{"id":"https://openalex.org/W2898740459","doi":"https://doi.org/10.20944/preprints201809.0406.v1","title":"RNA Sequence Analysis Reveals Expected and Novel Immuno-Modulatory Activities by Sutherlandia frutescens","display_name":"RNA Sequence Analysis Reveals Expected and Novel Immuno-Modulatory Activities by Sutherlandia frutescens","publication_year":2018,"publication_date":"2018-09-20","ids":{"openalex":"https://openalex.org/W2898740459","doi":"https://doi.org/10.20944/preprints201809.0406.v1","mag":"2898740459"},"language":"en","primary_location":{"id":"doi:10.20944/preprints201809.0406.v1","doi":"https://doi.org/10.20944/preprints201809.0406.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints201809.0406.v1","pdf_url":"https://www.preprints.org/manuscript/201809.0406/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.preprints.org/manuscript/201809.0406/v1/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024283686","display_name":"Wei Lei","orcid":"https://orcid.org/0000-0002-0374-8642","observed_orcids":["https://orcid.org/0000-0002-0374-8642"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Lei","raw_affiliation_strings":["Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA"],"raw_orcid":"https://orcid.org/0000-0002-0374-8642","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100672889","display_name":"Yuan L\u00fc","orcid":"https://orcid.org/0000-0002-2420-4804","observed_orcids":["https://orcid.org/0000-0002-2420-4804"]},"institutions":[{"id":"https://openalex.org/I13511017","display_name":"Texas State University","ror":"https://ror.org/05h9q1g27","country_code":"US","type":"education","lineage":["https://openalex.org/I13511017"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuan Lu","raw_affiliation_strings":["Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA","Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666, USA","institution_ids":["https://openalex.org/I13511017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022495891","display_name":"Jie Hou","orcid":"https://orcid.org/0000-0002-8584-5154","observed_orcids":["https://orcid.org/0000-0002-8584-5154","https://orcid.org/0009-0003-2250-0532"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Hou","raw_affiliation_strings":["Department of Computer Science, University of Missouri, Columbia, MO 65211, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Missouri, Columbia, MO 65211, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418423","display_name":"Chen Chen","orcid":"https://orcid.org/0000-0002-2973-461X","observed_orcids":["https://orcid.org/0000-0002-2973-461X"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Chen","raw_affiliation_strings":["Department of Computer Science, University of Missouri, Columbia, MO 65211, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Missouri, Columbia, MO 65211, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103980185","display_name":"Jimmy D. Browning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jimmy D. Browning","raw_affiliation_strings":["Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109058217","display_name":"Dennis B. Lubahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis B. Lubahn","raw_affiliation_strings":["Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044354277","display_name":"Jianlin Jack Cheng","orcid":"https://orcid.org/0000-0003-0305-2853","observed_orcids":["https://orcid.org/0000-0003-0305-2853"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianlin Cheng","raw_affiliation_strings":["Department of Computer Science, University of Missouri, Columbia, MO 65211, USA","Department of Pharmacology 1501 N Campbell Ave , PO Box 245050 University of Arizona Tucson , AZ 85716"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Missouri, Columbia, MO 65211, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Pharmacology 1501 N Campbell Ave , PO Box 245050 University of Arizona Tucson , AZ 85716","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080764909","display_name":"William R. Folk","orcid":"https://orcid.org/0000-0003-2216-3233","observed_orcids":["https://orcid.org/0000-0003-2216-3233"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Folk","raw_affiliation_strings":["Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101578487","display_name":"Grace Y. Sun","orcid":"https://orcid.org/0000-0003-4303-0317","observed_orcids":["https://orcid.org/0000-0003-4303-0317"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Y. Sun","raw_affiliation_strings":["Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043281277","display_name":"Kevin L. Fritsche","orcid":"https://orcid.org/0000-0002-0740-3801","observed_orcids":["https://orcid.org/0000-0002-0740-3801"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin L. Fritsche","raw_affiliation_strings":["Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USA"],"raw_orcid":"https://orcid.org/0000-0002-0740-3801","affiliations":[{"raw_affiliation_string":"Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USA","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024283686"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.6801999807357788,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.6801999807357788,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.06710000336170197,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.06499999761581421,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sutherlandia-frutescens","display_name":"Sutherlandia frutescens","score":1.0},{"id":"https://openalex.org/keywords/ethanol-extract","display_name":"ethanol extract","score":0.777999997138977},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8019999861717224},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.9779999852180481},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8019999861717224},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.824999988079071},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.7310000061988831},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6314436197280884},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5057761669158936},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5051968693733215},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4830377995967865},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47094476222991943},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4630688726902008},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.44202721118927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4352865219116211},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32670217752456665},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.32628002762794495},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3249335289001465},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3239843249320984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2759334444999695},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25698474049568176},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25123685598373413},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23449668288230896},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19261571764945984},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints201809.0406.v1","doi":"https://doi.org/10.20944/preprints201809.0406.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints201809.0406.v1","pdf_url":"https://www.preprints.org/manuscript/201809.0406/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints201809.0406.v1","doi":"https://doi.org/10.20944/preprints201809.0406.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints201809.0406.v1","pdf_url":"https://www.preprints.org/manuscript/201809.0406/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7200000286102295,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2322689132","display_name":null,"funder_award_id":"P50AT006273","funder_id":"https://openalex.org/F4320306096","funder_display_name":"Office of Dietary Supplements"},{"id":"https://openalex.org/G6669598133","display_name":"Mu Center for Botanical Interaction Studies","funder_award_id":"P50AT006273","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"}],"funders":[{"id":"https://openalex.org/F4320306096","display_name":"Office of Dietary Supplements","ror":"https://ror.org/01wtjyf13"},{"id":"https://openalex.org/F4320309568","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2898740459.pdf","grobid_xml":"https://content.openalex.org/works/W2898740459.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W30096994","https://openalex.org/W624645021","https://openalex.org/W1940255384","https://openalex.org/W1965685424","https://openalex.org/W1981509058","https://openalex.org/W1982671249","https://openalex.org/W1983688604","https://openalex.org/W1984230217","https://openalex.org/W1995744610","https://openalex.org/W1997413924","https://openalex.org/W2001601251","https://openalex.org/W2011291876","https://openalex.org/W2019922403","https://openalex.org/W2036832724","https://openalex.org/W2037092974","https://openalex.org/W2040223721","https://openalex.org/W2045252000","https://openalex.org/W2045949302","https://openalex.org/W2047512700","https://openalex.org/W2050345155","https://openalex.org/W2054472394","https://openalex.org/W2055727614","https://openalex.org/W2060968567","https://openalex.org/W2063316417","https://openalex.org/W2065519379","https://openalex.org/W2079859967","https://openalex.org/W2101735289","https://openalex.org/W2104738156","https://openalex.org/W2110065044","https://openalex.org/W2111412534","https://openalex.org/W2115185894","https://openalex.org/W2115206594","https://openalex.org/W2132822330","https://openalex.org/W2133579817","https://openalex.org/W2141224543","https://openalex.org/W2159675211","https://openalex.org/W2172518098","https://openalex.org/W2201941377","https://openalex.org/W2345571716","https://openalex.org/W2414061256","https://openalex.org/W2462996439","https://openalex.org/W2510592145","https://openalex.org/W2519159259","https://openalex.org/W2537623931","https://openalex.org/W2792382948","https://openalex.org/W2800486018"],"related_works":["https://openalex.org/W2475806954","https://openalex.org/W2548292511","https://openalex.org/W2172518098","https://openalex.org/W624645021","https://openalex.org/W3171712287","https://openalex.org/W2108478491","https://openalex.org/W2792287520","https://openalex.org/W2031406225","https://openalex.org/W3164302524","https://openalex.org/W2510592145"],"abstract_inverted_index":{"Sutherlandia":[0],"frutescens":[1,36,60,170],"(S.":[2],"frutescens)":[3],"has":[4],"been":[5],"traditionally":[6],"used":[7],"as":[8,20,22,116,121,123],"an":[9,56,176],"herbal":[10],"medicine":[11],"to":[12,30,65,92,106],"ameliorate":[13],"symptoms":[14],"associated":[15,126],"with":[16,55,68,127,139],"cancer,":[17],"infectious":[18],"diseases,":[19],"well":[21,122],"inflammation.":[23],"The":[24],"objective":[25],"of":[26,34,40,58,79,97,144,150,154,168],"this":[27,155,160],"investigation":[28],"was":[29,90],"explore":[31],"the":[32,38,66,77,87,95,151,162,166],"impact":[33,167],"S.":[35,59,169],"on":[37,165,171],"expression":[39,78,174],"genes":[41,81,98],"in":[42,82,175],"a":[43],"murine":[44],"macrophage":[45],"cell":[46,178],"line":[47],"(i.e.,":[48],"RAW":[49,83],"264.7).":[50],"We":[51],"found":[52],"that":[53,99,111],"treatment":[54],"ethanolic-extract":[57],"(SFE)":[61],"1":[62],"h":[63,74],"prior":[64],"stimulation":[67],"LPS":[69],"and":[70,119,146],"IFN\u03b3":[71],"for":[72],"24":[73],"significantly":[75,101],"affected":[76],"715":[80],"264.7":[84],"cells.":[85],"When":[86],"post-stimulation":[88],"period":[89],"shortened":[91],"8":[93],"h,":[94],"number":[96],"were":[100,130],"impacted":[102],"by":[103,132],"SFE":[104,133,145],"diminished":[105],"50.":[107],"Pathway":[108],"analysis":[109],"revealed":[110],"inflammatory":[112],"signaling":[113,124],"pathways,":[114],"such":[115],"NF-\u03baB,":[117],"MAPK,":[118],"TNF,":[120],"pathways":[125],"immune-related":[128],"responses,":[129],"inhibited":[131],"treatment.":[134],"These":[135],"findings":[136],"are":[137],"consistent":[138],"previously":[140],"reported":[141],"anti-inflammatory":[142],"activity":[143],"enable":[147],"better":[148],"understanding":[149],"immune-modulating":[152],"properties":[153],"botanical.":[156],"To":[157],"our":[158],"knowledge,":[159],"represents":[161],"first":[163],"report":[164],"global":[172],"gene":[173],"immune":[177],"population.":[179]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-11-09T00:00:00"}