{"id":"https://openalex.org/W2900513704","doi":"https://doi.org/10.1038/s41598-018-34582-6","title":"Molecular pain markers correlate with pH-sensitive MRI signal in a pig model of disc degeneration","display_name":"Molecular pain markers correlate with pH-sensitive MRI signal in a pig model of disc degeneration","publication_year":2018,"publication_date":"2018-11-20","ids":{"openalex":"https://openalex.org/W2900513704","doi":"https://doi.org/10.1038/s41598-018-34582-6","mag":"2900513704","pmid":"https://pubmed.ncbi.nlm.nih.gov/30478330","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6255799"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-34582-6","doi":"https://doi.org/10.1038/s41598-018-34582-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-34582-6","pdf_url":"https://www.nature.com/articles/s41598-018-34582-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-34582-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054826561","display_name":"Maxim Bez","orcid":"https://orcid.org/0000-0002-9487-9479","observed_orcids":["https://orcid.org/0000-0002-9487-9479"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Maxim Bez","raw_affiliation_strings":["Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","Skeletal Biotech Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, 91120, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Skeletal Biotech Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, 91120, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101526791","display_name":"Zhengwei Zhou","orcid":"https://orcid.org/0000-0002-7469-2658","observed_orcids":["https://orcid.org/0000-0002-7469-2658","https://orcid.org/0000-0002-7337-9133","https://orcid.org/0000-0002-8598-6133"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengwei Zhou","raw_affiliation_strings":["Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, CA, USA","Department of Bioengineering, University of California Los Angeles, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, CA, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Bioengineering, University of California Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081116926","display_name":"Dmitriy Sheyn","orcid":"https://orcid.org/0000-0002-3333-1485","observed_orcids":["https://orcid.org/0000-0002-3333-1485"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmitriy Sheyn","raw_affiliation_strings":["Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085348660","display_name":"Wafa Tawackoli","orcid":"https://orcid.org/0000-0003-3742-8644","observed_orcids":["https://orcid.org/0000-0003-3742-8644"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wafa Tawackoli","raw_affiliation_strings":["Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, CA, USA","Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, CA, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028956546","display_name":"Joseph C. Giaconi","orcid":"https://orcid.org/0000-0003-2339-9109","observed_orcids":["https://orcid.org/0000-0003-2339-9109"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph C. Giaconi","raw_affiliation_strings":["Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085999291","display_name":"Galina Shapiro","orcid":"https://orcid.org/0000-0001-9897-6383","observed_orcids":["https://orcid.org/0000-0001-9897-6383"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Galina Shapiro","raw_affiliation_strings":["Skeletal Biotech Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, 91120, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Skeletal Biotech Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, 91120, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021570609","display_name":"Shiran Ben\u2010David","orcid":"https://orcid.org/0000-0001-9512-7909","observed_orcids":["https://orcid.org/0000-0001-9512-7909"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiran Ben David","raw_affiliation_strings":["Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078917882","display_name":"Zulma Gazit","orcid":"https://orcid.org/0000-0001-9176-0889","observed_orcids":["https://orcid.org/0000-0001-9176-0889"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Zulma Gazit","raw_affiliation_strings":["Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","Skeletal Biotech Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, 91120, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Skeletal Biotech Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, 91120, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036741552","display_name":"Gadi Pelled","orcid":"https://orcid.org/0000-0003-3857-5531","observed_orcids":["https://orcid.org/0000-0003-3857-5531"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Gadi Pelled","raw_affiliation_strings":["Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","Skeletal Biotech Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, 91120, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Skeletal Biotech Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, 91120, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111962323","display_name":"Debiao Li","orcid":"https://orcid.org/0000-0001-8560-8231","observed_orcids":["https://orcid.org/0000-0001-8560-8231","https://orcid.org/0000-0003-3742-8644"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debiao Li","raw_affiliation_strings":["Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, CA, USA","Department of Bioengineering, University of California Los Angeles, Los Angeles, California, USA","Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, CA, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Bioengineering, University of California Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071238164","display_name":"Dan Gazit","orcid":"https://orcid.org/0000-0002-0554-0028","observed_orcids":["https://orcid.org/0000-0002-0554-0028"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL","US"],"is_corresponding":true,"raw_author_name":"Dan Gazit","raw_affiliation_strings":["Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, CA, USA. Dan.Gazit@csmc.edu","Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. Dan.Gazit@csmc.edu","Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. Dan.Gazit@csmc.edu","Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. Dan.Gazit@csmc.edu","Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. Dan.Gazit@csmc.edu","Skeletal Biotech Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, 91120, Jerusalem, Israel. Dan.Gazit@csmc.edu","Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, CA, USA. Dan.Gazit@csmc.edu","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. Dan.Gazit@csmc.edu","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. Dan.Gazit@csmc.edu","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. Dan.Gazit@csmc.edu","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. Dan.Gazit@csmc.edu","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Skeletal Biotech Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, 91120, Jerusalem, Israel. Dan.Gazit@csmc.edu","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071238164"],"corresponding_institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I197251160"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.7112,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.83585346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"17363","last_page":"17363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/discogenic-low-back-pain","display_name":"discogenic low back pain","score":0.8930000066757202},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5339999794960022},{"id":"https://openalex.org/keywords/non-invasive-imaging","display_name":"non-invasive imaging","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.7976450324058533},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.7424231767654419},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.608923614025116},{"id":"https://openalex.org/C2780907711","wikidata":"https://www.wikidata.org/wiki/Q852163","display_name":"Low back pain","level":3,"score":0.5737565159797668},{"id":"https://openalex.org/C2776501849","wikidata":"https://www.wikidata.org/wiki/Q5781808","display_name":"Back pain","level":3,"score":0.4691027104854584},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44042789936065674},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.42346781492233276},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3060939908027649},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2144157886505127},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21260344982147217},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09856444597244263},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013556","descriptor_name":"Swine, Miniature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017116","descriptor_name":"Low Back Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017116","descriptor_name":"Low Back Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-018-34582-6","doi":"https://doi.org/10.1038/s41598-018-34582-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-34582-6","pdf_url":"https://www.nature.com/articles/s41598-018-34582-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5242004","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6255799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6255799","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6255799","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:30478330","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30478330","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:77618b3913404fa8aa58f67b468d1dd3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/77618b3913404fa8aa58f67b468d1dd3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-34582-6","doi":"https://doi.org/10.1038/s41598-018-34582-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-34582-6","pdf_url":"https://www.nature.com/articles/s41598-018-34582-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3588944827","display_name":"Quantitative Multiparametric MRI to Assess the Effect of Stem Cell Therapy on Chronic Low Back Pain","funder_award_id":"R01AR066517","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G459654220","display_name":null,"funder_award_id":"R01AR066517","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G98742749","display_name":"Induced pluripotent stem cell therapy for degenerated IVD","funder_award_id":"K01AR071512","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2900513704.pdf","grobid_xml":"https://content.openalex.org/works/W2900513704.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1503882644","https://openalex.org/W1560267028","https://openalex.org/W1840912252","https://openalex.org/W1914174728","https://openalex.org/W1963799425","https://openalex.org/W1964714353","https://openalex.org/W1968105317","https://openalex.org/W1976821979","https://openalex.org/W1988543419","https://openalex.org/W2000723582","https://openalex.org/W2003162409","https://openalex.org/W2006188334","https://openalex.org/W2006563794","https://openalex.org/W2010843375","https://openalex.org/W2012678826","https://openalex.org/W2015829970","https://openalex.org/W2017384250","https://openalex.org/W2021311015","https://openalex.org/W2023664228","https://openalex.org/W2024069261","https://openalex.org/W2030118841","https://openalex.org/W2032990871","https://openalex.org/W2033568227","https://openalex.org/W2038703820","https://openalex.org/W2041997771","https://openalex.org/W2042594528","https://openalex.org/W2043752417","https://openalex.org/W2046232440","https://openalex.org/W2047778252","https://openalex.org/W2054500458","https://openalex.org/W2055705583","https://openalex.org/W2070176794","https://openalex.org/W2070231190","https://openalex.org/W2074136578","https://openalex.org/W2076778911","https://openalex.org/W2078910688","https://openalex.org/W2086242794","https://openalex.org/W2092242008","https://openalex.org/W2093864226","https://openalex.org/W2093957996","https://openalex.org/W2095925829","https://openalex.org/W2098717615","https://openalex.org/W2106755981","https://openalex.org/W2107686025","https://openalex.org/W2109900244","https://openalex.org/W2114899287","https://openalex.org/W2118436663","https://openalex.org/W2120864426","https://openalex.org/W2121787709","https://openalex.org/W2134318006","https://openalex.org/W2135324963","https://openalex.org/W2143348633","https://openalex.org/W2153598484","https://openalex.org/W2156279540","https://openalex.org/W2169504259","https://openalex.org/W2221532418","https://openalex.org/W2314466361","https://openalex.org/W2469165567","https://openalex.org/W2476265466","https://openalex.org/W2525455644","https://openalex.org/W2557122684","https://openalex.org/W2595806588","https://openalex.org/W4293765706"],"related_works":["https://openalex.org/W3202123559","https://openalex.org/W2525455644","https://openalex.org/W4404746633","https://openalex.org/W72015084","https://openalex.org/W7035848994","https://openalex.org/W1840912252","https://openalex.org/W2114899287","https://openalex.org/W7162677887","https://openalex.org/W4414838722","https://openalex.org/W2170326292"],"abstract_inverted_index":{"Intervertebral":[0],"disc":[1],"(IVD)":[2],"degeneration":[3,102],"is":[4,29,185],"a":[5,97,117,127],"leading":[6],"cause":[7],"of":[8,16,22,100,110,136,143,161],"chronic":[9],"low":[10,187],"back":[11,188],"pain":[12,28,162,195],"that":[13,67,175],"affects":[14],"millions":[15],"people":[17],"every":[18],"year.":[19],"Yet":[20],"identification":[21],"the":[23,113,131,159,165,168],"specific":[24],"IVD":[25,45,57,101,150,184],"causing":[26,186],"this":[27,95,176],"based":[30],"on":[31],"qualitative":[32],"visual":[33],"interpretation":[34],"rather":[35],"than":[36],"objective":[37],"findings.":[38],"One":[39],"possible":[40],"approach":[41,177],"to":[42,48,61,85,181],"diagnosing":[43],"pain-associated":[44],"could":[46,75],"be":[47,83,179],"identify":[49,182],"acidic":[50],"IVDs,":[51,80],"as":[52],"decreased":[53],"pH":[54,77,111,121],"within":[55],"an":[56],"has":[58],"been":[59],"postulated":[60],"mediate":[62],"discogenic":[63],"pain.":[64],"We":[65],"hypothesized":[66],"quantitative":[68],"chemical":[69],"exchange":[70],"saturation":[71],"transfer":[72],"(qCEST)":[73],"MRI":[74],"detect":[76],"changes":[78],"in":[79,103,120,130,167],"and":[81,91,146,164,196],"thence":[82],"used":[84,180],"diagnose":[86],"pathologically":[87],"painful":[88],"IVDs":[89,115,139],"objectively":[90],"noninvasively.":[92],"To":[93],"test":[94],"hypothesis,":[96],"surgical":[98,197],"model":[99],"Yucatan":[104],"minipigs":[105],"was":[106,156],"used.":[107],"Direct":[108],"measurement":[109],"inside":[112],"degenerated":[114,138],"revealed":[116,140],"significant":[118,128,141],"drop":[119],"after":[122,149],"degeneration,":[123],"which":[124,183],"correlated":[125],"with":[126],"increase":[129,166],"qCEST":[132,169],"signal.":[133,170],"Gene":[134],"analysis":[135],"harvested":[137],"upregulation":[142],"pain-,":[144],"nerve-":[145],"inflammatory-related":[147],"markers":[148,163],"degeneration.":[151],"A":[152],"strong":[153],"positive":[154],"correlation":[155],"observed":[157],"between":[158],"expression":[160],"Collectively,":[171],"these":[172],"findings":[173],"suggest":[174],"might":[178],"pain,":[189],"thereby":[190],"providing":[191],"valuable":[192],"guidance":[193],"for":[194],"management.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-11-29T00:00:00"}