{"id":"https://openalex.org/W2900490992","doi":null,"title":"Targeting Heat Shock Protein 70 to Improve Oxidative Stress and Mitochondrial Bioenergetics in Diabetic Sensory Neurons","display_name":"Targeting Heat Shock Protein 70 to Improve Oxidative Stress and Mitochondrial Bioenergetics in Diabetic Sensory Neurons","publication_year":2017,"publication_date":"2017-12-17","ids":{"openalex":"https://openalex.org/W2900490992","mag":"2900490992"},"language":"en","primary_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/27336","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1808/27336","pdf_url":null,"source":{"id":"https://openalex.org/S4377196285","display_name":"KU ScholarWorks (University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030826999","display_name":"Zhenyuan You","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zhenyuan You","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5030826999"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.19699999690055847,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.07599999755620956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-peripheral-neuropathy","display_name":"diabetic peripheral neuropathy","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.8040000200271606},{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mitochondrial-bioenergetics","display_name":"mitochondrial bioenergetics","score":0.9190000295639038},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7929999828338623},{"id":"https://openalex.org/keywords/mitochondrial-superoxide","display_name":"mitochondrial superoxide","score":0.871999979019165},{"id":"https://openalex.org/keywords/sensory-neurons","display_name":"sensory neurons","score":0.7120000123977661},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.859000027179718},{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.6240000128746033},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.6179999709129333},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.8658088445663452},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8165578842163086},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5717030763626099},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.5615642070770264},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.5454644560813904},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4792249798774719},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.4117937684059143},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3737894296646118},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3670484721660614},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3597743809223175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30015087127685547},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28207316994667053},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13287842273712158},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kuscholarworks.ku.edu:1808/27336","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1808/27336","pdf_url":null,"source":{"id":"https://openalex.org/S4377196285","display_name":"KU ScholarWorks (University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2900490992","doi":null,"is_oa":false,"landing_page_url":"https://kuscholarworks.ku.edu/handle/1808/27336","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":302,"referenced_works":["https://openalex.org/W56041028","https://openalex.org/W145770872","https://openalex.org/W1492946553","https://openalex.org/W1497853576","https://openalex.org/W1506738398","https://openalex.org/W1517722943","https://openalex.org/W1525481902","https://openalex.org/W1529592271","https://openalex.org/W1533321987","https://openalex.org/W1537164314","https://openalex.org/W1537274817","https://openalex.org/W1544860636","https://openalex.org/W1600715668","https://openalex.org/W1607586648","https://openalex.org/W1650965741","https://openalex.org/W1804610736","https://openalex.org/W1809230663","https://openalex.org/W1809723326","https://openalex.org/W1810991871","https://openalex.org/W1870696988","https://openalex.org/W1923506064","https://openalex.org/W1957036238","https://openalex.org/W1964079573","https://openalex.org/W1964126982","https://openalex.org/W1965142941","https://openalex.org/W1965975162","https://openalex.org/W1966923623","https://openalex.org/W1967122702","https://openalex.org/W1968100018","https://openalex.org/W1968816740","https://openalex.org/W1969171439","https://openalex.org/W1969587141","https://openalex.org/W1970944551","https://openalex.org/W1971082641","https://openalex.org/W1971108880","https://openalex.org/W1971287334","https://openalex.org/W1972370905","https://openalex.org/W1972398452","https://openalex.org/W1973347446","https://openalex.org/W1973766681","https://openalex.org/W1974560134","https://openalex.org/W1974939683","https://openalex.org/W1975707328","https://openalex.org/W1976374480","https://openalex.org/W1976489435","https://openalex.org/W1978362452","https://openalex.org/W1978631786","https://openalex.org/W1979016667","https://openalex.org/W1979340145","https://openalex.org/W1980444561","https://openalex.org/W1980599901","https://openalex.org/W1980763614","https://openalex.org/W1981597970","https://openalex.org/W1981791925","https://openalex.org/W1983072558","https://openalex.org/W1983651674","https://openalex.org/W1986628483","https://openalex.org/W1986841923","https://openalex.org/W1987963824","https://openalex.org/W1988614821","https://openalex.org/W1989053288","https://openalex.org/W1989352421","https://openalex.org/W1990313130","https://openalex.org/W1991645404","https://openalex.org/W1994051814","https://openalex.org/W1995210988","https://openalex.org/W1998048321","https://openalex.org/W2002359678","https://openalex.org/W2002467106","https://openalex.org/W2003199957","https://openalex.org/W2004673584","https://openalex.org/W2005485195","https://openalex.org/W2006735337","https://openalex.org/W2007185373","https://openalex.org/W2008154413","https://openalex.org/W2008632158","https://openalex.org/W2009876316","https://openalex.org/W2010344297","https://openalex.org/W2012248291","https://openalex.org/W2012312748","https://openalex.org/W2012523643","https://openalex.org/W2012717596","https://openalex.org/W2013548323","https://openalex.org/W2013970530","https://openalex.org/W2014061195","https://openalex.org/W2014175688","https://openalex.org/W2014670473","https://openalex.org/W2015640955","https://openalex.org/W2017009693","https://openalex.org/W2018964386","https://openalex.org/W2019332229","https://openalex.org/W2019455536","https://openalex.org/W2019979646","https://openalex.org/W2020444654","https://openalex.org/W2020742237","https://openalex.org/W2021242983","https://openalex.org/W2022012488","https://openalex.org/W2022428368","https://openalex.org/W2023262549","https://openalex.org/W2023542615","https://openalex.org/W2023953172","https://openalex.org/W2025666964","https://openalex.org/W2025909794","https://openalex.org/W2025958954","https://openalex.org/W2026702352","https://openalex.org/W2029799010","https://openalex.org/W2030564776","https://openalex.org/W2030660601","https://openalex.org/W2031140047","https://openalex.org/W2032646952","https://openalex.org/W2033979611","https://openalex.org/W2033994459","https://openalex.org/W2036181141","https://openalex.org/W2036466382","https://openalex.org/W2038394514","https://openalex.org/W2039603759","https://openalex.org/W2041085893","https://openalex.org/W2041255615","https://openalex.org/W2041587344","https://openalex.org/W2041906033","https://openalex.org/W2044206814","https://openalex.org/W2045865115","https://openalex.org/W2046380842","https://openalex.org/W2047094134","https://openalex.org/W2049481764","https://openalex.org/W2050297509","https://openalex.org/W2050849483","https://openalex.org/W2051192888","https://openalex.org/W2051323334","https://openalex.org/W2052385557","https://openalex.org/W2052406949","https://openalex.org/W2052998740","https://openalex.org/W2053765200","https://openalex.org/W2054005523","https://openalex.org/W2054290614","https://openalex.org/W2054614057","https://openalex.org/W2055124287","https://openalex.org/W2055572268","https://openalex.org/W2055684980","https://openalex.org/W2056611380","https://openalex.org/W2057522312","https://openalex.org/W2060085753","https://openalex.org/W2060811345","https://openalex.org/W2061991569","https://openalex.org/W2063666625","https://openalex.org/W2065809073","https://openalex.org/W2066290187","https://openalex.org/W2066746672","https://openalex.org/W2066981028","https://openalex.org/W2067184340","https://openalex.org/W2067511286","https://openalex.org/W2071893619","https://openalex.org/W2072925339","https://openalex.org/W2073687064","https://openalex.org/W2074265741","https://openalex.org/W2075589522","https://openalex.org/W2076282616","https://openalex.org/W2077087960","https://openalex.org/W2078629560","https://openalex.org/W2080019220","https://openalex.org/W2084536221","https://openalex.org/W2085029391","https://openalex.org/W2085857971","https://openalex.org/W2086185470","https://openalex.org/W2087177161","https://openalex.org/W2088012387","https://openalex.org/W2088241510","https://openalex.org/W2089663038","https://openalex.org/W2090384519","https://openalex.org/W2091078069","https://openalex.org/W2091601299","https://openalex.org/W2092377496","https://openalex.org/W2092485963","https://openalex.org/W2093070472","https://openalex.org/W2094861086","https://openalex.org/W2094871310","https://openalex.org/W2095113142","https://openalex.org/W2095342832","https://openalex.org/W2096554161","https://openalex.org/W2096955693","https://openalex.org/W2096966529","https://openalex.org/W2098703027","https://openalex.org/W2100321469","https://openalex.org/W2101141778","https://openalex.org/W2101457616","https://openalex.org/W2103309568","https://openalex.org/W2103970874","https://openalex.org/W2105042598","https://openalex.org/W2105598098","https://openalex.org/W2105731956","https://openalex.org/W2107066655","https://openalex.org/W2107449846","https://openalex.org/W2108250096","https://openalex.org/W2108326484","https://openalex.org/W2109977819","https://openalex.org/W2110185449","https://openalex.org/W2110582111","https://openalex.org/W2112100252","https://openalex.org/W2112133866","https://openalex.org/W2112241702","https://openalex.org/W2112374700","https://openalex.org/W2112670171","https://openalex.org/W2113384757","https://openalex.org/W2113531489","https://openalex.org/W2113651620","https://openalex.org/W2113716304","https://openalex.org/W2113999599","https://openalex.org/W2114443210","https://openalex.org/W2116749308","https://openalex.org/W2119064835","https://openalex.org/W2119590183","https://openalex.org/W2120293565","https://openalex.org/W2121532472","https://openalex.org/W2122339118","https://openalex.org/W2123106337","https://openalex.org/W2124521298","https://openalex.org/W2125316317","https://openalex.org/W2125326130","https://openalex.org/W2127560744","https://openalex.org/W2129166389","https://openalex.org/W2129248872","https://openalex.org/W2129826948","https://openalex.org/W2131914005","https://openalex.org/W2133444149","https://openalex.org/W2134175129","https://openalex.org/W2134502101","https://openalex.org/W2135932738","https://openalex.org/W2138311396","https://openalex.org/W2138948114","https://openalex.org/W2139640181","https://openalex.org/W2144795344","https://openalex.org/W2147592021","https://openalex.org/W2147893091","https://openalex.org/W2148026632","https://openalex.org/W2148308460","https://openalex.org/W2149966286","https://openalex.org/W2150037370","https://openalex.org/W2151619335","https://openalex.org/W2152101492","https://openalex.org/W2152667209","https://openalex.org/W2153916083","https://openalex.org/W2154893083","https://openalex.org/W2155015733","https://openalex.org/W2156935910","https://openalex.org/W2157441872","https://openalex.org/W2158040363","https://openalex.org/W2158563216","https://openalex.org/W2158905364","https://openalex.org/W2159581380","https://openalex.org/W2159829960","https://openalex.org/W2160114316","https://openalex.org/W2160675155","https://openalex.org/W2160836484","https://openalex.org/W2160902434","https://openalex.org/W2161277185","https://openalex.org/W2162583612","https://openalex.org/W2164005268","https://openalex.org/W2165201727","https://openalex.org/W2165268250","https://openalex.org/W2165598975","https://openalex.org/W2166451791","https://openalex.org/W2166550315","https://openalex.org/W2167614613","https://openalex.org/W2168536185","https://openalex.org/W2169320057","https://openalex.org/W2170048907","https://openalex.org/W2170219456","https://openalex.org/W2170492101","https://openalex.org/W2171260748","https://openalex.org/W2175029576","https://openalex.org/W2211730533","https://openalex.org/W2257505506","https://openalex.org/W2261267511","https://openalex.org/W2263525143","https://openalex.org/W2271272206","https://openalex.org/W2281111623","https://openalex.org/W2282593836","https://openalex.org/W2287994218","https://openalex.org/W2295616470","https://openalex.org/W2313457514","https://openalex.org/W2313945403","https://openalex.org/W2317177913","https://openalex.org/W2326884456","https://openalex.org/W2330895054","https://openalex.org/W2332612176","https://openalex.org/W2337789656","https://openalex.org/W2344891838","https://openalex.org/W2402590212","https://openalex.org/W2410013925","https://openalex.org/W2411943442","https://openalex.org/W2413356436","https://openalex.org/W2413732429","https://openalex.org/W2425825978","https://openalex.org/W2513455229","https://openalex.org/W2520432709","https://openalex.org/W2522937489","https://openalex.org/W2561727131","https://openalex.org/W2581074366","https://openalex.org/W2605679249","https://openalex.org/W2615684303","https://openalex.org/W4240304626","https://openalex.org/W4247088117"],"related_works":["https://openalex.org/W2903724444","https://openalex.org/W2077087960","https://openalex.org/W3187480395","https://openalex.org/W7149877850","https://openalex.org/W2107449846","https://openalex.org/W4256093295","https://openalex.org/W2755873288","https://openalex.org/W2003199957","https://openalex.org/W2439195794","https://openalex.org/W2119064835"],"abstract_inverted_index":{"Neuronal":[0],"mitochondrial":[1,46,162,237,258,281],"dysfunction":[2],"is":[3,14,156,275],"a":[4,15],"key":[5],"pathophysiologic":[6],"mechanism":[7,159],"of":[8,19,31,55,101,204,213,261,273,310,318],"diabetic":[9,34,50,81,108,135,144,186,210,262,322],"peripheral":[10,323],"neuropathy":[11],"(DPN).":[12],"KU-596":[13,62,97,120,128,205,235,253,319],"small":[16],"molecule":[17],"modulator":[18],"heat":[20],"shock":[21],"protein":[22],"90":[23],"(Hsp90)":[24],"that":[25,249,313],"can":[26,287,306],"reverse":[27],"clinically":[28],"relevant":[29],"measures":[30],"DPN":[32],"in":[33,49,70,98,124,132,143,185,265],"animal":[35],"models.":[36],"Mechanistically,":[37],"drug":[38],"efficacy":[39,317],"requires":[40],"Hsp70":[41,87,111,145],"and":[42,92,110,169,175,200,220,256,284],"correlates":[43],"with":[44,96],"improving":[45],"bioenergetics":[47],"(mtBE)":[48],"sensory":[51,263],"neurons.":[52,126],"The":[53],"goal":[54],"this":[56,221,246],"study":[57,247],"was":[58,222,240],"to":[59,160,206,242,293,315],"determine":[60],"if":[61],"improves":[63,254],"mtBE":[64,131,142,255,274],"by":[65,179,195,225,290,302],"decreasing":[66,280],"glucose-induced":[67],"oxidative":[68,177,259,282],"stress":[69,178,260,283],"an":[71,266],"Hsp70-dependent":[72,267],"manner.":[73,268],"Sensory":[74],"neurons":[75,137,188,264],"were":[76],"isolated":[77],"from":[78],"non-diabetic":[79],"or":[80,86,103],"mice":[82,91],"wild":[83],"type":[84],"(WT)":[85],"knockout":[88],"(Hsp70":[89],"KO)":[90],"treated":[93],"ex":[94],"vivo":[95],"the":[99,148,157,167,202,250,270,316],"presence":[100],"low":[102],"high":[104],"glucose":[105],"concentrations.":[106],"In":[107,209],"WT":[109,125,136,187],"KO":[112,146],"neurons,":[113,211],"hyperglycemia":[114],"significantly":[115,129,223],"increased":[116,189,215],"superoxide":[117,123,153,163,191,230,238],"levels,":[118],"but":[119,138,239],"only":[121],"decreased":[122,176,224,236],"Similarly,":[127],"improved":[130,173],"hyperglycemically":[133],"stressed":[134],"did":[139],"not":[140,276],"improve":[141,243,294,307],"under":[147],"same":[149],"conditions.":[150],"Since":[151],"manganese":[152],"dismutase":[154],"(MnSOD)":[155],"main":[158],"detoxify":[161],"radicals,":[164],"we":[165],"determined":[166],"cause":[168],"effect":[170],"relationship":[171],"between":[172],"respiration":[174],"knocking":[180],"down":[181],"MnSOD.":[182],"Downregulating":[183],"MnSOD":[184,214,233],"hyperglycemia-induced":[190],"levels":[192],"as":[193],"measured":[194],"electron":[196],"paramagnetic":[197],"resonance":[198],"spectroscopy":[199],"blocked":[201],"ability":[203],"enhance":[207],"mtBE.":[208,295],"knockdown":[212],"maximal":[216],"respiratory":[217],"capacity":[218],"(MRC)":[219],"mito-TEMPO-H":[226],"after":[227],"scavenging":[228],"overproduced":[229],"radicals.":[231],"Following":[232],"knockdown,":[234],"unable":[241],"MRC.":[244],"Overall,":[245],"shows":[248],"Hsp90":[251],"inhibitor":[252],"decreases":[257],"However,":[269],"drug-induced":[271],"improvement":[272],"necessarily":[277],"dependent":[278],"on":[279],"other":[285],"mechanisms":[286],"be":[288],"modulated":[289],"novologue":[291,304],"therapy":[292,305],"This":[296],"work":[297],"furthers":[298],"our":[299],"mechanistic":[300],"understanding":[301],"which":[303],"metabolic":[308],"aspects":[309],"neuronal":[311],"function":[312],"contribute":[314],"for":[320],"treating":[321],"neuropathy.":[324]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-11-29T00:00:00"}