{"id":"https://openalex.org/W2898727376","doi":null,"title":"Abstract 15784: Impact of SLCO1B1 Genotype on Pediatric Simvastatin Pharmacokinetics","display_name":"Abstract 15784: Impact of SLCO1B1 Genotype on Pediatric Simvastatin Pharmacokinetics","publication_year":2016,"publication_date":"2016-11-11","ids":{"openalex":"https://openalex.org/W2898727376","mag":"2898727376"},"language":"en","primary_location":{"id":"mag:2898727376","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.134.suppl_1.15784","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063675300","display_name":"Jonathan B. Wagner","orcid":"https://orcid.org/0000-0001-7690-6798","observed_orcids":["https://orcid.org/0000-0001-7690-6798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan B. Wagner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7690-6798","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000952484","display_name":"Susan M. Abdel\u2010Rahman","orcid":"https://orcid.org/0000-0002-5815-2029","observed_orcids":["https://orcid.org/0000-0002-5815-2029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan M. Abdel\u2010Rahman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5815-2029","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055843195","display_name":"Leon van Haandel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leon van Haandel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001681968","display_name":"Andrea Gaedigk","orcid":"https://orcid.org/0000-0001-6968-1893","observed_orcids":["https://orcid.org/0000-0001-6968-1893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Gaedigk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6968-1893","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048345455","display_name":"Roger Gaedigk","orcid":"https://orcid.org/0000-0001-5942-1609","observed_orcids":["https://orcid.org/0000-0001-5942-1609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roger Gaedigk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5942-1609","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037411420","display_name":"Geetha Raghuveer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geetha Raghuveer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020748297","display_name":"Ralph E. Kauffman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph E. Kauffman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Jane Leeder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jane Leeder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/slco1b1","display_name":"SLCO1B1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.6639999747276306},{"id":"https://openalex.org/keywords/pediatric-pharmacokinetics","display_name":"pediatric pharmacokinetics","score":0.902999997138977},{"id":"https://openalex.org/keywords/simvastatin-acid","display_name":"simvastatin acid","score":0.8880000114440918},{"id":"https://openalex.org/keywords/hepatic-cholesterol-synthesis","display_name":"hepatic cholesterol synthesis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.5580000281333923},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9611883163452148},{"id":"https://openalex.org/C2776598434","wikidata":"https://www.wikidata.org/wiki/Q18035517","display_name":"SLCO1B1","level":5,"score":0.767448902130127},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7156450748443604},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.7012455463409424},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4932522177696228},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.48950040340423584},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.43032246828079224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3586313724517822},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12486961483955383},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0826273262500763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2898727376","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.134.suppl_1.15784","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4249964811","https://openalex.org/W2948741418","https://openalex.org/W2314842092","https://openalex.org/W3000721237","https://openalex.org/W2156173568","https://openalex.org/W4395039602","https://openalex.org/W4410995055","https://openalex.org/W2428761922","https://openalex.org/W2142436506","https://openalex.org/W2434027658"],"abstract_inverted_index":{"Background:":[0],"Simvastatin":[1],"(SV)":[2],"is":[3],"administered":[4],"as":[5],"a":[6],"lactone":[7],"prodrug":[8],"requiring":[9],"hydrolysis":[10],"to":[11,18],"its":[12],"active":[13],"moiety,":[14],"simvastatin":[15],"acid":[16],"(SA),":[17],"disrupt":[19],"hepatic":[20],"cholesterol":[21],"biosynthesis.":[22],"In":[23],"adults,":[24],"allelic":[25],"v...":[26]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2018-11-09T00:00:00"}