https://doi.org/10.1097/ico.0000000000001808","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ico.0000000000001808","pdf_url":null,"source":{"id":"https://openalex.org/S145806103","display_name":"Cornea","issn_l":"0277-3740","issn":["0277-3740","1536-4798"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cornea","raw_type":"journal-article"},{"id":"pmid:30418275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30418275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cornea","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1861096173","https://openalex.org/W1979832276","https://openalex.org/W1982794477","https://openalex.org/W2072084159","https://openalex.org/W2115943500"],"related_works":["https://openalex.org/W4392106088","https://openalex.org/W4413028618","https://openalex.org/W2271644028","https://openalex.org/W7147518538","https://openalex.org/W7147441986","https://openalex.org/W7147454775","https://openalex.org/W3165166316","https://openalex.org/W7097213296","https://openalex.org/W4313909539","https://openalex.org/W4380768686"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1,135],"report":[2],"a":[3,47],"case":[4,145],"of":[5,39,49,84,99,138,158],"afatinib-related":[6,151],"bilateral":[7],"ulcerative":[8,77,152],"keratitis.":[9,153],"METHODS:":[10],"An":[11],"85-year-old":[12],"female":[13],"patient":[14,119],"on":[15],"treatment":[16,165],"with":[17,24,79,102,166],"afatinib":[18,41,167],"for":[19,82,156,168],"non-small-cell":[20,169],"lung":[21,170],"carcinoma":[22],"presented":[23],"progressive":[25],"redness,":[26],"pain,":[27],"and":[28,59,70,107,124],"decreased":[29],"vision":[30,126],"in":[31,95,146],"both":[32,100],"eyes.":[33],"Four":[34],"weeks":[35],"before":[36],"the":[37,96,115,136,143,147],"onset":[38],"symptoms,":[40],"therapy":[42,72],"had":[43],"been":[44],"commenced":[45,74],"at":[46,64],"dose":[48],"40":[50],"mg,":[51],"once":[52],"daily.":[53],"Clinical":[54],"examination,":[55],"OCT":[56],"imaging,":[57],"photographs,":[58],"corneal":[60,87,116],"scrapes":[61],"were":[62,73,112],"completed":[63],"presentation.":[65,133],"Afatinib":[66],"was":[67,93],"discontinued.":[68],"Topical":[69],"oral":[71],"to":[75,122,128],"treat":[76],"keratitis":[78],"close":[80],"monitoring":[81,155],"signs":[83,157],"progression":[85],"or":[86],"perforation.":[88],"RESULTS:":[89],"Significant":[90],"stromal":[91],"thinning":[92],"detected":[94],"inferior":[97],"cornea":[98],"eyes":[101],"an":[103],"overlying":[104],"epithelial":[105],"defect":[106],"no":[108],"infiltrate.":[109],"No":[110],"organisms":[111],"identified":[113],"from":[114],"scrapes.":[117],"The":[118],"responded":[120],"well":[121],"treatment,":[123],"her":[125],"returned":[127],"baseline":[129],"4":[130],"months":[131],"after":[132],"CONCLUSIONS:":[134],"best":[137],"our":[139],"knowledge,":[140],"this":[141],"is":[142,162],"first":[144],"literature":[148],"that":[149],"reports":[150],"Careful":[154],"ocular":[159],"adverse":[160],"events":[161],"recommended":[163],"during":[164],"carcinoma.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-11-29T00:00:00"}