{"id":"https://openalex.org/W2900320164","doi":null,"title":"Human knockout of a cell cycle gene CDC25B: a novel disease-causing gene for an Alstr\u00f6m-like syndrome with cataract, dilated cardiomyopathy and multiple endocrinopathies","display_name":"Human knockout of a cell cycle gene CDC25B: a novel disease-causing gene for an Alstr\u00f6m-like syndrome with cataract, dilated cardiomyopathy and multiple endocrinopathies","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2900320164","mag":"2900320164"},"language":"en","primary_location":{"id":"mag:2900320164","doi":null,"is_oa":false,"landing_page_url":"http://hub.hku.hk/handle/10722/262579","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109320277","display_name":"C.W.K. Lam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CW Lam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060868703","display_name":"Calvin Law","orcid":"https://orcid.org/0000-0002-6784-0085","observed_orcids":["https://orcid.org/0000-0002-6784-0085"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Calvin Law","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6784-0085","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23665444,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.04659999907016754,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.03629999980330467,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdc25b","display_name":"CDC25B","score":0.9789999723434448},{"id":"https://openalex.org/keywords/alstrom-syndrome","display_name":"Alstr\u00f6m syndrome","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cataract","display_name":"cataract","score":0.9490000009536743},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":1.0},{"id":"https://openalex.org/keywords/endocrine-disorders","display_name":"endocrine disorders","score":0.8999999761581421},{"id":"https://openalex.org/keywords/disease-genes","display_name":"disease-associated genes","score":0.6990000009536743},{"id":"https://openalex.org/keywords/knockout-mouse-models","display_name":"knockout mouse models","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C2776383484","wikidata":"https://www.wikidata.org/wiki/Q283656","display_name":"Dilated cardiomyopathy","level":3,"score":0.7404957413673401},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5859035849571228},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5228529572486877},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.5218126773834229},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44623643159866333},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4104387164115906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3238617181777954},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3148811459541321},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.09078070521354675}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2900320164","doi":null,"is_oa":false,"landing_page_url":"http://hub.hku.hk/handle/10722/262579","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3004759068","https://openalex.org/W2272180933","https://openalex.org/W2414145499","https://openalex.org/W2316725230","https://openalex.org/W2607681829","https://openalex.org/W3018692797","https://openalex.org/W7214754891","https://openalex.org/W4412755831","https://openalex.org/W7055703243","https://openalex.org/W39574319"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2018-11-16T00:00:00"}