{"id":"https://openalex.org/W2900369477","doi":"https://doi.org/10.1093/neuonc/noy148.551","title":"IMMU-48. GLIOMA IMMUNE PROFILING REVEALS UNIQUE IMMUNE THERAPEUTIC OPPORTUNITIES","display_name":"IMMU-48. GLIOMA IMMUNE PROFILING REVEALS UNIQUE IMMUNE THERAPEUTIC OPPORTUNITIES","publication_year":2018,"publication_date":"2018-11-01","ids":{"openalex":"https://openalex.org/W2900369477","doi":"https://doi.org/10.1093/neuonc/noy148.551","mag":"2900369477"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noy148.551","doi":"https://doi.org/10.1093/neuonc/noy148.551","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/noy148.551","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6216472","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043741628","display_name":"Martina Ott","orcid":"https://orcid.org/0000-0003-4397-2590","observed_orcids":["https://orcid.org/0000-0003-4397-2590"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martina Ott","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030122856","display_name":"Shouhao Zhou","orcid":"https://orcid.org/0000-0002-8124-5047","observed_orcids":["https://orcid.org/0000-0002-8124-5047"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shouhao Zhou","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101992718","display_name":"Jun Wei","orcid":"https://orcid.org/0000-0001-8888-0417","observed_orcids":["https://orcid.org/0000-0001-8888-0417"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Wei","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055183757","display_name":"John de Groot","orcid":"https://orcid.org/0000-0003-1454-6461","observed_orcids":["https://orcid.org/0000-0003-1454-6461"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John de Groot","raw_affiliation_strings":["Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024476694","display_name":"Jason T. Huse","orcid":"https://orcid.org/0000-0003-4514-0640","observed_orcids":["https://orcid.org/0000-0003-4514-0640","https://orcid.org/0000-0003-4933-9120"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason T Huse","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010502061","display_name":"Ian E. McCutcheon","orcid":"https://orcid.org/0000-0002-1638-3400","observed_orcids":["https://orcid.org/0000-0002-1638-3400"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian McCutcheon","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058544711","display_name":"Sujit S. Prabhu","orcid":"https://orcid.org/0000-0002-8155-0623","observed_orcids":["https://orcid.org/0000-0002-8155-0623"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sujit Prabhu","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050191637","display_name":"Sherise Desiree Ferguson","orcid":"https://orcid.org/0000-0002-6344-0615","observed_orcids":["https://orcid.org/0000-0002-6344-0615"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherise Ferguson","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049866871","display_name":"Jeffrey S. Weinberg","orcid":"https://orcid.org/0000-0001-5587-6673","observed_orcids":["https://orcid.org/0000-0001-5587-6673"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Weinberg","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091806633","display_name":"Raymond A. Sawaya","orcid":"https://orcid.org/0000-0002-6035-7939","observed_orcids":["https://orcid.org/0000-0002-6035-7939"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond Sawaya","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017578103","display_name":"Ganesh Rao","orcid":"https://orcid.org/0000-0003-3609-3491","observed_orcids":["https://orcid.org/0000-0003-3609-3491"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ganesh Rao","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026241338","display_name":"Frederick F. Lang","orcid":"https://orcid.org/0000-0003-3747-873X","observed_orcids":["https://orcid.org/0000-0003-3747-873X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick Lang","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079081497","display_name":"Amy B. Heimberger","orcid":"https://orcid.org/0000-0002-9970-8695","observed_orcids":["https://orcid.org/0000-0002-9970-8695"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Heimberger","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"suppl_6","first_page":"vi132","last_page":"vi132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.29420000314712524,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tumor-immune-profiling","display_name":"tumor immune profiling","score":0.8050000071525574},{"id":"https://openalex.org/keywords/immune-checkpoint-proteins","display_name":"immune checkpoint molecules","score":0.49900001287460327},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.7490000128746033},{"id":"https://openalex.org/keywords/adenosine-pathway","display_name":"adenosine pathway","score":0.8679999709129333},{"id":"https://openalex.org/keywords/adenosine-a2a-receptor","display_name":"adenosine A2A receptor","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.6899999976158142},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9409999847412109},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.7070000171661377},{"id":"https://openalex.org/keywords/tim-3","display_name":"TIM-3","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tigit","display_name":"TIGIT","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cd39","display_name":"CD39","score":0.8889999985694885},{"id":"https://openalex.org/keywords/b7-h3","display_name":"B7-H3","score":0.9900000095367432},{"id":"https://openalex.org/keywords/galectin-9","display_name":"galectin-9","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.8679999709129333},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.515999972820282},{"id":"https://openalex.org/keywords/recurrent-glioma","display_name":"recurrent glioma","score":0.6290000081062317},{"id":"https://openalex.org/keywords/glioma-grade","display_name":"glioma grade","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7872766256332397},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7232955098152161},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.656018078327179},{"id":"https://openalex.org/C2779118045","wikidata":"https://www.wikidata.org/wiki/Q21114021","display_name":"TIGIT","level":4,"score":0.5544270873069763},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5281106233596802},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46647530794143677},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4638298749923706},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.4488440752029419},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3394702076911926},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.27175384759902954}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/neuonc/noy148.551","doi":"https://doi.org/10.1093/neuonc/noy148.551","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/noy148.551","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5785910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6216472","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6216472","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6216472","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5785910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6216472","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3045875235","https://openalex.org/W2905105191","https://openalex.org/W2899888969","https://openalex.org/W3083722213","https://openalex.org/W2767682365","https://openalex.org/W4415283175","https://openalex.org/W2971029909","https://openalex.org/W2741644280","https://openalex.org/W2947942563","https://openalex.org/W2078992223"],"abstract_inverted_index":{"There":[0],"is":[1,20,227],"a":[2,295],"rapidly":[3],"evolving":[4],"portfolio":[5],"of":[6,14,47,57,80,113,219,268,279],"immune":[7,15,25,28,82,235,252,281],"therapeutic":[8],"modulators,":[9],"but":[10,242],"the":[11,45,53,78,91,119,123,184,222,230,257,277],"relative":[12],"incidence":[13],"targets":[16],"in":[17,98,118,122,173,183,216,229,245],"human":[18],"gliomas":[19,175],"unknown.":[21],"To":[22],"prioritize":[23],"available":[24],"therapeutics,":[26],"comprehensive":[27],"profiling":[29],"across":[30,102],"glioma":[31,71,103,166,220,265],"grades":[32,104],"was":[33,115,160,181],"conducted.":[34],"CD4+":[35,86],"and":[36,39,52,55,60,69,75,87,90,105,121,141,155,162,178,194,207,256,290],"CD8+":[37,135,148,192,201],"T-cells":[38],"CD11b+":[40,124,138,151],"monocytes/macrophages":[41,126],"were":[42,170,238],"isolated":[43],"from":[44],"blood":[46,54,144,197],"healthy":[48,130,188],"donors":[49,131,189],"(n=":[50,64,67,73],"6)":[51,68],"tumors":[56],"newly":[58],"diagnosed":[59],"recurrent":[61],"grade":[62,269],"II":[63],"7),":[65],"III":[66,177],"IV":[70],"patients":[72,266],"12),":[74],"profiled":[76],"for":[77,298],"expression":[79,96,158,210,250],"30":[81],"modulatory":[83,236],"targets.":[84],"In":[85],"CD8+T-cells,":[88],"PD-1":[89,255],"adenosine":[92,258],"pathway":[93,259],"showed":[94],"high":[95,244],"levels":[97],"tumor-infiltrating":[99],"lymphocytes":[100],"(TILs)":[101],"treatment":[106,272],"states.":[107],"The":[108],"mean":[109],"fluorescent":[110],"intensity":[111],"(MFI)":[112],"A2aR":[114],"appreciably":[116],"upregulated":[117,182,215,241],"TIL":[120,157,185],"glioma-infiltrating":[125],"(GIM)":[127],"compared":[128,186],"to":[129,187,263,293],"(CD4+":[132,145,190,198],"p=":[133,136,139,146,149,199],"0.0201;":[134],"0.0233;":[137],"0.0009)":[140],"matched":[142,195],"peripheral":[143,196],"0.0054;":[147],"0.019;":[150],"p<":[152,202],"0.0001).":[153,203],"LAG3":[154],"TIM3":[156],"frequency":[159],"low":[161],"not":[163,239],"associated":[164],"with":[165],"grade.":[167],"TIGIT":[168],"CD8+TIL":[169],"more":[171],"frequent":[172],"high-grade":[174],"(grade":[176],"IV).":[179],"CD39":[180],"p=0.0032;":[191],"p=0.0006)":[193],"0.0002;":[200],"B7-H3":[204],"(p=":[205,211,232],"0.0167)":[206],"Galectin-9":[208,291],"GIM":[209,231],"0.0042)":[212],"are":[213],"frequently":[214,240],"glioblastoma.":[217],"Regardless":[218],"grade,":[221],"T-cell":[223],"co-stimulatory":[224],"molecule":[225],"CD86":[226],"down-regulated":[228],"0.0019).":[233],"Many":[234],"markers":[237],"exceptionally":[243],"individual":[246],"patients.":[247],"Predicated":[248],"on":[249],"frequency,":[251],"therapeutics":[253],"targeting":[254],"would":[260],"be":[261],"applicable":[262],"most":[264],"regardless":[267],"or":[270],"prior":[271],"status.":[273],"Clinical":[274],"trials":[275],"considering":[276],"use":[278],"other":[280],"targets,":[282],"such":[283],"as":[284],"LAG3,":[285],"TIM3,":[286],"TIGIT,":[287],"BTLA,":[288],"B7-H3,":[289],"need":[292],"consider":[294],"companion":[296],"biomarker":[297],"enrollment":[299],"enrichment.":[300]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2018-11-16T00:00:00"}
