{"id":"https://openalex.org/W2900440448","doi":"https://doi.org/10.1093/neuonc/noy148.1144","title":"TMOD-32. GENERATION OF GLIOBLASTOMA PATIENT DERIVED INTRACRANIAL XENOGRAFTS FOR PRECLINICAL STUDIES","display_name":"TMOD-32. GENERATION OF GLIOBLASTOMA PATIENT DERIVED INTRACRANIAL XENOGRAFTS FOR PRECLINICAL STUDIES","publication_year":2018,"publication_date":"2018-11-01","ids":{"openalex":"https://openalex.org/W2900440448","doi":"https://doi.org/10.1093/neuonc/noy148.1144","mag":"2900440448"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noy148.1144","doi":"https://doi.org/10.1093/neuonc/noy148.1144","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noy148.1144","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/20/suppl_6/vi275/26280040/noy148.1144.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/20/suppl_6/vi275/26280040/noy148.1144.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055704980","display_name":"Amber E. Kerstetter-Fogle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amber Kerstetter-Fogle","raw_affiliation_strings":["Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113689613","display_name":"Peggy L.R. Harris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harris Peggy","raw_affiliation_strings":["Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089511408","display_name":"Andrew Edward Sloan","orcid":"https://orcid.org/0000-0001-9607-5063","observed_orcids":["https://orcid.org/0000-0001-9607-5063"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Sloan","raw_affiliation_strings":["University Hospitals-Cleveland Medical Center, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals-Cleveland Medical Center, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"suppl_6","first_page":"vi275","last_page":"vi275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9509999752044678},{"id":"https://openalex.org/keywords/intracranial-xenograft","display_name":"intracranial xenograft","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7170000076293945},{"id":"https://openalex.org/keywords/preclinical-drug-screening","display_name":"preclinical drug screening","score":0.6919999718666077},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.4320000112056732},{"id":"https://openalex.org/keywords/immunosuppressed-mice","display_name":"immunosuppressed mice","score":0.6840000152587891},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.6819623708724976},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6262217164039612},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6250550746917725},{"id":"https://openalex.org/C128473837","wikidata":"https://www.wikidata.org/wiki/Q7863603","display_name":"U87","level":3,"score":0.5552698969841003},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.5441781282424927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5208364129066467},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5200590491294861},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47937944531440735},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4765496850013733},{"id":"https://openalex.org/C2994463257","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain cancer","level":3,"score":0.4577431380748749},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43846583366394043},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3822644054889679},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33119601011276245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22472333908081055},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.20780110359191895},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13629654049873352},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07987964153289795}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/neuonc/noy148.1144","doi":"https://doi.org/10.1093/neuonc/noy148.1144","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noy148.1144","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/20/suppl_6/vi275/26280040/noy148.1144.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5786076","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6216683","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6216683","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6216683","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noy148.1144","doi":"https://doi.org/10.1093/neuonc/noy148.1144","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noy148.1144","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/20/suppl_6/vi275/26280040/noy148.1144.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2900440448.pdf","grobid_xml":"https://content.openalex.org/works/W2900440448.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3042796502","https://openalex.org/W2937176488","https://openalex.org/W4409630308","https://openalex.org/W2587385635","https://openalex.org/W2588635922","https://openalex.org/W4404237554","https://openalex.org/W6958936957","https://openalex.org/W2619457635","https://openalex.org/W2915819588","https://openalex.org/W3015179648"],"abstract_inverted_index":{"Glioblastoma":[0],"multiforme":[1],"(GBM)":[2],"is":[3],"the":[4,18,50,55,59,84,127,145,150,175,179,195],"most":[5],"malignant":[6],"primary":[7],"brain":[8],"cancer":[9],"affecting":[10],"adults.":[11],"Therapy":[12],"options":[13],"for":[14,20,36,228,240],"GBM":[15,105,215],"have":[16,33,47,92],"remained":[17],"same":[19],"over":[21],"a":[22,209],"decade":[23],"with":[24,189],"no":[25],"significant":[26],"advancements.":[27],"In":[28],"vitro":[29],"cell":[30],"line":[31],"models":[32,223],"minimal":[34],"success":[35],"screening":[37],"potential":[38],"therapies.":[39],"Many":[40],"therapies":[41],"that":[42,211],"were":[43,133],"successful":[44,134],"in":[45,49,58,67,135,194,208],"culture":[46,69],"failed":[48],"clinic,":[51],"likely":[52,167],"due":[53],"to":[54,64,82,95],"complex":[56],"microenvironment":[57,210],"brain,":[60],"which":[61,178,224],"has":[62],"yet":[63],"be":[65,226,238],"reproduced":[66],"any":[68],"model.":[70],"Furthermore,":[71],"high":[72],"passage":[73],"number":[74],"of":[75,89,144,149,174,199,220],"cultured":[76],"cells":[77,112],"and":[78,86,118,171,216],"clonal":[79],"selection":[80],"fail":[81],"recapitulate":[83],"molecular":[85],"genomic":[87],"signatures":[88],"GBM.":[90],"We":[91],"been":[93],"able":[94],"successfully":[96],"establish":[97],"37":[98],"patient":[99,106,115,129,176,222],"derived":[100,109],"xenografts":[101],"(PDX)":[102],"intracranially":[103,120],"from":[104,114,177],"tissue.":[107],"Tumor":[108],"glial":[110],"stem":[111],"isolated":[113],"resected":[116],"tissue":[117],"implanted":[119],"into":[121],"an":[122],"immunosuppressed":[123],"mouse":[124],"strain.":[125],"Of":[126],"69":[128],"samples":[130],"analyzed,":[131],"we":[132],"passaging":[136],"three":[137],"or":[138,162],"more":[139,187,212],"generations":[140],"through":[141],"mice":[142,184],"53.6%":[143],"time.":[146],"After":[147],"characterization":[148],"xenografted":[151],"tumor":[152,156],"tissue,":[153],"two":[154],"different":[155],"growth":[157],"patterns":[158],"emerged:":[159],"highly":[160],"invasive":[161],"localized.":[163],"This":[164],"phenotype":[165],"was":[166,181],"dependent":[168],"on":[169],"malignancy,":[170],"previous":[172],"treatment":[173,230],"xenograft":[180],"derived.":[182],"Physiologically,":[183],"exhibited":[185],"symptoms":[186],"quickly":[188],"each":[190],"subsequent":[191],"passage,":[192],"particularly":[193],"localized":[196],"tumors.":[197],"Development":[198],"these":[200],"physiologically":[201],"relevant":[202],"mice,":[203],"will":[204],"enable":[205],"therapy":[206],"screenings":[207],"closely":[213],"resembles":[214],"may":[217,236],"allow":[218],"development":[219],"individualized":[221],"can":[225],"used":[227],"simulating":[229],"effectors.":[231],"Once":[232],"established,":[233],"intracranial":[234],"PDX":[235],"also":[237],"useful":[239],"personalizing":[241],"medicine.":[242]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2018-11-16T00:00:00"}