{"id":"https://openalex.org/W2899345691","doi":"https://doi.org/10.7717/peerj.5602","title":"Assessment of a mouse xenograft model of primary colorectal cancer with special reference to perfluorooctane sulfonate","display_name":"Assessment of a mouse xenograft model of primary colorectal cancer with special reference to perfluorooctane sulfonate","publication_year":2018,"publication_date":"2018-11-02","ids":{"openalex":"https://openalex.org/W2899345691","doi":"https://doi.org/10.7717/peerj.5602","mag":"2899345691","pmid":"https://pubmed.ncbi.nlm.nih.gov/30405966","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6216948"},"language":"en","primary_location":{"id":"doi:10.7717/peerj.5602","doi":"https://doi.org/10.7717/peerj.5602","is_oa":true,"landing_page_url":"https://doi.org/10.7717/peerj.5602","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7717/peerj.5602","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063718775","display_name":"Jeffrey Wimsatt","orcid":"https://orcid.org/0000-0002-7818-2479","observed_orcids":["https://orcid.org/0000-0002-7818-2479"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey H. Wimsatt","raw_affiliation_strings":["Department of Epidemiology, West Virginia University, Morgantown, WV, United States of America","Department of Medicine, West Virginia University, Morgantown, WV, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, West Virginia University, Morgantown, WV, United States of America","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Department of Medicine, West Virginia University, Morgantown, WV, United States of America","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Caitlin Montgomery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlin Montgomery","raw_affiliation_strings":["Department of Epidemiology, West Virginia University, Morgantown, WV, United States of America","Department of Medicine, West Virginia University, Morgantown, WV, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, West Virginia University, Morgantown, WV, United States of America","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Department of Medicine, West Virginia University, Morgantown, WV, United States of America","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067392254","display_name":"Laurel S. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurel S. Thomas","raw_affiliation_strings":["Department of Medicine, West Virginia University, Morgantown, WV, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, West Virginia University, Morgantown, WV, United States of America","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025183688","display_name":"Charity Savard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charity Savard","raw_affiliation_strings":["Department of Medicine, West Virginia University, Morgantown, WV, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, West Virginia University, Morgantown, WV, United States of America","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021685149","display_name":"Rachel M. Tallman","orcid":"https://orcid.org/0000-0002-7800-4111","observed_orcids":["https://orcid.org/0000-0002-7800-4111"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Tallman","raw_affiliation_strings":["Department of Medicine, West Virginia University, Morgantown, WV, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, West Virginia University, Morgantown, WV, United States of America","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089043295","display_name":"Kim E. Innes","orcid":"https://orcid.org/0000-0002-6395-7972","observed_orcids":["https://orcid.org/0000-0002-6395-7972"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim Innes","raw_affiliation_strings":["Department of Epidemiology, West Virginia University, Morgantown, WV, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, West Virginia University, Morgantown, WV, United States of America","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072227403","display_name":"Nezar Y. Jrebi","orcid":"https://orcid.org/0000-0003-3267-0159","observed_orcids":["https://orcid.org/0000-0003-3267-0159"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nezar Jrebi","raw_affiliation_strings":["Department of Surgery, West Virginia University, Morgantown, WV, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, West Virginia University, Morgantown, WV, United States of America","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063718775"],"corresponding_institution_ids":["https://openalex.org/I12097938"],"apc_list":{"value":1395,"currency":"USD","value_usd":1395},"apc_paid":{"value":1395,"currency":"USD","value_usd":1395},"fwci":0.3465,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.51459293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":null,"first_page":"e5602","last_page":"e5602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11869","display_name":"Per- and polyfluoroalkyl substances research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11869","display_name":"Per- and polyfluoroalkyl substances research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9150000214576721},{"id":"https://openalex.org/keywords/perfluorooctane-sulfonate","display_name":"PFOS","score":0.972000002861023},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7820000052452087},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9300000071525574},{"id":"https://openalex.org/keywords/nsg-mice","display_name":"NSG mice","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tumor-engraftment","display_name":"tumor engraftment","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7900000214576721},{"id":"https://openalex.org/keywords/apcmin-mice","display_name":"ApcMin/+ mice","score":0.5879999995231628},{"id":"https://openalex.org/keywords/familial-adenomatous-polyposis","display_name":"familial adenomatous polyposis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tumor-location","display_name":"tumor location","score":0.3330000042915344},{"id":"https://openalex.org/keywords/ascending-colon","display_name":"ascending colon","score":0.49300000071525574},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.8450592756271362},{"id":"https://openalex.org/C2781314072","wikidata":"https://www.wikidata.org/wiki/Q421426","display_name":"Perfluorooctane","level":4,"score":0.834437370300293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7552000284194946},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5457087159156799},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5447396636009216},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48722782731056213},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4589653015136719},{"id":"https://openalex.org/C2780814781","wikidata":"https://www.wikidata.org/wiki/Q1369011","display_name":"Familial adenomatous polyposis","level":4,"score":0.41676396131515503},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40009063482284546},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3447660803794861},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0749576985836029},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2778894819","wikidata":"https://www.wikidata.org/wiki/Q922718","display_name":"Sulfonate","level":3,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.7717/peerj.5602","doi":"https://doi.org/10.7717/peerj.5602","is_oa":true,"landing_page_url":"https://doi.org/10.7717/peerj.5602","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5169878","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6216948","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6216948","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6216948","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"Text"},{"id":"pmid:30405966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30405966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"Journal Article"},{"id":"pmh:oai:researchrepository.wvu.edu:faculty_publications-2315","doi":null,"is_oa":false,"landing_page_url":"https://researchrepository.wvu.edu/faculty_publications/1348","pdf_url":null,"source":{"id":"https://openalex.org/S4306402612","display_name":"The Research Repository @ WVU (West Virginia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12097938","host_organization_name":"West Virginia University","host_organization_lineage":["https://openalex.org/I12097938"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty & Staff Scholarship","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ea183c8e8b794d93b019108b170d6c90","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ea183c8e8b794d93b019108b170d6c90","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PeerJ, Vol 6, p e5602 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7717/peerj.5602","doi":"https://doi.org/10.7717/peerj.5602","is_oa":true,"landing_page_url":"https://doi.org/10.7717/peerj.5602","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000871079","display_name":"West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health","funder_award_id":"U54GM104942","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W117749036","https://openalex.org/W1499018970","https://openalex.org/W1936217412","https://openalex.org/W1971448133","https://openalex.org/W1985091939","https://openalex.org/W1987443121","https://openalex.org/W1989431389","https://openalex.org/W1990539669","https://openalex.org/W1993409509","https://openalex.org/W1993650845","https://openalex.org/W1999374666","https://openalex.org/W2018393294","https://openalex.org/W2033751993","https://openalex.org/W2043667147","https://openalex.org/W2047717400","https://openalex.org/W2053696072","https://openalex.org/W2054931112","https://openalex.org/W2063292260","https://openalex.org/W2079379160","https://openalex.org/W2080730934","https://openalex.org/W2083802683","https://openalex.org/W2094156804","https://openalex.org/W2099251250","https://openalex.org/W2107332277","https://openalex.org/W2112558380","https://openalex.org/W2120447865","https://openalex.org/W2131636566","https://openalex.org/W2136043430","https://openalex.org/W2137368585","https://openalex.org/W2143590679","https://openalex.org/W2156890152","https://openalex.org/W2494935722","https://openalex.org/W2522708935","https://openalex.org/W2550296259","https://openalex.org/W2556785995","https://openalex.org/W2560030021","https://openalex.org/W4246863443"],"related_works":["https://openalex.org/W2560030021","https://openalex.org/W2253907336","https://openalex.org/W2016788833","https://openalex.org/W3135226820","https://openalex.org/W3083462072","https://openalex.org/W2318903285","https://openalex.org/W2921867725","https://openalex.org/W2580588788","https://openalex.org/W2010599938","https://openalex.org/W4403262586"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1,112,132],"ranks":[2],"third":[3,289],"among":[4],"the":[5,11,23,32,94,127,227,284,292,310,331],"most":[6],"commonly":[7],"diagnosed":[8],"cancers":[9],"in":[10,47,146,160,220,238,262,280,330,341],"United":[12],"States.":[13],"Current":[14],"therapies":[15,38],"have":[16,196,339],"a":[17,26,48,65,105,144,288],"range":[18,181],"of":[19,25,34,41,60,68,97,130,150,185,223,236,260,327,333],"side":[20],"effects,":[21],"and":[22,64,192,207,247,277,301,336],"development":[24],"reliable":[27],"animal":[28],"model":[29,107,320],"to":[30,78,122,153,164,168,195,215,274,304],"speed":[31],"discovery":[33],"safe":[35],"effective":[36],"preventative":[37],"would":[39],"be":[40,322],"great":[42],"value.":[43],"A":[44,71],"cross-sectional":[45],"study":[46,72],"large":[49],"Appalachian":[50],"population":[51],"recently":[52],"showed":[53],"an":[54,252],"association":[55],"between":[56],"low":[57,206],"circulating":[58],"levels":[59],"perfluorooctane":[61],"sulfonate":[62],"(PFOS)":[63],"reduced":[66],"prevalence":[67],"colorectal":[69,101,111,131,334],"cancer.":[70],"using":[73],"APCmin":[74],"(C57BL/6J-ApcMin/J)":[75],"mice":[76,151,163,186,269],"prone":[77],"familial":[79],"adenomatous":[80],"polyposis":[81],"found":[82],"PFOS":[83,98,142,155,213,241,337],"was":[84,255,295],"protective":[85],"when":[86],"exposure":[87],"occurred":[88],"during":[89,283],"tumor":[90,147,217,293],"development.":[91],"To":[92],"test":[93],"possible":[95],"benefit":[96],"on":[99,200],"spontaneous":[100],"cancer,":[102,335],"we":[103],"developed":[104],"mouse":[106,319],"utilizing":[108],"primary":[109,166],"patient":[110,189,209],"implants":[113],"into":[114],"NSG":[115],"(NOD.Cg-PrkdcscidIl2rgtm1Wjl/Sz)":[116],"mice.":[117],"Study":[118],"goals":[119],"included:":[120],"(1)":[121],"assess":[123],"potential":[124,328],"factors":[125],"supporting":[126],"successful":[128],"use":[129],"from":[133,226],"heterogeneous":[134],"tumors":[135,167,210,271],"for":[136,162,205,257,324],"PDX":[137],"studies;":[138],"and,":[139],"(2)":[140],"evaluate":[141],"as":[143],"therapy":[145],"matched":[148,266,306],"pairs":[149],"randomized":[152],"receive":[154],"or":[156],"vehicle.":[157],"The":[158],"time":[159],"days":[161],"grow":[165],"5":[169,234],"mm":[170],"took":[171],"almost":[172],"2":[173],"months":[174],"(mean":[175],"=":[176,179,182],"53.3,":[177],"se":[178],"5.7,":[180],"17\u2013136).":[183],"Age":[184],"at":[187],"implantation,":[188],"age,":[190],"gender":[191],"race":[193],"appeared":[194,214],"no":[197],"discernable":[198],"effect":[199,253],"engraftment":[201],"rates.":[202],"Engraftment":[203],"rates":[204],"high-grade":[208],"were":[211],"similar.":[212],"reduce":[216],"size":[218,281],"dramatically":[219,296],"one":[221],"group":[222],"tumors,":[224],"those":[225],"right":[228],"ascending":[229],"colon.":[230],"That":[231],"is,":[232],"by":[233],"weeks":[235,259],"treatment":[237,332],"two":[239],"mice,":[240],"had":[242,270],"eliminated":[243],"their":[244,264,305],"52.4":[245],"mm3":[246,249,276,279],"124.6":[248],"masses":[250],"completely,":[251],"that":[254,272,317],"sustained":[256],"10":[258],"treatment;":[261],"contrast,":[263],"corresponding":[265],"vehicle":[267,307],"control":[268],"grew":[273],"472.7":[275],"340.1":[278],"respectively":[282],"same":[285,311],"period.":[286,312],"In":[287],"xenograft":[290],"mouse,":[291],"growth":[294],"blunted":[297],"although":[298],"not":[299],"eliminated,":[300],"compared":[302],"favorably":[303],"controls":[308],"over":[309],"These":[313],"preliminary":[314],"findings":[315],"suggested":[316],"this":[318],"may":[321,338],"advantageous":[323],"testing":[325],"compounds":[326],"value":[329],"utility":[340],"selected":[342],"cases.":[343]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-11-09T00:00:00"}