{"id":"https://openalex.org/W2899009485","doi":"https://doi.org/10.1007/s12325-018-0819-5","title":"Addressing Clinical Inertia in Type 2 Diabetes Mellitus: A Review","display_name":"Addressing Clinical Inertia in Type 2 Diabetes Mellitus: A Review","publication_year":2018,"publication_date":"2018-10-29","ids":{"openalex":"https://openalex.org/W2899009485","doi":"https://doi.org/10.1007/s12325-018-0819-5","mag":"2899009485","pmid":"https://pubmed.ncbi.nlm.nih.gov/30374807","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6223992"},"language":"en","primary_location":{"id":"doi:10.1007/s12325-018-0819-5","doi":"https://doi.org/10.1007/s12325-018-0819-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12325-018-0819-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12325-018-0819-5.pdf","source":{"id":"https://openalex.org/S27230875","display_name":"Advances in Therapy","issn_l":"0741-238X","issn":["0741-238X","1865-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s12325-018-0819-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011413653","display_name":"Jennifer Okemah","orcid":"https://orcid.org/0000-0003-1858-3040","observed_orcids":["https://orcid.org/0000-0003-1858-3040"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jennifer Okemah","raw_affiliation_strings":["Western Washington Medical Group, Diabetes and Nutrition Education, Bothell, WA, USA. jenoke@comcast.net","Western Washington Medical Group, Diabetes and Nutrition Education, Bothell, WA, USA"],"raw_orcid":"https://orcid.org/0000-0003-1858-3040","affiliations":[{"raw_affiliation_string":"Western Washington Medical Group, Diabetes and Nutrition Education, Bothell, WA, USA. jenoke@comcast.net","institution_ids":[]},{"raw_affiliation_string":"Western Washington Medical Group, Diabetes and Nutrition Education, Bothell, WA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045730125","display_name":"John Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162580","display_name":"Virginia Mason Lynnwood Medical Center","ror":"https://ror.org/05fb1yp60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4210162580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Peng","raw_affiliation_strings":["Virginia Mason Medical Center, Lynnwood, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Mason Medical Center, Lynnwood, WA, USA","institution_ids":["https://openalex.org/I4210162580"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007479250","display_name":"Manuel J. Qui\u00f1ones","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manuel Qui\u00f1ones","raw_affiliation_strings":["HealthCare Partners, Anaheim, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HealthCare Partners, Anaheim, CA, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011413653"],"corresponding_institution_ids":[],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":3.2061,"has_fulltext":true,"cited_by_count":221,"citation_normalized_percentile":{"value":0.95392749,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"35","issue":"11","first_page":"1735","last_page":"1745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10793","display_name":"Diabetes Management and Education","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9660000205039978},{"id":"https://openalex.org/keywords/clinical-inertia","display_name":"clinical inertia","score":0.9679999947547913},{"id":"https://openalex.org/keywords/therapeutic-inertia","display_name":"therapeutic inertia","score":0.9129999876022339},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.9950000047683716},{"id":"https://openalex.org/keywords/treatment-intensification","display_name":"treatment intensification","score":0.7649999856948853},{"id":"https://openalex.org/keywords/antihyperglycemic-medications","display_name":"antihyperglycemic medications","score":0.8519999980926514},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.8999999761581421},{"id":"https://openalex.org/keywords/barriers-to-care","display_name":"barriers to care","score":0.6159999966621399},{"id":"https://openalex.org/keywords/patient-care","display_name":"patient care","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9489659070968628},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.6876205205917358},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5870801210403442},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5822662711143494},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5345059633255005},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.340501070022583},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16951203346252441}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061665","descriptor_name":"Time-to-Treatment","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s12325-018-0819-5","doi":"https://doi.org/10.1007/s12325-018-0819-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12325-018-0819-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12325-018-0819-5.pdf","source":{"id":"https://openalex.org/S27230875","display_name":"Advances in Therapy","issn_l":"0741-238X","issn":["0741-238X","1865-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5202249","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6223992","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6223992","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6223992","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Ther","raw_type":"Text"},{"id":"pmid:30374807","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30374807","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s12325-018-0819-5","doi":"https://doi.org/10.1007/s12325-018-0819-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12325-018-0819-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12325-018-0819-5.pdf","source":{"id":"https://openalex.org/S27230875","display_name":"Advances in Therapy","issn_l":"0741-238X","issn":["0741-238X","1865-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2899009485.pdf","grobid_xml":"https://content.openalex.org/works/W2899009485.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W144619522","https://openalex.org/W1553795439","https://openalex.org/W1556195576","https://openalex.org/W1613501644","https://openalex.org/W1964959186","https://openalex.org/W1997746831","https://openalex.org/W1999765386","https://openalex.org/W2022069934","https://openalex.org/W2046954222","https://openalex.org/W2059158127","https://openalex.org/W2064097337","https://openalex.org/W2070309137","https://openalex.org/W2075035869","https://openalex.org/W2075717569","https://openalex.org/W2079833621","https://openalex.org/W2096532988","https://openalex.org/W2097269681","https://openalex.org/W2099468119","https://openalex.org/W2117624309","https://openalex.org/W2123862325","https://openalex.org/W2123946565","https://openalex.org/W2126862523","https://openalex.org/W2128877551","https://openalex.org/W2132662207","https://openalex.org/W2133940413","https://openalex.org/W2144732984","https://openalex.org/W2149896325","https://openalex.org/W2166393441","https://openalex.org/W2175304727","https://openalex.org/W2226954704","https://openalex.org/W2287869177","https://openalex.org/W2340250892","https://openalex.org/W2404273804","https://openalex.org/W2493860075","https://openalex.org/W2521422828","https://openalex.org/W2529901556","https://openalex.org/W2591702989","https://openalex.org/W2595339385","https://openalex.org/W2610395923","https://openalex.org/W2610405354","https://openalex.org/W2615515448","https://openalex.org/W2624778660","https://openalex.org/W2653457112","https://openalex.org/W2731777658","https://openalex.org/W2736830708","https://openalex.org/W2738595939","https://openalex.org/W2739009446","https://openalex.org/W2748858803","https://openalex.org/W2792546087","https://openalex.org/W2795700244","https://openalex.org/W2800977298","https://openalex.org/W2916996193","https://openalex.org/W2917198334"],"related_works":["https://openalex.org/W1556195576","https://openalex.org/W4316469640","https://openalex.org/W2738595939","https://openalex.org/W2563198690","https://openalex.org/W2094524041","https://openalex.org/W4391215080","https://openalex.org/W2916401318","https://openalex.org/W2943649752","https://openalex.org/W2026068973","https://openalex.org/W17336522"],"abstract_inverted_index":{"The":[0],"current":[1],"epidemic":[2],"of":[3,19,49,83,96,113,122,160,170,210,217],"type":[4],"2":[5],"diabetes":[6,20,42],"(T2D)":[7],"represents":[8],"a":[9,139,181,228],"significant":[10],"global":[11],"and":[12,25,87,94,105,116,173,188,219],"national":[13],"health":[14],"concern.":[15],"Globally,":[16],"the":[17,29,45,47,69,80,92,108,111,120,158,214],"prevalence":[18],"has":[21],"doubled":[22],"between":[23,184],"1980":[24],"2014.":[26],"In":[27,44,203],"2014":[28],"World":[30],"Health":[31],"Organization":[32],"estimated":[33,55],"that":[34,192,225],"there":[35],"were":[36],"422":[37],"million":[38,61],"adults":[39],"living":[40],"with":[41,52,124],"worldwide.":[43],"USA,":[46],"number":[48],"people":[50,123],"diagnosed":[51],"T2D":[53,86,125,218],"is":[54,76,88,138],"to":[56,58,128,133,149,194],"increase":[57,109],"over":[59],"70":[60],"by":[62],"2050,":[63],"putting":[64],"an":[65,208],"immense":[66],"strain":[67],"on":[68,231],"US":[70],"healthcare":[71,186,189],"system.":[72],"Achieving":[73],"glycemic":[74,130,146],"control":[75],"widely":[77],"acknowledged":[78],"as":[79,100,150,200],"key":[81],"goal":[82],"treatment":[84,118,142],"in":[85,110,141,213],"critical":[89],"for":[90,222],"reducing":[91],"onset":[93],"progression":[95],"diabetes-related":[97],"complications":[98,172],"such":[99],"cardiovascular":[101],"diseases,":[102],"neuropathies,":[103],"retinopathies,":[104],"nephropathies.":[106],"Despite":[107],"availability":[112],"antihyperglycemic":[114],"medications":[115],"evidence-based":[117],"guidelines,":[119],"proportion":[121],"who":[126],"fail":[127],"achieve":[129],"goals":[131],"continues":[132],"rise.":[134],"One":[135],"major":[136],"contributor":[137],"delay":[140],"intensification":[143],"despite":[144],"suboptimal":[145],"control,":[147],"referred":[148],"clinical":[151,211,215],"or":[152],"therapeutic":[153],"inertia.":[154],"Clinical":[155,177],"inertia":[156,178,212],"prolongs":[157],"duration":[159],"patients'":[161],"hyperglycemia":[162],"which":[163],"subsequently":[164],"puts":[165],"them":[166],"at":[167],"increased":[168],"risk":[169],"diabetes-associated":[171],"reduced":[174],"life":[175],"expectancy.":[176],"results":[179],"from":[180],"complex":[182],"interaction":[183],"patient,":[185],"providers,":[187],"system":[190],"barriers":[191],"need":[193],"be":[195],"addressed":[196],"together,":[197],"rather":[198],"than":[199],"separate":[201],"entities.":[202],"this":[204],"article":[205],"we":[206],"provide":[207,220],"overview":[209],"management":[216],"suggestions":[221],"overcoming":[223],"aspects":[224],"may":[226],"have":[227],"negative":[229],"impact":[230],"patient":[232],"care.Funding:":[233],"Sanofi":[234],"US,":[235],"Inc.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":36},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":48},{"year":2020,"cited_by_count":31},{"year":2019,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-11-09T00:00:00"}