{"id":"https://openalex.org/W2899588487","doi":null,"title":"Production d'anticorps sp\u00e9cifiques in vitro par culture de lymphocytes B humains","display_name":"Production d'anticorps sp\u00e9cifiques in vitro par culture de lymphocytes B humains","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2899588487","mag":"2899588487"},"language":"fr","primary_location":{"id":"pmh:oai:theses.ulaval.ca:2008/25130","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.ulaval.ca/2008/25130/25130.pdf","pdf_url":"http://www.theses.ulaval.ca/2008/25130/25130.pdf","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071002023","display_name":"Nellie Dumont","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nellie Dumont","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5071002023"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.10339999943971634,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-production","display_name":"antibody production","score":0.640999972820282},{"id":"https://openalex.org/keywords/human-b-lymphocytes","display_name":"human B lymphocytes","score":0.9679999947547913},{"id":"https://openalex.org/keywords/in-vitro-antibody-production","display_name":"in vitro antibody production","score":0.6340000033378601},{"id":"https://openalex.org/keywords/lipopolysaccharide-stimulation","display_name":"lipopolysaccharide stimulation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8299999833106995},{"id":"https://openalex.org/keywords/secondary-immune-response","display_name":"secondary immune response","score":0.7639999985694885},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cos-7-cells","display_name":"COS-7 cells","score":0.7509999871253967},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.46743836998939514},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42410987615585327},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4236429035663605},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3441958725452423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28815656900405884},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28771817684173584},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12023842334747314}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:theses.ulaval.ca:2008/25130","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.ulaval.ca/2008/25130/25130.pdf","pdf_url":"http://www.theses.ulaval.ca/2008/25130/25130.pdf","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},{"id":"pmh:oai:corpus.ulaval.ca:20.500.11794/19802","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11794/19802","pdf_url":null,"source":{"id":"https://openalex.org/S4306400293","display_name":"Corpus Universit\u00e9 Laval (Universit\u00e9 Laval)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43406934","host_organization_name":"Universit\u00e9 Laval","host_organization_lineage":["https://openalex.org/I43406934"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"m\u00e9moire de ma\u00eetrise"},{"id":"mag:2899588487","doi":null,"is_oa":false,"landing_page_url":"https://corpus.ulaval.ca/jspui/bitstream/20.500.11794/19802/1/25130.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7143352004","https://openalex.org/W4394859309","https://openalex.org/W2043520770","https://openalex.org/W6889630933","https://openalex.org/W43724339","https://openalex.org/W7084265063","https://openalex.org/W2364707440","https://openalex.org/W6987826215","https://openalex.org/W427735628","https://openalex.org/W633865711"],"abstract_inverted_index":{"Les":[0],"anticorps,":[1],"piliers":[2],"de":[3,57,68,84,104,125],"la":[4,48,58,97,102,114,127,141],"r\u00e9ponse":[5,115],"immunitaire":[6],"humorale,":[7],"sont":[8,25],"fr\u00e9quemment":[9],"utilis\u00e9s":[10],"pour":[11,66],"traiter":[12],"certaines":[13],"immunod\u00e9ficiences":[14],"et":[15,101],"maladies":[16],"autoimmunes.":[17],"Des":[18],"pr\u00e9parations":[19],"d'anticorps":[20,99],"sp\u00e9cifiques":[21,72,100],"\u00e0":[22,28,32],"un":[23,33,36,138,157],"antig\u00e8ne":[24],"\u00e9galement":[26,123],"administr\u00e9es":[27],"des":[29,50,70,129],"individus,":[30],"suite":[31],"contact":[34],"avec":[35,92],"pathog\u00e8ne.":[37],"Cependant,":[38,148],"nous":[39,149],"sommes":[40],"limit\u00e9s":[41],"dans":[42,47],"leur":[43,54],"production":[44],"ainsi":[45],"que":[46,110],"vari\u00e9t\u00e9":[49],"sp\u00e9cificit\u00e9s":[51],"antig\u00e9niques":[52],"puisque":[53],"pr\u00e9paration":[55],"d\u00e9pend":[56],"disponibilit\u00e9":[59],"d'individus":[60],"hyperimmunis\u00e9s.":[61],"Ce":[62],"projet":[63],"a":[64],"donc":[65],"objectif":[67],"produire":[69],"anticorps":[71],"in":[73],"vitro":[74],"en":[75,133,153],"cultivant":[76],"les":[77,88,145],"lymphocytes":[78,89,130],"B":[79,90,131],"humains":[80,91,132],"isol\u00e9s":[81],"du":[82,93],"sang":[83],"participants.":[85],"En":[86],"stimulant":[87,140],"LPS":[94],"d'Escherichia":[95],"coli,":[96],"s\u00e9cr\u00e9tion":[98,103],"cytokines":[105],"ont":[106],"augment\u00e9.":[107],"Nous":[108,121],"pensons":[109],"ce":[111],"m\u00e9canisme":[112],"acc\u00e9l\u00e8re":[113],"secondaire":[116],"lors":[117],"d'une":[118],"infection":[119],"bact\u00e9rienne.":[120],"avons":[122],"tent\u00e9":[124],"stimuler":[126],"prolif\u00e9ration":[128],"surexprimant":[134],"le":[135],"g\u00e8ne":[136,139],"AgT,":[137],"croissance":[142],"cellulaire":[143],"chez":[144],"cellules":[146],"COS7.":[147],"n'avons":[150],"pas":[151],"\u00e9t\u00e9":[152],"mesure":[154],"d'obtenir":[155],"obtenir":[156],"effet":[158],"biologique.":[159]},"counts_by_year":[],"updated_date":"2026-09-03T10:48:47.769340","created_date":"2018-11-16T00:00:00"}
