{"id":"https://openalex.org/W2899994074","doi":"https://doi.org/10.1155/2018/3604320","title":"Impact of Additives on Heterogeneous Crystallization of Acetaminophen","display_name":"Impact of Additives on Heterogeneous Crystallization of Acetaminophen","publication_year":2018,"publication_date":"2018-11-11","ids":{"openalex":"https://openalex.org/W2899994074","doi":"https://doi.org/10.1155/2018/3604320","mag":"2899994074"},"language":"en","primary_location":{"id":"doi:10.1155/2018/3604320","doi":"https://doi.org/10.1155/2018/3604320","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/3604320","pdf_url":"http://downloads.hindawi.com/journals/ijce/2018/3604320.pdf","source":{"id":"https://openalex.org/S100353606","display_name":"International Journal of Chemical Engineering","issn_l":"1687-806X","issn":["1687-806X","1687-8078"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chemical Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://downloads.hindawi.com/journals/ijce/2018/3604320.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112199112","display_name":"Hsin-Yun Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsinyun Hsu","raw_affiliation_strings":["Department of Chemical Engineering, Purdue University, 480 Stadium Mall Drive, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Purdue University, 480 Stadium Mall Drive, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090835640","display_name":"Lynne S. Taylor","orcid":"https://orcid.org/0000-0002-4568-6021","observed_orcids":["https://orcid.org/0000-0002-4568-6021"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynne S. Taylor","raw_affiliation_strings":["Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056183554","display_name":"Michael T. Harris","orcid":"https://orcid.org/0000-0002-0797-8701","observed_orcids":["https://orcid.org/0000-0002-0797-8701"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael T. Harris","raw_affiliation_strings":["Department of Chemical Engineering, Purdue University, 480 Stadium Mall Drive, West Lafayette, IN 47907, USA"],"raw_orcid":"https://orcid.org/0000-0002-0797-8701","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Purdue University, 480 Stadium Mall Drive, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056183554"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1790,"currency":"USD","value_usd":1790},"fwci":0.0934,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.35790896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2018","issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10389","display_name":"Polymer crystallization and properties","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11278","display_name":"Calcium Carbonate Crystallization and Inhibition","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/heterogeneous-crystallization","display_name":"heterogeneous crystallization","score":0.9739999771118164},{"id":"https://openalex.org/keywords/crystallization-additives","display_name":"crystallization additives","score":0.7329999804496765},{"id":"https://openalex.org/keywords/polymorphism","display_name":"polymorphism","score":0.5519999861717224},{"id":"https://openalex.org/keywords/crystallization-kinetics","display_name":"crystallization kinetics","score":0.9459999799728394},{"id":"https://openalex.org/keywords/sodium-bis-2-ethylhexyl-sulfosuccinate","display_name":"sodium bis(2-ethylhexyl) sulfosuccinate","score":0.968999981880188},{"id":"https://openalex.org/keywords/poly-acrylic-acid","display_name":"poly(acrylic acid)","score":0.9589999914169312},{"id":"https://openalex.org/keywords/hydroxypropyl-methylcellulose","display_name":"hydroxypropyl methylcellulose","score":0.9990000128746033},{"id":"https://openalex.org/keywords/crystal-growth-rate","display_name":"crystal growth rate","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.8425701260566711},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.8171342611312866},{"id":"https://openalex.org/C160892712","wikidata":"https://www.wikidata.org/wiki/Q901559","display_name":"Fourier transform infrared spectroscopy","level":2,"score":0.7098314166069031},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5821338295936584},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.5596153736114502},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.5416905879974365},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.47733527421951294},{"id":"https://openalex.org/C153642686","wikidata":"https://www.wikidata.org/wiki/Q70906","display_name":"Infrared spectroscopy","level":2,"score":0.4236799478530884},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38151657581329346},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.36751455068588257},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2653422951698303},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1155/2018/3604320","doi":"https://doi.org/10.1155/2018/3604320","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/3604320","pdf_url":"http://downloads.hindawi.com/journals/ijce/2018/3604320.pdf","source":{"id":"https://openalex.org/S100353606","display_name":"International Journal of Chemical Engineering","issn_l":"1687-806X","issn":["1687-806X","1687-8078"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chemical Engineering","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:f448ff92efa9402d8877bfb1b351f9fb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f448ff92efa9402d8877bfb1b351f9fb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Chemical Engineering, Vol 2018 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2018/3604320","doi":"https://doi.org/10.1155/2018/3604320","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/3604320","pdf_url":"http://downloads.hindawi.com/journals/ijce/2018/3604320.pdf","source":{"id":"https://openalex.org/S100353606","display_name":"International Journal of Chemical Engineering","issn_l":"1687-806X","issn":["1687-806X","1687-8078"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chemical Engineering","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.4300000071525574,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2899994074.pdf","grobid_xml":"https://content.openalex.org/works/W2899994074.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1872029219","https://openalex.org/W1968587413","https://openalex.org/W1970027895","https://openalex.org/W1978806376","https://openalex.org/W1980292873","https://openalex.org/W1982156192","https://openalex.org/W1986114326","https://openalex.org/W2000817381","https://openalex.org/W2001338150","https://openalex.org/W2009176703","https://openalex.org/W2009237173","https://openalex.org/W2010381255","https://openalex.org/W2018272889","https://openalex.org/W2029277770","https://openalex.org/W2046217821","https://openalex.org/W2082536540","https://openalex.org/W2088192197","https://openalex.org/W2092210111","https://openalex.org/W2162211801","https://openalex.org/W2321893261","https://openalex.org/W2950224402"],"related_works":["https://openalex.org/W2014107273","https://openalex.org/W1982156192","https://openalex.org/W1580171861","https://openalex.org/W97115543","https://openalex.org/W2081202558","https://openalex.org/W2102751067","https://openalex.org/W2617761805","https://openalex.org/W7162245442","https://openalex.org/W2560914822","https://openalex.org/W4405660037"],"abstract_inverted_index":{"Introducing":[0],"foreign":[1],"substrates":[2,158],"or":[3,12],"additives":[4,76],"is":[5,147],"the":[6,20,28,31,36,45,73,90,109,125,130,136,144,152,157],"common":[7],"way":[8],"to":[9],"regulate":[10],"polymorphism":[11],"kinetics":[13,88],"of":[14,70,75,89,154],"crystallization.":[15],"Most":[16],"present":[17],"studies":[18],"consider":[19],"substrate":[21,37,95],"factor":[22,25],"and":[23,35,57,108,156],"additive":[24],"separately.":[26],"Here,":[27],"interplay":[29],"between":[30,79],"additive,":[32],"crystallizing":[33,141],"molecules,":[34],"was":[38,42,77,96,101,113],"investigated.":[39,98],"Acetaminophen":[40],"(APAP)":[41],"used":[43],"as":[44,63],"model":[46],"compound.":[47],"5":[48],"wt.%":[49],"dioctyl":[50],"sodium":[51],"sulfosuccinate":[52],"(AOT),":[53],"poly(acrylic)":[54],"acid":[55],"(PAA),":[56],"hydroxypropyl":[58],"methylcellulose":[59],"(HPMC)":[60],"were":[61],"employed":[62],"additives.":[64],"The":[65,86,99,121],"interfacial":[66,110,131],"crystal":[67],"growth":[68,132],"rate":[69],"APAP":[71],"in":[72,135],"presence":[74],"studied":[78,114],"slides":[80],"coated":[81],"with":[82],"chitosan":[83],"(CS)":[84],"film.":[85],"crystallization":[87,153],"additive/APAP":[91,100],"mixture":[92],"on":[93],"CS":[94],"also":[97],"characterized":[102],"by":[103,115],"differential":[104],"scanning":[105],"calorimetry":[106],"(DSC),":[107],"molecular":[111],"interaction":[112,127,146],"Fourier":[116],"transform":[117],"infrared":[118],"spectroscopy":[119],"(FTIR).":[120],"results":[122],"indicate":[123],"that":[124],"additive-substrate":[126],"can":[128],"change":[129],"behavior":[133],"observed":[134],"additive-APAP":[137,145],"binary":[138],"system.":[139],"Nevertheless,":[140],"without":[142],"confinement,":[143],"more":[148],"effective":[149],"at":[150],"controlling":[151],"APAP,":[155],"did":[159],"not":[160],"have":[161],"much":[162],"effect.":[163]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-09-08T07:41:39.490200","created_date":"2018-11-16T00:00:00"}