{"id":"https://openalex.org/W2899564017","doi":"https://doi.org/10.1038/s41467-018-06901-y","title":"A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates","display_name":"A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates","publication_year":2018,"publication_date":"2018-11-05","ids":{"openalex":"https://openalex.org/W2899564017","doi":"https://doi.org/10.1038/s41467-018-06901-y","mag":"2899564017","pmid":"https://pubmed.ncbi.nlm.nih.gov/30413697","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6226540"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-018-06901-y","doi":"https://doi.org/10.1038/s41467-018-06901-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-06901-y","pdf_url":"https://www.nature.com/articles/s41467-018-06901-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-018-06901-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072061510","display_name":"Vincent Denavit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116169","display_name":"PROTEO","ror":"https://ror.org/02etmf171","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210116169"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Vincent Denavit","raw_affiliation_strings":["D\u00e9partement de chimie, 1045 av. De la M\u00e9decine, Universit\u00e9 Laval PROTEO, RQRM, Qu\u00e9bec City, QC, G1V 0A6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de chimie, 1045 av. De la M\u00e9decine, Universit\u00e9 Laval PROTEO, RQRM, Qu\u00e9bec City, QC, G1V 0A6, Canada","institution_ids":["https://openalex.org/I4210116169","https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083533926","display_name":"Danny Lain\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116169","display_name":"PROTEO","ror":"https://ror.org/02etmf171","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210116169"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Danny Lain\u00e9","raw_affiliation_strings":["D\u00e9partement de chimie, 1045 av. De la M\u00e9decine, Universit\u00e9 Laval PROTEO, RQRM, Qu\u00e9bec City, QC, G1V 0A6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de chimie, 1045 av. De la M\u00e9decine, Universit\u00e9 Laval PROTEO, RQRM, Qu\u00e9bec City, QC, G1V 0A6, Canada","institution_ids":["https://openalex.org/I4210116169","https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017260371","display_name":"Jacob St\u2010Gelais","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116169","display_name":"PROTEO","ror":"https://ror.org/02etmf171","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210116169"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jacob St-Gelais","raw_affiliation_strings":["D\u00e9partement de chimie, 1045 av. De la M\u00e9decine, Universit\u00e9 Laval PROTEO, RQRM, Qu\u00e9bec City, QC, G1V 0A6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de chimie, 1045 av. De la M\u00e9decine, Universit\u00e9 Laval PROTEO, RQRM, Qu\u00e9bec City, QC, G1V 0A6, Canada","institution_ids":["https://openalex.org/I4210116169","https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058992816","display_name":"Paul A. Johnson","orcid":"https://orcid.org/0000-0003-1133-6880","observed_orcids":["https://orcid.org/0000-0003-1133-6880"]},"institutions":[{"id":"https://openalex.org/I4210116169","display_name":"PROTEO","ror":"https://ror.org/02etmf171","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210116169"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Paul A. Johnson","raw_affiliation_strings":["D\u00e9partement de chimie, 1045 av. De la M\u00e9decine, Universit\u00e9 Laval PROTEO, RQRM, Qu\u00e9bec City, QC, G1V 0A6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de chimie, 1045 av. De la M\u00e9decine, Universit\u00e9 Laval PROTEO, RQRM, Qu\u00e9bec City, QC, G1V 0A6, Canada","institution_ids":["https://openalex.org/I4210116169","https://openalex.org/I43406934"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055946875","display_name":"Denis Gigu\u00e8re","orcid":"https://orcid.org/0000-0003-2209-1428","observed_orcids":["https://orcid.org/0000-0003-2209-1428"]},"institutions":[{"id":"https://openalex.org/I4210116169","display_name":"PROTEO","ror":"https://ror.org/02etmf171","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210116169"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Denis Gigu\u00e8re","raw_affiliation_strings":["D\u00e9partement de chimie, 1045 av. De la M\u00e9decine, Universit\u00e9 Laval PROTEO, RQRM, Qu\u00e9bec City, QC, G1V 0A6, Canada. denis.giguere@chm.ulaval.ca","D\u00e9partement de chimie, 1045 av. De la M\u00e9decine, Universit\u00e9 Laval PROTEO, RQRM, Qu\u00e9bec City, QC, G1V 0A6, Canada"],"raw_orcid":"https://orcid.org/0000-0003-2209-1428","affiliations":[{"raw_affiliation_string":"D\u00e9partement de chimie, 1045 av. De la M\u00e9decine, Universit\u00e9 Laval PROTEO, RQRM, Qu\u00e9bec City, QC, G1V 0A6, Canada. denis.giguere@chm.ulaval.ca","institution_ids":["https://openalex.org/I4210116169","https://openalex.org/I43406934"]},{"raw_affiliation_string":"D\u00e9partement de chimie, 1045 av. De la M\u00e9decine, Universit\u00e9 Laval PROTEO, RQRM, Qu\u00e9bec City, QC, G1V 0A6, Canada","institution_ids":["https://openalex.org/I4210116169","https://openalex.org/I43406934"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055946875"],"corresponding_institution_ids":["https://openalex.org/I4210116169","https://openalex.org/I43406934"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":2.5474,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.90699949,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"4721","last_page":"4721"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chiral-pool-synthesis","display_name":"chiral pool synthesis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/stereoselective-synthesis","display_name":"stereoselective synthesis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/levoglucosan","display_name":"levoglucosan","score":0.9599999785423279},{"id":"https://openalex.org/keywords/4c1-conformation","display_name":"4C1 conformation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/lipophilicity","display_name":"lipophilicity","score":0.7689999938011169},{"id":"https://openalex.org/keywords/relative-configuration","display_name":"relative configuration","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.8754385113716125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4650014638900757},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3777843117713928},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36396074295043945},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.29487645626068115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27786126732826233},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.1618654727935791}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1038/s41467-018-06901-y","doi":"https://doi.org/10.1038/s41467-018-06901-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-06901-y","pdf_url":"https://www.nature.com/articles/s41467-018-06901-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5178680","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6226540","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30413697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30413697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6226540","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6226540/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06901-y","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-018-06901-y","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:71b3d4d6b81340a39a931d5a0fa20843","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/71b3d4d6b81340a39a931d5a0fa20843","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9851550dbd6041288a668b3a3190c745","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9851550dbd6041288a668b3a3190c745","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-018-06901-y","doi":"https://doi.org/10.1038/s41467-018-06901-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-06901-y","pdf_url":"https://www.nature.com/articles/s41467-018-06901-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310137","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03"},{"id":"https://openalex.org/F4320314000","display_name":"Compute Canada","ror":"https://ror.org/03ty8yr27"},{"id":"https://openalex.org/F4320323175","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F5911900618","display_name":"Compute Ontario","ror":"https://ror.org/02gq5c945"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2899564017.pdf","grobid_xml":"https://content.openalex.org/works/W2899564017.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1489025737","https://openalex.org/W1512299273","https://openalex.org/W1865966862","https://openalex.org/W1965001044","https://openalex.org/W1976493868","https://openalex.org/W1978796282","https://openalex.org/W1980325050","https://openalex.org/W1981502499","https://openalex.org/W1984599229","https://openalex.org/W1987806561","https://openalex.org/W1990478403","https://openalex.org/W1991387633","https://openalex.org/W1992846982","https://openalex.org/W2002534995","https://openalex.org/W2003732742","https://openalex.org/W2006142056","https://openalex.org/W2028253641","https://openalex.org/W2038767330","https://openalex.org/W2048254503","https://openalex.org/W2048426801","https://openalex.org/W2057509100","https://openalex.org/W2058267980","https://openalex.org/W2059758086","https://openalex.org/W2062852634","https://openalex.org/W2063915017","https://openalex.org/W2067759714","https://openalex.org/W2072017821","https://openalex.org/W2073417437","https://openalex.org/W2081557455","https://openalex.org/W2082774852","https://openalex.org/W2082886132","https://openalex.org/W2083444567","https://openalex.org/W2085759647","https://openalex.org/W2092157292","https://openalex.org/W2095474273","https://openalex.org/W2107024121","https://openalex.org/W2109623131","https://openalex.org/W2111383131","https://openalex.org/W2112203615","https://openalex.org/W2116087305","https://openalex.org/W2120350614","https://openalex.org/W2128655218","https://openalex.org/W2144869962","https://openalex.org/W2148624934","https://openalex.org/W2149517041","https://openalex.org/W2156708699","https://openalex.org/W2159065552","https://openalex.org/W2169655552","https://openalex.org/W2171585592","https://openalex.org/W2178707947","https://openalex.org/W2236663492","https://openalex.org/W2264719596","https://openalex.org/W2283549202","https://openalex.org/W2316492176","https://openalex.org/W2316869593","https://openalex.org/W2333129245","https://openalex.org/W2334721406","https://openalex.org/W2400473775","https://openalex.org/W2490681934","https://openalex.org/W2509108151","https://openalex.org/W2515502853","https://openalex.org/W2531090915","https://openalex.org/W2607047050","https://openalex.org/W2613466573","https://openalex.org/W2738313407","https://openalex.org/W2744291776","https://openalex.org/W2795534721","https://openalex.org/W2950096171","https://openalex.org/W4234310241","https://openalex.org/W4236035412"],"related_works":["https://openalex.org/W2029274355","https://openalex.org/W2946464614","https://openalex.org/W7055754425","https://openalex.org/W2306405992","https://openalex.org/W2950403118","https://openalex.org/W2031780753","https://openalex.org/W585054877","https://openalex.org/W2980232182","https://openalex.org/W2914321418","https://openalex.org/W608274359"],"abstract_inverted_index":{"Abstract":[0],"The":[1,31],"replacement":[2],"of":[3,18,33,54,58,67,90,100,130],"hydroxyl":[4],"groups":[5],"by":[6,37],"fluorine":[7,132],"atoms":[8,133],"on":[9,138],"hexopyranose":[10],"scaffolds":[11],"may":[12],"allow":[13],"access":[14],"to":[15,45,114],"the":[16,51,65,98,122,127,139],"discovery":[17],"new":[19],"chemical":[20,25],"entities":[21],"possessing":[22],"unique":[23],"physical,":[24],"and":[26,40,76,94],"ultimately":[27],"even":[28],"biological":[29],"properties.":[30],"prospect":[32],"significant":[34],"effects":[35],"generated":[36],"such":[38],"multiple":[39],"controlled":[41],"substitutions":[42],"encouraged":[43],"us":[44],"develop":[46],"diverse":[47],"synthetic":[48],"routes":[49],"towards":[50],"stereoselective":[52],"synthesis":[53,66],"polyfluorinated":[55],"hexopyranoses,":[56],"six":[57],"which":[59],"are":[60],"unprecedented.":[61],"Hence,":[62],"we":[63],"report":[64],"heavily":[68],"fluorinated":[69,105],"galactose,":[70],"glucose,":[71],"mannose,":[72],"talose,":[73],"allose,":[74],"fucose,":[75],"galacturonic":[77],"acid":[78],"methyl":[79],"ester":[80],"using":[81],"a":[82,109,135],"Chiron":[83],"approach":[84],"from":[85],"inexpensive":[86],"levoglucosan.":[87],"Structural":[88],"analysis":[89],"single-crystal":[91],"X-ray":[92],"diffractions":[93],"NMR":[95],"studies":[96],"confirm":[97],"conservation":[99],"favored":[101],"4C1":[102],"conformation":[103,112],"for":[104,121],"carbohydrate":[106],"analogs,":[107],"while":[108],"slightly":[110],"distorted":[111],"due":[113],"repulsive":[115],"1,3-diaxial":[116],"F\u00b7\u00b7\u00b7F":[117],"interaction":[118],"is":[119],"observed":[120],"trifluorinated":[123],"talose":[124],"derivative.":[125],"Finally,":[126],"relative":[128],"stereochemistry":[129],"multi-vicinal":[131],"has":[134],"strong":[136],"effect":[137],"lipophilicities":[140],"(logP).":[141]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-11-16T00:00:00"}