{"id":"https://openalex.org/W2899765334","doi":"https://doi.org/10.1093/neuonc/noy148.1070","title":"TMIC-10. AUTOPSY STUDY ON THE EFFECTS OF TUMOR TREATMENT FIELDS IN RECURRENT GLIOBLASTOMA: PRELIMINARY RESULTS","display_name":"TMIC-10. AUTOPSY STUDY ON THE EFFECTS OF TUMOR TREATMENT FIELDS IN RECURRENT GLIOBLASTOMA: PRELIMINARY RESULTS","publication_year":2018,"publication_date":"2018-11-01","ids":{"openalex":"https://openalex.org/W2899765334","doi":"https://doi.org/10.1093/neuonc/noy148.1070","mag":"2899765334"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noy148.1070","doi":"https://doi.org/10.1093/neuonc/noy148.1070","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noy148.1070","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/20/suppl_6/vi258/26280879/noy148.1070.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/20/suppl_6/vi258/26280879/noy148.1070.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002708951","display_name":"Alexander Barrington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Barrington","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025448851","display_name":"Sarah L. Hurrell","orcid":"https://orcid.org/0000-0002-2519-3473","observed_orcids":["https://orcid.org/0000-0002-2519-3473"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Hurrell","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032574031","display_name":"Peter S. LaViolette","orcid":"https://orcid.org/0000-0002-9602-6891","observed_orcids":["https://orcid.org/0000-0002-9602-6891"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Laviolette","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204308271"],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"suppl_6","first_page":"vi258","last_page":"vi258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-glioblastoma","display_name":"recurrent glioblastoma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tumor-treating-fields","display_name":"tumor treating fields","score":0.8159999847412109},{"id":"https://openalex.org/keywords/electric-field-therapy","display_name":"electric field treatment","score":0.7639999985694885},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5989999771118164},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7110000252723694},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.5910000205039978},{"id":"https://openalex.org/keywords/texture-features","display_name":"texture features","score":0.8270000219345093},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.7519999742507935},{"id":"https://openalex.org/keywords/treatment-failure-patterns","display_name":"treatment failure patterns","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7204679250717163},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.7146550416946411},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.662727415561676},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5516567826271057},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5075079798698425},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.4659256637096405},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.4545726478099823},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.38769373297691345},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38336172699928284},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.11323440074920654}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/neuonc/noy148.1070","doi":"https://doi.org/10.1093/neuonc/noy148.1070","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noy148.1070","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/20/suppl_6/vi258/26280879/noy148.1070.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5785807","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6216350","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6216350","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6216350","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noy148.1070","doi":"https://doi.org/10.1093/neuonc/noy148.1070","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noy148.1070","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/20/suppl_6/vi258/26280879/noy148.1070.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2899765334.pdf","grobid_xml":"https://content.openalex.org/works/W2899765334.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2767833272","https://openalex.org/W2988518302","https://openalex.org/W2767549378","https://openalex.org/W4311300246","https://openalex.org/W2741646938","https://openalex.org/W3173834180","https://openalex.org/W4393090219","https://openalex.org/W4409627462","https://openalex.org/W4308976567","https://openalex.org/W2767868273"],"abstract_inverted_index":{"Treatment":[0],"of":[1,24,87,93,133,158,177,195,226],"recurrent":[2,105],"glioblastoma":[3],"using":[4],"tumor":[5,47,65,134],"treatment":[6,136],"fields":[7],"(TTFields)":[8],"has":[9],"recently":[10],"been":[11,39,55,77],"approved.":[12],"This":[13],"resulted":[14],"from":[15,103,130,162],"a":[16,152],"recent":[17],"clinical":[18],"trial":[19],"that":[20],"showed":[21],"better":[22],"quality":[23],"life":[25],"and":[26,45,50,59,63,90,100,115,135,142,144,148,168,179],"comparable":[27],"overall":[28],"survival.":[29],"Low-intensity,":[30],"alternating":[31],"frequency":[32],"electric":[33],"fields,":[34],"known":[35],"as":[36,113],"TTFields,":[37],"have":[38,54,70,74],"shown":[40,60],"to":[41,81,216],"disrupt":[42],"cell":[43,51],"division":[44],"subsequently":[46],"growth.":[48],"Apoptosis":[49],"cycle":[52],"arrest":[53],"seen":[56],"in":[57,61,185,210],"vitro,":[58],"mice":[62],"rabbit":[64],"models.":[66],"Glioblastoma":[67],"patients":[68,107,111,120,187,211],"who":[69,121,188],"undergone":[71,123],"TTField":[72,88,124,190],"therapy":[73],"not":[75],"yet":[76],"assessed":[78],"at":[79,108],"autopsy":[80],"determine":[82],"both":[83],"the":[84,91,186,200],"pathological":[85],"signature":[86],"therapy,":[89],"pattern":[92],"failure.":[94],"Whole":[95],"brain":[96],"samples":[97,127],"were":[98,117,128,139,160,172,182],"acquired":[99,129],"analyzed":[101],"pathologically":[102,149],"six":[104],"GBM":[106],"autopsy.":[109],"Three":[110],"served":[112],"controls":[114],"three":[116],"considered":[118],"test":[119],"had":[122],"therapy.":[125,191],"Tissue":[126],"regions":[131],"suspicious":[132],"effects.":[137],"Samples":[138,171],"paraffin":[140],"embedded":[141],"hematoxylin":[143],"eosin":[145],"(H&E)":[146],"stained,":[147],"reviewed":[150],"by":[151],"board":[153],"certified":[154],"pathologist.":[155],"Pathomic":[156],"features":[157,167,194],"interest":[159,196],"extracted":[161],"each":[163],"sample,":[164],"including":[165],"texture":[166],"cellular":[169,180],"morphometrics.":[170],"then":[173],"compared":[174,215],"statistically.":[175],"Regions":[176],"necrosis":[178],"debris":[181],"more":[183],"prevalent":[184],"underwent":[189],"Some":[192],"pathomic":[193],"differed":[197],"significantly":[198],"between":[199],"two":[201],"groups.":[202],"These":[203],"findings":[204],"suggest":[205],"there":[206],"is":[207,222],"increased":[208],"apoptosis":[209],"treated":[212],"with":[213],"TTFields":[214],"those":[217],"on":[218],"chemoradiation":[219],"alone.":[220],"Recruitment":[221],"ongoing":[223],"for":[224],"expansion":[225],"this":[227],"study.":[228]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-11-16T00:00:00"}
