{"id":"https://openalex.org/W2900005503","doi":"https://doi.org/10.1530/ey.15.1.4","title":"Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function","display_name":"Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function","publication_year":2018,"publication_date":"2018-09-11","ids":{"openalex":"https://openalex.org/W2900005503","doi":"https://doi.org/10.1530/ey.15.1.4","mag":"2900005503"},"language":"en","primary_location":{"id":"doi:10.1530/ey.15.1.4","doi":"https://doi.org/10.1530/ey.15.1.4","is_oa":false,"landing_page_url":"https://doi.org/10.1530/ey.15.1.4","pdf_url":null,"source":{"id":"https://openalex.org/S4210193404","display_name":"Yearbook of pediatric endocrinology","issn_l":"1662-3991","issn":["1662-3991","1662-4009"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yearbook of Paediatric Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029039823","display_name":"Helen Eachus","orcid":"https://orcid.org/0000-0002-7939-1707","observed_orcids":["https://orcid.org/0000-0002-7939-1707"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eachus H","raw_affiliation_strings":["Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield S10\u00a02TN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield S10\u00a02TN, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bright C","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bright C","raw_affiliation_strings":["Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield S10\u00a02TN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield S10\u00a02TN, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032244258","display_name":"Vincent T. Cunliffe","orcid":"https://orcid.org/0000-0001-7483-7610","observed_orcids":["https://orcid.org/0000-0001-7483-7610"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cunliffe VT","raw_affiliation_strings":["The Bateson Centre, Department of Biomedical Science, Firth Court, Western Bank, Sheffield S10 2TN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Bateson Centre, Department of Biomedical Science, Firth Court, Western Bank, Sheffield S10 2TN, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066046626","display_name":"Marysia Placzek","orcid":"https://orcid.org/0000-0002-4106-9229","observed_orcids":["https://orcid.org/0000-0002-4106-9229"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Placzek M","raw_affiliation_strings":["The Bateson Centre, Department of Biomedical Science, Firth Court, Western Bank, Sheffield S10 2TN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Bateson Centre, Department of Biomedical Science, Firth Court, Western Bank, Sheffield S10 2TN, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045014477","display_name":"Wood Jd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Wood JD","raw_affiliation_strings":["Sheffield Institute for Translational Neuroscience, Department of Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheffield Institute for Translational Neuroscience, Department of Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"last","author":{"id":null,"display_name":"Watt PJ","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Watt PJ","raw_affiliation_strings":["Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield S10\u00a02TN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield S10\u00a02TN, UK","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11445013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.40869998931884766,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.40869998931884766,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.34279999136924744,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.03240000084042549,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disc1","display_name":"DISC1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hypothalamic-development","display_name":"hypothalamic development","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-interrenal-axis","display_name":"hypothalamic-pituitary-interrenal axis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neuroendocrine-differentiation","display_name":"neuroendocrine differentiation","score":0.75},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.5730000138282776},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.8519999980926514},{"id":"https://openalex.org/keywords/pomc-neurons","display_name":"POMC neurons","score":0.7609999775886536},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.6140000224113464},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.5820000171661377},{"id":"https://openalex.org/keywords/feeding-behaviour","display_name":"feeding behaviour","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C2777568134","wikidata":"https://www.wikidata.org/wiki/Q15321582","display_name":"DISC1","level":3,"score":0.9628309607505798},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8018508553504944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5590540170669556},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48698267340660095},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46518105268478394},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.4467862844467163},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3853161931037903},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18339642882347107},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1762070655822754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13580355048179626}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1530/ey.15.1.4","doi":"https://doi.org/10.1530/ey.15.1.4","is_oa":false,"landing_page_url":"https://doi.org/10.1530/ey.15.1.4","pdf_url":null,"source":{"id":"https://openalex.org/S4210193404","display_name":"Yearbook of pediatric endocrinology","issn_l":"1662-3991","issn":["1662-3991","1662-4009"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yearbook of Paediatric Endocrinology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.49000000953674316}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1965543302","https://openalex.org/W4415085459","https://openalex.org/W7097556417","https://openalex.org/W7097440547","https://openalex.org/W2167152214","https://openalex.org/W2060136398","https://openalex.org/W2624588939","https://openalex.org/W2759888061","https://openalex.org/W2167614851","https://openalex.org/W2028491630"],"abstract_inverted_index":{"Mutations":[0,88],"in":[1,24,127,137,140,163,186,190],"human":[2],"DISC1":[3,17,37,191],"have":[4,175,197],"been":[5,19],"previously":[6],"associated":[7],"with":[8],"mental":[9,39],"illness,":[10],"such":[11],"as":[12,132],"schizophrenia":[13],"and":[14,85,129,157,200],"depression.":[15],"Moreover,":[16],"has":[18],"shown":[20],"to":[21,57,83,92,97,116,124,161,170],"be":[22,168],"important":[23],"regulating":[25,154],"CNS":[26],"neurogenesis":[27],"through":[28,208],"the":[29,33,59,73,113,150],"Wnt/\u03b2-catenin":[30],"pathway.":[31],"However":[32],"mechanism":[34],"by":[35,71],"which":[36],"causes":[38],"illness":[40],"is":[41],"not":[42],"known.":[43],"In":[44],"this":[45,106],"elegant":[46],"work,":[47],"Eachus":[48],"et":[49],"al.":[50],"used":[51],"two":[52],"homozygous":[53],"mutant":[54],"zebrafish":[55],"lines":[56],"understand":[58],"role":[60],"of":[61,75,89,100,112,121,149,178],"disc1.":[62],"The":[63],"authors":[64],"show":[65,192],"that":[66,80],"disc1":[67,90,131],"affects":[68],"hypothalamic":[69,77,138],"development":[70,139],"controlling":[72],"proliferation":[74],"Rx3-positive":[76],"progenitors":[78],"neurons,":[79],"give":[81],"rise":[82],"SF1":[84],"Pomc1":[86],"neurons.":[87],"lead":[91,123],"abnormal":[93,176],"neuroendocrine":[94],"differentiation,":[95],"leading":[96,115],"decreased":[98],"levels":[99],"cortisol":[101],"after":[102],"environmental":[103],"stress.":[104],"Hence":[105],"paper":[107],"shows":[108],"how":[109],"developmental":[110],"abnormalities":[111,126,199],"hypothalamus,":[114],"endocrinopathies":[117],"at":[118],"early":[119],"stages":[120],"development,":[122],"behavioral":[125],"adulthood":[128],"places":[130],"a":[133],"new":[134],"key":[135],"player":[136],"fish":[141,174],"model.":[142],"POMC":[143,158],"neurones":[144],"form":[145],"an":[146],"integral":[147],"part":[148],"central":[151],"melanocortin":[152],"system":[153],"feeding":[155,179],"behaviour":[156],"deficiency":[159],"leads":[160],"obesity":[162],"humans.":[164],"Hence,":[165],"it":[166],"will":[167],"interesting":[169],"see":[171],"whether":[172],"these":[173,195,202],"regulation":[177],"besides":[180],"their":[181],"behavioural":[182],"abnormalities.":[183],"Further":[184],"studies":[185],"humans":[187],"carrying":[188],"mutations":[189],"assess":[193],"if":[194,201],"patients":[196],"HPA-axis":[198],"biological":[203],"mechanisms":[204],"are":[205],"evolutionarily":[206],"maintained":[207],"different":[209],"species.":[210]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2018-11-16T00:00:00"}
