{"id":"https://openalex.org/W2899487221","doi":"https://doi.org/10.1186/s12931-018-0890-0","title":"Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study","display_name":"Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study","publication_year":2018,"publication_date":"2018-10-29","ids":{"openalex":"https://openalex.org/W2899487221","doi":"https://doi.org/10.1186/s12931-018-0890-0","mag":"2899487221","pmid":"https://pubmed.ncbi.nlm.nih.gov/30373671","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6206739"},"language":"en","primary_location":{"id":"doi:10.1186/s12931-018-0890-0","doi":"https://doi.org/10.1186/s12931-018-0890-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-018-0890-0","pdf_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-018-0890-0","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-018-0890-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"on behalf of the COPDGene Investigators","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"on behalf of the COPDGene Investigators","raw_affiliation_strings":["Division of Respiratory Diseases, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory Diseases, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079296364","display_name":"Lystra P. Hayden","orcid":"https://orcid.org/0000-0001-6874-0097","observed_orcids":["https://orcid.org/0000-0001-6874-0097"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lystra P. Hayden","raw_affiliation_strings":["Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA. Lystra.Hayden@childrens.harvard.edu","Division of Respiratory Diseases, Boston Children's Hospital, Boston, MA, USA. Lystra.Hayden@childrens.harvard.edu","Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA"],"raw_orcid":"https://orcid.org/0000-0001-6874-0097","affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA. Lystra.Hayden@childrens.harvard.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Respiratory Diseases, Boston Children's Hospital, Boston, MA, USA. Lystra.Hayden@childrens.harvard.edu","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018495347","display_name":"Michael H. Cho","orcid":"https://orcid.org/0000-0002-4907-1657","observed_orcids":["https://orcid.org/0000-0002-4907-1657"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael H. Cho","raw_affiliation_strings":["Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA","Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054459458","display_name":"Benjamin A. Raby","orcid":"https://orcid.org/0000-0003-2206-5748","observed_orcids":["https://orcid.org/0000-0003-2206-5748"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin A. Raby","raw_affiliation_strings":["Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA","Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA","Division of Respiratory Diseases, Boston Children's Hospital, Boston, MA, USA","Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Division of Respiratory Diseases, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025950806","display_name":"Terri H. Beaty","orcid":"https://orcid.org/0000-0002-7644-1705","observed_orcids":["https://orcid.org/0000-0002-7644-1705"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terri H. Beaty","raw_affiliation_strings":["Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035524361","display_name":"Edwin K. Silverman","orcid":"https://orcid.org/0000-0002-3641-3822","observed_orcids":["https://orcid.org/0000-0002-3641-3822"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin K. Silverman","raw_affiliation_strings":["Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA","Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059655447","display_name":"Craig P. Hersh","orcid":"https://orcid.org/0000-0002-1342-4334","observed_orcids":["https://orcid.org/0000-0002-1342-4334"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig P. Hersh","raw_affiliation_strings":["Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA","Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5079296364"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1288882113","https://openalex.org/I136199984"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":4.117,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.94817083,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"19","issue":"1","first_page":"209","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.5990999937057495,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.5990999937057495,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.3467000126838684,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.04670000076293945,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-asthma","display_name":"childhood asthma","score":1.0},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9729999899864197},{"id":"https://openalex.org/keywords/asthma-copd-overlap","display_name":"asthma-COPD overlap","score":0.9679999947547913},{"id":"https://openalex.org/keywords/copdgene-study","display_name":"COPDGene Study","score":0.6819999814033508},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.7089999914169312},{"id":"https://openalex.org/keywords/st2","display_name":"ST2","score":0.7680000066757202},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":1.0},{"id":"https://openalex.org/keywords/gsdmb","display_name":"GSDMB","score":0.8629999756813049},{"id":"https://openalex.org/keywords/african-american-adults","display_name":"African American adults","score":0.5540000200271606},{"id":"https://openalex.org/keywords/self-reported-asthma","display_name":"self-reported asthma","score":0.6610000133514404},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.8761215209960938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7723625302314758},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7452631592750549},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7067548632621765},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5346251130104065},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.43263402581214905},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39656445384025574},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.26522576808929443},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08561468124389648},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06901207566261292},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06505131721496582}],"mesh":[{"descriptor_ui":"D000074285","descriptor_name":"Smokers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057566","descriptor_name":"Self Report","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12931-018-0890-0","doi":"https://doi.org/10.1186/s12931-018-0890-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-018-0890-0","pdf_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-018-0890-0","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5160964","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6206739","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6206739","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6206739","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respir Res","raw_type":"Text"},{"id":"pmid:30373671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30373671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:739153d1a3d8455c882f2e5edb001702","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/739153d1a3d8455c882f2e5edb001702","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Respiratory Research, Vol 19, Iss 1, Pp 1-11 (2018)","raw_type":"article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/200809","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/200809","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.ncbi.nlm.nih.gov/pubmed/30373671","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/200809","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/200809","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Respiratory Research, 19, 209","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12931-018-0890-0","doi":"https://doi.org/10.1186/s12931-018-0890-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-018-0890-0","pdf_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-018-0890-0","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8700000047683716,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1651414227","display_name":null,"funder_award_id":"NCT00608764","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1973225130","display_name":"Identifying Genetic Determinants of Severe, Early-Onset COPD","funder_award_id":"R01HL113264","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2191341599","display_name":"SYSTEMS GENETICS AND GENOMICS OF LUNG DISEASES","funder_award_id":"K12HL120004","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2417563097","display_name":null,"funder_award_id":"U01 HL089897","funder_id":"https://openalex.org/F4320310320","funder_display_name":"COPD Foundation"},{"id":"https://openalex.org/G303045146","display_name":"INTEGRATIVE GENOMICS OF CLINICAL SUBTYPES IN COPDGENE","funder_award_id":"R01HL125583","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G561959489","display_name":"Functional Genetics of COPD","funder_award_id":"P01HL105339","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5658329869","display_name":"(2 of 2) Genetic Epidemiology of COPD","funder_award_id":"U01HL089856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6809393842","display_name":"(1 of 2) Genetic Epidemiology of COPD","funder_award_id":"U01HL089897","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6912450330","display_name":"Genetic Epidemiology of Respiratory Function in Former Preterm Children","funder_award_id":"K23HL136851","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6977116042","display_name":"SYSTEMS GENOMICS OF THE ASTHMA-COPD OVERLAP SYNDROME","funder_award_id":"R01HL130512","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8407083364","display_name":"Clinical significance and genetic determinants of novel imaging measures of emphysema distribution in 9,743 smokers","funder_award_id":"K08HL141601","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8643874822","display_name":null,"funder_award_id":"NCT00608764","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8819318481","display_name":null,"funder_award_id":"NCT00608764","funder_id":"https://openalex.org/F4320310320","funder_display_name":"COPD Foundation"},{"id":"https://openalex.org/G9000339672","display_name":"Environmental Health Sciences Research Center","funder_award_id":"P30ES005605","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G993448119","display_name":null,"funder_award_id":"U01HL089856","funder_id":"https://openalex.org/F4320310320","funder_display_name":"COPD Foundation"}],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320310320","display_name":"COPD Foundation","ror":"https://ror.org/02qfkky73"},{"id":"https://openalex.org/F4320311407","display_name":"Sunovion","ror":"https://ror.org/030zc7t66"},{"id":"https://openalex.org/F4320313443","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333634","display_name":"Anschutz Medical Campus, University of Colorado","ror":"https://ror.org/03wmf1y16"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2899487221.pdf","grobid_xml":"https://content.openalex.org/works/W2899487221.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W1570824340","https://openalex.org/W1590687564","https://openalex.org/W1686440905","https://openalex.org/W1747499909","https://openalex.org/W1799799703","https://openalex.org/W1843924911","https://openalex.org/W1964998512","https://openalex.org/W1968886567","https://openalex.org/W1971000546","https://openalex.org/W1974090444","https://openalex.org/W1975784916","https://openalex.org/W1978145421","https://openalex.org/W1984852597","https://openalex.org/W1986142113","https://openalex.org/W2005623173","https://openalex.org/W2008599922","https://openalex.org/W2013524758","https://openalex.org/W2017795795","https://openalex.org/W2019966611","https://openalex.org/W2034952325","https://openalex.org/W2042103448","https://openalex.org/W2045020884","https://openalex.org/W2045616259","https://openalex.org/W2048710109","https://openalex.org/W2054544867","https://openalex.org/W2062732990","https://openalex.org/W2070024531","https://openalex.org/W2081882488","https://openalex.org/W2082907106","https://openalex.org/W2084526203","https://openalex.org/W2089627898","https://openalex.org/W2102687347","https://openalex.org/W2111307685","https://openalex.org/W2113782542","https://openalex.org/W2114360313","https://openalex.org/W2116868464","https://openalex.org/W2121029583","https://openalex.org/W2122483770","https://openalex.org/W2127951128","https://openalex.org/W2128028260","https://openalex.org/W2133281088","https://openalex.org/W2135772522","https://openalex.org/W2143488859","https://openalex.org/W2144041275","https://openalex.org/W2145034307","https://openalex.org/W2158206794","https://openalex.org/W2159556553","https://openalex.org/W2161633633","https://openalex.org/W2165277651","https://openalex.org/W2173807505","https://openalex.org/W2174579634","https://openalex.org/W2193414548","https://openalex.org/W2261793300","https://openalex.org/W2357940608","https://openalex.org/W2401811918","https://openalex.org/W2417315358","https://openalex.org/W2462668116","https://openalex.org/W2510730292","https://openalex.org/W2513297940","https://openalex.org/W2517677111","https://openalex.org/W2548531245","https://openalex.org/W2550112578","https://openalex.org/W2559028527","https://openalex.org/W2579844394","https://openalex.org/W2610225966","https://openalex.org/W2651023859","https://openalex.org/W2760326765","https://openalex.org/W2771400539","https://openalex.org/W2780232486","https://openalex.org/W2782174691","https://openalex.org/W2783654652","https://openalex.org/W3215332570","https://openalex.org/W4211263216","https://openalex.org/W4300196896"],"related_works":["https://openalex.org/W6920950260","https://openalex.org/W2062732990","https://openalex.org/W1536764887","https://openalex.org/W4241730561","https://openalex.org/W2149121310","https://openalex.org/W3080102594","https://openalex.org/W2145384535","https://openalex.org/W2130935734","https://openalex.org/W4410268425","https://openalex.org/W2901119117"],"abstract_inverted_index":{"BACKGROUND:":[0],"Childhood":[1,85,247],"asthma":[2,30,42,65,86,113,121,148,194,212,221,225,256],"is":[3,9,43,259],"strongly":[4],"influenced":[5],"by":[6,89,94,257],"genetics":[7],"and":[8,17,53,71,129,137,140,183,203,233,271,291],"a":[10,55,95,109],"risk":[11,50,252,264],"factor":[12],"for":[13,51,155,243,253,265],"reduced":[14],"lung":[15,47,124],"function":[16],"chronic":[18],"obstructive":[19],"pulmonary":[20],"disease":[21],"(COPD)":[22],"in":[23,31,135,142,174,178,208,217,227,234,261],"adults.":[24],"This":[25,280],"study":[26,58],"investigates":[27],"self-reported":[28],"childhood":[29,41,112,158,167,220,278],"adult":[32],"smokers":[33,73],"from":[34,150,199],"the":[35,175,179,200,209,218,235],"COPDGene":[36],"Study.":[37],"We":[38,68],"hypothesize":[39],"that":[40,54],"associated":[44],"with":[45,63,98,108,157,205,223,269,277],"decreased":[46],"function,":[48,125],"increased":[49,251],"COPD,":[52,128,266],"genome-wide":[56,172,206],"association":[57,62,156],"(GWAS)":[59],"will":[60],"show":[61],"established":[64,147],"variants.":[66],"METHODS:":[67],"evaluated":[69],"current":[70,219],"former":[72],"ages":[74],"45-80":[75],"of":[76,91,111,127,146,189,287],"non-Hispanic":[77],"white":[78],"(NHW)":[79],"or":[80,104,177],"African":[81],"American":[82],"(AA)":[83],"race.":[84],"was":[87,133],"defined":[88],"self-report":[90,258],"asthma,":[92],"diagnosed":[93],"medical":[96],"professional,":[97],"onset":[99],"at":[100,250,263],"<":[101,241],"16":[102],"years":[103],"during":[105],"childhood.":[106],"Subjects":[107],"history":[110],"were":[114,153,191,196,215],"compared":[115],"to":[116,275,283],"those":[117],"who":[118],"never":[119],"had":[120,166],"based":[122],"on":[123],"development":[126],"genetic":[130,272],"variation.":[131],"GWAS":[132,222],"performed":[134],"NHW":[136,182],"AA":[138,184],"populations,":[139],"combined":[141],"meta-analysis.":[143],"Two":[144],"sets":[145],"SNPs":[149,170,195],"published":[151],"literature":[152],"examined":[154],"asthma.":[159,168,279],"RESULTS:":[160],").":[161],"Among":[162],"AAs,":[163],"339":[164],"(12%)":[165],"No":[169],"reached":[171],"significance":[173,207],"AAs":[176],"meta-analysis":[180],"combining":[181],"subjects;":[185],"however,":[186],"potential":[187,282],"regions":[188],"interest":[190],"identified.":[192],"Established":[193],"examined,":[197],"seven":[198],"NHGRI-EBI":[201],"database":[202],"five":[204],"largest":[210],"pediatric":[211],"GWAS.":[213],"Associations":[214],"found":[216],"known":[224,274],"loci":[226],"IL1RL1,":[228],"IL13,":[229],"LINC01149,":[230],"near":[231],"GSDMB,":[232],"C11orf30-LRRC32":[236],"region":[237],"(Bonferroni":[238],"adjusted":[239],"p":[240],"0.05":[242],"all":[244],"comparisons).":[245],"CONCLUSIONS:":[246],"asthmatics":[248],"are":[249],"COPD.":[254],"Defining":[255],"valid":[260],"populations":[262],"identifying":[267],"subjects":[268],"clinical":[270,285],"characteristics":[273],"associate":[276],"has":[281],"improve":[284],"understanding":[286],"asthma-COPD":[288],"overlap":[289],"(ACO)":[290],"enhance":[292],"future":[293],"research":[294],"into":[295],"ACO-specific":[296],"treatment":[297],"regimens.":[298],"TRIAL":[299],"REGISTRATION:":[300],"ClinicalTrials.gov,":[301],"NCT00608764":[302],"(Active":[303],"since":[304],"January":[305],"28,":[306],"2008).":[307]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-11-09T00:00:00"}
