{"id":"https://openalex.org/W2899596606","doi":"https://doi.org/10.5772/intechopen.81888","title":"The Role of Inflammation in Amyloid Diseases","display_name":"The Role of Inflammation in Amyloid Diseases","publication_year":2019,"publication_date":"2019-02-07","ids":{"openalex":"https://openalex.org/W2899596606","doi":"https://doi.org/10.5772/intechopen.81888","mag":"2899596606"},"language":"en","primary_location":{"id":"doi:10.5772/intechopen.81888","doi":"https://doi.org/10.5772/intechopen.81888","is_oa":true,"landing_page_url":"https://doi.org/10.5772/intechopen.81888","pdf_url":"https://www.intechopen.com/citation-pdf-url/64236","source":{"id":"https://openalex.org/S4306463448","display_name":"IntechOpen eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310322558","host_organization_name":"IntechOpen","host_organization_lineage":["https://openalex.org/P4310322558"],"host_organization_lineage_names":["IntechOpen"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amyloid Diseases","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4250909424","display_name":"Amyloid Diseases"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.intechopen.com/citation-pdf-url/64236","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085647099","display_name":"Estefania P. Azevedo","orcid":"https://orcid.org/0000-0002-3149-7270","observed_orcids":["https://orcid.org/0000-0002-3149-7270"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Estefania P. Azevedo","raw_affiliation_strings":["Laboratory of Molecular Genetics , The Rockefeller University , New York , NY , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics , The Rockefeller University , New York , NY , USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037403938","display_name":"D\u00e9bora Foguel","orcid":"https://orcid.org/0000-0001-7312-7115","observed_orcids":["https://orcid.org/0000-0001-7312-7115"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Debora Foguel","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro , Rio de Janeiro , RJ , Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro , Rio de Janeiro , RJ , Brazil","institution_ids":["https://openalex.org/I122140584"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085647099"],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":null,"apc_paid":null,"fwci":2.6636,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.97086247,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloidosis","display_name":"amyloidosis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/amyloid-fibrils","display_name":"amyloid fibrils","score":0.8709999918937683},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8939999938011169},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.9819999933242798},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8960000276565552},{"id":"https://openalex.org/keywords/familial-amyloid-polyneuropathy","display_name":"hereditary transthyretin amyloidosis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/amyloidosis-treatment","display_name":"amyloidosis treatment","score":0.6119999885559082},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.8411015272140503},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.737484335899353},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6921044588088989},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5553961396217346},{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.511151134967804},{"id":"https://openalex.org/C55359608","wikidata":"https://www.wikidata.org/wiki/Q3113038","display_name":"Serum amyloid A","level":3,"score":0.49209922552108765},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44221022725105286},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.440321683883667},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4357280135154724},{"id":"https://openalex.org/C180081513","wikidata":"https://www.wikidata.org/wiki/Q4914721","display_name":"Biochemistry of Alzheimer's disease","level":5,"score":0.4113304615020752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36814767122268677},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3331613838672638},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.2227500081062317},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.1796630620956421},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.1754264533519745}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5772/intechopen.81888","doi":"https://doi.org/10.5772/intechopen.81888","is_oa":true,"landing_page_url":"https://doi.org/10.5772/intechopen.81888","pdf_url":"https://www.intechopen.com/citation-pdf-url/64236","source":{"id":"https://openalex.org/S4306463448","display_name":"IntechOpen eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310322558","host_organization_name":"IntechOpen","host_organization_lineage":["https://openalex.org/P4310322558"],"host_organization_lineage_names":["IntechOpen"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amyloid Diseases","raw_type":"book-chapter"},{"id":"pmh:oai:biblioboard.com:0aae1f43-1093-4478-8b72-abd82f2361f0","doi":null,"is_oa":true,"landing_page_url":"https://openresearchlibrary.org/viewer/0aae1f43-1093-4478-8b72-abd82f2361f0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401131","display_name":"BiblioBoard Library Catalog (Open Research Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"MODID-6d55e02e354:IntechOpen","raw_type":"CHAPTER"},{"id":"pmh:oai:intechopen.com:64236","doi":null,"is_oa":true,"landing_page_url":"http://www.intechopen.com/articles/show/title/the-role-of-inflammation-in-amyloid-diseases","pdf_url":null,"source":{"id":"https://openalex.org/S4306401291","display_name":"Contact-less Assessment of In-vivo Body Signals Using Microwave Doppler Radar (InTech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210154139","host_organization_name":"Intech (Slovakia)","host_organization_lineage":["https://openalex.org/I4210154139"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.intechopen.com/chapter/pdf-download/64236","raw_type":"9"}],"best_oa_location":{"id":"doi:10.5772/intechopen.81888","doi":"https://doi.org/10.5772/intechopen.81888","is_oa":true,"landing_page_url":"https://doi.org/10.5772/intechopen.81888","pdf_url":"https://www.intechopen.com/citation-pdf-url/64236","source":{"id":"https://openalex.org/S4306463448","display_name":"IntechOpen eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310322558","host_organization_name":"IntechOpen","host_organization_lineage":["https://openalex.org/P4310322558"],"host_organization_lineage_names":["IntechOpen"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amyloid Diseases","raw_type":"book-chapter"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2899596606.pdf","grobid_xml":"https://content.openalex.org/works/W2899596606.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W1039490062","https://openalex.org/W1234760403","https://openalex.org/W1508660396","https://openalex.org/W1644626269","https://openalex.org/W1937826833","https://openalex.org/W1967640115","https://openalex.org/W1969361825","https://openalex.org/W1974924674","https://openalex.org/W1976201852","https://openalex.org/W1976845082","https://openalex.org/W1977828303","https://openalex.org/W1980144587","https://openalex.org/W1982207977","https://openalex.org/W1982340002","https://openalex.org/W1984375147","https://openalex.org/W1985121447","https://openalex.org/W1988968306","https://openalex.org/W1990628853","https://openalex.org/W1992598058","https://openalex.org/W1998477180","https://openalex.org/W2000372325","https://openalex.org/W2002792886","https://openalex.org/W2007728674","https://openalex.org/W2011769584","https://openalex.org/W2017756051","https://openalex.org/W2027780772","https://openalex.org/W2042751066","https://openalex.org/W2046093999","https://openalex.org/W2049733399","https://openalex.org/W2050891813","https://openalex.org/W2058815861","https://openalex.org/W2060437562","https://openalex.org/W2063827358","https://openalex.org/W2066630911","https://openalex.org/W2080901528","https://openalex.org/W2080914865","https://openalex.org/W2082524462","https://openalex.org/W2083736189","https://openalex.org/W2084480313","https://openalex.org/W2084506085","https://openalex.org/W2085463327","https://openalex.org/W2088685810","https://openalex.org/W2091938868","https://openalex.org/W2093922849","https://openalex.org/W2098613848","https://openalex.org/W2099751992","https://openalex.org/W2106020004","https://openalex.org/W2109678074","https://openalex.org/W2110463517","https://openalex.org/W2121963977","https://openalex.org/W2129227455","https://openalex.org/W2130487415","https://openalex.org/W2131597939","https://openalex.org/W2148898943","https://openalex.org/W2151887542","https://openalex.org/W2152119060","https://openalex.org/W2155260769","https://openalex.org/W2156193029","https://openalex.org/W2158907165","https://openalex.org/W2161532460","https://openalex.org/W2162237466","https://openalex.org/W2163115168","https://openalex.org/W2169868229","https://openalex.org/W2171607771","https://openalex.org/W2178147107","https://openalex.org/W2202164390","https://openalex.org/W2237382665","https://openalex.org/W2280016073","https://openalex.org/W2316265097","https://openalex.org/W2317740219","https://openalex.org/W2397306041","https://openalex.org/W2407377680","https://openalex.org/W2410910499","https://openalex.org/W2435464245","https://openalex.org/W2473711714","https://openalex.org/W2502971339","https://openalex.org/W2513691138","https://openalex.org/W2566039288","https://openalex.org/W2611954341","https://openalex.org/W2614053601","https://openalex.org/W2614649425","https://openalex.org/W2737900099","https://openalex.org/W2755749904","https://openalex.org/W2766973321","https://openalex.org/W2767395458","https://openalex.org/W2772520664","https://openalex.org/W2774947569","https://openalex.org/W2800974699","https://openalex.org/W2807153072","https://openalex.org/W2809989268","https://openalex.org/W2886601168","https://openalex.org/W2886740009","https://openalex.org/W2889145334","https://openalex.org/W2889286462","https://openalex.org/W3011866592","https://openalex.org/W4245253137","https://openalex.org/W4252526962"],"related_works":["https://openalex.org/W4401118420","https://openalex.org/W2080563350","https://openalex.org/W71980671","https://openalex.org/W2265676874","https://openalex.org/W2024494606","https://openalex.org/W2389761429","https://openalex.org/W2386119554","https://openalex.org/W4300757997","https://openalex.org/W2037722295","https://openalex.org/W4205668311"],"abstract_inverted_index":{"Amyloid":[0,31],"diseases":[1,22,151],"are":[2],"characterized":[3,25],"by":[4,26],"the":[5,27,35,104,107,144],"abnormal":[6],"accumulation":[7,44],"of":[8,21,29,40,45,81,109],"proteinaceous":[9],"aggregates":[10],"(amyloid":[11],"fibrils":[12,32,47],"or":[13],"plaques)":[14],"in":[15,111,147,157],"tissues":[16],"and":[17,38,51,54,61,77,90,120,135,152],"organs.":[18],"This":[19],"class":[20],"is":[23],"also":[24],"presence":[28],"inflammation.":[30,83],"arise":[33],"from":[34],"partial":[36],"denaturing":[37],"unfolding":[39],"native":[41],"proteins.":[42],"The":[43],"amyloid":[46,75,112,128,150],"causes":[48],"tissue":[49,60,87],"damage":[50],"elicits":[52],"local":[53],"nonlocal":[55],"immune":[56],"cell":[57],"infiltration":[58],"into":[59],"proinflammatory":[62],"cytokine":[63],"production.":[64],"Moreover,":[65],"these":[66],"conditions":[67],"fuel":[68],"a":[69],"vicious":[70],"cycle":[71],"that":[72],"can":[73],"increase":[74],"production":[76],"create":[78],"an":[79],"environment":[80],"chronic":[82],"A":[84],"chronically":[85],"inflamed":[86],"rapidly":[88],"deteriorates":[89],"loses":[91],"its":[92],"function.":[93],"In":[94],"this":[95],"chapter,":[96],"we":[97,141],"will":[98,115,142],"discuss":[99,143],"important":[100],"data":[101],"gathered":[102],"over":[103],"years":[105],"describing":[106],"role":[108],"inflammation":[110,118,156],"diseases.":[113],"We":[114],"describe":[116],"how":[117,121,153],"begins":[119],"it":[122],"affects":[123],"disease":[124,133],"progression":[125],"for":[126,149],"major":[127],"diseases,":[129],"such":[130],"as":[131],"Alzheimer\u2019s":[132],"(AD)":[134],"hereditary":[136],"TTR":[137],"amyloidosis":[138],"(hATTR).":[139],"Lastly,":[140],"recent":[145],"advancements":[146],"treatments":[148],"they":[154],"address":[155],"affected":[158],"patients.":[159]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-11-16T00:00:00"}