{"id":"https://openalex.org/W2899487690","doi":"https://doi.org/10.1111/trf.14988","title":"Higher intraoperative plasma transfusion volumes are associated with inferior perioperative outcomes","display_name":"Higher intraoperative plasma transfusion volumes are associated with inferior perioperative outcomes","publication_year":2018,"publication_date":"2018-11-01","ids":{"openalex":"https://openalex.org/W2899487690","doi":"https://doi.org/10.1111/trf.14988","mag":"2899487690","pmid":"https://pubmed.ncbi.nlm.nih.gov/30383908","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6322936"},"language":"en","primary_location":{"id":"doi:10.1111/trf.14988","doi":"https://doi.org/10.1111/trf.14988","is_oa":false,"landing_page_url":"https://doi.org/10.1111/trf.14988","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6322936","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028980008","display_name":"Matthew A. Warner","orcid":"https://orcid.org/0000-0002-6625-8755","observed_orcids":["https://orcid.org/0000-0002-6625-8755"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew A. Warner","raw_affiliation_strings":["Division of Critical Care Medicine, Department of Anesthesiology and Perioperative Medicine Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Critical Care Medicine, Department of Anesthesiology and Perioperative Medicine Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008837356","display_name":"Ryan D. Frank","orcid":"https://orcid.org/0000-0002-5561-0637","observed_orcids":["https://orcid.org/0000-0002-5561-0637"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan D. Frank","raw_affiliation_strings":["Department of Biomedical Statistics and Informatics Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Statistics and Informatics Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010702370","display_name":"Timothy J. Weister","orcid":"https://orcid.org/0000-0003-1485-2338","observed_orcids":["https://orcid.org/0000-0003-1485-2338"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy J. Weister","raw_affiliation_strings":["Anesthesia Clinical Research Unit Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesia Clinical Research Unit Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049938177","display_name":"Mark M. Smith","orcid":"https://orcid.org/0000-0003-4153-4335","observed_orcids":["https://orcid.org/0000-0003-4153-4335"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark M. Smith","raw_affiliation_strings":["Division of Cardiothoracic Anesthesia, Department of Anesthesiology and Perioperative Medicine Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Anesthesia, Department of Anesthesiology and Perioperative Medicine Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041158130","display_name":"James R. Stubbs","orcid":"https://orcid.org/0000-0002-3270-4913","observed_orcids":["https://orcid.org/0000-0002-3270-4913"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R. Stubbs","raw_affiliation_strings":["Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103192518","display_name":"Daryl Jon Kor","orcid":"https://orcid.org/0000-0001-9110-1648","observed_orcids":["https://orcid.org/0000-0001-9110-1648"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daryl J. Kor","raw_affiliation_strings":["Division of Critical Care Medicine, Department of Anesthesiology and Perioperative Medicine Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Critical Care Medicine, Department of Anesthesiology and Perioperative Medicine Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028980008"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":0.6848,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.6822039,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"59","issue":"1","first_page":"112","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transfusion-volume","display_name":"transfusion volume","score":0.8190000057220459},{"id":"https://openalex.org/keywords/perioperative-coagulation","display_name":"perioperative coagulation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/international-normalized-ratio","display_name":"international normalized ratio","score":0.9700000286102295},{"id":"https://openalex.org/keywords/in-hospital-mortality","display_name":"in-hospital mortality","score":0.7789999842643738},{"id":"https://openalex.org/keywords/icu-free-days","display_name":"ICU-free days","score":0.796999990940094},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.7879999876022339},{"id":"https://openalex.org/keywords/estimated-blood-loss","display_name":"estimated blood loss","score":0.859000027179718},{"id":"https://openalex.org/keywords/surgical-bleeding","display_name":"surgical bleeding","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9526404738426208},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.8196884393692017},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.6340789794921875},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.6176932454109192},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.560896098613739},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4770742654800415},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.46382442116737366},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37227004766464233},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32497116923332214}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010953","descriptor_name":"Plasma Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016913","descriptor_name":"Blood Component Transfusion","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017707","descriptor_name":"Erythrocyte Transfusion","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017713","descriptor_name":"Platelet Transfusion","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/trf.14988","doi":"https://doi.org/10.1111/trf.14988","is_oa":false,"landing_page_url":"https://doi.org/10.1111/trf.14988","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},{"id":"pmid:30383908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30383908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5889601","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6322936","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6322936","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6322936","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Transfusion","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5889601","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6322936","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G146627777","display_name":"Point-of-Care RBC Washing to Prevent Transfusion-Related Pulmonary Complications","funder_award_id":"R01HL121232","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5918705860","display_name":"General Clinical Research Center","funder_award_id":"M01RR000585","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000857139","display_name":"Institutional Career Development Core","funder_award_id":"KL2TR002379","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000868933","display_name":"Mayo Clinic Center for Clinical and Translational Science (CCaTS)","funder_award_id":"UL1TR002377","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306143","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1519338957","https://openalex.org/W1964906546","https://openalex.org/W1968592812","https://openalex.org/W1970040976","https://openalex.org/W1970569414","https://openalex.org/W1998796763","https://openalex.org/W2003581849","https://openalex.org/W2004848451","https://openalex.org/W2013125286","https://openalex.org/W2031455100","https://openalex.org/W2037037745","https://openalex.org/W2042603596","https://openalex.org/W2044046314","https://openalex.org/W2061632494","https://openalex.org/W2080256233","https://openalex.org/W2117953661","https://openalex.org/W2118094100","https://openalex.org/W2127841934","https://openalex.org/W2129819526","https://openalex.org/W2132054698","https://openalex.org/W2133226878","https://openalex.org/W2139801997","https://openalex.org/W2146292166","https://openalex.org/W2147368252","https://openalex.org/W2155495795","https://openalex.org/W2158365306","https://openalex.org/W2158985195","https://openalex.org/W2166176554","https://openalex.org/W2168333649","https://openalex.org/W2275737843","https://openalex.org/W2275860668","https://openalex.org/W2314711013","https://openalex.org/W2338438098","https://openalex.org/W2409360329","https://openalex.org/W2465611599","https://openalex.org/W2481281886","https://openalex.org/W2586516672","https://openalex.org/W2599076725","https://openalex.org/W2774009472","https://openalex.org/W2800599446","https://openalex.org/W2883181532","https://openalex.org/W4211098689"],"related_works":["https://openalex.org/W2999507031","https://openalex.org/W6941841033","https://openalex.org/W2794634169","https://openalex.org/W3038444217","https://openalex.org/W2275860668","https://openalex.org/W2998074665","https://openalex.org/W4320920560","https://openalex.org/W2140811119","https://openalex.org/W2119346547","https://openalex.org/W1990040446"],"abstract_inverted_index":{"BACKGROUND:":[0],"Intraoperative":[1],"plasma":[2,34,46,115,180,224,258],"transfusion":[3,35,47,106,181,227,259],"is":[4,8,25],"common,":[5],"yet":[6],"little":[7],"known":[9],"regarding":[10],"its":[11],"effects":[12],"on":[13],"perioperative":[14],"coagulation":[15,51],"tests":[16],"or":[17],"clinical":[18,55,233],"outcomes.":[19,244],"STUDY":[20],"DESIGN":[21],"AND":[22],"METHODS:":[23],"This":[24],"a":[26,37,58],"retrospective":[27],"cohort":[28],"study":[29],"of":[30,61,97,107,187,264],"adults":[31],"receiving":[32,222],"intraoperative":[33,87,139,223],"at":[36],"single":[38],"center":[39],"from":[40],"2011":[41],"to":[42,158,166,250,256],"2015.":[43],"Relationships":[44],"between":[45],"volume,":[48],"changes":[49],"in":[50,174,238],"test":[52],"values,":[53],"and":[54,84,90,138,146,149,163,202,211,255],"outcomes,":[56,121],"including":[57],"primary":[59],"outcome":[60],"early":[62],"postoperative":[63,132,188],"red":[64],"blood":[65,92],"cell":[66],"(RBC)":[67],"transfusion,":[68,225],"were":[69,101,117,182,229,240],"assessed":[70],"with":[71,103,119,122,128,184,231,242],"multivariable":[72,112],"regression":[73],"analyses.":[74],"Secondary":[75],"outcomes":[76],"included":[77],"hospital":[78],"mortality,":[79],"intensive":[80],"care":[81],"unit":[82],"(ICU)-":[83],"hospital-free":[85,150,212],"days,":[86],"RBC":[88],"transfusions,":[89],"estimated":[91],"loss.":[93],"RESULTS:":[94],"A":[95],"total":[96],"3393":[98],"unique":[99],"patients":[100,221],"included,":[102],"median":[104],"(IQR)":[105],"2":[108],"(2-4)":[109],"units.":[110],"In":[111,220],"analyses,":[113],"higher":[114,226],"volumes":[116,228],"associated":[118,127,183,230,241],"worse":[120],"each":[123],"1":[124],"mL/kg":[125],"increase":[126],"increased":[129,203],"odds":[130,186],"for":[131],"(1.02":[133],"[1.01-1.03],":[134],"p":[135,143,160,168,192,199,208,216],"<":[136,144,161,169,193],"0.001)":[137,145],"RBCs":[140,189],"(1.17":[141],"[1.16-1.19],":[142],"fewer":[147],"ICU-":[148,205],"days":[151,213],"(mean":[152],"difference":[153],"[95%":[154],"CI],":[155],"-0.08":[156],"[-0.12":[157],"-0.05],":[159],"0.001;":[162],"-0.09":[164],"[-0.13":[165],"-0.06],":[167],"0.001,":[170],"respectively).":[171],"Greater":[172],"decreases":[173],"international":[175],"normalized":[176],"ratio":[177],"(INR)":[178],"following":[179],"decreased":[185,195],"(0.35":[190],"[0.25-0.47],":[191],"0.001),":[194],"mortality":[196],"(0.50":[197],"[0.31-0.83],":[198],"=":[200,209,217],"0.007),":[201],"mean":[204],"(1.31":[206],"[0.41-2.21],":[207],"0.004)":[210],"(1.15":[214],"[0.19-2.10],":[215],"0.018).":[218],"CONCLUSION:":[219],"inferior":[232],"outcomes;":[234],"however,":[235],"greater":[236],"improvements":[237],"INR":[239],"improved":[243],"Future":[245],"prospective":[246],"studies":[247],"are":[248],"necessary":[249],"better":[251],"define":[252],"these":[253],"relationships":[254],"explore":[257],"triggers":[260],"beyond":[261],"the":[262],"limitations":[263],"INR.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-11-09T00:00:00"}