{"id":"https://openalex.org/W2900526197","doi":"https://doi.org/10.1002/cphy.c170031","title":"Store\u2010Operated Calcium Entry Mediated by ORAI and STIM","display_name":"Store\u2010Operated Calcium Entry Mediated by ORAI and STIM","publication_year":2018,"publication_date":"2018-06-18","ids":{"openalex":"https://openalex.org/W2900526197","doi":"https://doi.org/10.1002/cphy.c170031","mag":"2900526197","pmid":"https://pubmed.ncbi.nlm.nih.gov/29978901"},"language":"en","primary_location":{"id":"doi:10.1002/cphy.c170031","doi":"https://doi.org/10.1002/cphy.c170031","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cphy.c170031","pdf_url":null,"source":{"id":"https://openalex.org/S18747983","display_name":"Comprehensive physiology","issn_l":"2040-4603","issn":["2040-4603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comprehensive Physiology","raw_type":"other"},"volume":{"id":"https://openalex.org/W2787983500","display_name":"Comprehensive Physiology"},"type":"other","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101888513","display_name":"Nhung T. Nguyen","orcid":"https://orcid.org/0000-0002-2802-2557","observed_orcids":["https://orcid.org/0000-0002-2802-2557"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nhung T. Nguyen","raw_affiliation_strings":["Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003662438","display_name":"Weidong Han","orcid":"https://orcid.org/0000-0001-7227-3671","observed_orcids":["https://orcid.org/0000-0001-7227-3671","https://orcid.org/0000-0002-5978-0641"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weidong Han","raw_affiliation_strings":["Department of Medical Oncology, Sir Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Sir Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063793314","display_name":"Wen\u2010Ming Cao","orcid":"https://orcid.org/0000-0002-5644-3156","observed_orcids":["https://orcid.org/0000-0002-5644-3156"]},"institutions":[{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen\u2010Ming Cao","raw_affiliation_strings":["Department of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004339250","display_name":"Youjun Wang","orcid":"https://orcid.org/0000-0003-0961-1716","observed_orcids":["https://orcid.org/0000-0003-0961-1716"]},"institutions":[{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youjun Wang","raw_affiliation_strings":["Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, China","institution_ids":["https://openalex.org/I25254941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005382133","display_name":"Shufan Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shufan Wen","raw_affiliation_strings":["Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044336968","display_name":"Yun Huang","orcid":"https://orcid.org/0000-0001-5950-9168","observed_orcids":["https://orcid.org/0000-0001-5950-9168"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Huang","raw_affiliation_strings":["Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032790556","display_name":"Minyong Li","orcid":"https://orcid.org/0000-0003-3276-4921","observed_orcids":["https://orcid.org/0000-0003-3276-4921"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minyong Li","raw_affiliation_strings":["Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, School of Pharmacy, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, School of Pharmacy, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064491215","display_name":"L\u00fcpei Du","orcid":"https://orcid.org/0000-0003-0531-8985","observed_orcids":["https://orcid.org/0000-0003-0531-8985"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lupei Du","raw_affiliation_strings":["Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, School of Pharmacy, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, School of Pharmacy, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073632725","display_name":"Yubin Zhou","orcid":"https://orcid.org/0000-0001-7962-0517","observed_orcids":["https://orcid.org/0000-0001-7962-0517"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yubin Zhou","raw_affiliation_strings":["Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas, USA","Department of Medical Physiology, College of Medicine, Texas A&M University, Temple, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Medical Physiology, College of Medicine, Texas A&M University, Temple, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5064491215","https://openalex.org/A5073632725"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I91045830"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"3","first_page":"981","last_page":"1002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/store-operated-calcium-entry","display_name":"store-operated calcium entry","score":0.9959999918937683},{"id":"https://openalex.org/keywords/crac-channels","display_name":"CRAC channels","score":0.8560000061988831},{"id":"https://openalex.org/keywords/orai1","display_name":"Orai1","score":0.996999979019165},{"id":"https://openalex.org/keywords/stromal-interaction-molecule-1","display_name":"STIM1","score":1.0},{"id":"https://openalex.org/keywords/calcium-release-activated-calcium-channels","display_name":"calcium release-activated calcium channels","score":0.7879999876022339},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.8130000233650208},{"id":"https://openalex.org/keywords/membrane-contact-sites","display_name":"membrane contact sites","score":0.9620000123977661},{"id":"https://openalex.org/keywords/structure-function-relationship","display_name":"structure-function relationship","score":0.7540000081062317},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5869051218032837},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5269672870635986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47363701462745667},{"id":"https://openalex.org/C2776610495","wikidata":"https://www.wikidata.org/wiki/Q18047835","display_name":"ORAI1","level":4,"score":0.4671420753002167},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.4228723347187042},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3516082167625427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24819505214691162},{"id":"https://openalex.org/C162740809","wikidata":"https://www.wikidata.org/wiki/Q15334560","display_name":"STIM1","level":3,"score":0.22783789038658142},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071736","descriptor_name":"Stromal Interaction Molecules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/cphy.c170031","doi":"https://doi.org/10.1002/cphy.c170031","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cphy.c170031","pdf_url":null,"source":{"id":"https://openalex.org/S18747983","display_name":"Comprehensive physiology","issn_l":"2040-4603","issn":["2040-4603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comprehensive Physiology","raw_type":"other"},{"id":"doi:10.1002/j.2040-4603.2018.tb00032.x","doi":"https://doi.org/10.1002/j.2040-4603.2018.tb00032.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.2040-4603.2018.tb00032.x","pdf_url":null,"source":{"id":"https://openalex.org/S18747983","display_name":"Comprehensive physiology","issn_l":"2040-4603","issn":["2040-4603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comprehensive Physiology","raw_type":"journal-article"},{"id":"pmid:29978901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29978901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comprehensive Physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2314872073","display_name":"Optogenetic toolkit for remote control of voltage-gated calcium channels","funder_award_id":"R21GM126532","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7781947735","display_name":"MOLECULAR CONTROL OF CALCIUM INFLUX AT THE ER-PLASMA MEMBRANE JUNCTIONS","funder_award_id":"R01GM112003","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":250,"referenced_works":["https://openalex.org/W78050658","https://openalex.org/W111410485","https://openalex.org/W182409224","https://openalex.org/W1485297825","https://openalex.org/W1488864483","https://openalex.org/W1495215957","https://openalex.org/W1500581977","https://openalex.org/W1521654988","https://openalex.org/W1544230004","https://openalex.org/W1546599127","https://openalex.org/W1554199623","https://openalex.org/W1581327117","https://openalex.org/W1593637618","https://openalex.org/W1599277155","https://openalex.org/W1608909099","https://openalex.org/W1761464554","https://openalex.org/W1773482870","https://openalex.org/W1843230840","https://openalex.org/W1856053518","https://openalex.org/W1934528477","https://openalex.org/W1964205844","https://openalex.org/W1965629349","https://openalex.org/W1967175288","https://openalex.org/W1967218656","https://openalex.org/W1967797998","https://openalex.org/W1970151239","https://openalex.org/W1971529415","https://openalex.org/W1972239832","https://openalex.org/W1975221601","https://openalex.org/W1976015442","https://openalex.org/W1976566307","https://openalex.org/W1978593035","https://openalex.org/W1979573280","https://openalex.org/W1981125908","https://openalex.org/W1981840225","https://openalex.org/W1982522146","https://openalex.org/W1982528213","https://openalex.org/W1982731106","https://openalex.org/W1985592845","https://openalex.org/W1985674147","https://openalex.org/W1985785210","https://openalex.org/W1985924867","https://openalex.org/W1985948706","https://openalex.org/W1986506306","https://openalex.org/W1986531910","https://openalex.org/W1988248740","https://openalex.org/W1989178712","https://openalex.org/W1990548229","https://openalex.org/W1992735552","https://openalex.org/W1993712825","https://openalex.org/W1993781709","https://openalex.org/W1995076152","https://openalex.org/W1995782709","https://openalex.org/W1996047650","https://openalex.org/W1996693518","https://openalex.org/W1999321414","https://openalex.org/W2001917660","https://openalex.org/W2004208753","https://openalex.org/W2004234324","https://openalex.org/W2004779826","https://openalex.org/W2004856071","https://openalex.org/W2005128153","https://openalex.org/W2005700813","https://openalex.org/W2006227978","https://openalex.org/W2007840462","https://openalex.org/W2008613689","https://openalex.org/W2009707152","https://openalex.org/W2009866298","https://openalex.org/W2009968707","https://openalex.org/W2010052045","https://openalex.org/W2010105936","https://openalex.org/W2015080011","https://openalex.org/W2015480034","https://openalex.org/W2019023589","https://openalex.org/W2019141252","https://openalex.org/W2019889005","https://openalex.org/W2020033048","https://openalex.org/W2020708758","https://openalex.org/W2023518937","https://openalex.org/W2024047363","https://openalex.org/W2024183493","https://openalex.org/W2025102008","https://openalex.org/W2026912177","https://openalex.org/W2026937490","https://openalex.org/W2027524220","https://openalex.org/W2028649950","https://openalex.org/W2029301182","https://openalex.org/W2031149920","https://openalex.org/W2031966403","https://openalex.org/W2035372385","https://openalex.org/W2035521053","https://openalex.org/W2036272929","https://openalex.org/W2039881470","https://openalex.org/W2041181951","https://openalex.org/W2041474455","https://openalex.org/W2041748354","https://openalex.org/W2042144124","https://openalex.org/W2042342392","https://openalex.org/W2043519102","https://openalex.org/W2044226511","https://openalex.org/W2044409707","https://openalex.org/W2044563193","https://openalex.org/W2045648578","https://openalex.org/W2046185478","https://openalex.org/W2047112668","https://openalex.org/W2048267983","https://openalex.org/W2050443418","https://openalex.org/W2052736373","https://openalex.org/W2054723193","https://openalex.org/W2055345629","https://openalex.org/W2055479746","https://openalex.org/W2058455075","https://openalex.org/W2060138967","https://openalex.org/W2060814030","https://openalex.org/W2062878517","https://openalex.org/W2063515143","https://openalex.org/W2068571139","https://openalex.org/W2069047064","https://openalex.org/W2069989784","https://openalex.org/W2070193172","https://openalex.org/W2070453934","https://openalex.org/W2070832223","https://openalex.org/W2074922566","https://openalex.org/W2074966060","https://openalex.org/W2075035705","https://openalex.org/W2076086192","https://openalex.org/W2076882136","https://openalex.org/W2077111687","https://openalex.org/W2077202018","https://openalex.org/W2077807460","https://openalex.org/W2079040727","https://openalex.org/W2080970129","https://openalex.org/W2081851104","https://openalex.org/W2086473130","https://openalex.org/W2087152030","https://openalex.org/W2087806872","https://openalex.org/W2090706449","https://openalex.org/W2091776886","https://openalex.org/W2091954923","https://openalex.org/W2093214713","https://openalex.org/W2094666006","https://openalex.org/W2094864024","https://openalex.org/W2094980526","https://openalex.org/W2095663313","https://openalex.org/W2097265484","https://openalex.org/W2098465830","https://openalex.org/W2100425049","https://openalex.org/W2100578216","https://openalex.org/W2101254822","https://openalex.org/W2101579411","https://openalex.org/W2101586949","https://openalex.org/W2101836766","https://openalex.org/W2102525336","https://openalex.org/W2109453374","https://openalex.org/W2109745844","https://openalex.org/W2111226345","https://openalex.org/W2112083386","https://openalex.org/W2112645751","https://openalex.org/W2114470082","https://openalex.org/W2114637214","https://openalex.org/W2117118135","https://openalex.org/W2118988881","https://openalex.org/W2119484090","https://openalex.org/W2119682654","https://openalex.org/W2120959166","https://openalex.org/W2121617556","https://openalex.org/W2124304575","https://openalex.org/W2124676418","https://openalex.org/W2125037856","https://openalex.org/W2125151502","https://openalex.org/W2125404510","https://openalex.org/W2126692145","https://openalex.org/W2129317826","https://openalex.org/W2130881126","https://openalex.org/W2132111454","https://openalex.org/W2132781656","https://openalex.org/W2132943662","https://openalex.org/W2133603157","https://openalex.org/W2134031561","https://openalex.org/W2134132437","https://openalex.org/W2134342374","https://openalex.org/W2136728678","https://openalex.org/W2137258759","https://openalex.org/W2137508826","https://openalex.org/W2137551688","https://openalex.org/W2138497474","https://openalex.org/W2139643829","https://openalex.org/W2139646760","https://openalex.org/W2139884458","https://openalex.org/W2140284566","https://openalex.org/W2141015134","https://openalex.org/W2141088469","https://openalex.org/W2142097010","https://openalex.org/W2143390270","https://openalex.org/W2143654194","https://openalex.org/W2144003637","https://openalex.org/W2145687779","https://openalex.org/W2146066778","https://openalex.org/W2146341872","https://openalex.org/W2146838746","https://openalex.org/W2149160854","https://openalex.org/W2155800261","https://openalex.org/W2156406395","https://openalex.org/W2158331725","https://openalex.org/W2158652398","https://openalex.org/W2159455449","https://openalex.org/W2161148501","https://openalex.org/W2161210718","https://openalex.org/W2163789582","https://openalex.org/W2165074913","https://openalex.org/W2165536982","https://openalex.org/W2166494286","https://openalex.org/W2166547308","https://openalex.org/W2169426597","https://openalex.org/W2170369801","https://openalex.org/W2171169948","https://openalex.org/W2174790514","https://openalex.org/W2182233439","https://openalex.org/W2196049046","https://openalex.org/W2259514396","https://openalex.org/W2268056330","https://openalex.org/W2314856468","https://openalex.org/W2329284707","https://openalex.org/W2335194711","https://openalex.org/W2336378996","https://openalex.org/W2345685532","https://openalex.org/W2407179146","https://openalex.org/W2439068677","https://openalex.org/W2469523769","https://openalex.org/W2504464965","https://openalex.org/W2526525809","https://openalex.org/W2537735000","https://openalex.org/W2547756768","https://openalex.org/W2559760636","https://openalex.org/W2562874465","https://openalex.org/W2570609964","https://openalex.org/W2576008281","https://openalex.org/W2589530664","https://openalex.org/W2589768345","https://openalex.org/W2605821164","https://openalex.org/W2610847187","https://openalex.org/W2620225514","https://openalex.org/W2736658962","https://openalex.org/W2755893663","https://openalex.org/W2756124964","https://openalex.org/W2763526200","https://openalex.org/W4211040987","https://openalex.org/W4247741685","https://openalex.org/W4250578545","https://openalex.org/W4255760236"],"related_works":["https://openalex.org/W163103868","https://openalex.org/W2769356085","https://openalex.org/W2093214713","https://openalex.org/W2336378996","https://openalex.org/W2104507912","https://openalex.org/W2029205555","https://openalex.org/W2913681907","https://openalex.org/W111410485","https://openalex.org/W3119625739","https://openalex.org/W1988238196"],"abstract_inverted_index":{"The":[0,24,88],"calcium":[1,3,20,74,86,96],"release-activated":[2],"(CRAC)":[4],"channel,":[5,119],"composed":[6],"of":[7,18,84,104,117,146],"ORAI":[8,92],"and":[9,41,80,93,132,138,152,169],"stromal":[10],"interaction":[11],"molecules":[12],"(STIM),":[13],"represents":[14],"a":[15,47,53,66,73,81,102,121],"prototypical":[16],"example":[17],"store-operated":[19],"entry":[21,97],"in":[22,58,149,166],"mammals.":[23],"ORAI-STIM":[25],"signaling":[26,148],"occurs":[27],"at":[28],"membrane":[29],"contact":[30],"sites":[31],"formed":[32],"by":[33],"close":[34],"appositions":[35],"between":[36,91,136],"the":[37,42,59,77,110,114,133,143],"endoplasmic":[38],"reticulum":[39],"(ER)":[40],"plasma":[43,60],"membrane.":[44,61],"ORAI1":[45,85,168],"is":[46,63],"four-pass":[48],"transmembrane":[49,68],"protein":[50,69],"that":[51,70,127],"forms":[52],"highly":[54],"calcium-selective":[55],"ion":[56],"channel":[57],"STIM1":[62,129,137],"an":[64],"ER-resident,":[65],"single-pass":[67],"serves":[71],"as":[72,154,156],"sensor":[75],"within":[76],"ER":[78],"lumen":[79],"potent":[82],"activator":[83],"channels.":[87],"intricate":[89],"interplay":[90],"STIM":[94],"controls":[95],"into":[98],"cells":[99],"to":[100],"regulate":[101],"myriad":[103],"physiological":[105,144],"processes.":[106],"We":[107],"highlight":[108],"herein":[109],"current":[111],"knowledge":[112],"on":[113,123],"structure-function":[115],"relationship":[116],"CRAC":[118],"with":[120],"focus":[122],"key":[124],"structural":[125],"elements":[126],"mediate":[128],"conformational":[130],"switch":[131],"dynamic":[134],"coupling":[135],"ORAI1.":[139],"Furthermore,":[140],"we":[141],"discuss":[142],"roles":[145],"STIM-ORAI":[147],"various":[150],"tissues":[151],"organs,":[153],"well":[155],"major":[157],"pathological":[158],"conditions":[159],"arising":[160],"from":[161],"loss-":[162],"or":[163],"gain-of-function":[164],"mutations":[165],"human":[167],"STIM1.":[170],"\u00a9":[171],"2017":[172],"American":[173],"Physiological":[174],"Society.":[175],"Compr":[176],"Physiol":[177],"8:981-1002,":[178],"2018.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-11-29T00:00:00"}
